Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRSS1 Gene

protein-coding   GIFtS: 68
GCID: GC07P142711

Protease, Serine, 1 (Trypsin 1)


(Previous symbol: TRY1)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protease, Serine, 1 (Trypsin 1)1 2     Nonfunctional Trypsin 12
TRY11 2 3 5     trypsin-12
Cationic Trypsinogen2 3     Trypsinogen 12
TRP12 3     Trypsinogen A2
TRYP12 3     Beta-trypsin3
EC 3.4.21.43 8     Serine Protease 13
TRY42     Trypsin I3
beta-trypsin2     EC 3.4.218
Digestive Zymogen2     

External Ids:    HGNC: 94751   Entrez Gene: 56442   Ensembl: ENSG000002049837   OMIM: 2760005   UniProtKB: P074773   

Export aliases for PRSS1 gene to outside databases

Previous GC identifers: GC07P140730 GC07P141820 GC07P141898 GC07P141901 GC07P141675 GC07P141943 GC07P142136 GC07P142458 GC07P142461 GC07P142572 GC07P142641


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PRSS1 Gene:
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is
secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages
involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary
pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on
chromosome 7. (provided by RefSeq, Jul 2008)

GeneCards Summary for PRSS1 Gene: 
PRSS1 (protease, serine, 1 (trypsin 1)) is a protein-coding gene. Diseases associated with PRSS1 include hereditary pancreatitis, and digestive diseases, and among its related super-pathways are Degradation of collagen and Metabolism of water-soluble vitamins and cofactors. GO annotations related to this gene include metal ion binding and serine-type endopeptidase activity. An important paralog of this gene is KLK10.

UniProtKB/Swiss-Prot: TRY1_HUMAN, P07477
Function: Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec,
Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against
all of these substrates

Gene Wiki entry for PRSS1 (Trypsin 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007914.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRSS1 gene promoter:
         AML1a   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   LCR-F1   Tal-1beta   POU3F2   FOXO4   Zic3   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): PRSS1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PRSS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRSS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

PRSS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRSS1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P142711:  view genomic region     (about GC identifiers)

Start:
142,457,319 bp from pter      End:
142,460,927 bp from pter
Size:
3,609 bases      Orientation:
plus strand

2 alternative locations:
Chr7+,NW_003571040 932,136-935,744      Chr7+,CRA_TCAG 141,828,623-141,832,231     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRY1_HUMAN, P07477 (See protein sequence)
Recommended Name: Trypsin-1 precursor  
Size: 247 amino acids; 26558 Da
Cofactor: Binds 1 calcium ion per subunit
Subcellular location: Secreted, extracellular space
Mass spectrometry: Mass=24348; Mass_error=2; Method=Electrospray; Range=24-247; Source=PubMed:8683601;
Caution: Tyr-154 was proposed to be phosphorylated (PubMed:8683601) but it has been shown (PubMed:17087724) to be
sulfated instead. Phosphate and sulfate groups are similar in mass and size, and this can lead to erroneous
interpretation of the results
3 PDB 3D structures from and Proteopedia for PRSS1:
1FXY (3D)        1TRN (3D)        2RA3 (3D)    
Secondary accessions: A1A509 A6NJ71 B2R5I5 Q5NV57 Q7M4N3 Q7M4N4 Q92955 Q9HAN4 Q9HAN5 Q9HAN6
Q9HAN7

Explore the universe of human proteins at neXtProt for PRSS1: NX_P07477

Explore proteomics data for PRSS1 at MOPED 

Post-translational modifications:

  • UniProtKB: Occurs in a single-chain form and a two-chain form, produced by proteolytic cleavage after Arg-122
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P07477

  • 4/23 DME Specific Peptides for PRSS1 (P07477) (see all 23)
     EGGKDSC  PGVYTKV  CEASYPG  IQVRLGE 

