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Aliases for PRSS1 Gene

Aliases for PRSS1 Gene

  • Protease, Serine, 1 (Trypsin 1) 2 3
  • TRY1 3 4 6
  • Cationic Trypsinogen 3 4
  • Beta-Trypsin 3 4
  • EC 3.4.21.4 4 63
  • TRYP1 3 4
  • TRP1 3 4
  • Nonfunctional Trypsin 1 3
  • Digestive Zymogen 3
  • Serine Protease 1 4
  • TCR V Beta 4.1 3
  • Trypsinogen 1 3
  • Trypsinogen A 3
  • Trypsin-1 3
  • Trypsin I 4
  • EC 3.4.21 63
  • TRY4 3

External Ids for PRSS1 Gene

Previous HGNC Symbols for PRSS1 Gene

  • TRY1

Previous GeneCards Identifiers for PRSS1 Gene

  • GC07P140730
  • GC07P141820
  • GC07P141898
  • GC07P141901
  • GC07P141675
  • GC07P141943
  • GC07P142136
  • GC07P142458
  • GC07P142461
  • GC07P142572
  • GC07P142641
  • GC07P142711
  • GC07P142773

Summaries for PRSS1 Gene

Entrez Gene Summary for PRSS1 Gene

  • This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRSS1 Gene

PRSS1 (Protease, Serine, 1 (Trypsin 1)) is a Protein Coding gene. Diseases associated with PRSS1 include trypsinogen deficiency and prss1-related hereditary pancreatitis. Among its related pathways are Disease and Degradation of the extracellular matrix. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is KLK12.

UniProtKB/Swiss-Prot for PRSS1 Gene

  • Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.

Gene Wiki entry for PRSS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS1 Gene

Genomics for PRSS1 Gene

Regulatory Elements for PRSS1 Gene

Genomic Location for PRSS1 Gene

Start:
142,749,468 bp from pter
End:
142,763,997 bp from pter
Size:
14,530 bases
Orientation:
Plus strand

Genomic View for PRSS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRSS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS1 Gene

Proteins for PRSS1 Gene

  • Protein details for PRSS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07477-TRY1_HUMAN
    Recommended name:
    Trypsin-1
    Protein Accession:
    P07477
    Secondary Accessions:
    • A1A509
    • A6NJ71
    • B2R5I5
    • Q5NV57
    • Q7M4N3
    • Q7M4N4
    • Q92955
    • Q9HAN4
    • Q9HAN5
    • Q9HAN6
    • Q9HAN7

    Protein attributes for PRSS1 Gene

    Size:
    247 amino acids
    Molecular mass:
    26558 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PRSS1 Gene

neXtProt entry for PRSS1 Gene

Proteomics data for PRSS1 Gene at MOPED

Post-translational modifications for PRSS1 Gene

  • Occurs in a single-chain form and a two-chain form, produced by proteolytic cleavage after Arg-122
  • Sulfation at Tyr-154 increases selectivity towards basic versus apolar residues at the P2 position of inhibitors that bind in a substrate-like fashion. Although the increase in selectivity is relatively small, it may facilitate digestion of a broader range of dietary proteins.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRSS1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PRSS1 (Trypsin 1/PRSS1)

Domains for PRSS1 Gene

Gene Families for PRSS1 Gene

HGNC:
  • PRSS :Serine peptidases / Serine peptidases

Graphical View of Domain Structure for InterPro Entry

P07477

UniProtKB/Swiss-Prot:

TRY1_HUMAN :
  • P07477
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS1: view

Function for PRSS1 Gene

Molecular function for PRSS1 Gene

GENATLAS Biochemistry:
protease serine 1,trypsin 1,expressed in pancreas
UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage: Arg- -Xaa, Lys- -Xaa
UniProtKB/Swiss-Prot Function:
Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.

