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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRSS12 Gene

protein-coding   GIFtS: 52
GCID: GC04M119201

protease, serine, 12 (neurotrypsin, motopsin)
 Explore 7 diseases affiliated with
PRSS12 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PRSS12    

Aliases
for PRSS12 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Protease, Serine, 12 (Neurotrypsin, Motopsin)1 2     Neurotrypsin1
MRT11 2 5     EC 3.4.21.-3
BSSP-31 2     Leydin3
BSSP32 5     Motopsin3
Brain-Specific Serine Protease 32     Serine Protease 123
Leydin3     EC 3.4.218

External Ids:    HGNC: 94771   Entrez Gene: 84922   Ensembl: ENSG000001640997   OMIM: 6067095   UniProtKB: P567303   

Export aliases for PRSS12 gene to outside databases

Previous GC identifers: GC04M119955 GC04M119483 GC04M119595 GC04M119662 GC04M119663 GC04M119560 GC04M114936


Summaries
for PRSS12 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PRSS12:
This gene encodes a member of the trypsin family of serine proteases. Studies in mouse suggest that the encoded enzyme
may be involved in structural reorganizations associated with learning and memory. The enzyme is also expressed in
Leydig cells in the testis, but its function in this tissue is unknown. Defects in this gene are a cause of mental
retardation autosomal recessive type 1 (MRT1). (provided by RefSeq, Jul 2010)

UniProtKB/Swiss-Prot: NETR_HUMAN, P56730
Function: Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations
associated with learning and memory operations (By similarity)




Genomic Views
for PRSS12 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRSS12 gene promoter:
         NF-1   NF-1/L   Pax-5   STAT5A   LUN-1   Evi-1   C/EBPalpha   HOXA5   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PRSS12 promoter sequence
   Search SABiosciences Chromatin IP Primers for PRSS12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRSS12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q28.1   Ensembl cytogenetic band:  4q26   HGNC cytogenetic band: 4q25-q26

PRSS12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRSS12 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M119201:  view genomic region     (about GC identifiers)

Start:
 119,201,193 bp from pter      End:
 119,274,158 bp from pter
Size:
 72,966 bases      Orientation:
 minus strand

Proteins
for PRSS12 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NETR_HUMAN, P56730 (See protein sequence)
Recommended Name: Neurotrypsin precursor  
Size: 875 amino acids; 97067 Da
Subcellular location: Secreted
Secondary accessions: Q9UP16

Explore the universe of human proteins at neXtProt for PRSS12: NX_P56730

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P56730

    • 4/39 DME Specific Peptides for PRSS12 (P56730) (see all 39)
     CYITGWG  LPEVVGF  PGVYTKV  VLTAAHC 

    PRSS12 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003610.2  
    ENSEMBL proteins: 
     ENSP00000296498  

    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PRSS12

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane ISS--
    GO:0016020membrane ----
    GO:0030424axon ISS--
    GO:0030425dendrite IEA--


    PRSS12 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for PRSS12

    Protein Domains /
    Families
    for PRSS12 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PRSS12 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR001314 Peptidase_S1A
     IPR001190 Srcr_rcpt
     IPR018056 Kringle_CS
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS

    Graphical View of Domain Structure for InterPro Entry P56730

    ProtoNet protein and cluster: P56730

    4 Blocks protein families:
    IPB000001 Kringle
    IPB001190 Speract/scavenger receptor
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: NETR_HUMAN, P56730
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 kringle domain
    Similarity: Contains 1 peptidase S1 domain
    Similarity: Contains 4 SRCR domains


    Function
    for PRSS12 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NETR_HUMAN, P56730
    Function: Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations
    associated with learning and memory operations (By similarity)

         Genatlas biochemistry entry for PRSS12:
    protease serine 12,neurotrypsin,motopsin,expressed in the nervous system,hippocampal formation amygdala and cerebral
    cortex

    Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.-1

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRSS12
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate PRSS12 (see all 9):
    hsa-miR-15a hsa-miR-497 hsa-miR-373* hsa-miR-587 hsa-miR-424 hsa-miR-16 hsa-miR-195 hsa-miR-616*
    SwitchGear 3'UTR luciferase reporter plasmid: PRSS12 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: PRSS12
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PRSS12

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRSS12 (see all 3)
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    Cell Line
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    Search LifeMap BioReagents cell lines for PRSS12

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0005044scavenger receptor activity IEA--
    GO:0008233peptidase activity ----
    GO:0008236serine-type peptidase activity TAS9540828