    PRSS1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PRSS1 Protein Expression
    REFSEQ proteins: NP_002760.1  
    ENSEMBL proteins: 
     ENSP00000417854   ENSP00000308720   ENSP00000419912  
    Reactome Protein details: P07477
    Human Recombinant Protein Products for PRSS1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for PRSS1 (Trypsin 1/PRSS1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PRSS1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for PRSS1
    GenScript Custom Purified and Recombinant Proteins Services for PRSS1
    Novus Biologicals PRSS1 Proteins
    Novus Biologicals PRSS1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for PRSS1
    Cloud-Clone Corp. Proteins for PRSS1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    PRSS1 for ontologies           About GeneDecksing



    PRSS1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRSS1
    R&D Systems Antibodies for PRSS1 (Trypsin 1/PRSS1)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PRSS1
    GenScript Custom Superior Antibodies Services for PRSS1
    Novus Biologicals PRSS1 Antibodies
    Abcam antibodies for PRSS1
    Cloud-Clone Corp. Antibodies for PRSS1 
    ThermoFisher Antibodies for PRSS1
    LSBio Antibodies in human, mouse, rat for PRSS1 

    Assay Products for PRSS1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PRSS1
    R&D Systems ELISAs for PRSS1 (Trypsin 1/PRSS1)
    GenScript Custom Assay Services for PRSS1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PRSS1 
    Cloud-Clone Corp. CLIAs for PRSS1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PRSS: Serine peptidases / Serine peptidases

    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry P07477

    ProtoNet protein and cluster: P07477

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: TRY1_HUMAN, P07477
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 peptidase S1 domain


    PRSS1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRY1_HUMAN, P07477
    Function: Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec,
    Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against
    all of these substrates
    Catalytic activity: Preferential cleavage: Arg- -Xaa, Lys- -Xaa

         Genatlas biochemistry entry for PRSS1:
    protease serine 1,trypsin 1,expressed in pancreas

         Enzyme Numbers (IUBMB): EC 3.4.21.41 2 EC 3.4.212

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity TAS8841182
    GO:0046872metal ion binding IEA--
         
    PRSS1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PRSS1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PRSS1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRSS1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRSS1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRSS1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PRSS1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PRSS1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRSS1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PRSS1
    Sirion Biotech Customized adenovirus for overexpression of PRSS1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PRSS1 (see all 6)
    OriGene ORF clones in mouse, rat for PRSS1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRSS1 (NM_002769)
    Sino Biological Human cDNA Clone for PRSS1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRSS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS1
    Sirion Biotech Customized lentivirus for stable overexpression of PRSS1 
                         Customized lentivirus expression plasmids for stable overexpression of PRSS1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PRSS1
    Search LifeMap BioReagents cell lines for PRSS1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PRSS1 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.79
    Activation of Matrix Metalloproteinases0.40
    2Metabolism of vitamins and cofactors
    Metabolism of water-soluble vitamins and cofactors1.00
    Metabolism of vitamins and cofactors1.00
    3Metabolism
    Metabolism0.40
    4Collagen biosynthesis and modifying enzymes
    Extracellular matrix organization0.39
    5Class A/1 (Rhodopsin-like receptors)
    Neuroactive ligand-receptor interaction0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5/7        Reactome Pathways for PRSS1 (see all 7)
        Extracellular matrix organization
    Metabolism
    Cobalamin (Cbl, vitamin B12) transport and metabolism
    Metabolism of vitamins and cofactors
    Degradation of the extracellular matrix


    4         Kegg Pathways  (Kegg details for PRSS1):
        Neuroactive ligand-receptor interaction
    Pancreatic secretion
    Protein digestion and absorption
    Influenza A


    PRSS1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRSS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/33 Interacting proteins for PRSS1 (P074773 ENSP000003087204) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SERPINF2P086973, ENSP000003218534I2D: score=2 STRING: ENSP00000321853
    APPP050673, ENSP000002849814I2D: score=1 STRING: ENSP00000284981
    SERPINA1P010093, ENSP000003480684I2D: score=1 STRING: ENSP00000348068
    DEFA5Q015233, ENSP000003298904I2D: score=1 STRING: ENSP00000329890
    PTPN4P290743, ENSP000002637084I2D: score=1 STRING: ENSP00000263708
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0006766vitamin metabolic process TAS--
    GO:0006767water-soluble vitamin metabolic process TAS--
    GO:0007586digestion IEA--
    GO:0009235cobalamin metabolic process TAS--

