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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRSS2 Gene

protein-coding   GIFtS: 59
GCID: GC07P9T0974

Protease, Serine, 2 (Trypsin 2)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protease, Serine, 2 (Trypsin 2)1 2     TRY82
TRY22 3 5     Protease Serine 2 Preproprotein2
Anionic Trypsinogen2 3     Protease, Serine, 2, Preproprotein2
Serine Protease 22 3     Trypsin 22
Trypsin II2 3     trypsin-22
TRYP22 3     Trypsinogen 22
EC 3.4.21.43 8     EC 3.4.218

External Ids:    HGNC: 94831   Entrez Gene: 56452   OMIM: 6015645   UniProtKB: P074783   

Export aliases for PRSS2 gene to outside databases

Previous GC identifers: GC07P140772 GC07P140731 GC07P141821 GC07P141899 GC07P141902 GC07P141676 GC07P141990 GC07P142167 GC07P142178 GC07P142457 GC07P142298 GC07Pg41870


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PRSS2 Gene:
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is
secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages
involving the carboxyl group of lysine or arginine. This gene and several other trypsinogen genes are localized
to the T cell receptor beta locus on chromosome 7. (provided by RefSeq, Jul 2008)

GeneCards Summary for PRSS2 Gene: 
PRSS2 (protease, serine, 2 (trypsin 2)) is a protein-coding gene. Diseases associated with PRSS2 include ovarian cyst, and malignant ovarian cyst, and among its related super-pathways are Degradation of the extracellular matrix and Immune System. GO annotations related to this gene include serine-type endopeptidase activity and calcium ion binding.

UniProtKB/Swiss-Prot: TRY2_HUMAN, P07478
Function: In the ileum, may be involved in defensin processing, including DEFA5




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:NT_079596.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for PRSS2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): PRSS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PRSS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRSS2


Genomic Location:
Chromosome:7   

Entrez Gene cytogenetic band: 7q34   HGNC cytogenetic band: 7q34

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P9T0974:       (about GC identifiers)

Start:
974,021 bp from start of contig NW_003571040      End:
977,604 bp from start of contig NW_003571040
Size:
3,584 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 141,870,508-141,874,093     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRY2_HUMAN, P07478 (See protein sequence)
Recommended Name: Trypsin-2 precursor  
Size: 247 amino acids; 26488 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)
Subcellular location: Secreted, extracellular space

Explore the universe of human proteins at neXtProt for PRSS2: NX_P07478

Explore proteomics data for PRSS2 at MOPED 

Post-translational modifications:

  • UniProtKB: Sulfated on tyrosine
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P07478

  • 4/20 DME Specific Peptides for PRSS2 (P07478) (see all 20)
     EGGKDSC  PGVYTKV  QGIVSWG  CEASYPG 

    PRSS2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PRSS2 Protein Expression
    REFSEQ proteins: NP_002761.1  Reactome Protein details: P07478
    Human Recombinant Protein Products for PRSS2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals PRSS2 Protein
    Novus Biologicals PRSS2 Lysates
    Sino Biological Recombinant Protein for PRSS2
    Sino Biological Cell Lysate for PRSS2 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PRSS2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IMP16192646
    GO:0031012extracellular matrix TAS12731883

    PRSS2 for ontologies           About GeneDecksing



    PRSS2 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for PRSS2 

    Assay Products for PRSS2: 
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    Cloud-Clone Corp. ELISAs for PRSS2 
    Cloud-Clone Corp. CLIAs for PRSS2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PRSS: Serine peptidases / Serine peptidases

    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry P07478

    ProtoNet protein and cluster: P07478

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: TRY2_HUMAN, P07478
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 peptidase S1 domain


    PRSS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRY2_HUMAN, P07478
    Function: In the ileum, may be involved in defensin processing, including DEFA5
    Catalytic activity: Preferential cleavage: Arg- -Xaa, Lys- -Xaa

