Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PRRX2 Gene

protein-coding GIFtS: 49
GCID: GC09P132427

Paired Related Homeobox 2

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Paired Related Homeobox 2¹ ²		PRX-2² ³
PRX2² ³ ⁵		Paired Mesoderm Homeobox Protein 2²
Paired-Related Homeobox Protein 2² ³		Paired-Like Homeodomain Protein PRX2²
PMX2² ³

External Ids:	HGNC: 21338¹	Entrez Gene: 51450²	Ensembl: ENSG00000167157⁷	OMIM: 604675⁵	UniProtKB: Q99811³

Export aliases for PRRX2 gene to outside databases

Previous GC identifers: GC09P127803 GC09P129507 GC09P131467 GC09P102027

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PRRX2 Gene:

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression

is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in

adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role

in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The

expression patterns provide evidence consistent with a role in fetal skin development and a possible role in

cellular proliferation. (provided by RefSeq, Jul 2008)

GeneCards Summary for PRRX2 Gene:

PRRX2 (paired related homeobox 2) is a protein-coding gene. Diseases associated with PRRX2 include acute myeloid leukemia, and myeloid leukemia. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ALX1.

UniProtKB/Swiss-Prot: PRRX2_HUMAN, Q99811

Function: May play a role in the scarless healing of cutaneous wounds during the first two trimesters of

development

Gene Wiki entry for PRRX2 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.2 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PRRX2 gene promoter:
HOXA9B SRF AML1a SRF (504 AA) FOXD3 Meis-1 Meis-1b
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for PRRX2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRRX2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.1 Ensembl cytogenetic band: 9q34.11 HGNC cytogenetic band: 9q34.11

PRRX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRRX2 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P132427: view genomic region (about GC identifiers)

Start:	132,427,920 bp from pter	End:	132,484,953 bp from pter
Size:	57,034 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PRRX2_HUMAN, Q99811 (See protein sequence)

Recommended Name: Paired mesoderm homeobox protein 2

Size: 253 amino acids; 27079 Da

Subcellular location: Nucleus (By similarity)

Developmental stage: Higher expression in fetus than in adult

Secondary accessions: Q5SZB5 Q9UIB3

Explore the universe of human proteins at neXtProt for PRRX2: NX_Q99811

Explore proteomics data for PRRX2 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q99811

PRRX2 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_057391.1

ENSEMBL proteins:

ENSP00000361547

Human Recombinant Protein Products for PRRX2:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom MassSpec OriGene Custom Protein Services for PRRX2
	GenScript Custom Purified and Recombinant Proteins Services for PRRX2
	Novus Biologicals PRRX2 Proteins Novus Biologicals PRRX2 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for PRRX2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000228	nuclear chromosome	NAS	--

PRRX2 for ontologies About GeneDecksing

PRRX2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for PRRX2
	GenScript Custom Superior Antibodies Services for PRRX2
	Novus Biologicals PRRX2 Antibodies
	Abcam antibodies for PRRX2
	Cloud-Clone Corp. Antibodies for PRRX2
	Search ThermoFisher Antibodies for PRRX2
	LSBio Antibodies in human, mouse, rat for PRRX2

Assay Products for PRRX2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for PRRX2
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PRRX2
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for PRRX2 Cloud-Clone Corp. CLIAs for PRRX2

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

PRD: Homeoboxes / PRD class

4 InterPro protein domains:

IPR003654 OAR_dom

IPR017970 Homeobox_CS

IPR001356 Homeodomain

IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry Q99811

ProtoNet protein and cluster: Q99811

2 Blocks protein domains:

IPB000047 Lambda and other repressor helix-turn-helix signature

IPB003654 Paired-like homeodomain protein

UniProtKB/Swiss-Prot: PRRX2_HUMAN, Q99811

Similarity: Belongs to the paired homeobox family

Similarity: Contains 1 homeobox DNA-binding domain

PRRX2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PRRX2_HUMAN, Q99811

Function: May play a role in the scarless healing of cutaneous wounds during the first two trimesters of

development

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003700	sequence-specific DNA binding transcription factor activity	NAS	11063257
GO:0043565	sequence-specific DNA binding	IEA	--

