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PRSS21 Gene

protein-coding   GIFtS: 59
GCID: GC16P002867

Protease, Serine, 21 (Testisin)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Protease, Serine, 21 (Testisin)1 2     Serine Protease From Eosinophils2
ESP12 3 5     testisin2
Eosinophil Serine Protease 12 3     EC 3.4.21.-3
ESP-12 3     Serine Protease 213
TEST12 3     EC 3.4.218
TESTISIN2     

External Ids:    HGNC: 94851   Entrez Gene: 109422   Ensembl: ENSG000000070387   OMIM: 6081595   UniProtKB: Q9Y6M03   
ORGUL members:         

Export aliases for PRSS21 gene to outside databases

Previous GC identifers: GC16P002887 GC16P002807 GC16P002833


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRSS21 Gene:
This gene encodes a cell-surface anchored serine protease, which is a member of the trypsin family of serine
proteases. The encoded protein is predicted to be active on peptide linkages involving the carboxyl group of
lysine or arginine. The encoded protein localizes to the cytoplasm and the plasma membrane of premeiotic
testicular germ cells and may be involved in progression of testicular tumors of germ cell origin. Alternatively
spliced transcript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Jul
2012)

GeneCards Summary for PRSS21 Gene:
PRSS21 (protease, serine, 21 (testisin)) is a protein-coding gene. Diseases associated with PRSS21 include dracunculiasis, and testicular germ cell tumor. GO annotations related to this gene include serine-type peptidase activity and serine-type endopeptidase activity. An important paralog of this gene is PRSS46.

UniProtKB/Swiss-Prot: TEST_HUMAN, Q9Y6M0
Function: Could regulate proteolytic events associated with testicular germ cell maturation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010393.17  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRSS21 gene promoter:
         AhR   NF-1   NRSF form 1   LCR-F1   NRSF form 2   Arnt   Roaz   RORalpha1   MRF-2   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRSS21 promoter sequence
   Search Chromatin IP Primers for PRSS21

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRSS21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

PRSS21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRSS21 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P002867:  view genomic region     (about GC identifiers)

Start:
2,867,164 bp from pter      End:
2,876,305 bp from pter
Size:
9,142 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TEST_HUMAN, Q9Y6M0 (See protein sequence)
Recommended Name: Testisin precursor  
Size: 314 amino acids; 34884 Da
Secondary accessions: Q9NS34 Q9P2V6
Alternative splicing: 3 isoforms:  Q9Y6M0-1   Q9Y6M0-2   Q9Y6M0-3   

Explore the universe of human proteins at neXtProt for PRSS21: NX_Q9Y6M0

Explore proteomics data for PRSS21 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn167, Asn200, Asn273
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for PRSS21 (Q9Y6M0)
     GDSGGPL  CWVTGWG  LTAAHCF 


    See PRSS21 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001257381.1  NP_006790.1  NP_659205.1  NP_659206.1  

    ENSEMBL proteins: 
     ENSP00000407741   ENSP00000005995   ENSP00000460417   ENSP00000459664   ENSP00000458341  
     ENSP00000460351   ENSP00000400632  

    PRSS21 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PRSS: Serine peptidases / Serine peptidases

    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y6M0

    ProtoNet protein and cluster: Q9Y6M0

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: TEST_HUMAN, Q9Y6M0
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 peptidase S1 domain


    PRSS21 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TEST_HUMAN, Q9Y6M0
    Function: Could regulate proteolytic events associated with testicular germ cell maturation

         Genatlas biochemistry entry for PRSS21:
    protease serine 21,testisin,abundantly expressed in the testis and in testicular tumors,see TSG16D (role in
    progression of testicular tumor of germ cell origin)

         Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0005515protein binding IPI--
    GO:0008236serine-type peptidase activity TAS10397266
         
    PRSS21 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PRSS21:
     Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 3 alleles(MGI details for Prss21):
     reproductive system 

    PRSS21 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PRSS21: Prss21tm1Anta Prss21tm1Tba Prss21tm1Lex

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRSS21
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRSS21

    miRNA
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    miRTarBase miRNAs that target PRSS21:
    hsa-mir-155-5p (MIRT021022), hsa-mir-1 (MIRT001346)

    Block miRNA regulation of human, mouse, rat PRSS21 using miScript Target Protectors
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    Predesigned siRNA for gene silencing in human, mouse, rat PRSS21

