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Aliases for PRSS16 Gene

Aliases for PRSS16 Gene

  • Protease, Serine 16 2 3 5
  • Thymus-Specific Serine Protease 2 3
  • Serine Protease 16 3 4
  • TSSP 3 4
  • Thymus Specific Serine Peptidase 3
  • Protease, Serine, 16 (Thymus) 3
  • EC 3.4.-.- 4

External Ids for PRSS16 Gene

Previous GeneCards Identifiers for PRSS16 Gene

  • GC06P027273
  • GC06P027323
  • GC06P027217
  • GC06P027023

Summaries for PRSS16 Gene

Entrez Gene Summary for PRSS16 Gene

  • This gene encodes a serine protease expressed exclusively in the thymus. It is thought to play a role in the alternative antigen presenting pathway used by cortical thymic epithelial cells during the positive selection of T cells. The gene is found in the large histone gene cluster on chromosome 6, near the major histocompatibility complex (MHC) class I region. A second transcript variant has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRSS16 Gene

PRSS16 (Protease, Serine 16) is a Protein Coding gene. Diseases associated with PRSS16 include Diabetes Mellitus, Insulin-Dependent. GO annotations related to this gene include serine-type peptidase activity. An important paralog of this gene is DPP7.

UniProtKB/Swiss-Prot for PRSS16 Gene

  • Protease that may play a role in T-cell development.

Gene Wiki entry for PRSS16 Gene

Additional gene information for PRSS16 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS16 Gene

Genomics for PRSS16 Gene

Regulatory Elements for PRSS16 Gene

Enhancers for PRSS16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H027161 1.2 Ensembl ENCODE 5.9 -85.6 -85568 1.1 HDGF ATF1 ARNT ZNF2 GTF3C2 ZNF766 GATA2 ZNF143 FOS ATF7 ZKSCAN8 ABT1 ZNF322 LOC102724851 BTN2A3P HIST1H2AK HIST1H2BN HIST1H4K PRSS16 TRH-GTG1-5
GH06H027154 0.5 ENCODE 3.9 -92.6 -92637 1 EGR1 ZNF512 ZBTB33 MLLT1 EMSY HIST1H2BL HIST1H3H BTN2A2 PRSS16 GC06P027188 GC06P027154
GH06H027250 1.1 ENCODE 0.7 +3.8 3798 2.1 HDGF PKNOX1 ARNT SIN3A ZNF2 ZBTB7B CBX5 ZNF143 ZNF207 SP3 ZSCAN9 ABT1 ZKSCAN8 BTN3A2 BTN2A3P HCG11 BTN2A2 RNU6-471P BTN2A1 HIST1H2AH
GH06H027236 1.3 Ensembl ENCODE 0.4 -9.8 -9809 2.6 PKNOX1 ARNT ZNF2 ETS1 GTF3C2 ZNF766 CBX5 FOS ATF7 RUNX3 ZKSCAN8 ZNF322 BTN3A2 ABT1 BTN2A3P ZSCAN9 ZNF204P GUSBP2 RNU6-471P BTN2A2
GH06H027260 0.4 ENCODE 0.4 +12.9 12863 0.3 ZBTB33 POM121L2 RNU6-471P BTN2A2 ZNF204P ZNF192P1 LOC442172 PRSS16
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRSS16 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PRSS16 Gene

Genomic Locations for PRSS16 Gene
chr6:27,247,701-27,256,624
(GRCh38/hg38)
Size:
8,924 bases
Orientation:
Plus strand
chr6:27,215,480-27,224,403
(GRCh37/hg19)

Genomic View for PRSS16 Gene

Genes around PRSS16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS16 Gene

Proteins for PRSS16 Gene

  • Protein details for PRSS16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQE7-TSSP_HUMAN
    Recommended name:
    Thymus-specific serine protease
    Protein Accession:
    Q9NQE7
    Secondary Accessions:
    • O75416

    Protein attributes for PRSS16 Gene

    Size:
    514 amino acids
    Molecular mass:
    55049 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB94769.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for PRSS16 Gene

Post-translational modifications for PRSS16 Gene

  • Glycosylation at isoforms=70, Asn172, and isoforms=321
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PRSS16 Gene