PRRX2 for ontologies About GeneDecksing

Phenotypes:
15 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Prrx2):

behavior/neurological	cardiovascular system	craniofacial	digestive/alimentary	embryogenesis
growth/size	hearing/vestibular/ear	homeostasis/metabolism	limbs/digits/tail	mortality/aging
nervous system	normal	respiratory system	skeleton	vision/eye

PRRX2 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Prrx2^tm1Mjk for PRRX2

inGenious Targeting Laboratory - Custom generated mouse model solutions for PRRX2

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PRRX2

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRRX2

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRRX2

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRRX2
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate PRRX2:
		hsa-miR-374c hsa-miR-655 hsa-miR-548u
		SwitchGear 3'UTR luciferase reporter plasmid: PRRX2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for PRRX2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRRX2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for PRRX2
			Sirion Biotech Customized adenovirus for overexpression of PRRX2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for PRRX2 (see all 4) OriGene ORF clones in mouse, rat for PRRX2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PRRX2 (NM_016307)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRRX2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRRX2
		Sirion Biotech Customized lentivirus for stable overexpression of PRRX2 Customized lentivirus expression plasmids for stable overexpression of PRRX2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PRRX2
		Search LifeMap BioReagents cell lines for PRRX2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRRX2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PRRX2

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for PRRX2 (Q99811³ ENSP00000361547⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SOX10	P56693³, ENSP00000354130⁴	I2D: score=1 STRING: ENSP00000354130

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002053	positive regulation of mesenchymal cell proliferation	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	NAS	9665387
GO:0030326	embryonic limb morphogenesis	IEA	--
GO:0042472	inner ear morphogenesis	IEA	--
GO:0042474	middle ear morphogenesis	IEA	--

PRRX2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PRRX2

Search CenterWatch for drugs/clinical trials and news about PRRX2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PRRX2 gene:

NM_016307.3

Unigene Cluster for PRRX2:

Paired related homeobox 2

Hs.660115 [show with all ESTs]

Unigene Representative Sequence: BM909706

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000372469(uc004byh.3)

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRRX2
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate PRRX2:
		hsa-miR-374c hsa-miR-655 hsa-miR-548u
		SwitchGear 3'UTR luciferase reporter plasmid: PRRX2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for PRRX2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRRX2

Clone Products:		OriGene clones in human, mouse for PRRX2 (see all 4) OriGene ORF clones in mouse, rat for PRRX2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PRRX2 (NM_016307)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRRX2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRRX2
		Sirion Biotech Customized lentivirus for stable overexpression of PRRX2 Customized lentivirus expression plasmids for stable overexpression of PRRX2

Primer Products:		OriGene qPCR primer pairs and template standards for PRRX2 OriGene qSTAR qPCR primer pairs in human, mouse for PRRX2
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PRRX2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRRX2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRRX2

Additional mRNA sequence:

AF061970.1 BC014645.1 U81600.1

2 DOTS entries:

DT.203595 DT.121156198

24/43 AceView cDNA sequences (see all 43):

AI821507 BU731241 BM716252 AI917607 AI923085 BE645185 NM_016307 BC014645

BF939198 AI420043 BM694729 AA548667 AI674514 BX097188 AW167940 AF061970

U81600 BG055248 BM800161 AI697307 CB050583 AI203915 AI936570 AI808278

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PRRX2 expression in normal human tissues (normalized intensities) PRRX2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCCAACAGCA

About this image

PRRX2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/33 selected tissues (see all 33) fully expand


Fibroblast
Human Conjunctival Fibroblasts (HConF)

Tooth
Dental Papilla Cells Dental Papilla
Dental pulp Stem Cells (DPSC)
visceral organ/oral region/upper jaw

