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Aliases for PRSS2 Gene

Aliases for PRSS2 Gene

  • Protease, Serine 2 2 3 5
  • Anionic Trypsinogen 3 4
  • EC 3.4.21.4 4 61
  • Trypsin II 3 4
  • TRYP2 3 4
  • TRY2 3 4
  • Protease Serine 2 Preproprotein 3
  • Protease, Serine, 2 (Trypsin 2) 3
  • Serine Protease 2 4
  • Trypsinogen 2 3
  • Trypsin 2 2
  • Trypsin-2 3
  • EC 3.4.21 61
  • TRY8 3

External Ids for PRSS2 Gene

Previous GeneCards Identifiers for PRSS2 Gene

  • GC07P140772
  • GC07P140731
  • GC07P141821
  • GC07P141899
  • GC07P141902
  • GC07P141676
  • GC07P141990
  • GC07P142167
  • GC07P142178
  • GC07P142457
  • GC07P142298
  • GC07Pg41870
  • GC07P9T0974
  • GC07P9T0097
  • GC07P142858
  • GC07P142980
  • GC07P143131
  • GC07P143194

Summaries for PRSS2 Gene

Entrez Gene Summary for PRSS2 Gene

  • This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015]

GeneCards Summary for PRSS2 Gene

PRSS2 (Protease, Serine 2) is a Protein Coding gene. Diseases associated with PRSS2 include Pancreatitis, Hereditary and Linitis Plastica. Among its related pathways are Immune System and Influenza A. GO annotations related to this gene include calcium ion binding and serine-type endopeptidase activity. An important paralog of this gene is PRSS1.

UniProtKB/Swiss-Prot for PRSS2 Gene

  • In the ileum, may be involved in defensin processing, including DEFA5.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS2 Gene

Genomics for PRSS2 Gene

Regulatory Elements for PRSS2 Gene

Enhancers for PRSS2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F142754 0.4 ENCODE 0.4 -5.4 -5434 0.2 ZNF263 JUN PRSS2 PRSS1
GH07F142755 0.4 ENCODE 0.4 -5.2 -5174 0.2 ZNF263 PRSS2 PRSS1
GH07F142748 0.4 ENCODE 0.4 -11.1 -11080 0.9 EBF1 TRBV28 PRSS1 PRSS2
GH07F142742 0.2 ENCODE 0.3 -18.2 -18240 0.1 PRSS1 PRSS2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRSS2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRSS2 Gene

Chromosome:
7
Start:
142,760,398 bp from pter
End:
142,774,564 bp from pter
Size:
14,167 bases
Orientation:
Plus strand

Genomic View for PRSS2 Gene

Genes around PRSS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS2 Gene

Proteins for PRSS2 Gene

  • Protein details for PRSS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07478-TRY2_HUMAN
    Recommended name:
    Trypsin-2
    Protein Accession:
    P07478

    Protein attributes for PRSS2 Gene

    Size:
    247 amino acids
    Molecular mass:
    26488 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

neXtProt entry for PRSS2 Gene

Selected DME Specific Peptides for PRSS2 Gene

P07478:
  • VSWGYGCA
  • IQVRLGE
  • GADYPDEL
  • LQGIVSWG
  • SGWGNTLS
  • EGGKDSC
  • GYHFCGGSLI
  • GFLEGGKDSC
  • VRLGEHNI
  • FCGGSLI
  • LQCLDAP
  • PGVYTKV
  • DSCQGDSGG
  • CEASYPG
  • HFCGGSL
  • VRLGEHN
  • CQGDSGGP
  • QGIVSWG
  • DKIVGGY
  • PGVYTKVYNYV

Post-translational modifications for PRSS2 Gene

  • Sulfated on tyrosine.
  • Sulfation at Tyr-154 increases selectivity towards basic versus apolar residues at the P2 position of inhibitors that bind in a substrate-like fashion. Although the increase in selectivity is relatively small, it may facilitate digestion of a broader range of dietary proteins.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRSS2 Gene

Antibody Products

  • R&D Systems Antibodies for PRSS2 (Trypsin 2/PRSS2)
  • Abcam antibodies for PRSS2
  • Cloud-Clone Corp. Antibodies for PRSS2

Domains & Families for PRSS2 Gene

Gene Families for PRSS2 Gene

Suggested Antigen Peptide Sequences for PRSS2 Gene

Graphical View of Domain Structure for InterPro Entry

P07478

UniProtKB/Swiss-Prot:

TRY2_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS2: view

Function for PRSS2 Gene

Molecular function for PRSS2 Gene

GENATLAS Biochemistry:
protease serine 2,trypsin 2,expressed in pancreas
UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage: Arg- -Xaa, Lys- -Xaa.
UniProtKB/Swiss-Prot Function:
In the ileum, may be involved in defensin processing, including DEFA5.

