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PRRX2 Gene(Protein Coding)

Paired Related Homeobox 2

GCID:
GC09P129665
GIFtS:
49
Genes Participants
UDN Logo

Aliases for PRRX2 Gene

Aliases for PRRX2 Gene

  • Paired Related Homeobox 2 2 3 5
  • Paired-Related Homeobox Protein 2 3 4
  • PRX-2 3 4
  • PRX2 3 4
  • PMX2 3 4
  • Paired-Like Homeodomain Protein PRX2 3
  • Testicular Tissue Protein Li 148 3
  • Testicular Tissue Protein Li 160 3

External Ids for PRRX2 Gene

Previous GeneCards Identifiers for PRRX2 Gene

  • GC09P127803
  • GC09P129507
  • GC09P131467
  • GC09P132427
  • GC09P102027

Summaries for PRRX2 Gene

Entrez Gene Summary for PRRX2 Gene

  • The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRRX2 Gene

PRRX2 (Paired Related Homeobox 2) is a Protein Coding gene. Diseases associated with PRRX2 include acrofacial dysostosis 1, nager type. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is PHOX2B.

UniProtKB/Swiss-Prot for PRRX2 Gene

  • May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development.

Gene Wiki entry for PRRX2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRRX2 Gene

Genomics for PRRX2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for PRRX2 Gene

Enhancers for PRRX2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRRX2 on UCSC Golden Path with GeneCards custom track

Promoters for PRRX2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRRX2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the PRRX2 gene promoter:

Genomic Location for PRRX2 Gene

Chromosome:
9
Start:
129,665,641 bp from pter
End:
129,722,674 bp from pter
Size:
57,034 bases
Orientation:
Plus strand

Genomic View for PRRX2 Gene

Genes around PRRX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRRX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRRX2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PRRX2 Gene

Proteins for PRRX2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for PRRX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99811-PRRX2_HUMAN
    Recommended name:
    Paired mesoderm homeobox protein 2
    Protein Accession:
    Q99811
    Secondary Accessions:
    • Q5SZB5
    • Q9UIB3

    Protein attributes for PRRX2 Gene

    Size:
    253 amino acids
    Molecular mass:
    27079 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRRX2 Gene

Proteomics data for PRRX2 Gene at MOPED

Post-translational modifications for PRRX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRRX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRRX2 Gene

Domains & Families for PRRX2 Gene

Gene Families for PRRX2 Gene

HGNC:

Protein Domains for PRRX2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PRRX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99811

UniProtKB/Swiss-Prot:

PRRX2_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the paired homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the paired homeobox family.
genes like me logo Genes that share domains with PRRX2: view

Function for PRRX2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for PRRX2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development.

Gene Ontology (GO) - Molecular Function for PRRX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with PRRX2: view

Phenotypes for PRRX2 Gene

MGI mutant phenotypes for PRRX2:
inferred from 2 alleles
GenomeRNAi human phenotypes for PRRX2:
genes like me logo Genes that share phenotypes with PRRX2: view

Animal Models for PRRX2 Gene

MGI Knock Outs for PRRX2:

Animal Model Products

CRISPR Products

miRNA for PRRX2 Gene

miRTarBase miRNAs that target PRRX2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRRX2 Gene

Localization for PRRX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRRX2 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRRX2 Gene COMPARTMENTS Subcellular localization image for PRRX2 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for PRRX2 Gene

Pathways & Interactions for PRRX2 Gene

SuperPathways for PRRX2 Gene

PathCards logoMore details on SuperPathways for PRRX2
No Data Available

Gene Ontology (GO) - Biological Process for PRRX2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PRRX2 Gene

Drugs & Compounds for PRRX2 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for PRRX2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for PRRX2 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(43) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRRX2 Gene

Paired related homeobox 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRRX2 Gene

No ASD Table

Relevant External Links for PRRX2 Gene

GeneLoc Exon Structure for
PRRX2
ECgene alternative splicing isoforms for
PRRX2

Expression for PRRX2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for PRRX2 Gene

mRNA expression in normal human tissues for PRRX2 Gene
mRNA expression by BioGPS for PRRX2 GenemRNA expression by GTEx for PRRX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRRX2 Gene

This gene is overexpressed in Artery - Aorta (x7.2).