Bone (Muscoskeletal System) fully expand to see all 8 entries
Mandibular Process
HyStem+BMP4-induced SK11 cells
Human Calvarial Osteoblasts (HCO)
skeleton/cranium

Cartilage (Muscoskeletal System) fully expand to see all 6 entries
HyStem+BMP4-induced E15 cells
Human Annulus Fibrosus Cells (HAFC)
skeleton/cranium

Dermis (Uncategorized) fully expand to see all 6 entries
Human Dermal Fibroblasts-adult (HDF-a)

See PRRX2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PRRX2

SOURCE GeneReport for Unigene cluster: Hs.660115

UniProtKB/Swiss-Prot: PRRX2_HUMAN, Q99811

Tissue specificity: In fetal skin, highest expression found in cells of mesodermal origin within the dermal

papilla of the developing hair shaft. Not detected in epidermis or dermis. In adult skin, weakly expressed within

the basal layers of the epidermis. Not expressed in dermis

SABiosciences Custom PCR Arrays for PRRX2

Primer Products:		OriGene qPCR primer pairs and template standards for PRRX2 OriGene qSTAR qPCR primer pairs in human, mouse for PRRX2
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PRRX2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRRX2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRRX2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRRX2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PRRX2 gene from 4/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Prrx2^{1 , 5}	paired related homeobox 2^{1, 5}	85.23(n)¹ 92.68(a)¹		2 (21.74 cM)⁵ 20204¹ NM_009116.2¹ NP_033142.2¹ 30834972⁵
chicken (Gallus gallus)	Aves	PRRX2¹	paired related homeobox 2	77.5(n) 84.17(a)		396314 XM_415476.3 XP_415476.3
fruit fly (Drosophila melanogaster)	Insecta	repo⁶ CG9876⁶ (see all 4)	--	9(a) 24(a) (see all 4)	possible ortholog 1 ↔ many (see all 4)	3R(14061916-14065324) 2R(18977626-18981785)
worm (Caenorhabditis elegans)	Secernentea	alr-1⁶	Protein ALR-1	16(a)	1 → many	X(11122597-11125615)

ENSEMBL Gene Tree for PRRX2 (if available)
TreeFam Gene Tree for PRRX2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PRRX2 gene

ALX1² PHOX2B² ARX² RAX² DRGX² PRRX1² SHOX2² PHOX2A²

ALX4² ISX² RAX2² ALX3² SHOX² OTP²

17 SIMAP similar genes for PRRX2 using alignment to 2 protein entries: PRRX2_HUMAN (see all proteins):

PITX2 PRRX1 NKX2-5 SHOX2 HOXB1 PHOX2A

DUX2 MNX1 POU6F1 OTX2 PHOX2B RAX

PAX6 HOXA4 RAX2 ARX OTP

PRRX2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs139917922^1,2	C	--	132425940(+)	`GTAGTA/GGCCCT`	1	--	us2k¹		0	--	--	--	--
rs7864717^1,2	C,F	--	132426059(+)	`ACTGGC/TGCCTC`	1	--	us2k¹		1		WA	118
rs149409904^1,2		--	132426160(+)	`CACCTA/GCACGG`	1	--	us2k¹		0	--	--	--	--
rs10739756^1,2	C,A,H	--	132426231(+)	`TATTTT/AATTTA`	1	--	us2k¹		9		NA WA CSA EA	371
rs181780915^1,2		--	132426242(+)	`ATTTAC/TATATA`	1	--	us2k¹		0	--	--	--	--
rs186163819^1,2		--	132426256(+)	`TTTGAA/GATGGA`	1	--	us2k¹		0	--	--	--	--
rs190930649^1,2		--	132426327(+)	`CGCCTC/TCCAGG`	1	--	us2k¹		0	--	--	--	--
rs147497339^1,2		--	132426382(+)	`CAGGCA/GCCTGC`	1	--	us2k¹		0	--	--	--	--
rs147854305^1,2		--	132426411(+)	`TTTTTA/TATTAT`	1	--	us2k¹		0	--	--	--	--
rs13291228^1,2	C,F	--	132426773(+)	`GGCCAA/GCATGG`	1	--	us2k¹		7		NA WA CSA EA	131

