Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PRSS1 Gene

Aliases for PRSS1 Gene

  • Protease, Serine 1 2 3 5
  • Cationic Trypsinogen 3 4
  • Beta-Trypsin 3 4
  • EC 3.4.21.4 4 63
  • TRYP1 3 4
  • TRY1 3 4
  • TRP1 3 4
  • Nonfunctional Trypsin 1 3
  • Digestive Zymogen 3
  • Serine Protease 1 4
  • TCR V Beta 4.1 3
  • Trypsinogen 1 3
  • Trypsinogen A 3
  • Trypsin 1 2
  • Trypsin I 4
  • EC 3.4.21 63
  • TRY4 3

External Ids for PRSS1 Gene

Previous HGNC Symbols for PRSS1 Gene

  • TRY1

Previous GeneCards Identifiers for PRSS1 Gene

  • GC07P140730
  • GC07P141820
  • GC07P141898
  • GC07P141901
  • GC07P141675
  • GC07P141943
  • GC07P142136
  • GC07P142458
  • GC07P142461
  • GC07P142572
  • GC07P142641
  • GC07P142711
  • GC07P142773
  • GC07P142841
  • GC07P142887

Summaries for PRSS1 Gene

Entrez Gene Summary for PRSS1 Gene

  • This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRSS1 Gene

PRSS1 (Protease, Serine 1) is a Protein Coding gene. Diseases associated with PRSS1 include Pancreatitis, Hereditary and Prss1-Related Hereditary Pancreatitis. Among its related pathways are Pancreatic secretion and Metabolism of water-soluble vitamins and cofactors. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is KLK12.

UniProtKB/Swiss-Prot for PRSS1 Gene

  • Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.

Gene Wiki entry for PRSS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRSS1 Gene

Genomics for PRSS1 Gene

Regulatory Elements for PRSS1 Gene

Enhancers for PRSS1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRSS1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRSS1 Gene

Chromosome:
7
Start:
142,740,235 bp from pter
End:
142,763,997 bp from pter
Size:
23,763 bases
Orientation:
Plus strand

Genomic View for PRSS1 Gene

Genes around PRSS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRSS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRSS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRSS1 Gene

Proteins for PRSS1 Gene

  • Protein details for PRSS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07477-TRY1_HUMAN
    Recommended name:
    Trypsin-1
    Protein Accession:
    P07477
    Secondary Accessions:
    • A1A509
    • A6NJ71
    • B2R5I5
    • Q5NV57
    • Q7M4N3
    • Q7M4N4
    • Q92955
    • Q9HAN4
    • Q9HAN5
    • Q9HAN6
    • Q9HAN7

    Protein attributes for PRSS1 Gene

    Size:
    247 amino acids
    Molecular mass:
    26558 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PRSS1 Gene

neXtProt entry for PRSS1 Gene

Proteomics data for PRSS1 Gene at MOPED

Post-translational modifications for PRSS1 Gene

  • Occurs in a single-chain form and a two-chain form, produced by proteolytic cleavage after Arg-122.
  • Sulfation at Tyr-154 increases selectivity towards basic versus apolar residues at the P2 position of inhibitors that bind in a substrate-like fashion. Although the increase in selectivity is relatively small, it may facilitate digestion of a broader range of dietary proteins.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRSS1 Gene

Antibody Products

  • R&D Systems Antibodies for PRSS1 (Trypsin 1/PRSS1)
  • Abcam antibodies for PRSS1

Domains & Families for PRSS1 Gene

Gene Families for PRSS1 Gene

Graphical View of Domain Structure for InterPro Entry

P07477

UniProtKB/Swiss-Prot:

TRY1_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PRSS1: view

Function for PRSS1 Gene

Molecular function for PRSS1 Gene

GENATLAS Biochemistry:
protease serine 1,trypsin 1,expressed in pancreas
UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage: Arg- -Xaa, Lys- -Xaa.
UniProtKB/Swiss-Prot Function:
Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.