         Genatlas biochemistry entry for PRSS2:
    protease serine 2,trypsin 2,expressed in pancreas

         Enzyme Numbers (IUBMB): EC 3.4.21.41 2 EC 3.4.212

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004252serine-type endopeptidase activity IDA12709065
    GO:0005509calcium ion binding IDA12709065
    GO:0005515protein binding IPI16192646
         
    PRSS2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PRSS2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PRSS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRSS2 
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    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PRSS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRSS2

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of PRSS2

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    Sino Biological Human cDNA Clone for PRSS2
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PRSS2 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.79
    Activation of Matrix Metalloproteinases0.40
    Degradation of collagen0.79
    2Immune System
    Immune System0.56
    Innate Immune System0.50
    3Beta defensins
    Defensins0.80
    4Collagen biosynthesis and modifying enzymes
    Extracellular matrix organization0.39
    5Class A/1 (Rhodopsin-like receptors)
    Neuroactive ligand-receptor interaction0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5/8        Reactome Pathways for PRSS2 (see all 8)
        Alpha-defensins
    Degradation of collagen
    Activation of Matrix Metalloproteinases
    Extracellular matrix organization
    Defensins


    4         Kegg Pathways  (Kegg details for PRSS2):
        Neuroactive ligand-receptor interaction
    Pancreatic secretion
    Protein digestion and absorption
    Influenza A


    PRSS2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRSS2

    5 Interacting proteins for PRSS2 (P074783) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPP050673I2D: score=1 
    BPIP172133I2D: score=1 
    MMP9P147803I2D: score=1 
    SERPINA1P010093I2D: score=1 
    SLPIP039733I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IDA12731883
    GO:0007586digestion IEA--
    GO:0022617extracellular matrix disassembly TAS--
    GO:0030198extracellular matrix organization TAS--
    GO:0030307positive regulation of cell growth TAS12731883

    PRSS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PRSS2 for compounds           About GeneDecksing

    EMD Millipore small molecules for PRSS2:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PRSS2 (TRY2)

    1 HMDB Compound for PRSS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    7 DrugBank Compounds for PRSS2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2-Phenylethylamine-- 64-04-0target--17139284 17016423 10592235
    3-Phenylpropylamine-- --target--17139284 17016423 10592235
    Benzamidine-- 618-39-3target--17139284 17016423 10592235
    Benzylamine-- 100-46-9target--17139284 17016423 10592235
    Monoisopropylphosphorylserine-- --target--17139284 17016423 10592235
    O-Benzylsulfonyl-Serine-- --target--17139284 17016423 10592235
    Phosphorylisopropane-- --target--17139284 17016423 10592235

    3 Novoseek inferred chemical compound relationships for PRSS2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trypsinogen 79.6 12 11391623 (4), 14695529 (2), 18986305 (1), 15901841 (1) (see all 5)
    serine 65.7 24 12396005 (1), 12731883 (1), 14568388 (1), 19887787 (1) (see all 20)
    cysteine 0 1 16783151 (1)

    Search CenterWatch for drugs/clinical trials and news about PRSS2 / TRY2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PRSS2 gene: 
    NM_002770.2  

    Unigene Clusters for PRSS2:

    Protease, serine, 2 (trypsin 2)
    Hs.726742  [show with all ESTs], Hs.728780  [show with all ESTs]
    Unigene Representative Sequences: BM805032, BE970192

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRSS2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PRSS2
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    Browse for Gene Knock-down Tools from EMD Millipore
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRSS2 (NM_002770)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRSS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS2
    Sirion Biotech Customized lentivirus for stable overexpression of PRSS2 
                         Customized lentivirus expression plasmids for stable overexpression of PRSS2 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRSS2
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    Additional mRNA sequence: 

    AY052784.1 BC103997.2 BC107784.1 DQ846872.1 DQ846873.1 NR_001296.3 

    24/39 DOTS entries (see all 39):

