PRRX2 Gene
protein-coding GIFtS : 48 GCID: GC09 P132427
paired related homeobox 2
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Aliasesfor PRRX2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Paired Related Homeobox 2 1 2 PRX-22 3 PRX21 2 3 5 Paired Mesoderm Homeobox Protein 22 PMX21 2 3 Paired-Like Homeodomain Protein PRX22 Paired-Related Homeobox Protein 22 3
Export aliases for PRRX2 gene to outside databases Previous GC identifers: GC09P127803 GC09P129507 GC09P131467 GC09P102027
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Summariesfor PRRX2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for PRRX2 : The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: PRRX2_HUMAN, Q99811 Function : May play a role in the scarless healing of cutaneous wounds during the first two trimesters of developmentGene Wiki entry for PRRX2
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Genomic Viewsfor PRRX2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000009.11 NC_018920.1 NT_008470.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the PRRX2 gene promoter:HOXA9B SRF AML1a SRF (504 AA) FOXD3 Meis-1 Meis-1b Other transcription factors Search SABiosciences Chromatin IP Primers for PRRX2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 9q34.1 Ensembl cytogenetic band: 9q34.11 HGNC cytogenetic band: 9q34.11 PRRX2 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 9 GeneLoc Exon Structure
GeneLoc location for GC09P132427: view genomic region
(about GC identifiers )
Start: 132,427,920 bp from pter End:
132,484,953 bp from pter
Size: 57,034 bases Orientation:
plus strand
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Proteinsfor PRRX2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: PRRX2_HUMAN, Q99811 See
protein sequence )Recommended Name: Size : 253 amino acids; 27079 DaSubcellular location : Nucleus (By similarity)Developmental stage : Higher expression in fetus than in adultSecondary accessions : Q5SZB5 Q9UIB3Explore the universe of human proteins at neXtProt for PRRX2: NX_Q99811 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q99811 PRRX2 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_057391.1 ENSEMBL proteins: ENSP00000361547 ENSP00000450512 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0000228 nuclear chromosome
NAS --
About GeneDecksing PRRX2 Antibody Products: Assay Products for PRRX2:
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Protein
Domains /for PRRX2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q99811 ProtoNet protein and cluster: Q99811
2 Blocks protein families : IPB000047 IPB003654 UniProtKB/Swiss-Prot: PRRX2_HUMAN, Q99811 Similarity : Belongs to the paired homeobox familySimilarity : Contains 1 homeobox DNA-binding domain
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Functionfor PRRX2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: PRRX2_HUMAN, Q99811 Function : May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development
Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: PRRX2 (NM_016307 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRRX2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat PRRX2
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003700 sequence-specific DNA binding transcription factor activity
NAS 11063257 GO:0043565 sequence-specific DNA binding
IEA --
About GeneDecksing Animal Models: Prrx2 tm1Mjk for PRRX215 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Prrx2) :About GeneDecksing
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Pathways & Interactionsfor PRRX2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PRRX2 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for PRRX2 (Q99811 3 ENSP00000361547 4 via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0002053 positive regulation of mesenchymal cell proliferation
IEA -- GO:0006355 regulation of transcription, DNA-dependent
NAS 9665387 GO:0030326 embryonic limb morphogenesis
IEA -- GO:0042472 inner ear morphogenesis
IEA -- GO:0042474 middle ear morphogenesis
IEA --
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Drugs & Compoundsfor PRRX2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for PRRX2 PRRX2
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Transcriptsfor PRRX2 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for PRRX2 gene: NM_016307.3 Unigene Cluster for PRRX2:
Paired related homeobox 2 Hs.660115 [show with all ESTs ] Unigene Representative Sequence: BM909706 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000372469 (uc004byh.3 ) ENST00000557730 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: PRRX2 (NM_016307 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRRX2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat PRRX2
Additional cDNA sequence: AF061970.1 BC014645.1 U81600.1
2 DOTS entries : DT.203595 DT.121156198
24/43 AceView cDNA sequences (see all 43 ):
NM_016307 BC014645 BE645185 AA548667 BX097188 AI674514 BM716252 AI420043 AI917607 AI923085 BU731241 BM694729 AI821507 BF939198 AF061970 AI470349 AI669686 CB050583 AI751739 BU624928 AI203915 BG055248 U81600 AW167940 GeneLoc Exon Structure
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Expression for PRRX2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section PRRX2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GCCAACAGCA
About this image PRRX2 expression in embryonic tissues and stem cells About this table See PRRX2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for PRRX2 SOURCE GeneReport for Unigene cluster: Hs.660115 UniProtKB/Swiss-Prot: PRRX2_HUMAN, Q99811 Tissue specificity : In fetal skin, highest expression found in cells of mesodermal origin within the dermal papilla ofthe developing hair shaft. Not detected in epidermis or dermis. In adult skin, weakly expressed within the basal layers of the epidermis. Not expressed in dermis SABiosciences Custom PCR Arrays for PRRX2 Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat
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Orthologsfor PRRX2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for PRRX2 gene from 4/14 species (see all 14 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves PRRX21
paired related homeobox 2
77.5(n) 84.17(a)
396314 XM_415476.3 XP_415476.3
zebrafish Actinopterygii BX908797.16
--
14(a)
possible ortholog
3(43523240-43528947)
fruit fly Insecta CG98766 6
Ods-site homeobox
26(a) 10(a)
1 ↔ manypossible ortholog
2R(18977626-18981785) X(17685083-17708021)
worm Secernentea unc-46
Homeobox protein unc-4
15(a)
possible ortholog
II(9897701-9900198)
ENSEMBL Gene Tree for PRRX2 (if available)TreeFam Gene Tree for PRRX2 (if available)
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Paralogsfor PRRX2 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for PRRX2 gene ALX1 2 PITX1 2 PHOX2B 2 RAX 2 ARX 2 VSX1 2 DRGX 2 PRRX1 2 PITX2 2 PHOX2A 2 VSX2 2 ALX4 2 ISX 2 PITX3 2 RAX2 2 ALX3 2 18/19 SIMAP similar genes for PRRX2 using alignment to 2 protein entries: PRRX2_HUMAN (see all proteins )
(see all similar genes ):PITX2 PRRX1 NKX2-5 HOXB1 SHOX2 PHOX2A DUX2 MNX1 POU6F1 OTX2 PHOX2B RAX PAX6 HOXA4 RAX2 ARX OTP CDX2 About GeneDecksing
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Genomic Variantsfor PRRX2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 9 pos Sequence # AA Type More # Allele Pop Total More
Browse Tocris compounds for 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
Selective marker
Curated
In-situ hybridization