HapMap Linkage Disequilibrium report for PRRX2 (132427920 - 132484953 bp)

Structural Variations
Database of Genomic Variants (DGV) 8 variations for PRRX2: About this table

Variant ID	Type	Subtype	PubMed ID
nsv893919	CNV	Loss	21882294
nsv466589	CNV	Loss	19166990
nsv469901	CNV	Loss	18288195
nsv893924	CNV	Loss	21882294
nsv893909	CNV	Loss	21882294
nsv893927	CNV	Loss	21882294
nsv893925	CNV	Gain	21882294
nsv893926	CNV	Gain	21882294

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing PRRX2

DNA2.0 Custom Variant and Variant Library Synthesis for PRRX2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 604675 OMIM disorders: --

3 diseases for PRRX2: About MalaCards

acute myeloid leukemia myeloid leukemia leukemia

PRRX2 for disorders About GeneDecksing

Genetic Association Database (GAD): PRRX2
Human Genome Epidemiology (HuGE) Navigator: PRRX2 (1 document)

Export disorders for PRRX2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PRRX2 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with PRRX2)

Utopia: connect your pdf to the dynamic
world of online information

Human PRRX1 and PRRX2 genes: cloning, expression, genomic localization, and exclusion as disease genes for Nager syndrome. (PubMed id 11063257)^{1, 2, 3, 9} Norris R.A.... Kern M.J. (2000)
Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds. (PubMed id 9665387)^{1, 2, 9} Stelnicki E.J....Largman C. (1998)
Web-based, participant-driven studies yield novel gen etic associations for common traits. (PubMed id 20585627)^{1, 4} Eriksson N....Mountain J. (2010)
Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)^{1, 4} Jugessur A....Murray J.C. (2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
GeneChip microarrays facilitate identification of Protease Nexin-1 as a target gene of the Prx2 (S8) homeoprotein. (PubMed id 12713735)^{1, 9} Scott K.K....Kern M.J. (2003)
Model for the exceptional reactivity of peroxiredoxin s 2 and 3 with hydrogen peroxide: a kinetic and computational study. (PubMed id 21385867)¹ Nagy P....Winterbourn C.C. (2011)
Oxidation of Prx2 and phosphorylation of GRP58 by angiotensin II in human coronary smooth muscle cells identified by 2D-DIGE analysis. (PubMed id 17964282)¹ Tokutomi Y....Kim-Mitsuyama S. (2007)
The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. (PubMed id 16582099)¹ Wissmuller S....Wegner M. (2006)
A new translocation t(9;11)(q34;p15) fuses NUP98 to a novel homeobox partner gene, PRRX2, in a therapy-related acute myeloid leukemia. (PubMed id 15496970)¹ Gervais C.... Lessard M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 51450	HGNC: 21338	AceView: PRRX2	Ensembl:ENSG00000167157	euGenes: HUgn51450
ECgene: PRRX2	H-InvDB: PRRX2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PRRX2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PRRX2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for PRRX2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for PRRX2 gene:
Search GeneIP for patents involving PRRX2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for PRRX2
	OriGene qPCR primer pairs and template standards for PRRX2		Browse OriGene Protein Over-expression Lysates
	OriGene Custom Mass Spec		OriGene clones in human, mouse for PRRX2
	OriGene qSTAR qPCR primer pairs in human, mouse for PRRX2		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for PRRX2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for PRRX2		OriGene Custom Protein Services for PRRX2

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PRRX2
	QIAGEN SeqTarget long-range PCR primers for resequencing PRRX2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRRX2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRRX2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRRX2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRRX2

