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Aliases for PRSS2 Gene

Aliases for PRSS2 Gene

  • Protease, Serine, 2 (Trypsin 2) 2 3
  • TRY2 3 4 6
  • Anionic Trypsinogen 3 4
  • EC 3.4.21.4 4 63
  • Trypsin II 3 4
  • TRYP2 3 4
  • Protease Serine 2 Preproprotein 3
  • Serine Protease 2 4
  • Trypsinogen 2 3
  • Trypsin-2 3
  • EC 3.4.21 63
  • TRY8 3

External Ids for PRSS2 Gene

Previous GeneCards Identifiers for PRSS2 Gene

  • GC07P140772
  • GC07P140731
  • GC07P141821
  • GC07P141899
  • GC07P141902
  • GC07P141676
  • GC07P141990
  • GC07P142167
  • GC07P142178
  • GC07P142457
  • GC07P142298
  • GC07Pg41870
  • GC07P9T0974
  • GC07P9T0097

Summaries for PRSS2 Gene

Entrez Gene Summary for PRSS2 Gene

  • This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015]

GeneCards Summary for PRSS2 Gene

PRSS2 (Protease, Serine, 2 (Trypsin 2)) is a Protein Coding gene. Diseases associated with PRSS2 include malignant ovarian cyst and linitis plastica. Among its related pathways are Degradation of the extracellular matrix and Defensins. GO annotations related to this gene include calcium ion binding and serine-type endopeptidase activity.

UniProtKB/Swiss-Prot for PRSS2 Gene

  • In the ileum, may be involved in defensin processing, including DEFA5.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS2 Gene

Genomics for PRSS2 Gene

Genomic Location for PRSS2 Gene

Start:
142,770,976 bp from pter
End:
142,774,560 bp from pter
Size:
3,585 bases
Orientation:
Plus strand

Genomic View for PRSS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRSS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS2 Gene

No data available for Regulatory Elements for PRSS2 Gene

Proteins for PRSS2 Gene

  • Protein details for PRSS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07478-TRY2_HUMAN
    Recommended name:
    Trypsin-2
    Protein Accession:
    P07478
    Secondary Accessions:

    Protein attributes for PRSS2 Gene

    Size:
    247 amino acids
    Molecular mass:
    26488 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
    Quaternary structure:
    No Data Available

neXtProt entry for PRSS2 Gene

Proteomics data for PRSS2 Gene at MOPED

Post-translational modifications for PRSS2 Gene

  • Sulfated on tyrosine.
  • Sulfation at Tyr-154 increases selectivity towards basic versus apolar residues at the P2 position of inhibitors that bind in a substrate-like fashion. Although the increase in selectivity is relatively small, it may facilitate digestion of a broader range of dietary proteins.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRSS2 Gene

Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PRSS2 (Trypsin 2/PRSS2)

Domains for PRSS2 Gene

Gene Families for PRSS2 Gene

HGNC:
  • PRSS :Serine peptidases / Serine peptidases

Suggested Antigen Peptide Sequences for PRSS2 Gene

Graphical View of Domain Structure for InterPro Entry

P07478

UniProtKB/Swiss-Prot:

TRY2_HUMAN :
  • P07478
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS2: view

Function for PRSS2 Gene

Molecular function for PRSS2 Gene

GENATLAS Biochemistry: protease serine 2,trypsin 2,expressed in pancreas
UniProtKB/Swiss-Prot CatalyticActivity: Preferential cleavage: Arg- -Xaa, Lys- -Xaa
UniProtKB/Swiss-Prot Function: In the ileum, may be involved in defensin processing, including DEFA5.

Enzyme Numbers (IUBMB) for PRSS2 Gene

Gene Ontology (GO) - Molecular Function for PRSS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IDA 12709065
GO:0005509 calcium ion binding IDA 12709065
GO:0005515 protein binding IPI 16192646
genes like me logo Genes that share ontologies with PRSS2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRSS2

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PRSS2 Gene

Localization for PRSS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS2 Gene

Secreted, extracellular space.

