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Aliases for PRRX2 Gene

Aliases for PRRX2 Gene

  • Paired Related Homeobox 2 2 3
  • PRX2 3 4 6
  • Paired-Related Homeobox Protein 2 3 4
  • PRX-2 3 4
  • PMX2 3 4
  • Paired-Like Homeodomain Protein PRX2 3
  • Paired Mesoderm Homeobox Protein 2 3

External Ids for PRRX2 Gene

Previous GeneCards Identifiers for PRRX2 Gene

  • GC09P127803
  • GC09P129507
  • GC09P131467
  • GC09P132427
  • GC09P102027

Summaries for PRRX2 Gene

Entrez Gene Summary for PRRX2 Gene

  • The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRRX2 Gene

PRRX2 (Paired Related Homeobox 2) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is PHOX2B.

UniProtKB/Swiss-Prot for PRRX2 Gene

  • May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development.

Gene Wiki entry for PRRX2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRRX2 Gene

Genomics for PRRX2 Gene

Regulatory Elements for PRRX2 Gene

Genomic Location for PRRX2 Gene

Start:
129,665,641 bp from pter
End:
129,722,674 bp from pter
Size:
57,034 bases
Orientation:
Plus strand

Genomic View for PRRX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRRX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRRX2 Gene

Proteins for PRRX2 Gene

  • Protein details for PRRX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99811-PRRX2_HUMAN
    Recommended name:
    Paired mesoderm homeobox protein 2
    Protein Accession:
    Q99811
    Secondary Accessions:
    • Q5SZB5
    • Q9UIB3

    Protein attributes for PRRX2 Gene

    Size:
    253 amino acids
    Molecular mass:
    27079 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRRX2 Gene

Proteomics data for PRRX2 Gene at MOPED

Post-translational modifications for PRRX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRRX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRRX2 Gene

Domains for PRRX2 Gene

Gene Families for PRRX2 Gene

HGNC:
  • PRD :Homeoboxes / PRD class

Suggested Antigen Peptide Sequences for PRRX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99811

UniProtKB/Swiss-Prot:

PRRX2_HUMAN :
  • Q99811
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the paired homeobox family.
genes like me logo Genes that share domains with PRRX2: view

Function for PRRX2 Gene

Molecular function for PRRX2 Gene

UniProtKB/Swiss-Prot Function: May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development.

Gene Ontology (GO) - Molecular Function for PRRX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 11063257
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with PRRX2: view
genes like me logo Genes that share phenotypes with PRRX2: view

Animal Models for PRRX2 Gene

MGI Knock Outs for PRRX2:

miRNA for PRRX2 Gene

miRTarBase miRNAs that target PRRX2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PRRX2 Gene

Localization for PRRX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRRX2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRRX2 Gene COMPARTMENTS Subcellular localization image for PRRX2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for PRRX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with PRRX2: view

Pathways for PRRX2 Gene

SuperPathways for PRRX2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRRX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002053 positive regulation of mesenchymal cell proliferation IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 9665387
GO:0030326 embryonic limb morphogenesis IEA --
GO:0042472 inner ear morphogenesis IEA --
GO:0042474 middle ear morphogenesis IEA --
genes like me logo Genes that share ontologies with PRRX2: view

No data available for Pathways by source for PRRX2 Gene

Transcripts for PRRX2 Gene

mRNA/cDNA for PRRX2 Gene

Unigene Clusters for PRRX2 Gene

Paired related homeobox 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRRX2 Gene

No ASD Table

Relevant External Links for PRRX2 Gene

GeneLoc Exon Structure for
PRRX2
ECgene alternative splicing isoforms for
PRRX2

Expression for PRRX2 Gene

mRNA expression in normal human tissues for PRRX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRRX2 Gene

This gene is overexpressed in Artery - Aorta (7.2).