	GenScript Custom Purified and Recombinant Proteins Services for PRRX2		GenScript cDNA clones with any tag delivered in your preferred vector for PRRX2
	GenScript Custom Assay Services for PRRX2		GenScript Custom Superior Antibodies Services for PRRX2
	GenScript Custom overexpressing Cell Line Services for PRRX2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in PRRX2 promoter
	Search Chromatin IP Primers for PRRX2
	RT² qPCR Primer Assay in human, mouse, rat PRRX2
	Search GNC Networks for PRRX2
	SABiosciences Custom PCR Arrays for PRRX2

Search Tocris compounds for PRRX2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	PRRX2 antibodies
	PRRX2 proteins
	PRRX2 lysates

	Antibodies for PRRX2
	See all of Abcam's Antibodies, Kits and Proteins for PRRX2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for PRRX2
	Antibodies for PRRX2
	ELISAs for PRRX2
	CLIAs for PRRX2

Search LifeMap BioReagents cell lines for PRRX2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRRX2

	SwitchGear 3'UTR luciferase reporter plasmids for PRRX2
	Browse SwitchGear Promoter luciferase reporter plasmids for PRRX2

Search ThermoFisher Antibodies for PRRX2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRRX2

	inGenious Targeting Laboratory - Custom generated mouse model solutions for PRRX2
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PRRX2

Customized:

	lentivirus for stable overexpression of PRRX2
	lentivirus expression plasmids for stable overexpression of PRRX2
	adenovirus for overexpression of PRRX2

LSBio Antibodies in human, mouse, rat for PRRX2

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes PRRX2 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

PRRX2 Gene

Paired Related Homeobox 2

Aliases
for PRRX2 gene

Summaries
for PRRX2 gene

Genomic Views
for PRRX2 gene

Proteins
for PRRX2 gene

Protein Domains /
Families
for PRRX2 gene

Function
for PRRX2 gene

Pathways & Interactions
for PRRX2 gene

Drugs & Compounds
for PRRX2 gene

Transcripts
for PRRX2 gene

Expression
for PRRX2 gene

Orthologs
for PRRX2 gene

Paralogs
for PRRX2 gene

Genomic Variants
for PRRX2 gene

Disorders / Diseases
for PRRX2 gene

Publications
for PRRX2 gene

External Searches for PRRX2 gene

Genome Databases showing PRRX2 gene

Other Databases showing PRRX2 gene

Specialized Databases showing PRRX2 gene

Intellectual Property
for PRRX2 gene

Products
for PRRX2 gene

View Random Gene

Advanced Search

Export list of displayed genes

PRRX2 Gene

Paired Related Homeobox 2

Aliasesfor PRRX2 gene

Summariesfor PRRX2 gene

Genomic Viewsfor PRRX2 gene

Proteinsfor PRRX2 gene

Protein Domains /Familiesfor PRRX2 gene

Functionfor PRRX2 gene

Pathways & Interactionsfor PRRX2 gene

Drugs & Compoundsfor PRRX2 gene

Transcriptsfor PRRX2 gene

Expression for PRRX2 gene

Orthologsfor PRRX2 gene

Paralogsfor PRRX2 gene

Genomic Variantsfor PRRX2 gene

Disorders / Diseasesfor PRRX2 gene

Publicationsfor PRRX2 gene

External Searches for PRRX2 gene

Genome Databases showing PRRX2 gene

Other Databases showing PRRX2 gene

Specialized Databases showing PRRX2 gene

Intellectual Propertyfor PRRX2 gene

Productsfor PRRX2 gene

View Random Gene

Aliases
for PRRX2 gene

Summaries
for PRRX2 gene

Genomic Views
for PRRX2 gene

Proteins
for PRRX2 gene

Protein Domains /
Families
for PRRX2 gene

Function
for PRRX2 gene

Pathways & Interactions
for PRRX2 gene

Drugs & Compounds
for PRRX2 gene

Transcripts
for PRRX2 gene

Expression
for PRRX2 gene

Orthologs
for PRRX2 gene

Paralogs
for PRRX2 gene

Genomic Variants
for PRRX2 gene

Disorders / Diseases
for PRRX2 gene

Publications
for PRRX2 gene

Intellectual Property
for PRRX2 gene

Products
for PRRX2 gene