Domains & Families for PRSS16 Gene

Gene Families for PRSS16 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for PRSS16 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PRSS16 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NQE7

UniProtKB/Swiss-Prot:

TSSP_HUMAN :
  • Belongs to the peptidase S28 family.
Family:
  • Belongs to the peptidase S28 family.
genes like me logo Genes that share domains with PRSS16: view

Function for PRSS16 Gene

Molecular function for PRSS16 Gene

GENATLAS Biochemistry:
protease serine 16,expressed in thymus,located in cortical thymic epithelial cells
UniProtKB/Swiss-Prot Function:
Protease that may play a role in T-cell development.

Enzyme Numbers (IUBMB) for PRSS16 Gene

Phenotypes From GWAS Catalog for PRSS16 Gene

Gene Ontology (GO) - Molecular Function for PRSS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA,NAS 10527559
GO:0008239 dipeptidyl-peptidase activity IBA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PRSS16: view
genes like me logo Genes that share phenotypes with PRSS16: view

Animal Models for PRSS16 Gene

MGI Knock Outs for PRSS16:

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRSS16 Gene

Localization for PRSS16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS16 Gene

Cytoplasmic vesicle. Note=Vesicular, either lysosomal or endosomal.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRSS16 gene
Compartment Confidence
lysosome 5
endosome 5
extracellular 3
plasma membrane 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for PRSS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IDA 10527559
GO:0005768 endosome IDA,IEA 10527559
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with PRSS16: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRSS16 Gene

Pathways & Interactions for PRSS16 Gene

SuperPathways for PRSS16 Gene

No Data Available

Interacting Proteins for PRSS16 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000230582%0d%0a9606.ENSP00000357873%0d%0a
Selected Interacting proteins: ENSP00000230582 Q9NQE7-TSSP_HUMAN for PRSS16 Gene via STRING IID

Gene Ontology (GO) - Biological Process for PRSS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IBA,IEA --
GO:0030163 protein catabolic process NAS 10527559
genes like me logo Genes that share ontologies with PRSS16: view

No data available for Pathways by source and SIGNOR curated interactions for PRSS16 Gene

Drugs & Compounds for PRSS16 Gene

No Compound Related Data Available

Transcripts for PRSS16 Gene

Unigene Clusters for PRSS16 Gene

Protease, serine, 16 (thymus):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS16 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e · 9f ^ 10a · 10b · 10c ^ 11a · 11b ^
SP1: - - - - - - -
SP2: - - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - - - - - - - -
SP13: - - - - - - - - - - - - -
SP14: - - - - - - - - - -
SP15: - - - - - - -
SP16: - - - - - - - - - - -
SP17: - - - - -
SP18: - -
SP19:
SP20: - - - - -
SP21: - - - - - -

ExUns: 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b · 14c · 14d · 14e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: - -
SP8:
SP9:
SP10:
SP11: - -
SP12:
SP13: - -
SP14: - -
SP15:
SP16: - -
SP17:
SP18:
SP19:
SP20:
SP21: - -

Relevant External Links for PRSS16 Gene

GeneLoc Exon Structure for
PRSS16
ECgene alternative splicing isoforms for
PRSS16

Expression for PRSS16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRSS16 Gene

mRNA differential expression in normal tissues according to GTEx for PRSS16 Gene

This gene is overexpressed in Pancreas (x10.6) and Thyroid (x4.3).

Protein differential expression in normal tissues from HIPED for PRSS16 Gene

This gene is overexpressed in Pancreatic juice (64.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRSS16 Gene



Protein tissue co-expression partners for PRSS16 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRSS16 Gene:

PRSS16

SOURCE GeneReport for Unigene cluster for PRSS16 Gene:

Hs.274407

mRNA Expression by UniProt/SwissProt for PRSS16 Gene:

Q9NQE7-TSSP_HUMAN
Tissue specificity: Expressed predominantly in cortical thymic epithelial cells.
genes like me logo Genes that share expression patterns with PRSS16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRSS16 Gene