SOURCE GeneReport for Unigene cluster for PRRX2 Gene Hs.660115

mRNA Expression by UniProt/SwissProt for PRRX2 Gene

Q99811-PRRX2_HUMAN
Tissue specificity: In fetal skin, highest expression found in cells of mesodermal origin within the dermal papilla of the developing hair shaft. Not detected in epidermis or dermis. In adult skin, weakly expressed within the basal layers of the epidermis. Not expressed in dermis.
genes like me logo Genes that share expression patterns with PRRX2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PRRX2 Gene

Orthologs for PRRX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRRX2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia PRRX2 35
  • 90.39 (n)
  • 94.59 (a)
PRRX2 36
  • 97 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia PRRX2 35
  • 89.19 (n)
  • 91.35 (a)
PRRX2 36
  • 84 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Prrx2 35
  • 85.09 (n)
  • 92.28 (a)
Prrx2 16
Prrx2 36
  • 92 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia PRRX2 35
  • 99.74 (n)
  • 100 (a)
PRRX2 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Prrx2 35
  • 84.95 (n)
  • 91.53 (a)
oppossum
(Monodelphis domestica)
 Mammalia PRRX2 36
  • 77 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves PRRX2 35
  • 78.44 (n)
  • 86.24 (a)
PRRX2 36
  • 79 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia prrx2 35
  • 67.28 (n)
  • 67.43 (a)
zebrafish
(Danio rerio)
 Actinopterygii phox2ba 36
  • 36 (a)
 ManyToMany
fruit fly
(Drosophila melanogaster)
 Insecta CG9876 36
  • 29 (a)
 OneToMany
Species with no ortholog for PRRX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRRX2 Gene

ENSEMBL:
Gene Tree for PRRX2 (if available)
TreeFam:
Gene Tree for PRRX2 (if available)

Paralogs for PRRX2 Gene

Paralogs for PRRX2 Gene

(10) SIMAP similar genes for PRRX2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PRRX2: view

Variants for PRRX2 Gene

Sequence variations from dbSNP and Humsavar for PRRX2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs729523 -- 129,678,799(-) GAGAG(A/C)GCCCC intron-variant
rs729524 -- 129,678,505(-) AAACC(G/T)TCCCT intron-variant
rs735781 -- 129,696,637(-) GGAAC(C/T)GAGGG intron-variant
rs735782 -- 129,696,619(-) GCTTT(A/T)TAAAA intron-variant
rs737188 -- 129,699,430(+) AAAAA(A/T)ATATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRRX2 Gene

Variant ID Type Subtype PubMed ID
nsv893909 CNV Loss 21882294
nsv893919 CNV Loss 21882294
nsv469901 CNV Loss 18288195
nsv893924 CNV Loss 21882294
nsv893925 CNV Gain 21882294
nsv893926 CNV Gain 21882294
nsv466589 CNV Loss 19166990
nsv893927 CNV Loss 21882294

Variation tolerance for PRRX2 Gene

Residual Variation Intolerance Score: 58.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRRX2 Gene

HapMap Linkage Disequilibrium report
PRRX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRRX2 Gene

Disorders for PRRX2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRRX2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
acrofacial dysostosis 1, nager type
  • nager acrofacial dysostosis
- elite association - COSMIC cancer census association via MalaCards
Search PRRX2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRRX2

Genetic Association Database (GAD)
PRRX2
Human Genome Epidemiology (HuGE) Navigator
PRRX2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRRX2
genes like me logo Genes that share disorders with PRRX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRRX2 Gene

Publications for PRRX2 Gene

  1. Human PRRX1 and PRRX2 genes: cloning, expression, genomic localization, and exclusion as disease genes for Nager syndrome. (PMID: 11063257) Norris R.A. … Kern M.J. (Mamm. Genome 2000) 2 3 4 23 67
  2. GeneChip microarrays facilitate identification of Protease Nexin-1 as a target gene of the Prx2 (S8) homeoprotein. (PMID: 12713735) Scott K.K. … Kern M.J. (DNA Cell Biol. 2003) 3 23
  3. Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds. (PMID: 9665387) Stelnicki E.J. … Largman C. (J. Invest. Dermatol. 1998) 3 23
  4. Model for the exceptional reactivity of peroxiredoxins 2 and 3 with hydrogen peroxide: a kinetic and computational study. (PMID: 21385867) Nagy P. … Winterbourn C.C. (J. Biol. Chem. 2011) 3
  5. Web-based, participant-driven studies yield novel genetic associations for common traits. (PMID: 20585627) Eriksson N. … Mountain J. (PLoS Genet. 2010) 3

Products for PRRX2 Gene

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