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Aliases for PRSS21 Gene

Aliases for PRSS21 Gene

  • Protease, Serine 21 2 3 5
  • Eosinophil Serine Protease 1 3 4
  • ESP-1 3 4
  • TEST1 3 4
  • ESP1 3 4
  • Serine Protease From Eosinophils 3
  • Protease, Serine, 21 (Testisin) 3
  • Serine Protease 21 4
  • EC 3.4.21.- 4
  • EC 3.4.21 63
  • Testisin 2
  • TESTISIN 3

External Ids for PRSS21 Gene

Previous GeneCards Identifiers for PRSS21 Gene

  • GC16P002887
  • GC16P002867
  • GC16P002807
  • GC16P002833

Summaries for PRSS21 Gene

Entrez Gene Summary for PRSS21 Gene

  • This gene encodes a cell-surface anchored serine protease, which is a member of the trypsin family of serine proteases. The encoded protein is predicted to be active on peptide linkages involving the carboxyl group of lysine or arginine. The encoded protein localizes to the cytoplasm and the plasma membrane of premeiotic testicular germ cells and may be involved in progression of testicular tumors of germ cell origin. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for PRSS21 Gene

PRSS21 (Protease, Serine 21) is a Protein Coding gene. Diseases associated with PRSS21 include dracunculiasis. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is TPSAB1.

UniProtKB/Swiss-Prot for PRSS21 Gene

  • Could regulate proteolytic events associated with testicular germ cell maturation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS21 Gene

Genomics for PRSS21 Gene

Regulatory Elements for PRSS21 Gene

Enhancers for PRSS21 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRSS21 on UCSC Golden Path with GeneCards custom track

Promoters for PRSS21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRSS21 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRSS21 Gene

Chromosome:
16
Start:
2,817,163 bp from pter
End:
2,826,304 bp from pter
Size:
9,142 bases
Orientation:
Plus strand

Genomic View for PRSS21 Gene

Genes around PRSS21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS21 Gene

Proteins for PRSS21 Gene

  • Protein details for PRSS21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6M0-TEST_HUMAN
    Recommended name:
    Testisin
    Protein Accession:
    Q9Y6M0
    Secondary Accessions:
    • Q9NS34
    • Q9P2V6

    Protein attributes for PRSS21 Gene

    Size:
    314 amino acids
    Molecular mass:
    34884 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PRSS21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRSS21 Gene

Proteomics data for PRSS21 Gene at MOPED

Selected DME Specific Peptides for PRSS21 Gene

Post-translational modifications for PRSS21 Gene

  • Glycosylation at Asn 167, Asn 200, and Asn 273
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for PRSS21 (Testisin/Prss21)

Domains & Families for PRSS21 Gene

Gene Families for PRSS21 Gene

Suggested Antigen Peptide Sequences for PRSS21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6M0

UniProtKB/Swiss-Prot:

TEST_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS21: view

Function for PRSS21 Gene

Molecular function for PRSS21 Gene

GENATLAS Biochemistry:
protease serine 21,testisin,abundantly expressed in the testis and in testicular tumors,see TSG16D (role in progression of testicular tumor of germ cell origin)
UniProtKB/Swiss-Prot Function:
Could regulate proteolytic events associated with testicular germ cell maturation.

Enzyme Numbers (IUBMB) for PRSS21 Gene

genes like me logo Genes that share phenotypes with PRSS21: view

Animal Models for PRSS21 Gene

MGI Knock Outs for PRSS21:

Animal Model Products

  • Taconic Biosciences Mouse Models for PRSS21

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRSS21 Gene

Localization for PRSS21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS21 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRSS21 Gene COMPARTMENTS Subcellular localization image for PRSS21 gene
Compartment Confidence
plasma membrane 4
extracellular 3
cytosol 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PRSS21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 10397266
genes like me logo Genes that share ontologies with PRSS21: view

Pathways & Interactions for PRSS21 Gene

SuperPathways for PRSS21 Gene

No Data Available

SIGNOR curated interactions for PRSS21 Gene

Activates:

Gene Ontology (GO) - Biological Process for PRSS21 Gene

None

No data available for Pathways by source for PRSS21 Gene

Drugs & Compounds for PRSS21 Gene

(2) Drugs for PRSS21 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
PMSF Pharma Serine proteinases inhibitor, irreversible 0

(1) ApexBio Compounds for PRSS21 Gene

Compound Action Cas Number
PMSF Serine proteinases inhibitor, irreversible 329-98-6
genes like me logo Genes that share compounds with PRSS21: view

Transcripts for PRSS21 Gene

Unigene Clusters for PRSS21 Gene

Protease, serine, 21 (testisin):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS21 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d
SP1: - -
SP2: -
SP3: - - -
SP4: -
SP5: -
SP6:

Relevant External Links for PRSS21 Gene

GeneLoc Exon Structure for
PRSS21
ECgene alternative splicing isoforms for
PRSS21

Expression for PRSS21 Gene

mRNA expression in normal human tissues for PRSS21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRSS21 Gene

This gene is overexpressed in Testis (x34.4).