    PRSS12 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for PRSS12: Prss12tm1Mits Prss12tm1.1Peso
         3 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Prss12):
     behavior/neurological  nervous system  no phenotypic analysis 

    PRSS12 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PRSS12 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PRSS12

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0006887exocytosis ISS--
    GO:0031638zymogen activation IEA--


    PRSS12 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PRSS12 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PRSS12 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PRSS12
    1 Novoseek chemical compound relationship for PRSS12 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 59.9 8 10343120 (1), 9540828 (1), 18272678 (1), 12624642 (1) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about PRSS12 / NETR 

    Transcripts
    for PRSS12 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PRSS12 gene: 
    NM_003619.3  

    Unigene Cluster for PRSS12:

    Protease, serine, 12 (neurotrypsin, motopsin)
    Hs.445857  [show with all ESTs]
    Unigene Representative Sequence: NM_003619
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296498(uc003ica.2) ENST00000510903 ENST00000515089 ENST00000503043


    miRNA
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate PRSS12 (see all 9):
    hsa-miR-15a hsa-miR-497 hsa-miR-373* hsa-miR-587 hsa-miR-424 hsa-miR-16 hsa-miR-195 hsa-miR-616*
    SwitchGear 3'UTR luciferase reporter plasmid: PRSS12 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: PRSS12
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    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRSS12

    Additional cDNA sequence: 

    AF077298.1 AJ001531.1 BC007761.2 

    6 DOTS entries:

    DT.441307  DT.86854386  DT.92037405  DT.40125925  DT.91743268  DT.100731056 

    24/113 AceView cDNA sequences (see all 113):

    BQ221229 BQ684957 BM678493 BU675077 BU196990 AA127383 BQ686222 BU185804 
    AA373034 BU625160 BX280928 AL519577 BQ686944 CB149352 BM721978 AI653707 
    AW206795 CB132161 AA367407 CR601629 BQ691996 BM695627 AW014036 BQ222916 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PRSS12    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
    SP1:                                                        -     -                                       
    SP2:                                                                                                      
    SP3:                                                                                -                     


    ECgene alternative splicing isoforms for PRSS12

    Expression
    for PRSS12 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRSS12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PRSS12 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PRSS12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRSS12

    SOURCE GeneReport for Unigene cluster: Hs.445857

    UniProtKB/Swiss-Prot: NETR_HUMAN, P56730
    Tissue specificity: Brain and Leydig cells of the testis

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    In Situ
    Assay Products:     
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    Orthologs
    for PRSS12 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for PRSS12 gene from 3/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PRSS121 protease, serine, 12 (neurotrypsin, motopsin) 78.64(n)
    84.44(a)    		   422685  XM_420637.3  XP_420637.3 
    lizard
    (Anolis carolinensis)    		 Reptilia PRSS126
    		 --
    		 79(a)
    		 1 ↔ 1
    		 5(140420114-140485372)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5668091 neurotrypsin-like 63.1(n)
    64.28(a)    		   566809  XM_001920264.1  XP_001920299.1 


    ENSEMBL Gene Tree for PRSS12 (if available)
    TreeFam Gene Tree for PRSS12 (if available) 

    Paralogs
    for PRSS12 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRSS12 gene
    LOXL22  CD62  CD163L12  LOXL42  LOXL32  CD1632  SSC5D2  CD5L2  
    LOX2  SRCRB4D2  LOC6192072  LOXL12  
    18/60 SIMAP similar genes for PRSS12 using alignment to 1 protein entry:     NETR_HUMAN(see all similar genes):
    F12    CELA2B    CELA3A    DKFZp779M0222    DKFZp586F0824    KLK13
    PRSS22    CTRL    CELA3B    PROC1    TMPRSS11D    PROC
    F9    CD5L    CELA1    CFD    CMA1    DF