Enzyme Numbers (IUBMB) for PRSS1 Gene

Gene Ontology (GO) - Molecular Function for PRSS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity TAS 8841182
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PRSS1: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRSS1

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PRSS1 Gene

Localization for PRSS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS1 Gene

Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRSS1 Gene COMPARTMENTS Subcellular localization image for PRSS1 gene
Compartment Confidence
extracellular 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PRSS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0070062 extracellular exosome IDA 23376485
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with PRSS1: view

Pathways for PRSS1 Gene

SuperPathways for PRSS1 Gene

Superpath Contained pathways
1 Defective BTD causes biotidinase deficiency
2 Degradation of the extracellular matrix
3 Disease
4 Metabolism
5 Pancreatic secretion
genes like me logo Genes that share pathways with PRSS1: view

Gene Ontology (GO) - Biological Process for PRSS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IBA --
GO:0006766 vitamin metabolic process TAS --
GO:0006767 water-soluble vitamin metabolic process TAS --
GO:0007586 digestion IBA --
GO:0009235 cobalamin metabolic process TAS --
genes like me logo Genes that share ontologies with PRSS1: view

Compounds for PRSS1 Gene

(4) ApexBio Compounds for PRSS1 Gene

Compound Action Cas Number
"Leupeptin, Microbial" Inhibitor of serine and cysteine proteases [103476-89-7]
AEBSF.HCl Serine protease inhibitor [30827-99-7]
Aprotinin Inhibitor of bovine pancreatic trypsin [9087-70-1]
Nafamostat Mesylate(FUT-175) Serine protease inhibitor [82956-11-4]

(1) HMDB Compounds for PRSS1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(9) Novoseek inferred chemical compound relationships for PRSS1 Gene

Compound -log(P) Hits PubMed IDs
trypsinogen 95.6 57
serine 60.4 17
arginine 17 2
asparagine 13.6 1
histidine 8.73 1
genes like me logo Genes that share compounds with PRSS1: view

Transcripts for PRSS1 Gene

mRNA/cDNA for PRSS1 Gene

(4) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRSS1 Gene

Protease, serine, 1 (trypsin 1):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRSS1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS1 Gene

No ASD Table

Relevant External Links for PRSS1 Gene

GeneLoc Exon Structure for
PRSS1
ECgene alternative splicing isoforms for
PRSS1

Expression for PRSS1 Gene

mRNA expression in normal human tissues for PRSS1 Gene

mRNA differential expression in normal tissues according to GTEx for PRSS1 Gene

This gene is overexpressed in Pancreas (52.8).

Protein differential expression in normal tissues for PRSS1 Gene

This gene is overexpressed in Pancreatic juice (35.9) and Pancreas (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRSS1 Gene

SOURCE GeneReport for Unigene cluster for PRSS1 Gene Hs.449281

genes like me logo Genes that share expressions with PRSS1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Expression partners for PRSS1 Gene

Orthologs for PRSS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRSS1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Try10 35
  • 82.66 (n)
  • 78.86 (a)
Prss1 16
Gm10334 36
  • 77 (a)
ManyToMany
Gm5771 36
  • 77 (a)
ManyToMany
Prss1 36
  • 77 (a)
ManyToMany
Prss2 36
  • 75 (a)
ManyToMany
Prss3 36
  • 77 (a)
ManyToMany
Try10 36
  • 79 (a)
ManyToMany
Try4 36
  • 77 (a)
ManyToMany
Try5 36
  • 76 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC742453 35
  • 97.3 (n)
  • 96.76 (a)
PRSS1 36
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRSS2 36
  • 77 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 80 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 77 (a)
ManyToMany
-- 36
  • 74 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 65 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
PRSS2 36
  • 66 (a)
ManyToMany
PRSS3 36
  • 58 (a)
ManyToMany
PRSS3 36
  • 67 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 66 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii try 35
try 36
  • 68 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10405 37
  • 33 (a)
CG16998 37
  • 34 (a)
CG17239 37
  • 35 (a)
CG17571 37
  • 35 (a)
CG4386 37
  • 41 (a)
CG5197 37
  • 36 (a)
CG6041 37
  • 37 (a)
CG6048 37
  • 33 (a)
CG7829 37
  • 34 (a)
eegrTry 37
  • 33 (a)
egrTry 37
  • 36 (a)
kgrTry 37
  • 33 (a)
lgrTry 37
  • 37 (a)
Try29F 37
  • 41 (a)
zgrTry 37
  • 36 (a)
CG10663 35
  • 47.64 (n)
  • 37.9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
CSA.4402 36
  • 43 (a)
ManyToMany
CSA.4556 36
  • 45 (a)
ManyToMany
Species with no ortholog for PRSS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRSS1 Gene

ENSEMBL:
Gene Tree for PRSS1 (if available)
TreeFam:
Gene Tree for PRSS1 (if available)