    PRSS1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PRSS1 for compounds           About GeneDecksing

    EMD Millipore small molecules for PRSS1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PRSS1 (TRY1)

    1 HMDB Compound for PRSS1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    10/101 DrugBank Compounds for PRSS1 (see all 101)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2s,4r)-1-Acetyl-N-[(1s)-4-[(Aminoiminomethyl)Amino]-1-(2-Benzothiazolylcarbonyl)Butyl]-4-Hydroxy-2-Pyrrolidinecarboxamide-- --target--17139284 17016423 10592235
    1-(4-Tert-Butylcarbamoyl-Piperazine-1-Carbonyl)-3-(3-Guanidino-Propyl)-4-Oxo-Azetidine-2-Carboxylic Acid-- --target--17139284 17016423 10592235
    2-(2-Oxo-1,2-Dihydro-Pyridin-3-Yl)-1h-Benzoimidazole-5-Carboxamidine-- --target--17139284 17016423 10592235
    2-Phenylethylamine-- 64-04-0target--17139284 17016423 10592235
    3-Phenylpropylamine-- --target--17139284 17016423 10592235
    4-Fluorobenzylamine-- --target--17139284 17016423 10592235
    4-Phenylbutylamine-- --target--17139284 17016423 10592235
    4-{[1-Methyl-5-(2-Methyl-Benzoimidazol-1-Ylmethyl)-1h-Benzoimidazol-2-Ylmethyl]-Amino}-Benzamidine-- --target--17139284 17016423 10592235
    Aeruginosin 98-B-- --target--17139284 17016423 10592235
    Aminomethylcyclohexane-- 3218-02-8target--17139284 17016423 10592235

    9 Novoseek inferred chemical compound relationships for PRSS1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trypsinogen 95.6 82 11391623 (3), 19287144 (3), 17613931 (2), 11708864 (2) (see all 45)
    serine 60.4 27 10878362 (2), 15776435 (2), 17177967 (1), 15786540 (1) (see all 15)
    arginine 17 2 15786540 (1), 10204851 (1)
    asparagine 13.6 1 17217378 (1)
    histidine 8.73 1 10204851 (1)
    fibrinogen 2.22 3 15685507 (1), 17539966 (1), 18456010 (1)
    tyrosine 0 2 8683601 (1), 15256063 (1)
    polysaccharide 0 1 17384412 (1)
    cysteine 0 1 15786540 (1)

    Search CenterWatch for drugs/clinical trials and news about PRSS1 / TRY1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PRSS1 gene: 
    NM_002769.4  

    Unigene Cluster for PRSS1:

    Protease, serine, 1 (trypsin 1)
    Hs.449281  [show with all ESTs]
    Unigene Representative Sequence: BM906438
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486171 ENST00000485223(uc011ksm.1) ENST00000311737(uc003wak.2)
    ENST00000497041 ENST00000492062 ENST00000463701(uc003wam.2)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRSS1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PRSS1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PRSS1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRSS1
    Clone
    Products:
         
    OriGene clones in human, mouse for PRSS1 (see all 6)
    OriGene ORF clones in mouse, rat for PRSS1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRSS1 (NM_002769)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRSS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS1
    Sirion Biotech Customized lentivirus for stable overexpression of PRSS1 
                         Customized lentivirus expression plasmids for stable overexpression of PRSS1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PRSS1
    OriGene qSTAR qPCR primer pairs in human, mouse for PRSS1
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat PRSS1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRSS1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRSS1

    Additional mRNA sequence: 

    AK312199.1 BC005814.2 BC103998.2 BC128226.1 DQ778083.1 M22612.1 M27602.1 

    24/69 DOTS entries (see all 69):