    DT.100043423  DT.121076322  DT.87078490  DT.121076949  DT.121075973  DT.91767689  DT.100828689  DT.100828691 
    DT.100045920  DT.91721728  DT.100828698  DT.121076237  DT.121076760  DT.97857442  DT.100045917  DT.121076636 
    DT.95235519  DT.121076424  DT.121075905  DT.95096077  DT.95259214  DT.102841077  DT.101976063  DT.100798707 

    5 AceView cDNA sequences:

    BC005814 NM_002770 M27602 BC030260 AY052784 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRSS2 expression in normal human tissues (normalized intensities)      PRSS2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTGTGTGG
    PRSS2 Expression
    About this image


    PRSS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 3 entries
             Duct Cells Pancreatic Ducts
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
             Pancreatic Islet   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 3 entries
             small intestine   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Primitive Streak (Early Embryonic Tissues)
             Definitive endoderm-like cells ( Generation and expansion of endodermal progenitor...
     
     Neural Tube (Nervous System)
             Prosencephalon

    See PRSS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRSS2

    SOURCE GeneReport for Unigene clusters: Hs.726742 Hs.728780

    UniProtKB/Swiss-Prot: TRY2_HUMAN, P07478
    Tissue specificity: Expressed in Paneth cells, at the base of small intestinal crypts

        SABiosciences Custom PCR Arrays for PRSS2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PRSS2 gene from 3 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prss25 protease, serine, 2   --   6 (19.67 cM) 41521787 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.82612 Transcribed sequence with weak similarity to protein more 79(n)    CF225765.1 
    rainbow trout
    (Oncorhynchus mykiss)
    Actinopterygii Omy.86542 Oncorhynchus mykiss transcribed sequence with weak more 78.78(n)    BX076451.1 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRSS2 gene
    18/109 SIMAP similar genes for PRSS2 using alignment to 3 protein entries:     TRY2_HUMAN (see all proteins) (see all similar genes):
    TRY8    TRY6    PRSS3    PRSS1    KLK6    KLK5
    KLK8    KLK12    KLK15    KLK1    KLK9    KLK7
    KLK14    DKFZp586F0824    CTRB1    KLK11    KLK4    TMPRSS9

    PRSS2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/312 SNPs in PRSS2 are shown (see all 312)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs617346591,2
    C,Fother11(+) TCGAGG/AGAGGC 2 /R /G mis11Minor allele frequency- A:0.03NS 70
    VAR_0518584
    ----see VAR_0518582 A V mis40--------
    rs125365181,2
    C,F,A,H--1(+) AGAAGA/CAGCTT 3 -- ds50019Minor allele frequency- C:0.45NS NA WA 366
    rs737403121,2
    C,F--1(+) CTCTCC/AATAAA 3 -- int12Minor allele frequency- A:0.22WA 120
    rs737424441,2
    C,F--1(+) CATTTC/TTCTGG 3 -- int12Minor allele frequency- T:0.22WA 120
    rs746567621,2
    C--1(+) TATCAA/C/GTGAGT 3 -- int11NA 2
    rs2003356371,2
    C--1(+) ACATA-/GCCGAG
            
    CTGAT
    3 -- us2k1 int10--------
    rs2016978151,2
    C--1(+) TAGAC-/CAACCCTT 3 -- int10--------
    rs3700763291,2
    C--1(+) GTGCC-/ACATGG 3 -- int10--------
    rs20726251,2
    C--141872430(+) CAGGCA/GCTGTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for PRSS2 (974021 - 977604 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/17 variations for PRSS2 (see all 17):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2421493CNV Deletion20811451
    dgv1244e199CNV Deletion23128226
    dgv1167e201CNV Deletion23290073
    dgv1170e201CNV Deletion23290073
    esv2740741CNV Deletion23290073
    dgv1169e201CNV Deletion23290073
    nsv428187CNV Loss18775914
    dgv841n27CNV Loss19166990
    nsv818563CNV Loss17921354
    nsv824336CNV Loss20364138