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS21


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TEST_HUMAN, Q9Y6M0: Cell membrane; Lipid-anchor, GPI-anchor (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    extracellular3
    lysosome1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS10397266
    GO:0005886plasma membrane IEA--
    GO:0016020membrane TAS9826525
    GO:0031225anchored component of membrane IEA--

    PRSS21 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRSS21
    Interactions:

        Search GeneGlobe Interaction Network for PRSS21

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for PRSS21 (Q9Y6M01, 2, 3 ENSP000000059954) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SERPINB5P369521, 2, 3, ENSP000003722214EBI-7054564,EBI-2371394 MINT-7712188 MINT-7712162 MINT-7712176 MINT-7712215 MINT-7712147 MINT-7712115 MINT-7712128 I2D: score=1 STRING: ENSP00000372221
    PARP2Q9UGN52, 3, ENSP000002504164MINT-8201940 I2D: score=1 STRING: ENSP00000250416
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0007283spermatogenesis IEA--

    PRSS21 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRSS21 (TEST)

    1 Novoseek inferred chemical compound relationship for PRSS21 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 68.7 20 12630572 (3), 10397266 (3), 19571264 (2), 15705885 (2) (see all 12)



    PRSS21 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PRSS21 gene (4 alternative transcripts): 
    NM_001270452.1  NM_006799.3  NM_144956.2  NM_144957.2  

    Unigene Cluster for PRSS21:

    Protease, serine, 21 (testisin)
    Hs.72026  [show with all ESTs]
    Unigene Representative Sequence: BM911057
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000450020 ENST00000005995 ENST00000570629 ENST00000570594 ENST00000574813
    ENST00000571141 ENST00000577043 ENST00000575199 ENST00000574265 ENST00000575739
    ENST00000455114(uc002crr.3 uc002crs.3 uc002crt.3)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat PRSS21
      QuantiFast Probe-based Assays in human, mouse, rat PRSS21

    Additional mRNA sequence: 

    AB031329.1 AB031330.1 AB031331.1 AF058300.1 AY359034.1 BC074999.2 BC075000.2 NR_073012.1 

    8 DOTS entries:

    DT.112480  DT.95165830  DT.99999792  DT.92419292  DT.100747074  DT.92419291  DT.40115243  DT.40196498 

    Selected AceView cDNA sequences (see all 61):

    CR605277 BQ690114 NM_144956 BI259237 CA307787 BX454526 AB031330 CB158100 
    AA758406 NM_006799 NM_144957 AF058300 CR590593 CB105865 AB031331 CF144777 
    AA447596 BI827608 BI334059 AA448095 AL555870 BX417595 BM553333 AA729680 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PRSS21 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d
    SP1:                                            -     -                           
    SP2:                                                  -                           
    SP3:              -                             -     -                           
    SP4:                                                  -                           
    SP5:                                -                                             


    ECgene alternative splicing isoforms for PRSS21

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRSS21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCCTGGGG
    PRSS21 Expression
    About this image


    PRSS21 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Bone marrow-derived hematopoietic stem cells (family)
     
     Brain (Nervous System)
             Lateral Ventricle
     
     Testis (Reproductive System)
    PRSS21 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRSS21 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.72026

    UniProtKB/Swiss-Prot: TEST_HUMAN, Q9Y6M0
    Tissue specificity: Expressed predominantly in premeiotic testicular germ cells, mostly late pachytene and
    diplotene spermatocytes

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS21

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PRSS21 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prss211 , 5 protease, serine, 215
    protease, serine 211
    72.72(n)1
    68.84(a)1
      17 (12.11 cM)5
    572561  NM_020487.41  NP_065233.21 
     238680565 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    38(a)
    many ↔ many
    AAWZ02038407(4848-10882)


    ENSEMBL Gene Tree for PRSS21 (if available)
    TreeFam Gene Tree for PRSS21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRSS21 gene
    PRSS462  PRSS482  PRSS222  PRSS272  TMPRSS92  PRSS452  TPSG12  TPSD12  
    PRSS382  TPSAB12  PRSS532  PRSS502  PRSS422  PRSS362  PRSS332  PRSS82  
    TPSB22  
    Selected SIMAP similar genes for PRSS21 using alignment to 5 protein entries:     TEST_HUMAN (see all proteins) (see all similar genes):
    PRSS41    F2    MGC52282    KLKB1    PRSS27    HP
    PRSS22    PRSS33    TMPRSS3    CELA3A    PRSS1    PRSS48
    F12    CELA2B    PROC1    PRSS36    PRSS44    TMPRSS13