    DT.121076531  DT.100045934  DT.97862759  DT.97857442  DT.100043423  DT.100828696  DT.97862767  DT.95224978 
    DT.121076107  DT.121076237  DT.100828691  DT.100045926  DT.101976063  DT.121076881  DT.91767689  DT.87078490 
    DT.100045920  DT.121076949  DT.100045929  DT.100828689  DT.121076322  DT.121075945  DT.121076801  DT.121075973 

    4 AceView cDNA sequences:

    NM_002769 BC035777 M22612 CR627200 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRSS1 expression in normal human tissues (normalized intensities)      PRSS1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PRSS1 Expression
    About this image


    PRSS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 3 entries
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
             Pancreatic Islet   

    See PRSS1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRSS1

    SOURCE GeneReport for Unigene cluster: Hs.449281
        SABiosciences Custom PCR Arrays for PRSS1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PRSS1
    OriGene qSTAR qPCR primer pairs in human, mouse for PRSS1
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat PRSS1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRSS1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRSS1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PRSS1 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prss15
    2210010C04Rik1
    protease, serine, 1 (trypsin 1)5
    RIKEN cDNA 2210010C04 gene1
    74.93(n)1
    75.61(a)1
      6 (19.60 cM)5
    673731  NM_023333.41  NP_075822.31 
     414589325 
    chicken
    (Gallus gallus)
    Aves LOC1008571241 trypsin I-P1-like 68.62(n)
    66.53(a)
      100857124  XM_003640446.1  XP_003640494.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    Uncharacterized protein
    (see all 4)
    69(a)
    66(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    GL343499.1(516263-524830)
    GL343499.1(468698-476089)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia CF593108.12   -- 78.28(n)    CF593108.1 
    zebrafish
    (Danio rerio)
    Actinopterygii try2 trypsin 77.51(n)   65223  AF541952.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Try29F3
    alphaTry1
    trypsin3
    alphaTrypsin1
    41(a)
    (best of 15)3
    52.04(n)1
    40.93(a)1
      2 29F73
    483161  NM_057423.31  NP_476771.11 


    ENSEMBL Gene Tree for PRSS1 (if available)
    TreeFam Gene Tree for PRSS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRSS1 gene
    KLK102  ENSG000002697412  KLK12  KLK42  PRSS372  KLK112  KLK72  KLK142  
    KLK92  KLK122  KLK132  KLK62  KLK22  KLK152  KLK52  PRSS582  
    PRSS32  KLK82  KLK32  
    18/120 SIMAP similar genes for PRSS1 using alignment to 17 protein entries:     TRY1_HUMAN (see all proteins) (see all similar genes):
    PRSS3    TRY6    TRY8    PRSS2    HAT    TMPRSS11B
    PRSS36    KLK8    TMPRSS11D    PRSS46    TMPRSS7    KLK6
    DESC1    F10    KLK5    KLK15    TMPRSS13    ACR

    PRSS1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PRSS1
    PGOHUM00000233021


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/376 SNPs in PRSS1 are shown (see all 376)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0116934
    Pancreatitis (PCTT)4--see VAR_0116932 A V mis40--------
    VAR_0116544
    Pancreatitis (PCTT)4--see VAR_0116542 L P mis40--------
    VAR_0379094
    Pancreatitis (PCTT)4--see VAR_0379092 E K mis40--------
    VAR_0067214
    Pancreatitis (PCTT)4--see VAR_0067212 R H mis40--------
    VAR_0127134
    Pancreatitis (PCTT)4--see VAR_0127132 R C mis40--------
    VAR_0116554
    Pancreatitis (PCTT)4--see VAR_0116552 R C mis40--------
    VAR_0067204
    Pancreatitis (PCTT)4--see VAR_0067202 N I mis40--------
    VAR_0116524
    Pancreatitis (PCTT)4--see VAR_0116522 D G mis40--------
    VAR_0379084
    Pancreatitis (PCTT)4--see VAR_0379082 N S mis40--------
    VAR_0116564
    Pancreatitis (PCTT)4--see VAR_0116562 C F mis40--------

