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PRSS2 Gene

protein-coding   GIFtS: 54
GCID: GC07P9T0097

Protease, Serine, 2 (Trypsin 2)

  See PRSS2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protease, Serine, 2 (Trypsin 2)1 2     TRY82
TRY22 3 5     Protease Serine 2 Preproprotein2
Anionic Trypsinogen2 3     Protease, Serine, 2, Preproprotein2
Serine Protease 22 3     Trypsin 22
Trypsin II2 3     trypsin-22
TRYP22 3     Trypsinogen 22
EC 3.4.21.43 8     EC 3.4.218

External Ids:    HGNC: 94831   Entrez Gene: 56452   OMIM: 6015645   UniProtKB: P074783   

Export aliases for PRSS2 gene to outside databases

Previous GC identifers: GC07P140772 GC07P140731 GC07P141821 GC07P141899 GC07P141902 GC07P141676 GC07P141990 GC07P142167 GC07P142178 GC07P142457 GC07P142298 GC07Pg41870 GC07P9T0974


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRSS2 Gene:
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is
secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages
involving the carboxyl group of lysine or arginine. This gene and several other trypsinogen genes are localized
to the T cell receptor beta locus on chromosome 7. (provided by RefSeq, Jul 2008)

GeneCards Summary for PRSS2 Gene:
PRSS2 (protease, serine, 2 (trypsin 2)) is a protein-coding gene. Diseases associated with PRSS2 include ovarian cyst, and malignant ovarian cyst. GO annotations related to this gene include serine-type endopeptidase activity and calcium ion binding.

UniProtKB/Swiss-Prot: TRY2_HUMAN, P07478
Function: In the ileum, may be involved in defensin processing, including DEFA5




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for PRSS2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): PRSS2 promoter sequence
   Search Chromatin IP Primers for PRSS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRSS2


Genomic Location:
Chromosome:7   

Entrez Gene cytogenetic band: 7q34   HGNC cytogenetic band: 7q34

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P9T0097:       (about GC identifiers)

Start:
974,021 bp from start of contig NW_003571040      End:
977,604 bp from start of contig NW_003571040
Size:
3,584 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 141,870,508-141,874,093     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TRY2_HUMAN, P07478 (See protein sequence)
Recommended Name: Trypsin-2 precursor  
Size: 247 amino acids; 26488 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)

Explore the universe of human proteins at neXtProt for PRSS2: NX_P07478

Explore proteomics data for PRSS2 at MOPED

Post-translational modifications: 

  • Sulfated on tyrosine1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PRSS2 (P07478) (see all 20)
     EGGKDSC  PGVYTKV  QGIVSWG  CEASYPG 


    See PRSS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002761.1  Reactome Protein details: P07478

    PRSS2 Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for PRSS2
    Sino Biological Cell Lysate for PRSS2
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PRSS: Serine peptidases / Serine peptidases

    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry P07478

    ProtoNet protein and cluster: P07478

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: TRY2_HUMAN, P07478
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 peptidase S1 domain


    Find genes that share domains with PRSS2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRY2_HUMAN, P07478
    Function: In the ileum, may be involved in defensin processing, including DEFA5
    Catalytic activity: Preferential cleavage: Arg- -Xaa, Lys- -Xaa

         Genatlas biochemistry entry for PRSS2:
    protease serine 2,trypsin 2,expressed in pancreas

         Enzyme Numbers (IUBMB): EC 3.4.21.41 2 EC 3.4.212

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004252serine-type endopeptidase activity IDA12709065
    GO:0005509calcium ion binding IDA12709065
    GO:0005515protein binding IPI16192646
         
    Find genes that share ontologies with PRSS2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRSS2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRSS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRSS2
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    miRNA
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    Sino Biological Human cDNA Clone for PRSS2
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRY2_HUMAN, P07478: Secreted, extracellular space

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IMP16192646
    GO:0031012extracellular matrix TAS12731883

    Find genes that share ontologies with PRSS2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRSS2 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    Collagen degradation0.43
    2Defensins
    Defensins0.80
    Alpha-defensins0.00
    3Matrix Metalloproteinases
    Activation of Matrix Metalloproteinases0.37
    4Peptide ligand-binding receptors
    Neuroactive ligand-receptor interaction0.36
    5Influenza A
    Influenza A0.34


    Find genes that share SuperPaths with PRSS2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3 Reactome Pathways for PRSS2
        Alpha-defensins
    Collagen degradation
    Activation of Matrix Metalloproteinases


    4 Kegg Pathways  (Kegg details for PRSS2):
        Neuroactive ligand-receptor interaction
    Pancreatic secretion
    Protein digestion and absorption
    Influenza A

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRSS2
    Interactions:

        GeneGlobe Interaction Network for PRSS2

    5 Interacting proteins for PRSS2 (P074783) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPP050673I2D: score=1 
    BPIP172133I2D: score=1 
    MMP9P147803I2D: score=1 
    SERPINA1P010093I2D: score=1 
    SLPIP039733I2D: score=1 
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    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IDA12731883
    GO:0007586digestion IEA--
    GO:0022617extracellular matrix disassembly TAS--
    GO:0030198extracellular matrix organization TAS--
    GO:0030307positive regulation of cell growth TAS12731883

    Find genes that share ontologies with PRSS2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRSS2 (TRY2)

    1 HMDB Compound for PRSS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    7 DrugBank Compounds for PRSS2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2-Phenylethylamine-- 64-04-0target--17139284 17016423 10592235
    3-Phenylpropylamine-- --target--17139284 17016423 10592235
    Benzamidine-- 618-39-3target--17139284 17016423 10592235
    Benzylamine-- 100-46-9target--17139284 17016423 10592235
    Monoisopropylphosphorylserine-- --target--17139284 17016423 10592235
    O-Benzylsulfonyl-Serine-- --target--17139284 17016423 10592235
    Phosphorylisopropane-- --target--17139284 17016423 10592235

    3 Novoseek inferred chemical compound relationships for PRSS2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trypsinogen 79.6 12 11391623 (4), 14695529 (2), 18986305 (1), 15901841 (1) (see all 5)
    serine 65.7 24 12396005 (1), 12731883 (1), 14568388 (1), 19887787 (1) (see all 20)
    cysteine 0 1 16783151 (1)



    Find genes that share compounds with PRSS2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRSS2 gene: 
    NM_002770.2  

    miRNA
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    GenScript: all cDNA clones in your preferred vector: PRSS2 (NM_002770)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRSS2
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      QuantiTect SYBR Green Assays in human, mouse, rat PRSS2
      QuantiFast Probe-based Assays in human, mouse, rat PRSS2

    5 AceView cDNA sequences:

    NM_002770 BC005814 M27602 BC030260 AY052784 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRSS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTGTGTGG
    PRSS2 Expression
    About this image


    PRSS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Duct Cells Pancreatic Ducts
             Islets of Langerhans
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
     
     NULL (Uncategorized)
             Definitive endoderm-like cells
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    PRSS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRSS2 Protein Expression

    UniProtKB/Swiss-Prot: TRY2_HUMAN, P07478
    Tissue specificity: Expressed in Paneth cells, at the base of small intestinal crypts

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PRSS2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prss21 , 5 protease, serine, 25
    protease, serine 21
    81.03(n)1
    77.24(a)1
      6 (19.67 cM)5
    220721  NM_009430.21  NP_033456.11 
     415217875 
    chicken
    (Gallus gallus)
    Aves PRSS21 protease, serine, 2 (trypsin 2) 70.85(n)
    71.3(a)
      396344  NM_205384.1  NP_990715.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.82612 Transcribed sequence with weak similarity to protein more 79(n)    CF225765.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch73-103b2.31 si:ch73-103b2.3 69.06(n)
    66.37(a)
      100535672  XM_003200190.2  XP_003200238.2 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0099661 AgaP_AGAP009966 51.73(n)
    44.81(a)
      1279386  XM_319102.4  XP_319102.4 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRSS2 gene
    Selected SIMAP similar genes for PRSS2 using alignment to 3 protein entries:     TRY2_HUMAN (see all proteins) (see all similar genes):
    TRY8    PRSS3    PRSS1    KLK6    KLK5    KLK8
    KLK12    KLK7    KLK15    KLK1    KLK9    KLK14
    DKFZp586F0824    CTRB1    KLK11    KLK4    TMPRSS9    CTRB2

    Find genes that share paralogs with PRSS2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRSS2 (see all 312)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs617346591,2
    C,Fother11(+) TCGAGG/AGAGGC 2 /R /G mis11Minor allele frequency- A:0.03NS 70
    rs125365181,2
    C,F,A,H--1(+) AGAAGA/CAGCTT 3 -- ds50019Minor allele frequency- C:0.45NS NA WA 366
    rs737403121,2
    C,F--1(+) CTCTCC/AATAAA 3 -- int12Minor allele frequency- A:0.22WA 120
    rs737424441,2
    C,F--1(+) CATTTC/TTCTGG 3 -- int12Minor allele frequency- T:0.22WA 120
    rs746567621,2
    C--1(+) TATCAA/C/GTGAGT 3 -- int11NA 2
    rs2003356371,2
    C--1(+) ACATA-/GCCGAG
            