Enzyme Numbers (IUBMB) for PRSS2 Gene

Gene Ontology (GO) - Molecular Function for PRSS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity TAS --
GO:0005509 calcium ion binding IDA 12709065
GO:0005515 protein binding IPI 16192646
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA,TAS --
genes like me logo Genes that share ontologies with PRSS2: view
genes like me logo Genes that share phenotypes with PRSS2: view

Human Phenotype Ontology for PRSS2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRSS2 Gene

Localization for PRSS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS2 Gene

Secreted, extracellular space.

Gene Ontology (GO) - Cellular Components for PRSS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IMP 16192646
GO:0031012 extracellular matrix TAS 12731883
genes like me logo Genes that share ontologies with PRSS2: view

No data available for Subcellular locations from COMPARTMENTS for PRSS2 Gene

Pathways & Interactions for PRSS2 Gene

genes like me logo Genes that share pathways with PRSS2: view

Interacting Proteins for PRSS2 Gene

Selected Interacting proteins: P07478-TRY2_HUMAN for PRSS2 Gene via IID

Gene Ontology (GO) - Biological Process for PRSS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,IDA 12731883
GO:0007586 digestion IBA --
GO:0022617 extracellular matrix disassembly TAS --
GO:0030307 positive regulation of cell growth TAS 12731883
GO:0030574 collagen catabolic process IMP,TAS --
genes like me logo Genes that share ontologies with PRSS2: view

No data available for SIGNOR curated interactions for PRSS2 Gene

Drugs & Compounds for PRSS2 Gene

(16) Drugs for PRSS2 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Isopropyl alcohol Approved Pharma Target 0
Aprotinin Approved, Withdrawn Pharma Inhibitor of bovine pancreatic trypsin 24
Benzylamine Experimental Pharma Target 0
3-Phenylpropylamine Experimental Pharma Target 0
benzamidine Experimental Pharma Target 0

(1) Additional Compounds for PRSS2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(4) ApexBio Compounds for PRSS2 Gene

Compound Action Cas Number
AEBSF.HCl Serine protease inhibitor 30827-99-7
Aprotinin Inhibitor of bovine pancreatic trypsin 9087-70-1
Leupeptin, Microbial Inhibitor of serine and cysteine proteases 103476-89-7
Nafamostat Mesylate(FUT-175) Serine protease inhibitor 82956-11-4
genes like me logo Genes that share compounds with PRSS2: view

Transcripts for PRSS2 Gene

mRNA/cDNA for PRSS2 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRSS2 Gene

Protease, serine, 2 (trypsin 2):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS2 Gene

No ASD Table

Relevant External Links for PRSS2 Gene

GeneLoc Exon Structure for
PRSS2
ECgene alternative splicing isoforms for
PRSS2

Expression for PRSS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRSS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PRSS2 Gene

This gene is overexpressed in Pancreatic juice (47.9) and Pancreas (14.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRSS2 Gene



Protein tissue co-expression partners for PRSS2 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRSS2 Gene:

PRSS2

SOURCE GeneReport for Unigene cluster for PRSS2 Gene:

Hs.726742

mRNA Expression by UniProt/SwissProt for PRSS2 Gene:

P07478-TRY2_HUMAN
Tissue specificity: Expressed in Paneth cells, at the base of small intestinal crypts.
genes like me logo Genes that share expression patterns with PRSS2: view

Primer Products

No data available for mRNA differential expression in normal tissues for PRSS2 Gene

Orthologs for PRSS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRSS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100615529 34
  • 96.71 (n)
dog
(Canis familiaris)
Mammalia LOC100686744 34
  • 85.43 (n)
cow
(Bos Taurus)
Mammalia PRSS2 34
  • 84.08 (n)
rat
(Rattus norvegicus)
Mammalia Prss1 34
  • 81.44 (n)
mouse
(Mus musculus)
Mammalia Prss2 34 16
  • 81.03 (n)
chicken
(Gallus gallus)
Aves PRSS2 34
  • 70.85 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia try10 34
  • 68.59 (n)
Str.8261 34
zebrafish
(Danio rerio)
Actinopterygii si:ch73-103b2.3 34
  • 69.06 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8654 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009966 34
  • 51.73 (n)
fruit fly
(Drosophila melanogaster)
Insecta Try29F 36
  • 43 (a)
CG18735 36
  • 42 (a)
CG4386 36
  • 42 (a)
CG8299 36
  • 38 (a)
egrTry 36
  • 38 (a)
CG17239 36
  • 37 (a)
CG17571 36
  • 37 (a)
CG18065 36
  • 37 (a)
CG5197 36
  • 37 (a)
CG6041 36
  • 37 (a)
CG9294 36
  • 37 (a)
lgrTry 36
  • 37 (a)
zgrTry 36
  • 36 (a)
CG16998 36
  • 35 (a)
eegrTry 36
  • 35 (a)
CG10472 36
  • 34 (a)
CG7829 36
  • 34 (a)
kgrTry 36
  • 33 (a)
Species where no ortholog for PRSS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRSS2 Gene