Paralogs for PRSS1 Gene

Pseudogenes.org Pseudogenes for PRSS1 Gene

genes like me logo Genes that share paralogs with PRSS1: view

Variants for PRSS1 Gene

Sequence variations from dbSNP and Humsavar for PRSS1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs6666 -- 142,752,462(-) GGAGC(A/G)TCCAG synonymous-codon, reference
rs6667 -- 142,753,014(-) TAGCT(A/G)TTGGC synonymous-codon, reference
rs700323 -- 142,750,605(+) ACTGT(A/G)AGGAG missense, reference
rs1042921 -- 142,752,981(+) AACTA(C/T)GTGAA synonymous-codon, reference
rs1804561 -- 142,752,537(+) GTGGG(C/T)TTCCT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for PRSS1 Gene

Variant ID Type Subtype PubMed ID
nsv831166 CNV Gain+Loss 17160897
nsv428187 CNV Loss 18775914
dgv2145e1 CNV Complex 17122850
dgv841n27 CNV Loss 19166990
essv19150 CNV CNV 17122850
nsv824336 CNV Loss 20364138
esv34617 CNV Loss 17911159
nsv818563 CNV Loss 17921354
nsv831167 CNV Gain+Loss 17160897
nsv819176 CNV Loss 19587683
nsv889274 CNV Loss 21882294
esv2735271 CNV Deletion 23290073
dgv1167e201 CNV Deletion 23290073
nsv515039 CNV Complex 21397061

Relevant External Links for PRSS1 Gene

HapMap Linkage Disequilibrium report
PRSS1
Human Gene Mutation Database (HGMD)
PRSS1
Locus Specific Mutation Databases (LSDB)
PRSS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS1 Gene

Disorders for PRSS1 Gene

(2) OMIM Diseases for PRSS1 Gene (276000)

UniProtKB/Swiss-Prot

TRY1_HUMAN
  • Pancreatitis, hereditary (PCTT) [MIM:167800]: A disease characterized by pancreas inflammation, permanent destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks. {ECO:0000269 PubMed:10204851, ECO:0000269 PubMed:10381903, ECO:0000269 PubMed:10930381, ECO:0000269 PubMed:11073545, ECO:0000269 PubMed:11788572, ECO:0000269 PubMed:11866271, ECO:0000269 PubMed:14695529, ECO:0000269 PubMed:15776435, ECO:0000269 PubMed:8841182, ECO:0000269 PubMed:9322498, ECO:0000269 PubMed:9633818}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(4) University of Copenhagen DISEASES for PRSS1 Gene

(11) Novoseek inferred disease relationships for PRSS1 Gene

Disease -log(P) Hits PubMed IDs
pancreatitis hereditary 96.9 47
chronic pancreatitis 88.4 47
pancreatitis 83.2 34
pancreatic cancer 72.5 7
cystic fibrosis 57 4

Relevant External Links for PRSS1

Genetic Association Database (GAD)
PRSS1
Human Genome Epidemiology (HuGE) Navigator
PRSS1
genes like me logo Genes that share disorders with PRSS1: view

No data available for Genatlas for PRSS1 Gene

Publications for PRSS1 Gene

  1. Mutations in the cationic trypsinogen gene and evidence for genetic heterogeneity in hereditary pancreatitis. (PMID: 10204851) Ferec C. … Le Bodic L. (J. Med. Genet. 1999) 3 4 23
  2. Crystal structure of human trypsin 1: unexpected phosphorylation of Tyr151. (PMID: 8683601) Gaboriaud C. … Fontecilla-Camps J.-C. (J. Mol. Biol. 1996) 3 4 23
  3. CFTR and cationic trypsinogen mutations in idiopathic pancreatitis and neonatal hypertrypsinemia. (PMID: 12120234) Gomez Lira M. … Pignatti P.F. (Pancreatology 2001) 3 23 48
  4. Gene mutations in children with chronic pancreatitis. (PMID: 12120220) Witt H. (Pancreatology 2001) 3 23 48
  5. [Mutations of SPINK1 and PRSS1 gene in Korean patients with chronic pancreatitis]. (PMID: 15329520) Lee K.H. … Kim C.Y. (Korean J Gastroenterol 2004) 3 23 48

Products for PRSS1 Gene

Sources for PRSS1 Gene

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