    HapMap Linkage Disequilibrium report for PRSS1 (142457319 - 142460927 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for PRSS1 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2735271CNV Deletion23290073
    dgv1167e201CNV Deletion23290073
    nsv428187CNV Loss18775914
    dgv841n27CNV Loss19166990
    nsv818563CNV Loss17921354
    nsv824336CNV Loss20364138
    esv34617CNV Loss17911159
    nsv889274CNV Loss21882294
    nsv819176CNV Loss19587683
    nsv831166CNV Gain+Loss17160897


    Human Gene Mutation Database (HGMD): PRSS1

    Locus Specific Mutation Databases (LSDB): PRSS1
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing PRSS1
    DNA2.0 Custom Variant and Variant Library Synthesis for PRSS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 276000   
    OMIM disorders: 167800  
    UniProtKB/Swiss-Prot: TRY1_HUMAN, P07477
  • Pancreatitis (PCTT) [MIM:167800]: A disease characterized by the presence of calculi in pancreatic ducts.
    It causes severe abdominal pain attacks. Note=The disease is caused by mutations affecting the gene represented
    in this entry

  • 20/32 diseases for PRSS1 (see all 32):    About MalaCards
    hereditary pancreatitis    digestive diseases    prss1-related hereditary pancreatitis    alcoholic pancreatitis
    tropical calcific pancreatitis    intestinal pseudo-obstruction    steatorrhea    pancreatic cancer
    biliary tract cancer    pancreatitis    primary hyperparathyroidism    hyperparathyroidism
    acute pancreatitis    cystic fibrosis    gastric adenocarcinoma    non-small cell lung carcinoma
    purpura    hepatitis c    duodenitis    nephritis

    4 diseases from the University of Copenhagen DISEASES database for PRSS1:
    Pancreatitis     Pancreatic cancer     Cystic fibrosis     Pancreatic steatorrhea

    PRSS1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/11 Novoseek inferred disease relationships for PRSS1 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatitis hereditary 96.9 63 17087933 (3), 15528017 (3), 17072318 (2), 17613931 (2) (see all 32)
    chronic pancreatitis 88.4 52 18522894 (5), 15082592 (3), 18272034 (3), 18442214 (2) (see all 33)
    pancreatitis 83.2 44 18852684 (3), 15786540 (2), 12765848 (2), 18442214 (2) (see all 25)
    pancreatic cancer 72.5 7 15786540 (1), 15749231 (1), 12120238 (1), 10508123 (1) (see all 7)
    cystic fibrosis 57 10 18953248 (1), 20387681 (1), 17981921 (1), 18336667 (1)
    adenocarcinoma 41.4 2 15749231 (1), 15528017 (1)
    myeloma 3.21 2 2347596 (1), 12193285 (1)
    inflammation 2.32 7 16354799 (1), 17981921 (1), 17090903 (1), 17087933 (1)
    tumors 0 13 11391623 (2), 17981921 (1)
    hepatitis c 0 1 17177967 (1)

    Genetic Association Database (GAD): PRSS1
    Human Genome Epidemiology (HuGE) Navigator: PRSS1 (43 documents)

