Aliases for PRRX2 Gene
Aliases for PRRX2 Gene
External Ids for PRRX2 Gene
- HGNC: 21338
- Entrez Gene: 51450
- Ensembl: ENSG00000167157
- OMIM: 604675
- UniProtKB: Q99811
Previous GeneCards Identifiers for PRRX2 Gene
- GC09P127803
- GC09P129507
- GC09P131467
- GC09P132427
- GC09P102027
Summaries for PRRX2 Gene
-
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation. [provided by RefSeq, Jul 2008]
GeneCards Summary for PRRX2 Gene
PRRX2 (Paired Related Homeobox 2) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is PRRX1.
UniProtKB/Swiss-Prot for PRRX2 Gene
-
May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRRX2 Gene
Genomics for PRRX2 Gene
Regulatory Elements for PRRX2 Gene
Enhancers for PRRX2 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around PRRX2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the PRRX2 gene promoter:
Regulatory Element Products
Genomic Location for PRRX2 Gene
- Chromosome:
- 9
- Start:
- 129,665,641 bp from pter
- End:
- 129,722,674 bp from pter
- Size:
- 57,034 bases
- Orientation:
- Plus strand
Genomic View for PRRX2 Gene
Genes around PRRX2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q34.11 by Ensembl
- 9q34.11 by Entrez Gene
- 9q34.11 by HGNC
PRRX2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PRRX2 Gene
Proteins for PRRX2 Gene
-
Protein details for PRRX2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99811-PRRX2_HUMAN
- Recommended name:
- Paired mesoderm homeobox protein 2
- Protein Accession:
- Q99811
- Q5SZB5
- Q9UIB3
Protein attributes for PRRX2 Gene
- Size:
- 253 amino acids
- Molecular mass:
- 27079 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for PRRX2 Gene
Other Protein References for PRRX2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for PRRX2
- Invitrogen Antibodies for PRRX2
- antibodies-online Antibodies for PRRX2: See all 42
- Search GeneTex for Antibodies for PRRX2
-
Santa Cruz Biotechnology (SCBT) Antibodies for PRRX2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for PRRX2
- Origene Custom Protein Services for PRRX2
- antibodies-online Proteins for PRRX2: See all 9
- Search antibodies-online for peptides
- Search GeneTex for Proteins for PRRX2
Assay Products
No data available for DME Specific Peptides for PRRX2 Gene
Domains & Families for PRRX2 Gene
Gene Families for PRRX2 Gene
Protein Domains for PRRX2 Gene
Suggested Antigen Peptide Sequences for PRRX2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q99811- Family:
-
- Belongs to the paired homeobox family.
Function for PRRX2 Gene
Molecular function for PRRX2 Gene
- UniProtKB/Swiss-Prot Function:
- May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | NAS | 11063257 |
| GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for PRRX2 Gene
- MGI mutant phenotypes for PRRX2:
-
inferred from 2 alleles
- mortality/aging
- behavior/neurological phenotype
- normal phenotype
- growth/size/body region phenotype
- nervous system phenotype
- homeostasis/metabolism phenotype
- cardiovascular system phenotype
- respiratory system phenotype
- digestive/alimentary phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- embryo phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for PRRX2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for PRRX2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PRRX2 gene
- Search ViGene Biosciences for PRRX2
CRISPR Products
-
OriGene CRISPR knockouts for PRRX2
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRRX2
- GenScript: Design CRISPR guide RNA sequences for PRRX2
miRNA for PRRX2 Gene
- miRTarBase miRNAs that target PRRX2
miRNA Products
- Search ViGene Biosciences for PRRX2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for PRRX2
- Browse OriGene Inhibitory RNA Products For PRRX2
-
ViGene Biosciences ready-to-package AAV shRNAs for PRRX2 gene
Clone Products
-
OriGene ORF clones in human for PRRX2
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Cell Line Products
-
Horizon Cell Lines for PRRX2
-
ViGene Biosciences adenoviral particle packaged cDNA for PRRX2 gene
-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRRX2 Gene
Localization for PRRX2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PRRX2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
Pathways & Interactions for PRRX2 Gene
No Data Available
Interacting Proteins for PRRX2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | NAS | 9665387 |
| GO:0007275 | multicellular organism development | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for PRRX2 Gene
Transcripts for PRRX2 Gene
mRNA/cDNA for PRRX2 Gene
- (2) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (43) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PRRX2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PRRX2
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRRX2
- GenScript: Design CRISPR guide RNA sequences for PRRX2
miRNA Products
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Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for PRRX2 gene
Clone Products
-
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Flow Cytometry Products
Expression for PRRX2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Fibroblasts (Uncategorized)
- Dermis (Integumentary System)
-
Head Mesenchyme (Muscoskeletal System)
- Dental Mesenchymal Cells Branchial Arch 1
- Branchial Arch 1
- Branchial Arch 2
- Head Mesenchyme
- Bone (Muscoskeletal System)
-
Tooth (Integumentary System)
- Dental Papilla Cells Dental Papilla
- Dental Mesenchymal Cells Branchial Arch 1
- Dental Follicle Cells Dental Papilla
- Cartilage (Muscoskeletal System)
-
Placenta (Extraembryonic Tissues)
- Allantois Cells Allantois
- Allantois
-
Heart (Cardiovascular System)
- Cushion Mesenchymal Cells Endocardium
- Heart Tube
- Neural Crest (Gastrulation Derivatives)
- Adipose (Muscoskeletal System)
- Brain (Nervous System)
- Gut Tube (Gastrointestinal Tract)
- Neural Tube (Nervous System)
- Limb (Muscoskeletal System)
- Mesoderm (Gastrulation Derivatives)
- Tendon amp Ligament
- Intestine
mRNA differential expression in normal tissues according to GTEx for PRRX2 Gene
This gene is overexpressed in Artery - Aorta (x7.2).