SOURCE GeneReport for Unigene cluster for PRRX2 Gene Hs.660115

mRNA Expression by UniProt/SwissProt for PRRX2 Gene

Q99811-PRRX2_HUMAN
Tissue specificity: In fetal skin, highest expression found in cells of mesodermal origin within the dermal papilla of the developing hair shaft. Not detected in epidermis or dermis. In adult skin, weakly expressed within the basal layers of the epidermis. Not expressed in dermis.
genes like me logo Genes that share expressions with PRRX2: view

No data available for Protein expression for PRRX2 Gene

Orthologs for PRRX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRRX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRRX2 35
  • 99.74 (n)
  • 100 (a)
PRRX2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRRX2 35
  • 90.39 (n)
  • 94.59 (a)
PRRX2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRRX2 35
  • 89.19 (n)
  • 91.35 (a)
PRRX2 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prrx2 35
  • 85.09 (n)
  • 92.28 (a)
Prrx2 16
Prrx2 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRRX2 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prrx2 35
  • 84.95 (n)
  • 91.53 (a)
chicken
(Gallus gallus)
Aves PRRX2 35
  • 78.44 (n)
  • 86.24 (a)
PRRX2 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prrx2 35
  • 67.28 (n)
  • 67.43 (a)
zebrafish
(Danio rerio)
Actinopterygii phox2ba 36
  • 36 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG9876 36
  • 29 (a)
OneToMany
Species with no ortholog for PRRX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRRX2 Gene

ENSEMBL:
Gene Tree for PRRX2 (if available)
TreeFam:
Gene Tree for PRRX2 (if available)

Paralogs for PRRX2 Gene

Paralogs for PRRX2 Gene

Selected SIMAP similar genes for PRRX2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PRRX2: view

Variants for PRRX2 Gene

Sequence variations from dbSNP and Humsavar for PRRX2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs729523 -- 129,678,799(-) GAGAG(A/C)GCCCC intron-variant
rs729524 -- 129,678,505(-) AAACC(G/T)TCCCT intron-variant
rs735781 -- 129,696,637(-) GGAAC(C/T)GAGGG intron-variant
rs735782 -- 129,696,619(-) GCTTT(A/T)TAAAA intron-variant
rs737188 -- 129,699,430(+) AAAAA(A/T)ATATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRRX2 Gene

Variant ID Type Subtype PubMed ID
nsv893909 CNV Loss 21882294
nsv893919 CNV Loss 21882294
nsv469901 CNV Loss 18288195
nsv893924 CNV Loss 21882294
nsv893925 CNV Gain 21882294
nsv893926 CNV Gain 21882294
nsv466589 CNV Loss 19166990
nsv893927 CNV Loss 21882294

Relevant External Links for PRRX2 Gene

HapMap Linkage Disequilibrium report
PRRX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRRX2 Gene

Disorders for PRRX2 Gene

Relevant External Links for PRRX2

Genetic Association Database (GAD)
PRRX2
Human Genome Epidemiology (HuGE) Navigator
PRRX2
genes like me logo Genes that share disorders with PRRX2: view

No data available for UniProtKB/Swiss-Prot for PRRX2 Gene

Publications for PRRX2 Gene

  1. Human PRRX1 and PRRX2 genes: cloning, expression, genomic localization, and exclusion as disease genes for Nager syndrome. (PMID: 11063257) Norris R.A. … Kern M.J. (Mamm. Genome 2000) 2 3 4 23
  2. Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds. (PMID: 9665387) Stelnicki E.J. … Largman C. (J. Invest. Dermatol. 1998) 3 4 23
  3. Web-based, participant-driven studies yield novel genetic associations for common traits. (PMID: 20585627) Eriksson N. … Mountain J. (PLoS Genet. 2010) 3 48
  4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 48
  5. GeneChip microarrays facilitate identification of Protease Nexin-1 as a target gene of the Prx2 (S8) homeoprotein. (PMID: 12713735) Scott K.K. … Kern M.J. (DNA Cell Biol. 2003) 3 23

Products for PRRX2 Gene

Sources for PRRX2 Gene

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