Enzyme Numbers (IUBMB) for PRSS1 Gene

Gene Ontology (GO) - Molecular Function for PRSS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity TAS 8841182
genes like me logo Genes that share ontologies with PRSS1: view
genes like me logo Genes that share phenotypes with PRSS1: view

Human Phenotype Ontology for PRSS1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRSS1 Gene

Localization for PRSS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRSS1 Gene

Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRSS1 Gene COMPARTMENTS Subcellular localization image for PRSS1 gene
Compartment Confidence
extracellular 5
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for PRSS1 Gene

Pathways & Interactions for PRSS1 Gene

genes like me logo Genes that share pathways with PRSS1: view

Gene Ontology (GO) - Biological Process for PRSS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006766 vitamin metabolic process TAS --
GO:0022617 extracellular matrix disassembly TAS --
GO:0030198 extracellular matrix organization TAS --
genes like me logo Genes that share ontologies with PRSS1: view

No data available for SIGNOR curated interactions for PRSS1 Gene

Drugs & Compounds for PRSS1 Gene

(114) Drugs for PRSS1 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aprotinin Approved, Withdrawn Pharma Target Inhibitor of bovine pancreatic trypsin 24
Benzydamine Experimental Pharma Target 9
Cyclohexane Experimental Pharma Target 0
Hexane Experimental Pharma Target 0
(2s,4r)-1-Acetyl-N-[(1s)-4-[(Aminoiminomethyl)Amino]-1-(2-Benzothiazolylcarbonyl)Butyl]-4-Hydroxy-2-Pyrrolidinecarboxamide Experimental Pharma Target 0

(3) Additional Compounds for PRSS1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(4) ApexBio Compounds for PRSS1 Gene

Compound Action Cas Number
AEBSF.HCl Serine protease inhibitor 30827-99-7
Aprotinin Inhibitor of bovine pancreatic trypsin 9087-70-1
Leupeptin, Microbial Inhibitor of serine and cysteine proteases 103476-89-7
Nafamostat Mesylate(FUT-175) Serine protease inhibitor 82956-11-4
genes like me logo Genes that share compounds with PRSS1: view

Transcripts for PRSS1 Gene

mRNA/cDNA for PRSS1 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRSS1 Gene

Protease, serine, 1 (trypsin 1):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRSS1 Gene

No ASD Table

Relevant External Links for PRSS1 Gene

GeneLoc Exon Structure for
PRSS1
ECgene alternative splicing isoforms for
PRSS1

Expression for PRSS1 Gene

mRNA expression in normal human tissues for PRSS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRSS1 Gene

This gene is overexpressed in Pancreas (x52.8).

Protein differential expression in normal tissues from HIPED for PRSS1 Gene

This gene is overexpressed in Pancreatic juice (35.9) and Pancreas (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRSS1 Gene



SOURCE GeneReport for Unigene cluster for PRSS1 Gene Hs.449281

genes like me logo Genes that share expression patterns with PRSS1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PRSS1 Gene

Orthologs for PRSS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRSS1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Try10 35
  • 82.66 (n)
  • 78.86 (a)
Try10 16
Gm10334 36
  • 77 (a)
ManyToMany
Gm5771 36
  • 77 (a)
ManyToMany
Prss1 36
  • 77 (a)
ManyToMany
Prss2 36
  • 75 (a)
ManyToMany
Prss3 36
  • 77 (a)
ManyToMany
Try10 36
  • 79 (a)
ManyToMany
Try4 36
  • 77 (a)
ManyToMany
Try5 36
  • 76 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC742453 35
  • 97.3 (n)
  • 96.76 (a)
PRSS1 36
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRSS2 36
  • 77 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 80 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 77 (a)
ManyToMany
-- 36
  • 74 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 65 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
PRSS2 36
  • 66 (a)
ManyToMany
PRSS3 36
  • 58 (a)
ManyToMany
PRSS3 36
  • 67 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 66 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii try 35
try 36
  • 68 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10405 37
  • 33 (a)
CG16998 37
  • 34 (a)
CG17239 37
  • 35 (a)
CG17571 37
  • 35 (a)
CG4386 37
  • 41 (a)
CG5197 37
  • 36 (a)
CG6041 37
  • 37 (a)
CG6048 37
  • 33 (a)
CG7829 37
  • 34 (a)
eegrTry 37
  • 33 (a)
egrTry 37
  • 36 (a)
kgrTry 37
  • 33 (a)
lgrTry 37
  • 37 (a)
Try29F 37
  • 41 (a)
zgrTry 37
  • 36 (a)
CG10663 35
  • 47.64 (n)
  • 37.9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
CSA.4402 36
  • 43 (a)
ManyToMany
CSA.4556 36
  • 45 (a)
ManyToMany
Species with no ortholog for PRSS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRSS1 Gene

