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Aliases for PRSS16 Gene

Aliases for PRSS16 Gene

  • Protease, Serine, 16 (Thymus) 2 3
  • Serine Protease 16 3 4
  • TSSP 3 4
  • Thymus Specific Serine Peptidase 3
  • EC 3.4.-.- 4

External Ids for PRSS16 Gene

Previous GeneCards Identifiers for PRSS16 Gene

  • GC06P027273
  • GC06P027323
  • GC06P027217
  • GC06P027023

Summaries for PRSS16 Gene

Entrez Gene Summary for PRSS16 Gene

  • This gene encodes a serine protease expressed exclusively in the thymus. It is thought to play a role in the alternative antigen presenting pathway used by cortical thymic epithelial cells during the positive selection of T cells. The gene is found in the large histone gene cluster on chromosome 6, near the major histocompatibility complex (MHC) class I region. A second transcript variant has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRSS16 Gene

PRSS16 (Protease, Serine, 16 (Thymus)) is a Protein Coding gene. Diseases associated with PRSS16 include diabetes mellitus, insulin-dependent. GO annotations related to this gene include serine-type peptidase activity. An important paralog of this gene is PRCP.

UniProtKB/Swiss-Prot for PRSS16 Gene

  • Protease that may play a role in T-cell development

Gene Wiki entry for PRSS16 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS16 Gene

Genomics for PRSS16 Gene

Regulatory Elements for PRSS16 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PRSS16 Gene

Chromosome:
6
Start:
27,247,701 bp from pter
End:
27,256,624 bp from pter
Size:
8,924 bases
Orientation:
Plus strand

Genomic View for PRSS16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRSS16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS16 Gene

Proteins for PRSS16 Gene

  • Protein details for PRSS16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQE7-TSSP_HUMAN
    Recommended name:
    Thymus-specific serine protease
    Protein Accession:
    Q9NQE7
    Secondary Accessions:
    • O75416

    Protein attributes for PRSS16 Gene

    Size:
    514 amino acids
    Molecular mass:
    55049 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB94769.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for PRSS16 Gene

Proteomics data for PRSS16 Gene at MOPED

Post-translational modifications for PRSS16 Gene

  • Glycosylation at Asn 70, Asn 172, and Asn 321
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PRSS16 Gene

Domains & Families for PRSS16 Gene

Gene Families for PRSS16 Gene

Protein Domains for PRSS16 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PRSS16 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NQE7

UniProtKB/Swiss-Prot:

TSSP_HUMAN :
  • Belongs to the peptidase S28 family.
Family:
  • Belongs to the peptidase S28 family.
genes like me logo Genes that share domains with PRSS16: view

Function for PRSS16 Gene

Molecular function for PRSS16 Gene

GENATLAS Biochemistry:
protease serine 16,expressed in thymus,located in cortical thymic epithelial cells
UniProtKB/Swiss-Prot Function:
Protease that may play a role in T-cell development

Enzyme Numbers (IUBMB) for PRSS16 Gene

Gene Ontology (GO) - Molecular Function for PRSS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008236 serine-type peptidase activity NAS 10527559
genes like me logo Genes that share ontologies with PRSS16: view
genes like me logo Genes that share phenotypes with PRSS16: view

Animal Models for PRSS16 Gene

MGI Knock Outs for PRSS16:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRSS16

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PRSS16 Gene

Localization for PRSS16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS16 Gene

Cytoplasmic vesicle. Note=Vesicular, either lysosomal or endosomal.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRSS16 Gene COMPARTMENTS Subcellular localization image for PRSS16 gene
Compartment Confidence
endosome 5
lysosome 5
vacuole 5

Gene Ontology (GO) - Cellular Components for PRSS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IDA 10527559
GO:0005768 endosome IDA 10527559
GO:0016023 cytoplasmic membrane-bounded vesicle IEA --
genes like me logo Genes that share ontologies with PRSS16: view

Pathways & Interactions for PRSS16 Gene

SuperPathways for PRSS16 Gene

No Data Available

Interacting Proteins for PRSS16 Gene

Selected Interacting proteins: Q9NQE7-TSSP_HUMAN for PRSS16 Gene via I2D

Symbol External ID(s) Details
CCDC47

Gene Ontology (GO) - Biological Process for PRSS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0030163 protein catabolic process NAS 10527559
genes like me logo Genes that share ontologies with PRSS16: view

No data available for Pathways by source and SIGNOR curated interactions for PRSS16 Gene

Drugs & Compounds for PRSS16 Gene

No Compound Related Data Available

Transcripts for PRSS16 Gene

Unigene Clusters for PRSS16 Gene

Protease, serine, 16 (thymus):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRSS16

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS16 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e · 9f ^ 10a · 10b · 10c ^ 11a · 11b ^
SP1: - - - - - - -
SP2: - - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - - - - - - - -
SP13: - - - - - - - - - - - - -
SP14: - - - - - - - - - -
SP15: - - - - - - -
SP16: - - - - - - - - - - -
SP17: - - - - -
SP18: - -
SP19:
SP20: - - - - -
SP21: - - - - - -

ExUns: 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b · 14c · 14d · 14e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: - -
SP8:
SP9:
SP10:
SP11: - -
SP12:
SP13: - -
SP14: - -
SP15:
SP16: - -
SP17:
SP18:
SP19:
SP20:
SP21: - -

Relevant External Links for PRSS16 Gene

GeneLoc Exon Structure for
PRSS16
ECgene alternative splicing isoforms for
PRSS16

Expression for PRSS16 Gene

mRNA expression in normal human tissues for PRSS16 Gene

mRNA differential expression in normal tissues according to GTEx for PRSS16 Gene

This gene is overexpressed in Pancreas (x10.6) and Thyroid (x4.3).