NURSA nuclear receptor signaling pathways regulating expression of PRRX2 Gene:
PRRX2SOURCE GeneReport for Unigene cluster for PRRX2 Gene:
Hs.660115mRNA Expression by UniProt/SwissProt for PRRX2 Gene:
Q99811-PRRX2_HUMAN
Tissue specificity:
In fetal skin, highest expression found in cells of mesodermal origin within the dermal papilla of the developing hair shaft. Not detected in epidermis or dermis. In adult skin, weakly expressed within the basal layers of the epidermis. Not expressed in dermis.
Primer Products
-
OriGene qPCR primer pairs for PRRX2
-
OriGene qPCR primer pairs and template standards for PRRX2
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRRX2 Gene
Orthologs for PRRX2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PRRX2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | PRRX2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | PRRX2 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Prrx2 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Prrx2 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PRRX2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PRRX2 34 35 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | prrx2 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | phox2ba 35 |
|
ManyToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG9876 35 |
|
OneToMany |
- Species where no ortholog for PRRX2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for PRRX2 Gene
Paralogs for PRRX2 Gene
(10) SIMAP similar genes for PRRX2 Gene using alignment to 1 proteins:
Variants for PRRX2 Gene
| SNP ID | Clin | Chr 09 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000022897 | -- | 129,702,490(+) | GTGTG(G/T)ATATT | intron-variant | |
| rs1000029259 | -- | 129,707,511(+) | CCGGG(C/T)GCGGT | intron-variant | |
| rs1000042261 | -- | 129,672,351(+) | GCCTC(A/G)CTGGA | intron-variant | |
| rs1000086474 | -- | 129,703,711(+) | CTTCT(C/T)GCCTC | intron-variant | |
| rs1000089438 | -- | 129,718,569(+) | CTCTC(A/G)TACCC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1511e214 | CNV | gain | 21293372 |
| esv3621839 | CNV | loss | 21293372 |
| nsv1046477 | CNV | gain | 25217958 |
| nsv1137671 | CNV | deletion | 24896259 |
| nsv466589 | CNV | loss | 19166990 |
| nsv469901 | CNV | loss | 18288195 |
| nsv472169 | CNV | novel sequence insertion | 20440878 |
| nsv615496 | CNV | loss | 21841781 |
| nsv615497 | CNV | loss | 21841781 |
| nsv951785 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
58.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.99;
20.33% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for PRRX2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PRRX2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRRX2 Gene
Disorders for PRRX2 Gene
Relevant External Links for PRRX2
No disorders were found for PRRX2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRRX2 Gene
Publications for PRRX2 Gene
- Human PRRX1 and PRRX2 genes: cloning, expression, genomic localization, and exclusion as disease genes for Nager syndrome. (PMID: 11063257) Norris R.A. … Kern M.J. (Mamm. Genome 2000) 2 3 4 22 64
- Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds. (PMID: 9665387) Stelnicki E.J. … Largman C. (J. Invest. Dermatol. 1998) 3 4 22 64
- Web-based, participant-driven studies yield novel genetic associations for common traits. (PMID: 20585627) Eriksson N. … Mountain J. (PLoS Genet. 2010) 3 46 64
- Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 46 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
Products for PRRX2 Gene
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- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
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- Novus Biologicals Antibodies for PRRX2
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- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for PRRX2: See all 42
- Search antibodies-online for kits
- antibodies-online Proteins for PRRX2: See all 9
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for PRRX2
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- ViGene Biosciences adenoviral particle packaged cDNA for PRRX2 gene
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- VectorBuilder custom plasmid, inducible vectors for PRRX2
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for PRRX2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer