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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRRX2 Gene

protein-coding   GIFtS: 49
GCID: GC09P132427

Paired Related Homeobox 2
  3 related diseases
at
MalaCards
 

Aliases
for PRRX2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Paired Related Homeobox 21 2     PRX-22 3
PRX22 3 5     Paired Mesoderm Homeobox Protein 22
Paired-Related Homeobox Protein 22 3     Paired-Like Homeodomain Protein PRX22
PMX22 3     

External Ids:    HGNC: 213381   Entrez Gene: 514502   Ensembl: ENSG000001671577   OMIM: 6046755   UniProtKB: Q998113   

Export aliases for PRRX2 gene to outside databases

Previous GC identifers: GC09P127803 GC09P129507 GC09P131467 GC09P102027


Summaries
for PRRX2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PRRX2 Gene:
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression
is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in
adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role
in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The
expression patterns provide evidence consistent with a role in fetal skin development and a possible role in
cellular proliferation. (provided by RefSeq, Jul 2008)

GeneCards Summary for PRRX2 Gene: 
PRRX2 (paired related homeobox 2) is a protein-coding gene. Diseases associated with PRRX2 include acute myeloid leukemia, and myeloid leukemia. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ALX1.

UniProtKB/Swiss-Prot: PRRX2_HUMAN, Q99811
Function: May play a role in the scarless healing of cutaneous wounds during the first two trimesters of
development

Gene Wiki entry for PRRX2 Gene


Genomic Views
for PRRX2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRRX2 gene promoter:
         HOXA9B   SRF   AML1a   SRF (504 AA)   FOXD3   Meis-1   Meis-1b   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for PRRX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRRX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.1   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.11

PRRX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRRX2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P132427:  view genomic region     (about GC identifiers)

Start:
 132,427,920 bp from pter      End:
 132,484,953 bp from pter
Size:
 57,034 bases      Orientation:
 plus strand

Proteins
for PRRX2 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: PRRX2_HUMAN, Q99811 (See protein sequence)
Recommended Name: Paired mesoderm homeobox protein 2  
Size: 253 amino acids; 27079 Da
Subcellular location: Nucleus (By similarity)
Developmental stage: Higher expression in fetus than in adult
Secondary accessions: Q5SZB5 Q9UIB3

Explore the universe of human proteins at neXtProt for PRRX2: NX_Q99811

Explore proteomics data for PRRX2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99811

    • PRRX2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PRRX2 Protein Expression
    REFSEQ proteins: NP_057391.1  
    ENSEMBL proteins: 
     ENSP00000361547  

    Human Recombinant Protein Products for PRRX2: 
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    Novus Biologicals PRRX2 Proteins
    Novus Biologicals PRRX2 Lysates
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for PRRX2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000228nuclear chromosome NAS--

    PRRX2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for PRRX2 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    PRD: Homeoboxes / PRD class

    4 InterPro protein domains:
     IPR003654 OAR_dom
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q99811

    ProtoNet protein and cluster: Q99811

    2 Blocks protein domains:
    IPB000047 Lambda and other repressor helix-turn-helix signature
    IPB003654 Paired-like homeodomain protein


    UniProtKB/Swiss-Prot: PRRX2_HUMAN, Q99811
    Similarity: Belongs to the paired homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    PRRX2 for domains           About GeneDecksing


    Function
    for PRRX2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRRX2_HUMAN, Q99811
    Function: May play a role in the scarless healing of cutaneous wounds during the first two trimesters of
    development

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity NAS11063257
    GO:0043565sequence-specific DNA binding IEA--
         
    PRRX2 for ontologies           About GeneDecksing


    Phenotypes:
         15 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Prrx2):
     behavior/neurological  cardiovascular system  craniofacial  digestive/alimentary  embryogenesis 
     growth/size  hearing/vestibular/ear  homeostasis/metabolism  limbs/digits/tail  mortality/aging 
     nervous system  normal  respiratory system  skeleton  vision/eye 

    PRRX2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Prrx2tm1Mjk for PRRX2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PRRX2 
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    miRNA
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    hsa-miR-374c hsa-miR-655 hsa-miR-548u
    SwitchGear 3'UTR luciferase reporter plasmid: PRRX2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Cell Line
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    In Situ Assay
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    Pathways & Interactions
    for PRRX2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PRRX2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for PRRX2 (Q998113 ENSP000003615474) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SOX10P566933, ENSP000003541304I2D: score=1 STRING: ENSP00000354130
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002053positive regulation of mesenchymal cell proliferation IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS9665387
    GO:0030326embryonic limb morphogenesis IEA--
    GO:0042472inner ear morphogenesis IEA--
    GO:0042474middle ear morphogenesis IEA--

    PRRX2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PRRX2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PRRX2

    Search CenterWatch for drugs/clinical trials and news about PRRX2

    Transcripts
    for PRRX2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PRRX2 gene: 
    NM_016307.3  

    Unigene Cluster for PRRX2:

    Paired related homeobox 2
    Hs.660115  [show with all ESTs]
    Unigene Representative Sequence: BM909706
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000372469(uc004byh.3)
    miRNA
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    hsa-miR-374c hsa-miR-655 hsa-miR-548u
    SwitchGear 3'UTR luciferase reporter plasmid: PRRX2 3' UTR sequence
    Inhib. RNA
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRRX2

    Additional mRNA sequence: 

    AF061970.1 BC014645.1 U81600.1 

    2 DOTS entries:

    DT.203595  DT.121156198 

    24/43 AceView cDNA sequences (see all 43):

    AI821507 BU731241 BM716252 AI917607 AI923085 BE645185 NM_016307 BC014645 
    BF939198 AI420043 BM694729 AA548667 AI674514 BX097188 AW167940 AF061970 
    U81600 BG055248 BM800161 AI697307 CB050583 AI203915 AI936570 AI808278 

    GeneLoc Exon Structure


    Expression
    for PRRX2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRRX2 expression in normal human tissues (normalized intensities)      PRRX2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCAACAGCA
    PRRX2 Expression
    About this image


    PRRX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/33 selected tissues (see all 33) fully expand
     
     Fibroblast
             Human Conjunctival Fibroblasts (HConF)   
     
     Tooth
             Dental Papilla Cells Dental Papilla
             Dental pulp Stem Cells (DPSC)   
             visceral organ/oral region/upper jaw   
     
     Bone (Muscoskeletal System)    fully expand to see all 8 entries
             Mandibular Process
             HyStem+BMP4-induced SK11 cells
             Human Calvarial Osteoblasts (HCO)   
             skeleton/cranium   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 6 entries
             HyStem+BMP4-induced E15 cells
             Human Annulus Fibrosus Cells (HAFC)   
             skeleton/cranium   
     
     Dermis (Uncategorized)    fully expand to see all 6 entries
             Human Dermal Fibroblasts-adult (HDF-a)   

    See PRRX2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRRX2

    SOURCE GeneReport for Unigene cluster: Hs.660115

    UniProtKB/Swiss-Prot: PRRX2_HUMAN, Q99811
    Tissue specificity: In fetal skin, highest expression found in cells of mesodermal origin within the dermal
    papilla of the developing hair shaft. Not detected in epidermis or dermis. In adult skin, weakly expressed within
    the basal layers of the epidermis. Not expressed in dermis

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    Orthologs
    for PRRX2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PRRX2 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Prrx21 , 5 paired related homeobox 21, 5 85.23(n)1
    92.68(a)1    		   2 (21.74 cM)5
    202041  NM_009116.21  NP_033142.21 
     308349725 
    chicken
    (Gallus gallus)    		 Aves PRRX21 paired related homeobox 2 77.5(n)
    84.17(a)    		   396314  XM_415476.3  XP_415476.3 
    fruit fly
    (Drosophila melanogaster)    		 Insecta repo6
    CG98766
    (see all 4)    		 --
    		 9(a)
    24(a)
    (see all 4)    		 possible ortholog
    1 ↔ many
    (see all 4)    		 3R(14061916-14065324)
    2R(18977626-18981785)
    worm
    (Caenorhabditis elegans)    		 Secernentea alr-16
    		 Protein ALR-1
    		 16(a)
    		 1 → many
    		 X(11122597-11125615)


    ENSEMBL Gene Tree for PRRX2 (if available)
    TreeFam Gene Tree for PRRX2 (if available)

    Paralogs
    for PRRX2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRRX2 gene
    ALX12  PHOX2B2  ARX2  RAX2  DRGX2  PRRX12  SHOX22  PHOX2A2  
    ALX42  ISX2  RAX22  ALX32  SHOX2  OTP2  
    17 SIMAP similar genes for PRRX2 using alignment to 2 protein entries:     PRRX2_HUMAN (see all proteins):
    PITX2    PRRX1    NKX2-5    SHOX2    HOXB1    PHOX2A
    DUX2    MNX1    POU6F1    OTX2    PHOX2B    RAX
    PAX6    HOXA4    RAX2    ARX    OTP

    PRRX2 for paralogs           About GeneDecksing



    Genomic Variants
    for PRRX2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1323 SNPs in PRRX2 are shown (see all 1323)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1399179221,2
    		C--132425940(+) GTAGTA/GGCCCT 1 -- us2k10--------
    rs78647171,2
    		C,F--132426059(+) ACTGGC/TGCCTC 1 -- us2k11Minor allele frequency- T:0.16WA 118
    rs1494099041,2
    		--132426160(+) CACCTA/GCACGG 1 -- us2k10--------
    rs107397561,2
    		C,A,H--132426231(+) TATTTT/AATTTA 1 -- us2k19Minor allele frequency- A:0.27NA WA CSA EA 371
    rs1817809151,2
    		--132426242(+) ATTTAC/TATATA 1 -- us2k10--------
    rs1861638191,2
    		--132426256(+) TTTGAA/GATGGA 1 -- us2k10--------
    rs1909306491,2
    		--132426327(+) CGCCTC/TCCAGG 1 -- us2k10--------
    rs1474973391,2
    		--132426382(+) CAGGCA/GCCTGC 1 -- us2k10--------
    rs1478543051,2
    		--132426411(+) TTTTTA/TATTAT 1 -- us2k10--------
    rs132912281,2
    		C,F--132426773(+) GGCCAA/GCATGG 1 -- us2k17Minor allele frequency- G:0.16NA WA CSA EA 131

    HapMap Linkage Disequilibrium report for PRRX2 (132427920 - 132484953 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for PRRX2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv893919CNV Loss21882294
    nsv466589CNV Loss19166990
    nsv469901CNV Loss18288195
    nsv893924CNV Loss21882294
    nsv893909CNV Loss21882294
    nsv893927CNV Loss21882294
    nsv893925CNV Gain21882294
    nsv893926CNV Gain21882294

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    Disorders / Diseases
    for PRRX2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 604675    OMIM disorders: --

    3 diseases for PRRX2:    About MalaCards
    acute myeloid leukemia    myeloid leukemia    leukemia


    PRRX2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PRRX2
    Human Genome Epidemiology (HuGE) Navigator: PRRX2 (1 document)

    Export disorders for PRRX2 gene to outside databases

    Publications
    for PRRX2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRRX2 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with PRRX2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human PRRX1 and PRRX2 genes: cloning, expression, genomic localization, and exclusion as disease genes for Nager syndrome. (PubMed id 11063257)1, 2, 3, 9 Norris R.A.... Kern M.J. (2000)
    2. Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds. (PubMed id 9665387)1, 2, 9 Stelnicki E.J....Largman C. (1998)
    3. Web-based, participant-driven studies yield novel gen etic associations for common traits. (PubMed id 20585627)1, 4 Eriksson N....Mountain J. (2010)
    4. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. GeneChip microarrays facilitate identification of Protease Nexin-1 as a target gene of the Prx2 (S8) homeoprotein. (PubMed id 12713735)1, 9 Scott K.K....Kern M.J. (2003)
    7. Model for the exceptional reactivity of peroxiredoxin s 2 and 3 with hydrogen peroxide: a kinetic and computational study. (PubMed id 21385867)1 Nagy P....Winterbourn C.C. (2011)
    8. Oxidation of Prx2 and phosphorylation of GRP58 by angiotensin II in human coronary smooth muscle cells identified by 2D-DIGE analysis. (PubMed id 17964282)1 Tokutomi Y....Kim-Mitsuyama S. (2007)
    9. The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. (PubMed id 16582099)1 Wissmuller S....Wegner M. (2006)
    10. A new translocation t(9;11)(q34;p15) fuses NUP98 to a novel homeobox partner gene, PRRX2, in a therapy-related acute myeloid leukemia. (PubMed id 15496970)1 Gervais C.... Lessard M. (2005)

    External Searches for PRRX2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing PRRX2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51450 HGNC: 21338 AceView: PRRX2 Ensembl:ENSG00000167157 euGenes: HUgn51450
    ECgene: PRRX2 H-InvDB: PRRX2

    Other Databases showing PRRX2 gene

    (According to HUGE)
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    		   --

    Specialized Databases showing PRRX2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRRX2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRRX2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for PRRX2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PRRX2 gene:
    Search GeneIP for patents involving PRRX2

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