Protein differential expression in normal tissues from HIPED for PRSS16 Gene

This gene is overexpressed in Pancreatic juice (64.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRSS16 Gene



SOURCE GeneReport for Unigene cluster for PRSS16 Gene Hs.274407

mRNA Expression by UniProt/SwissProt for PRSS16 Gene

Q9NQE7-TSSP_HUMAN
Tissue specificity: Expressed predominantly in cortical thymic epithelial cells
genes like me logo Genes that share expression patterns with PRSS16: view

Protein tissue co-expression partners for PRSS16 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PRSS16 Gene

Orthologs for PRSS16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRSS16 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRSS16 35
  • 83.89 (n)
  • 82.57 (a)
PRSS16 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRSS16 35
  • 82.82 (n)
  • 79.06 (a)
PRSS16 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prss16 35
  • 79.23 (n)
  • 79.96 (a)
Prss16 16
Prss16 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRSS16 35
  • 99.42 (n)
  • 99.03 (a)
PRSS16 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prss16 35
  • 79.52 (n)
  • 79.52 (a)
oppossum
(Monodelphis domestica)
Mammalia PRSS16 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRSS16 36
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRSS16 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prss16 35
  • 53.01 (n)
  • 45.44 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9988 35
zebrafish
(Danio rerio)
Actinopterygii LOC100334526 35
  • 48.31 (n)
  • 43.79 (a)
prss16 36
  • 35 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3734 37
  • 27 (a)
CG3739 37
  • 26 (a)
CG9953 37
  • 35 (a)
CG11626 36
  • 28 (a)
OneToMany
CG18493 36
  • 25 (a)
OneToMany
CG3734 36
  • 25 (a)
OneToMany
CG3739 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C26B9.5 37
  • 29 (a)
F56F10.1 37
  • 28 (a)
K12H4.7a 37
  • 32 (a)
K12H4.7b 37
  • 30 (a)
C26B9.5 36
  • 25 (a)
OneToMany
F19C7.2 36
  • 24 (a)
OneToMany
F28E10.5 36
  • 29 (a)
OneToMany
F56F10.1 36
  • 25 (a)
OneToMany
K12H4.7 36
  • 29 (a)
OneToMany
pcp-2 36
  • 13 (a)
OneToMany
pcp-3 36
  • 12 (a)
OneToMany
pcp-4 36
  • 13 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G36190 35
  • 43.03 (n)
  • 37.57 (a)
rice
(Oryza sativa)
Liliopsida Os10g0511400 35
  • 41.2 (n)
  • 33.8 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8568 36
  • 31 (a)
OneToOne
Species with no ortholog for PRSS16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRSS16 Gene

ENSEMBL:
Gene Tree for PRSS16 (if available)
TreeFam:
Gene Tree for PRSS16 (if available)

Paralogs for PRSS16 Gene

Paralogs for PRSS16 Gene

(1) SIMAP similar genes for PRSS16 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with PRSS16: view

Variants for PRSS16 Gene

Sequence variations from dbSNP and Humsavar for PRSS16 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1062834 -- 27,254,760(-) TCACA(A/C/T)AGGTC reference, synonymous-codon
rs1234145 -- 27,249,069(-) TGGGG(A/G)GGTGA intron-variant
rs2273565 -- 27,255,195(-) AGAAG(A/G)AGGGA intron-variant
rs2295603 -- 27,253,111(-) ATGCA(C/T)ACACT intron-variant
rs3734576 -- 27,255,688(+) TTAGA(A/T)CCTGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PRSS16 Gene

Variant ID Type Subtype PubMed ID
nsv883505 CNV Gain 21882294

Variation tolerance for PRSS16 Gene

Residual Variation Intolerance Score: 34.26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.45; 81.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRSS16 Gene

HapMap Linkage Disequilibrium report
PRSS16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS16 Gene

Disorders for PRSS16 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRSS16 Gene - From: DISEASES and NovoSeek

Disorder Aliases PubMed IDs
diabetes mellitus, insulin-dependent
  • diabetes, type 1
- elite association

Relevant External Links for PRSS16

Genetic Association Database (GAD)
PRSS16
Human Genome Epidemiology (HuGE) Navigator
PRSS16
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRSS16
genes like me logo Genes that share disorders with PRSS16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRSS16 Gene

Publications for PRSS16 Gene

  1. Cloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymus. (PMID: 10527559) Bowlus C.L. … Gruen J.R. (Cell. Immunol. 1999) 2 23 67
  2. Inferring selection in the Anopheles gambiae species complex: an example from immune-related serine protease inhibitors. (PMID: 19497100) Obbard D.J. … Little T.J. (Malar. J. 2009) 23 67
  3. Association analysis in type 1 diabetes of the PRSS16 gene encoding a thymus-specific serine protease. (PMID: 17584581) Lie B.A. … Undlien D.E. (Hum. Immunol. 2007) 23 67
  4. Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B. (PMID: 15713485) Shia S. … Eigenbrot C. (J. Mol. Biol. 2005) 23 67
  5. Alternatively spliced transcripts of the thymus-specific protease PRSS16 are differentially expressed in human thymus. (PMID: 15592422) Luther C. … Tolosa E. (Genes Immun. 2005) 23 67

Products for PRSS16 Gene

Sources for PRSS16 Gene

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