    PRSS12 for paralogs           About GeneDecksing



    Genomic Variants
    for PRSS12 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2434 NCBI SNPs in PRSS12 are shown (see all 2434)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 4 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs19931,2
    		C,H,--114936259(-) TAAGTC/TCATTG 1 -- ds50016Minor allele frequency- T:0.00MN NS EA 614
    rs743920461,2
    		--114936267(+) TTATCG/CTAGTT 1 -- ds50011Minor allele frequency- C:0.01WA 118
    rs794509181,2
    		C,F,--114936365(+) AGGTGG/TTCCGT 1 -- ds50013Minor allele frequency- T:0.06CSA WA 122
    rs762933251,2
    		F,--114936436(+) ATAGAC/TGGAAA 1 -- ds50013Minor allele frequency- T:0.06CSA WA 122
    rs769051651,2
    		F,--114936476(+) AGTGTT/CACACG 1 -- ds50013Minor allele frequency- C:0.06CSA WA 122
    rs725246731,2
    		C--114936958(+) AAAAG-/TTTATCA 2 -- ut310--------
    rs100154611,2
    		C,H,--114937260(+) TTTAAA/GTTTGA 1 -- ut315Minor allele frequency- G:0.00NS EA WA 536
    rs99953511,2
    		C,H,--114937384(+) AAAATC/AAGCAT 1 -- ut314Minor allele frequency- A:0.00NS EA 412
    rs102127451,2
    		C,F,H,--114937605(+) TTTGAC/TTAGTA 1 -- ut3110Minor allele frequency- T:0.02NS EA NA CSA WA 926
    rs110984311,2
    		H,--114937753(+) AAATAT/CAGTAG 1 -- ut314Minor allele frequency- C:0.00NS EA 384

    HapMap Linkage Disequilibrium report for PRSS12 (119201193 - 119274158 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for PRSS12
         5 CNVs: 32638 47878 2542 3511 8453
    Human Gene Mutation Database (HGMD): PRSS12

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRSS12
    DNA2.0 Custom Variant and Variant Library Synthesis for PRSS12

    Disorders / Diseases
    for PRSS12 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PRSS12 for disorders           About GeneDecksing

    OMIM gene information: 606709   
    OMIM disorders: 249500  
    UniProtKB/Swiss-Prot: NETR_HUMAN, P56730
  • Defects in PRSS12 are the cause of mental retardation autosomal recessive type 1 (MRT1) [MIM:249500]. Mental
    • retardation is a mental disorder characterized by significantly sub-average general intellectual functioning
    associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic
    mental retardation patients do not manifest other clinical signs

    7 diseases for PRSS12:    About MalaCards
    mental retardation, autosomal recessive 1    intellectual disability    alcohol dependence    mental disorders
    alcoholism    cerebritis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for PRSS12:
    Intellectual disability

    1 Novoseek disease relationship for PRSS12 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mental retardation 57.8 6 17223089 (2), 12459588 (1), 12836380 (1), 17965832 (1)

    Human Genome Epidemiology (HuGE) Navigator: PRSS12 (1 document)

    Export disorders for PRSS12 gene to outside databases

    Publications
    for PRSS12 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRSS12 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with PRSS12)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and sequencing of the cDNA encoding human neurotrypsin. (PubMed id 9540828)1, 2, 3, 9 Proba K.... Sonderegger P. (1998)
    2. Cloning and structural analysis of leydin, a novel human serine protease expressed by the Leydig cells of the testis. (PubMed id 10103056)1, 2, 9 Poorafshar M. and Hellman L. (1999)
    3. Truncating neurotrypsin mutation in autosomal recessive nonsyndromic mental retardation. (PubMed id 12459588)1, 2, 9 Molinari F....Colleaux L. (2002)
    4. Neurotrypsin, a novel multidomain serine protease expressed in the nervous system. (PubMed id 9245503)1, 3 Gschwend T.P....Sonderegger P. (1997)
    5. Assignment of the gene encoding the neuronal multidomain serine protease neurotrypsin (PRSS12) to human chromosome band 4q25-->q26 by in situ hybridization. (PubMed id 10343120)1, 9 Kozlov S.V....Sonderegger P. (1999)
    6. A systematic gene-based screen of chr4q22-q32 identif ies association of a novel susceptibility gene, DKK2, with the quantitative tra it of alcohol dependence symptom counts. (PubMed id 20332099)1 Kalsi G....Riley B.P. (2010)
    7. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Activity-induced synaptic capture and exocytosis of the neuronal serine protease neurotrypsin. (PubMed id 18272678)9 Frischknecht R....Sonderegger P. (2008)
    10. Enzymatic properties and localization of motopsin (PRSS12), a protease whose absence causes mental retardation. (PubMed id 17223089)9 Mitsui S....Yuri K. (2007)

    External Searches for PRSS12 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PRSS12 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8492 HGNC: 9477 AceView: PRSS12 Ensembl:ENSG00000164099 euGenes: HUgn8492
    ECgene: PRSS12 H-InvDB: PRSS12

    Other Databases showing PRSS12 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PRSS12 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRSS12 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PRSS12 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PRSS12 gene:
    Search GeneIP for patents involving PRSS12

    GeneCards and IP:
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