Aliases for PRSS21 Gene
External Ids for PRSS21 Gene
Previous GeneCards Identifiers for PRSS21 Gene
This gene encodes a cell-surface anchored serine protease, which is a member of the trypsin family of serine proteases. The encoded protein is predicted to be active on peptide linkages involving the carboxyl group of lysine or arginine. The encoded protein localizes to the cytoplasm and the plasma membrane of premeiotic testicular germ cells and may be involved in progression of testicular tumors of germ cell origin. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for PRSS21 Gene
PRSS21 (Protease, Serine, 21 (Testisin)) is a Protein Coding gene. Diseases associated with PRSS21 include late congenital syphilis and hypertropia. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is TPSAB1.
UniProtKB/Swiss-Prot for PRSS21 Gene
Could regulate proteolytic events associated with testicular germ cell maturation