Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PRSS21 Gene

Aliases for PRSS21 Gene

  • Protease, Serine 21 2 3 5
  • Eosinophil Serine Protease 1 3 4
  • Testisin 2 3
  • ESP-1 3 4
  • TEST1 3 4
  • ESP1 3 4
  • Serine Protease From Eosinophils 3
  • Serine Protease 21 4
  • EC 3.4.21.- 4
  • EC 3.4.21 61

External Ids for PRSS21 Gene

Previous GeneCards Identifiers for PRSS21 Gene

  • GC16P002887
  • GC16P002867
  • GC16P002807
  • GC16P002833
  • GC16P002823
  • GC16P002834

Summaries for PRSS21 Gene

Entrez Gene Summary for PRSS21 Gene

  • This gene encodes a cell-surface anchored serine protease, which is a member of the trypsin family of serine proteases. The encoded protein is predicted to be active on peptide linkages involving the carboxyl group of lysine or arginine. The encoded protein localizes to the cytoplasm and the plasma membrane of premeiotic testicular germ cells and may be involved in progression of testicular tumors of germ cell origin. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for PRSS21 Gene

PRSS21 (Protease, Serine 21) is a Protein Coding gene. Diseases associated with PRSS21 include Dracunculiasis and Loiasis. Among its related pathways are Post-translational modification- synthesis of GPI-anchored proteins and Metabolism of proteins. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is PRSS41.

UniProtKB/Swiss-Prot for PRSS21 Gene

  • Could regulate proteolytic events associated with testicular germ cell maturation.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS21 Gene

Genomics for PRSS21 Gene

Regulatory Elements for PRSS21 Gene

Enhancers for PRSS21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G002816 1.2 ENCODE 0.7 +0.4 364 1.7 CREB3L1 MLX DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 MEF2D ZNF610 ZNF598 ZNF263 LOC106660606 TRAF7 ENSG00000255513 SNORA64 LOC105371055 THOC6 SNORD60 ENSG00000260095
GH16G002799 1.2 Ensembl ENCODE 0.4 -17.2 -17213 1.7 PKNOX1 FOXA2 SIN3A FEZF1 ZNF2 FOS ZNF548 ZHX2 TSHZ1 ZNF518A ZNF263 SNORA64 LOC105371055 ENSG00000255513 ZNF597 THOC6 ZNF598 GC16M002791 PRSS21
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRSS21 on UCSC Golden Path with GeneCards custom track

Promoters for PRSS21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082549 337 601 TBP HDAC1 ATF1 RB1 SIN3A ZBTB40 ZNF335 EGR1 SMARCC1 HCFC1

Genomic Location for PRSS21 Gene

Chromosome:
16
Start:
2,817,163 bp from pter
End:
2,826,304 bp from pter
Size:
9,142 bases
Orientation:
Plus strand

Genomic View for PRSS21 Gene

Genes around PRSS21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS21 Gene

Proteins for PRSS21 Gene

  • Protein details for PRSS21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6M0-TEST_HUMAN
    Recommended name:
    Testisin
    Protein Accession:
    Q9Y6M0
    Secondary Accessions:
    • Q9NS34
    • Q9P2V6

    Protein attributes for PRSS21 Gene

    Size:
    314 amino acids
    Molecular mass:
    34884 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PRSS21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRSS21 Gene

Selected DME Specific Peptides for PRSS21 Gene

Q9Y6M0:
  • GDSGGPL
  • CWVTGWG
  • LTAAHCF

Post-translational modifications for PRSS21 Gene

  • Glycosylation at isoforms=2, 3167, Asn200, and Asn273
  • Modification sites at PhosphoSitePlus

Domains & Families for PRSS21 Gene

Gene Families for PRSS21 Gene

Suggested Antigen Peptide Sequences for PRSS21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6M0

UniProtKB/Swiss-Prot:

TEST_HUMAN :
  • Belongs to the peptidase S1 family.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS21: view

Function for PRSS21 Gene

Molecular function for PRSS21 Gene

GENATLAS Biochemistry:
protease serine 21,testisin,abundantly expressed in the testis and in testicular tumors,see TSG16D (role in progression of testicular tumor of germ cell origin)
UniProtKB/Swiss-Prot Function:
Could regulate proteolytic events associated with testicular germ cell maturation.

Enzyme Numbers (IUBMB) for PRSS21 Gene

Gene Ontology (GO) - Molecular Function for PRSS21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 20211623
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA,TAS 10397266
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PRSS21: view
genes like me logo Genes that share phenotypes with PRSS21: view

Animal Models for PRSS21 Gene

MGI Knock Outs for PRSS21:

Animal Model Products

  • Taconic Biosciences Mouse Models for PRSS21

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRSS21 Gene

Localization for PRSS21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS21 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRSS21 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 2
lysosome 1

Gene Ontology (GO) - Cellular Components for PRSS21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm TAS 10397266
GO:0005886 plasma membrane TAS --
GO:0016020 membrane TAS 9826525
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with PRSS21: view

Pathways & Interactions for PRSS21 Gene

genes like me logo Genes that share pathways with PRSS21: view

SIGNOR curated interactions for PRSS21 Gene

Activates:

Gene Ontology (GO) - Biological Process for PRSS21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
GO:0006508 proteolysis IEA --
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with PRSS21: view