    Export disorders for PRSS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRSS1 gene, integrated from 9 sources (see all 230):
    (articles sorted by number of sources associating them with PRSS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutational screening of patients with nonalcoholic chronic pancreatitis: identification of further trypsinogen variants. (PubMed id 11866271)1, 2, 4 Teich N.... Keim V. (2002)
    2. A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis. (PubMed id 10381903)1, 2, 4 Witt H.... Becker M. (1999)
    3. [Mutations of SPINK1 and PRSS1 gene in Korean patients with chronic pancreatitis] (PubMed id 15329520)1, 4, 9 Lee K.H....Kim C.Y. (2004)
    4. Absence of PRSS1 mutations and association of SPINK1 trypsin inhibitor mutations in hereditary and non-hereditary chronic pancreatitis. (PubMed id 15082592)1, 4, 9 Chandak G.R....Singh L. (2004)
    5. Prevalence of pancreatic diabetes in patients carryin g mutations or polymorphisms of the PRSS1 gene in the Han population. (PubMed id 20001681)1, 4, 9 Liu Q.C....Wang Z.Q. (2009)
    6. Novel mutation and polymorphism of PRSS1 gene in the Chinese patients with hereditary pancreatitis and chronic pancreatitis. (PubMed id 18272034)1, 4, 9 Liu Q.C....Cheng Z.J. (2008)
    7. SPINK1 and PRSS1 mutations in benign pancreatic hyperenzymemia. (PubMed id 18580441)1, 4, 9 Gullo L....Malesci A. (2008)
    8. Analysis of CFTR, SPINK1, PRSS1 and AAT mutations in children with acute or chronic pancreatitis. (PubMed id 16954950)1, 4, 9 Sobczynska-Tomaszewska A....Bal J. (2006)
    9. Crystal structure of human trypsin 1: unexpected phosphorylation of Tyr151. (PubMed id 8683601)1, 2, 9 Gaboriaud C....Fontecilla-Camps J.-C. (1996)
    10. Genetic mutations in a Spanish population with chroni c pancreatitis. (PubMed id 19657220)1, 4, 9 Mora J....FarrAc A. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5644 HGNC: 9475 AceView: PRSS1 Ensembl:ENSG00000204983 euGenes: HUgn5644
    ECgene: PRSS1 Kegg: 5644 H-InvDB: PRSS1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRSS1 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/PRSS1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PRSS1 gene:
    Search GeneIP for patents involving PRSS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore small molecules (inhibitor) for PRSS1
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of PRSS1
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for PRSS1 (Trypsin 1/PRSS1)   Browse Cell Culture Products  
     ELISAs for PRSS1 (Trypsin 1/PRSS1)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for PRSS1 (Trypsin 1/PRSS1)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PRSS1  
     OriGene qPCR primer pairs and template standards for PRSS1   OriGene Protein Over-expression Lysate for PRSS1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PRSS1  
     OriGene qSTAR qPCR primer pairs in human, mouse for PRSS1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PRSS1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PRSS1   OriGene Custom Protein Services for PRSS1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PRSS1
     QIAGEN SeqTarget long-range PCR primers for resequencing PRSS1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRSS1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRSS1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRSS1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRSS1
     GenScript Custom Purified and Recombinant Proteins Services for PRSS1 GenScript cDNA clones with any tag delivered in your preferred vector for PRSS1
     GenScript Custom Assay Services for PRSS1 GenScript Custom Superior Antibodies Services for PRSS1
     GenScript Custom overexpressing Cell Line Services for PRSS1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PRSS1 promoter
     Search Chromatin IP Primers for PRSS1
     RT2 qPCR Primer Assay in human, mouse / rat PRSS1
     GNC Network for PRSS1
     SABiosciences Custom PCR Arrays for PRSS1
     Search Tocris compounds for PRSS1 (TRY1)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for PRSS1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PRSS1 antibodies
     PRSS1 proteins
     PRSS1 lysates
     Antibodies for PRSS1
     See all of Abcam's Antibodies, Kits and Proteins for PRSS1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for PRSS1




     Proteins for PRSS1
     Antibodies for PRSS1
     ELISAs for PRSS1
     CLIAs for PRSS1
     Search LifeMap BioReagents cell lines for PRSS1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRSS1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for PRSS1
     SwitchGear Promoter luciferase reporter plasmids for PRSS1
     ThermoFisher Antibodies for PRSS1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRSS1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PRSS1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PRSS1
    Customized:
     lentivirus for stable overexpression of PRSS1
     lentivirus expression plasmids for stable overexpression of PRSS1
     adenovirus for overexpression of PRSS1
     LSBio Antibodies in human, mouse, rat for PRSS1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PRSS1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4