    Human Gene Mutation Database (HGMD): PRSS2
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing PRSS2
    DNA2.0 Custom Variant and Variant Library Synthesis for PRSS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601564    OMIM disorders: --

    20/34 diseases for PRSS2 (see all 34):    About MalaCards
    ovarian cyst    malignant ovarian cyst    linitis plastica    tropical calcific pancreatitis
    acute pancreatitis    hereditary pancreatitis    hereditary angioedema    pemphigus foliaceus
    angioedema    pancreatic diseases    bronchopulmonary dysplasia    pemphigus
    keratoconus    synovitis    sjogren's syndrome    insulinoma
    pancreatitis    colorectal cancer    rheumatoid arthritis    pneumonia


    PRSS2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10 Novoseek inferred disease relationships for PRSS2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatitis 38.1 3 14695529 (2), 19077465 (1)
    acute pancreatitis 26.9 2 8760740 (2)
    respiratory distress syndrome 16.9 3 12949286 (2), 15879299 (1)
    colorectal cancer 14.3 2 11391623 (1), 17850591 (1)
    lung diseases 13.3 2 11585105 (1), 15879299 (1)
    metastasis 10.5 1 9261109 (1)
    tumors 4.92 8 11391623 (2), 9261109 (1), 18221368 (1), 17855650 (1)
    inflammation 0 1 15879299 (1)
    rheumatoid arthritis 0 3 16192646 (3)
    cancer 0 1 18062964 (1)

    Genetic Association Database (GAD): PRSS2
    Human Genome Epidemiology (HuGE) Navigator: PRSS2 (8 documents)

    Export disorders for PRSS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRSS2 gene, integrated from 9 sources (see all 111):
    (articles sorted by number of sources associating them with PRSS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, characterization and nucleotide sequences of two cDNAs encoding human pancreatic trypsinogens. (PubMed id 3011602)1, 2, 3 Emi M....Matsubara K. (1986)
    2. Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk. (PubMed id 19690177)1, 4 McWilliams R.R....Petersen G.M. (2009)
    3. Trypsinogen copy number mutations in patients with idiopathic chronic pancreatitis. (PubMed id 18063422)1, 4 Masson E....Ferec C. (2008)
    4. Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in Japanese patients. (PubMed id 19096130)1, 4 Kitahara K....Ota M. (2008)
    5. A loss-of-function p.G191R variant in the anionic trypsinogen (PRSS2) gene in Japanese patients with pancreatic disorders. (PubMed id 19052022)1, 4 Kume K....Shimosegawa T. (2008)
    6. A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis. (PubMed id 16699518)1, 4 Witt H....Ferec C. (2006)
    7. Immunoreactive anionic and cationic trypsin in human serum. (PubMed id 2598466)1, 2 Kimland M.... Borgstroem A. (1989)
    8. Intracellular co-localization of trypsin-2 and matrix metalloprotease-9: possible proteolytic cascade of trypsin-2, MMP-9 and enterokinase in carcinoma. (PubMed id 18062964)1, 9 Vilen S.T....Salo T. (2008)
    9. Trypsin-2 degrades human type II collagen and is expressed and activated in mesenchymally transformed rheumatoid arthritis synovitis tissue. (PubMed id 16192646)1, 9 Stenman M....Konttinen Y.T. (2005)
    10. Activation of type IV procollagenases by human tumor-associated trypsin-2. (PubMed id 9261109)1, 9 Sorsa T....Stenman U.H. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5645 HGNC: 9483 AceView: PRSS2 euGenes: HUgn5645 ECgene: PRSS2 Kegg: 5645
    H-InvDB: PRSS2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRSS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PRSS2 gene:
    Search GeneIP for patents involving PRSS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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