    CTGAT
    3 -- us2k1 int10--------
    rs2016978151,2
    C--1(+) TAGAC-/CAACCCTT 3 -- int10--------
    rs3700763291,2
    C--1(+) GTGCC-/ACATGG 3 -- int10--------
    rs20726251,2
    C--141872430(+) CAGGCA/GCTGTG 1 -- int10--------
    rs617363611,2
    F--141873963(+) GCCCAG/AAAGAA 2 /Q syn11Minor allele frequency- A:0.11NS 18

    HapMap Linkage Disequilibrium report for PRSS2 (974021 - 977604 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PRSS2 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2421493CNV Deletion20811451
    dgv1244e199CNV Deletion23128226
    dgv1167e201CNV Deletion23290073
    dgv1170e201CNV Deletion23290073
    esv2740741CNV Deletion23290073
    dgv1169e201CNV Deletion23290073
    nsv428187CNV Loss18775914
    dgv841n27CNV Loss19166990
    nsv818563CNV Loss17921354
    nsv824336CNV Loss20364138

    Human Gene Mutation Database (HGMD): PRSS2
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing PRSS2
    DNA2.0 Custom Variant and Variant Library Synthesis for PRSS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601564   
    OMIM disorders: 167800  
    12 diseases for PRSS2:    
    About MalaCards
    ovarian cyst    malignant ovarian cyst    linitis plastica    pancreatitis, chronic, protection against
    tropical calcific pancreatitis    prss1-related hereditary pancreatitis    hereditary angioedema    acute pancreatitis
    pancreatitis, chronic    hereditary pancreatitis    pancreatitis    primary hyperparathyroidism


    Find genes that share disorders with PRSS2           About GenesLikeMe

    10 Novoseek inferred disease relationships for PRSS2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatitis 38.1 3 14695529 (2), 19077465 (1)
    acute pancreatitis 26.9 2 8760740 (2)
    respiratory distress syndrome 16.9 3 12949286 (2), 15879299 (1)
    colorectal cancer 14.3 2 11391623 (1), 17850591 (1)
    lung diseases 13.3 2 11585105 (1), 15879299 (1)
    metastasis 10.5 1 9261109 (1)
    tumors 4.92 8 11391623 (2), 9261109 (1), 18221368 (1), 17855650 (1)
    inflammation 0 1 15879299 (1)
    rheumatoid arthritis 0 3 16192646 (3)
    cancer 0 1 18062964 (1)

    Genetic Association Database (GAD): PRSS2
    Human Genome Epidemiology (HuGE) Navigator: PRSS2 (8 documents)

    Export disorders for PRSS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRSS2 gene, integrated from 10 sources (see all 112):
    (articles sorted by number of sources associating them with PRSS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, characterization and nucleotide sequences of two cDNAs encoding human pancreatic trypsinogens. (PubMed id 3011602)1, 2, 3 Emi M....Matsubara K. (Gene 1986)
    2. A loss-of-function p.G191R variant in the anionic trypsinogen (PRSS2) gene in Japanese patients with pancreatic disorders. (PubMed id 19052022)1, 4 Kume K....Shimosegawa T. (Gut 2009)
    3. Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk. (PubMed id 19690177)1, 4 McWilliams R.R....Petersen G.M. (amp 2009)
    4. Trypsinogen copy number mutations in patients with idiopathic chronic pancreatitis. (PubMed id 18063422)1, 4 Masson E....FAcrec C. (Clin. Gastroenterol. Hepatol. 2008)
    5. Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in Japanese patients. (PubMed id 19096130)1, 4 Kitahara K....Ota M. (Dis. Markers 2008)
    6. A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis. (PubMed id 16699518)1, 4 Witt H....FAcrec C. (Nat. Genet. 2006)
    7. Immunoreactive anionic and cationic trypsin in human serum. (PubMed id 2598466)1, 2 Kimland M.... Borgstroem A. (Clin. Chim. Acta 1989)
    8. Intracellular co-localization of trypsin-2 and matrix metalloprotease-9: possible proteolytic cascade of trypsin-2, MMP-9 and enterokinase in carcinoma. (PubMed id 18062964)1, 9 Vilen S.T....Salo T. (Exp. Cell Res. 2008)
    9. Trypsin-2 degrades human type II collagen and is expressed and activated in mesenchymally transformed rheumatoid arthritis synovitis tissue. (PubMed id 16192646)1, 9 Stenman M....Konttinen Y.T. (Am. J. Pathol. 2005)
    10. Activation of type IV procollagenases by human tumor-associated trypsin-2. (PubMed id 9261109)1, 9 Sorsa T....Stenman U.H. (J. Biol. Chem. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
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      Query String
    PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5645 HGNC: 9483 AceView: PRSS2 euGenes: HUgn5645 ECgene: PRSS2 Kegg: 5645
    H-InvDB: PRSS2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRSS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRSS2 gene:
    Search GeneIP for patents involving PRSS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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