Gene Ontology (GO) - Cellular Components for PRSS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IMP 16192646
GO:0031012 extracellular matrix TAS 12731883
genes like me logo Genes that share ontologies with PRSS2: view

No data available for Subcellular locations from COMPARTMENTS for PRSS2 Gene

Pathways for PRSS2 Gene

genes like me logo Genes that share pathways with PRSS2: view

Interacting Proteins for PRSS2 Gene

Selected Interacting proteins: P07478-TRY2_HUMAN for PRSS2 Gene via I2D

Gene Ontology (GO) - Biological Process for PRSS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA 12731883
GO:0007586 digestion IBA --
GO:0022617 extracellular matrix disassembly TAS --
GO:0030198 extracellular matrix organization TAS --
GO:0030307 positive regulation of cell growth TAS 12731883
genes like me logo Genes that share ontologies with PRSS2: view

Compounds for PRSS2 Gene

(1) HMDB Compounds for PRSS2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(7) Drugbank Compounds for PRSS2 Gene

(3) Novoseek inferred chemical compound relationships for PRSS2 Gene

Compound -log(P) Hits PubMed IDs
trypsinogen 79.6 9
serine 65.7 20
cysteine 0 1
genes like me logo Genes that share compounds with PRSS2: view

Transcripts for PRSS2 Gene

mRNA/cDNA for PRSS2 Gene

(5) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(2) REFSEQ mRNAs :

Unigene Clusters for PRSS2 Gene

Protease, serine, 2 (trypsin 2):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRSS2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS2 Gene

No ASD Table

Relevant External Links for PRSS2 Gene

GeneLoc Exon Structure for
PRSS2
ECgene alternative splicing isoforms for
PRSS2

Expression for PRSS2 Gene

mRNA expression in normal human tissues for PRSS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for PRSS2 Gene

SOURCE GeneReport for Unigene cluster for PRSS2 Gene Hs.726742

mRNA Expression by UniProt/SwissProt for PRSS2 Gene

P07478-TRY2_HUMAN
Tissue specificity: Expressed in Paneth cells, at the base of small intestinal crypts.
genes like me logo Genes that share expressions with PRSS2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PRSS2 Gene

Orthologs for PRSS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRSS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100615529 35
  • 96.71 (n)
  • 95.88 (a)
cow
(Bos Taurus)
Mammalia PRSS2 35
  • 84.08 (n)
  • 78.95 (a)
dog
(Canis familiaris)
Mammalia LOC100686744 35
  • 85.43 (n)
  • 81.78 (a)
mouse
(Mus musculus)
Mammalia Prss2 35
  • 81.03 (n)
  • 77.24 (a)
Prss2 16
rat
(Rattus norvegicus)
Mammalia Prss1 35
  • 81.44 (n)
  • 76.42 (a)
chicken
(Gallus gallus)
Aves PRSS2 35
  • 70.85 (n)
  • 71.3 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8261 35
try10 35
  • 68.59 (n)
  • 67.9 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8654 35
zebrafish
(Danio rerio)
Actinopterygii si:ch73-103b2.3 35
  • 69.06 (n)
  • 66.37 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009966 35
  • 51.73 (n)
  • 44.81 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5197 37
  • 37 (a)
CG10472 37
  • 34 (a)
Try29F 37
  • 43 (a)
eegrTry 37
  • 35 (a)
CG17571 37
  • 37 (a)
lgrTry 37
  • 37 (a)
CG4386 37
  • 42 (a)
zgrTry 37
  • 36 (a)
kgrTry 37
  • 33 (a)
CG18735 37
  • 42 (a)
CG17239 37
  • 37 (a)
egrTry 37
  • 38 (a)
CG16998 37
  • 35 (a)
CG7829 37
  • 34 (a)
CG6041 37
  • 37 (a)
CG9294 37
  • 37 (a)
CG8299 37
  • 38 (a)
CG18065 37
  • 37 (a)
Species with no ortholog for PRSS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

No data available for Evolution for PRSS2 Gene

Paralogs for PRSS2 Gene

genes like me logo Genes that share paralogs with PRSS2: view

No data available for Paralogs for PRSS2 Gene

Variants for PRSS2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS2 Gene

P07478-TRY2_HUMAN
His-153 variation is a common polymorphism in African populations with a minor allele frequency of 9.2%, it eliminates sulfation at Tyr-154, with no consequences on digestive physiology.