Drugs & Compounds for PRSS21 Gene

(2) Drugs for PRSS21 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
PMSF Pharma Serine proteinases inhibitor, irreversible 0

(1) ApexBio Compounds for PRSS21 Gene

Compound Action Cas Number
PMSF Serine proteinases inhibitor, irreversible 329-98-6
genes like me logo Genes that share compounds with PRSS21: view

Drug Products

Transcripts for PRSS21 Gene

Unigene Clusters for PRSS21 Gene

Protease, serine, 21 (testisin):
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS21 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d
SP1: - -
SP2: -
SP3: - - -
SP4: -
SP5: -
SP6:

Relevant External Links for PRSS21 Gene

GeneLoc Exon Structure for
PRSS21
ECgene alternative splicing isoforms for
PRSS21

Expression for PRSS21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRSS21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRSS21 Gene

This gene is overexpressed in Testis (x34.4).

Protein differential expression in normal tissues from HIPED for PRSS21 Gene

This gene is overexpressed in Testis (40.7) and Ovary (28.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRSS21 Gene



Protein tissue co-expression partners for PRSS21 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRSS21 Gene:

PRSS21

SOURCE GeneReport for Unigene cluster for PRSS21 Gene:

Hs.72026

mRNA Expression by UniProt/SwissProt for PRSS21 Gene:

Q9Y6M0-TEST_HUMAN
Tissue specificity: Expressed predominantly in premeiotic testicular germ cells, mostly late pachytene and diplotene spermatocytes.

Evidence on tissue expression from TISSUES for PRSS21 Gene

  • Blood(4.2)
genes like me logo Genes that share expression patterns with PRSS21: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PRSS21 Gene

Orthologs for PRSS21 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRSS21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRSS21 34 35
  • 99.28 (n)
dog
(Canis familiaris)
Mammalia PRSS21 34
  • 76.21 (n)
-- 35
  • 25 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia PRSS21 34 35
  • 74.43 (n)
rat
(Rattus norvegicus)
Mammalia Prss21 34
  • 73.45 (n)
mouse
(Mus musculus)
Mammalia Prss21 34 16 35
  • 72.72 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 40 (a)
OneToMany
-- 35
  • 38 (a)
OneToMany
-- 35
  • 35 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 38 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11824 36
  • 38 (a)
CG8170 36
  • 37 (a)
CG13744 36
  • 31 (a)
worm
(Caenorhabditis elegans)
Secernentea ZK546.15 36
  • 33 (a)
Species where no ortholog for PRSS21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for PRSS21 Gene

ENSEMBL:
Gene Tree for PRSS21 (if available)
TreeFam:
Gene Tree for PRSS21 (if available)

Paralogs for PRSS21 Gene

Pseudogenes.org Pseudogenes for PRSS21 Gene

genes like me logo Genes that share paralogs with PRSS21: view

Variants for PRSS21 Gene

Sequence variations from dbSNP and Humsavar for PRSS21 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000507369 -- 2,820,072(+) CCTCA(A/G)TTCAC intron-variant
rs1000968942 -- 2,818,001(+) GGGAC(A/C/G)GGCAG intron-variant
rs1001195163 -- 2,816,839(+) GGGCC(A/G)AGGAC upstream-variant-2KB
rs1001349126 -- 2,820,643(+) CAGCT(A/G)CCTTC intron-variant
rs1002683412 -- 2,820,302(+) GCTGC(C/T)TGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRSS21 Gene

Variant ID Type Subtype PubMed ID
esv2760067 CNV gain+loss 17122850
nsv952905 CNV deletion 24416366

Variation tolerance for PRSS21 Gene

Residual Variation Intolerance Score: 61.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.99; 49.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRSS21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRSS21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS21 Gene

Disorders for PRSS21 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PRSS21 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
dracunculiasis
  • dracontiasis
loiasis
  • african eye worm
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PRSS21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRSS21
genes like me logo Genes that share disorders with PRSS21: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRSS21 Gene

Publications for PRSS21 Gene

  1. Testisin, a new human serine proteinase expressed by premeiotic testicular germ cells and lost in testicular germ cell tumors. (PMID: 10397266) Hooper J.D. … Antalis T.M. (Cancer Res. 1999) 2 3 4 22 64
  2. Localization, expression and genomic structure of the gene encoding the human serine protease testisin. (PMID: 11004480) Hooper J.D. … Antalis T.M. (Biochim. Biophys. Acta 2000) 3 4 22 64
  3. Cloning and tissue distribution of a novel serine protease esp-1 from human eosinophils. (PMID: 9826525) Inoue M. … Kido H. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 64
  4. The glycosylphosphatidylinositol-anchored serine protease PRSS21 (testisin) imparts murine epididymal sperm cell maturation and fertilizing ability. (PMID: 19571264) Netzel-Arnett S. … Antalis T.M. (Biol. Reprod. 2009) 3 22 64
  5. Epigenetic silencing of the putative tumor suppressor gene testisin in testicular germ cell tumors. (PMID: 16810501) Kempkensteffen C. … Schrader M. (J. Cancer Res. Clin. Oncol. 2006) 3 22 64

Products for PRSS21 Gene

Sources for PRSS21 Gene

Content
Loading form....