ENSEMBL:
Gene Tree for PRSS1 (if available)
TreeFam:
Gene Tree for PRSS1 (if available)

Paralogs for PRSS1 Gene

Pseudogenes.org Pseudogenes for PRSS1 Gene

genes like me logo Genes that share paralogs with PRSS1: view

Variants for PRSS1 Gene

Sequence variations from dbSNP and Humsavar for PRSS1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_006720 Pancreatitis, hereditary (PCTT)
VAR_006721 Pancreatitis, hereditary (PCTT)
VAR_011652 Pancreatitis, hereditary (PCTT)
VAR_011653 Pancreatitis, hereditary (PCTT)
VAR_011654 Pancreatitis, hereditary (PCTT)

Structural Variations from Database of Genomic Variants (DGV) for PRSS1 Gene

Variant ID Type Subtype PubMed ID
nsv831166 CNV Gain+Loss 17160897
nsv428187 CNV Loss 18775914
dgv2145e1 CNV Complex 17122850
dgv841n27 CNV Loss 19166990
essv19150 CNV CNV 17122850
nsv824336 CNV Loss 20364138
esv34617 CNV Loss 17911159
nsv818563 CNV Loss 17921354
nsv831167 CNV Gain+Loss 17160897
nsv819176 CNV Loss 19587683
nsv889274 CNV Loss 21882294
esv2735271 CNV Deletion 23290073
dgv1167e201 CNV Deletion 23290073
nsv515039 CNV Complex 21397061

Variation tolerance for PRSS1 Gene

Residual Variation Intolerance Score: 80.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.07; 21.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRSS1 Gene

Human Gene Mutation Database (HGMD)
PRSS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRSS1 Gene

Disorders for PRSS1 Gene

MalaCards: The human disease database

(17) MalaCards diseases for PRSS1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pancreatitis, hereditary
  • pancreatitis, chronic
prss1-related hereditary pancreatitis
pancreatitis
trypsinogen deficiency
  • pancreatic trypsinogen deficiency
pancreas disease
  • pancreatic diseases
- elite association - COSMIC cancer census association via MalaCards
Search PRSS1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TRY1_HUMAN
  • Pancreatitis, hereditary (PCTT) [MIM:167800]: A disease characterized by pancreas inflammation, permanent destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks. {ECO:0000269 PubMed:10204851, ECO:0000269 PubMed:10381903, ECO:0000269 PubMed:10930381, ECO:0000269 PubMed:11073545, ECO:0000269 PubMed:11788572, ECO:0000269 PubMed:11866271, ECO:0000269 PubMed:14695529, ECO:0000269 PubMed:15776435, ECO:0000269 PubMed:8841182, ECO:0000269 PubMed:9322498, ECO:0000269 PubMed:9633818}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for PRSS1

Genetic Association Database (GAD)
PRSS1
Human Genome Epidemiology (HuGE) Navigator
PRSS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRSS1
genes like me logo Genes that share disorders with PRSS1: view

No data available for Genatlas for PRSS1 Gene

Publications for PRSS1 Gene

  1. Mutational screening of patients with nonalcoholic chronic pancreatitis: identification of further trypsinogen variants. (PMID: 11866271) Teich N. … Keim V. (Am. J. Gastroenterol. 2002) 3 4 48 67
  2. The natural history of hereditary pancreatitis: a national series. (PMID: 18755888) Rebours V. … LAcvy P. (Gut 2009) 3 23
  3. Analysis of PRSS1 and SPINK1 mutations in Korean patients with idiopathic and familial pancreatitis. (PMID: 18852684) Oh H.C. … Kim G.H. (Pancreas 2009) 3 23
  4. Association and differential role of PRSS1 and SPINK1 mutation in early-onset and late-onset idiopathic chronic pancreatitis in Chinese subjects. (PMID: 19433603) Chang Y.T. … Chang M.C. (Gut 2009) 3 23
  5. Hereditary pancreatitis: clinical features and inheritance characteristics of the R122C mutation in the cationic trypsinogen gene (PRSS1) in six Spanish families. (PMID: 19454815) de las Heras-CastaA+o G. … SA!nchez-JuA!n P. (JOP 2009) 3 23

Products for PRSS1 Gene

Sources for PRSS1 Gene

Content