Protein differential expression in normal tissues from HIPED for PRSS21 Gene

This gene is overexpressed in Testis (40.7) and Ovary (28.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRSS21 Gene



SOURCE GeneReport for Unigene cluster for PRSS21 Gene Hs.72026

mRNA Expression by UniProt/SwissProt for PRSS21 Gene

Q9Y6M0-TEST_HUMAN
Tissue specificity: Expressed predominantly in premeiotic testicular germ cells, mostly late pachytene and diplotene spermatocytes.
genes like me logo Genes that share expression patterns with PRSS21: view

Protein tissue co-expression partners for PRSS21 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for PRSS21 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRSS21 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRSS21 35
  • 74.43 (n)
  • 65.95 (a)
PRSS21 36
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRSS21 35
  • 76.21 (n)
  • 67.56 (a)
-- 36
  • 25 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Prss21 35
  • 72.72 (n)
  • 68.84 (a)
Prss21 16
Prss21 36
  • 63 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRSS21 35
  • 99.28 (n)
  • 99.28 (a)
PRSS21 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prss21 35
  • 73.45 (n)
  • 69.12 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 35 (a)
OneToMany
-- 36
  • 38 (a)
OneToMany
-- 36
  • 40 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 38 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11824 37
  • 38 (a)
CG13744 37
  • 31 (a)
CG8170 37
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea ZK546.15 37
  • 33 (a)
Species with no ortholog for PRSS21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for PRSS21 Gene

ENSEMBL:
Gene Tree for PRSS21 (if available)
TreeFam:
Gene Tree for PRSS21 (if available)

Paralogs for PRSS21 Gene

Pseudogenes.org Pseudogenes for PRSS21 Gene

genes like me logo Genes that share paralogs with PRSS21: view

Variants for PRSS21 Gene

Sequence variations from dbSNP and Humsavar for PRSS21 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs2072273 - 2,821,451(-) TGGGC(C/T)GACCA nc-transcript-variant, reference, missense, utr-variant-3-prime
rs10641 -- 2,821,554(+) TGGCC(A/G)CTACT nc-transcript-variant, reference, synonymous-codon, utr-variant-3-prime
rs62035373 -- 2,815,644(+) CCTTG(A/C)GCAGC upstream-variant-2KB
rs62035374 -- 2,817,447(+) CGGCG(A/C)CGTTA nc-transcript-variant, reference, missense
rs62035375 -- 2,822,115(+) TAGGT(C/G)CAGGT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for PRSS21 Gene

Variant ID Type Subtype PubMed ID
nsv905152 CNV Loss 21882294
dgv793e1 CNV Complex 17122850
nsv905162 CNV Gain 21882294
nsv905165 CNV Loss 21882294
dgv2573n71 CNV Loss 21882294
nsv905169 CNV Loss 21882294
nsv905170 CNV Loss 21882294
nsv905173 CNV Loss 21882294

Variation tolerance for PRSS21 Gene

Residual Variation Intolerance Score: 61.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.99; 49.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRSS21 Gene

HapMap Linkage Disequilibrium report
PRSS21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS21 Gene

Disorders for PRSS21 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRSS21 Gene - From: DISEASES

Disorder Aliases PubMed IDs
dracunculiasis
  • dracontiasis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PRSS21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRSS21
genes like me logo Genes that share disorders with PRSS21: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRSS21 Gene

Publications for PRSS21 Gene

  1. Testisin, a new human serine proteinase expressed by premeiotic testicular germ cells and lost in testicular germ cell tumors. (PMID: 10397266) Hooper J.D. … Antalis T.M. (Cancer Res. 1999) 2 3 4 23 67
  2. The glycosylphosphatidylinositol-anchored serine protease PRSS21 (testisin) imparts murine epididymal sperm cell maturation and fertilizing ability. (PMID: 19571264) Netzel-Arnett S. … Antalis T.M. (Biol. Reprod. 2009) 3 23
  3. Epigenetic silencing of the putative tumor suppressor gene testisin in testicular germ cell tumors. (PMID: 16810501) Kempkensteffen C. … Schrader M. (J. Cancer Res. Clin. Oncol. 2006) 3 23
  4. Hypermethylation of the 5' CpG island of the gene encoding the serine protease Testisin promotes its loss in testicular tumorigenesis. (PMID: 15685234) Manton K.J. … Antalis T.M. (Br. J. Cancer 2005) 3 23
  5. Localization, expression and genomic structure of the gene encoding the human serine protease testisin. (PMID: 11004480) Hooper J.D. … Antalis T.M. (Biochim. Biophys. Acta 2000) 3 23

Products for PRSS21 Gene

Sources for PRSS21 Gene

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