    PRSS21 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PRSS21
    PGOHUM00000262309


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRSS21 (see all 198)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1831977651,2
    --2865167(+) GAACAA/GTGAGG 5 -- us2k10--------
    rs1430762761,2
    --2865288(+) AAGACC/TCCTCT 5 -- us2k10--------
    rs754487661,2
    C,F--2865369(+) CCCTGC/TAGCCC 5 -- us2k11Minor allele frequency- T:0.06EA 120
    rs1865889861,2
    --2865416(+) CTCACC/TGGAGG 5 -- us2k10--------
    rs1116005151,2
    F--2865422(+) GGAGGC/TAAGAA 5 -- us2k12Minor allele frequency- T:0.04CSA WA 119
    rs1909819201,2
    --2865493(+) CAGGAG/TCTGAC 5 -- us2k10--------
    rs1483609571,2
    C--2865556(+) CCTGCC/TGGCTG 5 -- us2k10--------
    rs1141269011,2
    F--2865731(+) GCTGCG/ACCCTC 5 -- us2k11Minor allele frequency- A:0.07WA 118
    rs1415261061,2
    C--2865758(+) TACCAC/TGCTCT 5 -- us2k10--------
    rs1837481271,2
    --2865761(+) CATGCA/TCTGTG 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for PRSS21 (2867164 - 2876305 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for PRSS21:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv905173CNV Loss21882294
    nsv905165CNV Loss21882294
    nsv905152CNV Loss21882294
    nsv905170CNV Loss21882294
    dgv2573n71CNV Loss21882294
    nsv905169CNV Loss21882294
    nsv905162CNV Gain21882294
    dgv793e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608159    OMIM disorders: --

    11 diseases for PRSS21:    
    About MalaCards
    dracunculiasis    testicular germ cell tumor    testicular cancer    epididymitis
    germ cell tumors    papillary carcinoma    ovarian cancer    cervical cancer
    cervicitis    asthma    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for PRSS21:
    Dracunculiasis

    PRSS21 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for PRSS21 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    testicular cancer 59.4 3 15685234 (1), 11004480 (1), 11231276 (1)
    ovarian carcinoma 49.8 3 11111072 (3)
    ovarian cancer 24.4 4 15705885 (3)
    tumors 16.5 12 15705885 (3), 11004480 (2), 11111072 (1), 10397266 (1) (see all 6)


    Export disorders for PRSS21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRSS21 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with PRSS21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Testisin, a new human serine proteinase expressed by premeiotic testicular germ cells and lost in testicular germ cell tumors. (PubMed id 10397266)1, 2, 3, 9 Hooper J.D.... Antalis T.M. (Cancer Res. 1999)
    2. Cloning and tissue distribution of a novel serine protease esp-1 from human eosinophils. (PubMed id 9826525)1, 2, 3 Inoue M.... Kido H. (Biochem. Biophys. Res. Commun. 1998)
    3. Localization, expression and genomic structure of the gene encoding the human serine protease testisin. (PubMed id 11004480)1, 2, 9 Hooper J.D.... Antalis T.M. (Biochim. Biophys. Acta 2000)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. Structural analysis of esp-1 gene (PRSS 21). (PubMed id 10600542)1, 2 Inoue M.... Kido H. (Biochem. Biophys. Res. Commun. 1999)
    7. Hypermethylation of the 5' CpG island of the gene encoding the serine protease Testisin promotes its loss in testicular tumorigenesis. (PubMed id 15685234)1, 9 Manton K.J....Antalis T.M. (Br. J. Cancer 2005)
    8. The glycosylphosphatidylinositol-anchored serine protease PRSS21 (testisin) imparts murine epididymal sperm cell maturation and fertilizing ability. (PubMed id 19571264)1, 9 Netzel-Arnett S....Antalis T.M. (Biol. Reprod. 2009)
    9. Epigenetic silencing of the putative tumor suppressor gene testisin in testicular germ cell tumors. (PubMed id 16810501)1, 9 Kempkensteffen C....Schrader M. (J. Cancer Res. Clin. Oncol. 2006)
    10. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10942 HGNC: 9485 AceView: PRSS21 Ensembl:ENSG00000007038 euGenes: HUgn10942
    ECgene: PRSS21 H-InvDB: PRSS21

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRSS21 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRSS21 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRSS21 gene:
    Search GeneIP for patents involving PRSS21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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