Sequence variations from dbSNP and Humsavar for PRSS2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs2017144 -- 142,774,206(+) CCTGT(A/C)TGCTT intron-variant, utr-variant-3-prime
rs3211359 -- 142,774,520(+) TGGTC(A/C/T)CTCTG utr-variant-3-prime
rs4145394 -- 142,770,138(+) AGCCC(A/C)AAGCA upstream-variant-2KB
rs4276598 -- 142,770,033(+) AAATC(C/T)CTACC upstream-variant-2KB
rs4500012 -- 142,770,008(+) TATGT(C/G)ACCCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PRSS2 Gene

Variant ID Type Subtype PubMed ID
nsv831166 CNV Gain+Loss 17160897
nsv428187 CNV Loss 18775914
dgv2145e1 CNV Complex 17122850
dgv841n27 CNV Loss 19166990
essv19150 CNV CNV 17122850
nsv824336 CNV Loss 20364138
esv34617 CNV Loss 17911159
nsv818563 CNV Loss 17921354
nsv831167 CNV Gain+Loss 17160897
nsv889274 CNV Loss 21882294
dgv1167e201 CNV Deletion 23290073
esv2740741 CNV Deletion 23290073
dgv1169e201 CNV Deletion 23290073
dgv1170e201 CNV Deletion 23290073
dgv1244e199 CNV Deletion 23128226
nsv442207 CNV CNV 18776908
esv2421493 CNV Deletion 20811451

Relevant External Links for PRSS2 Gene

HapMap Linkage Disequilibrium report
PRSS2
Human Gene Mutation Database (HGMD)
PRSS2

Disorders for PRSS2 Gene

(1) OMIM Diseases for PRSS2 Gene (601564)

(10) Novoseek inferred disease relationships for PRSS2 Gene

Disease -log(P) Hits PubMed IDs
pancreatitis 38.1 3
acute pancreatitis 26.9 2
respiratory distress syndrome 16.9 3
colorectal cancer 14.3 2
lung diseases 13.3 2

Relevant External Links for PRSS2

Genetic Association Database (GAD)
PRSS2
Human Genome Epidemiology (HuGE) Navigator
PRSS2
genes like me logo Genes that share disorders with PRSS2: view

No data available for UniProtKB/Swiss-Prot for PRSS2 Gene

Publications for PRSS2 Gene

  1. A common African polymorphism abolishes tyrosine sulfation of human anionic trypsinogen (PRSS2). (PMID: 18986305) RA^nai Z. … Sahin-TA^th M. (Biochem. J. 2009) 3 4 23
  2. Cloning, characterization and nucleotide sequences of two cDNAs encoding human pancreatic trypsinogens. (PMID: 3011602) Emi M. … Matsubara K. (Gene 1986) 2 3 4
  3. Immunoreactive anionic and cationic trypsin in human serum. (PMID: 2598466) Kimland M. … Borgstroem A. (Clin. Chim. Acta 1989) 3 4
  4. A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis. (PMID: 16699518) Witt H. … FAcrec C. (Nat. Genet. 2006) 3 48
  5. Trypsinogen copy number mutations in patients with idiopathic chronic pancreatitis. (PMID: 18063422) Masson E. … FAcrec C. (Clin. Gastroenterol. Hepatol. 2008) 3 48

Products for PRSS2 Gene

Sources for PRSS2 Gene

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