Orthologs for PRSS16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRSS16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRSS16 33 34
  • 99.42 (n)
cow
(Bos Taurus)
Mammalia PRSS16 33 34
  • 83.89 (n)
dog
(Canis familiaris)
Mammalia PRSS16 33 34
  • 82.82 (n)
rat
(Rattus norvegicus)
Mammalia Prss16 33
  • 79.52 (n)
mouse
(Mus musculus)
Mammalia Prss16 33 16 34
  • 79.23 (n)
oppossum
(Monodelphis domestica)
Mammalia PRSS16 34
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRSS16 34
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRSS16 34
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prss16 33
  • 53.01 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9988 33
zebrafish
(Danio rerio)
Actinopterygii LOC100334526 33
  • 48.31 (n)
prss16 34
  • 35 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9953 35
  • 35 (a)
CG11626 34
  • 28 (a)
OneToMany
CG3734 35 34
  • 27 (a)
CG3739 35 34
  • 26 (a)
CG18493 34
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K12H4.7a 35
  • 32 (a)
K12H4.7b 35
  • 30 (a)
C26B9.5 35 34
  • 29 (a)
F28E10.5 34
  • 29 (a)
OneToMany
K12H4.7 34
  • 29 (a)
OneToMany
F56F10.1 35 34
  • 28 (a)
F19C7.2 34
  • 24 (a)
OneToMany
pcp-4 34
  • 13 (a)
OneToMany
pcp-2 34
  • 13 (a)
OneToMany
pcp-3 34
  • 12 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G36190 33
  • 43.03 (n)
rice
(Oryza sativa)
Liliopsida Os10g0511400 33
  • 41.2 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8568 34
  • 31 (a)
OneToOne
Species where no ortholog for PRSS16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRSS16 Gene

ENSEMBL:
Gene Tree for PRSS16 (if available)
TreeFam:
Gene Tree for PRSS16 (if available)

Paralogs for PRSS16 Gene

Paralogs for PRSS16 Gene

(1) SIMAP similar genes for PRSS16 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with PRSS16: view

Variants for PRSS16 Gene

Sequence variations from dbSNP and Humsavar for PRSS16 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000427791 -- 27,248,647(+) TCAAA(A/G)ATTTG intron-variant
rs1000673604 -- 27,256,539(+) CCTCA(G/T)GCTGT downstream-variant-500B, utr-variant-3-prime
rs1000898514 -- 27,250,874(+) GATAA(C/T)AGGAA intron-variant
rs1001431196 -- 27,250,411(+) TTGGA(A/C)ATTTT intron-variant
rs1001817675 -- 27,252,211(+) GGTCA(C/T)GTAGA intron-variant

Variation tolerance for PRSS16 Gene

Residual Variation Intolerance Score: 34.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.45; 81.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRSS16 Gene

Human Gene Mutation Database (HGMD)
PRSS16
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRSS16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PRSS16 Gene

Disorders for PRSS16 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRSS16 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
diabetes mellitus, insulin-dependent
  • diabetes, type 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PRSS16

Genetic Association Database (GAD)
PRSS16
Human Genome Epidemiology (HuGE) Navigator
PRSS16
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRSS16
genes like me logo Genes that share disorders with PRSS16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRSS16 Gene

Publications for PRSS16 Gene

  1. Cloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymus. (PMID: 10527559) Bowlus CL … Gruen JR (Cellular immunology 1999) 2 3 4 22 60
  2. Polymorphisms in the gene encoding thymus-specific serine protease in the extended HLA complex: a potential candidate gene for autoimmune and HLA-associated diseases. (PMID: 12140752) Lie BA … Undlien DE (Genes and immunity 2002) 3 22 45 60
  3. Reproducible association with type 1 diabetes in the extended class I region of the major histocompatibility complex. (PMID: 19295542) Viken MK … Lie BA (Genes and immunity 2009) 3 45 60
  4. Common variants conferring risk of schizophrenia. (PMID: 19571808) Stefansson H … Collier DA (Nature 2009) 3 45 60
  5. Common variants on chromosome 6p22.1 are associated with schizophrenia. (PMID: 19571809) Shi J … Gejman PV (Nature 2009) 3 45 60

Products for PRSS16 Gene

Sources for PRSS16 Gene

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