ENSEMBL:
Gene Tree for PRSS2 (if available)
TreeFam:
Gene Tree for PRSS2 (if available)

Paralogs for PRSS2 Gene

Pseudogenes.org Pseudogenes for PRSS2 Gene

genes like me logo Genes that share paralogs with PRSS2: view

Variants for PRSS2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS2 Gene

TRY2_HUMAN-P07478
His-153 variation is a common polymorphism in African populations with a minor allele frequency of 9.2%, it eliminates sulfation at Tyr-154, with no consequences on digestive physiology.

Sequence variations from dbSNP and Humsavar for PRSS2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs61734659 other 142,774,035(+) TCGAG(A/G)GAGGC nc-transcript-variant, reference, missense
rs111221541 -- 142,774,986(+) TGTGT(C/T)GGCAC downstream-variant-500B
rs111221893 -- 142,771,996(+) GGAGC(A/G)CCACC intron-variant
rs111221894 -- 142,774,886(+) ATCTT(C/T)GAGGT downstream-variant-500B
rs111224807 -- 142,774,923(+) CTTCT(A/T)GCTAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for PRSS2 Gene

Variant ID Type Subtype PubMed ID
nsv428187 CNV loss 18775914
nsv465148 CNV loss 19166990
nsv470396 CNV loss 18288195
nsv5982 CNV deletion 18451855
nsv818563 CNV loss 17921354
nsv824336 CNV loss 20364138
nsv831167 CNV gain+loss 17160897
nsv1028035 CNV loss 25217958
esv3576450 CNV gain 25503493
esv34617 CNV loss 17911159
esv2759569 CNV loss 17122850
dgv841n27 CNV loss 19166990
dgv1969e212 CNV loss 25503493
dgv1968e212 CNV gain 25503493
dgv11652n54 CNV loss 21841781
dgv11644n54 CNV loss 21841781

Relevant External Links for PRSS2 Gene

Human Gene Mutation Database (HGMD)
PRSS2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRSS2

No data available for Variation tolerance for PRSS2 Gene

Disorders for PRSS2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for PRSS2 Gene - From: OMIM, GeneTests, Orphanet, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pancreatitis, hereditary
  • pancreatitis, chronic
linitis plastica
  • leather-bottle stomach
pancreatitis
tropical calcific pancreatitis
  • fibrocalculous pancreatic diabetes
prss1-related hereditary pancreatitis
- elite association - COSMIC cancer census association via MalaCards
Search PRSS2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRSS2

Genetic Association Database (GAD)
PRSS2
Human Genome Epidemiology (HuGE) Navigator
PRSS2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRSS2
genes like me logo Genes that share disorders with PRSS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRSS2 Gene

Publications for PRSS2 Gene

  1. A common African polymorphism abolishes tyrosine sulfation of human anionic trypsinogen (PRSS2). (PMID: 18986305) RA^nai Z. … Sahin-TA^th M. (Biochem. J. 2009) 3 4 22 64
  2. Cloning, characterization and nucleotide sequences of two cDNAs encoding human pancreatic trypsinogens. (PMID: 3011602) Emi M. … Matsubara K. (Gene 1986) 2 3 4 64
  3. Identification of pancreatic juice proteins as biomarkers of pancreatic cancer. (PMID: 20428826) Gao J. … Ma L. (Oncol. Rep. 2010) 3 22 64
  4. A loss-of-function p.G191R variant in the anionic trypsinogen (PRSS2) gene in Japanese patients with pancreatic disorders. (PMID: 19052022) Kume K. … Shimosegawa T. (Gut 2009) 3 46 64
  5. Divergent roles of SPINK1 and PRSS2 variants in tropical calcific pancreatitis. (PMID: 19077465) Sundaresan S. … Drenth J.P. (Pancreatology 2009) 3 22 64

Products for PRSS2 Gene

Sources for PRSS2 Gene

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