Aliases for PRSS2 Gene
External Ids for PRSS2 Gene
Previous GeneCards Identifiers for PRSS2 Gene
This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015]
GeneCards Summary for PRSS2 Gene
PRSS2 (Protease, Serine 2) is a Protein Coding gene. Diseases associated with PRSS2 include Pancreatitis, Hereditary and Linitis Plastica. Among its related pathways are Degradation of the extracellular matrix and Collagen chain trimerization. GO annotations related to this gene include calcium ion binding and serine-type endopeptidase activity. An important paralog of this gene is PRSS1.
UniProtKB/Swiss-Prot for PRSS2 Gene
In the ileum, may be involved in defensin processing, including DEFA5.