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PRRX2 Gene

protein-coding   GIFtS: 50
GCID: GC09P132427

Paired Related Homeobox 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Paired Related Homeobox 21 2     PRX-22 3
PRX22 3 5     Paired Mesoderm Homeobox Protein 22
Paired-Related Homeobox Protein 22 3     Paired-Like Homeodomain Protein PRX22
PMX22 3     

External Ids:    HGNC: 213381   Entrez Gene: 514502   Ensembl: ENSG000001671577   OMIM: 6046755   UniProtKB: Q998113   

Export aliases for PRRX2 gene to outside databases

Previous GC identifers: GC09P127803 GC09P129507 GC09P131467 GC09P102027


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRRX2 Gene:
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression
is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in
adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role
in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The
expression patterns provide evidence consistent with a role in fetal skin development and a possible role in
cellular proliferation. (provided by RefSeq, Jul 2008)

GeneCards Summary for PRRX2 Gene:
PRRX2 (paired related homeobox 2) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ALX1.

UniProtKB/Swiss-Prot: PRRX2_HUMAN, Q99811
Function: May play a role in the scarless healing of cutaneous wounds during the first two trimesters of
development

Gene Wiki entry for PRRX2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRRX2 gene promoter:
         HOXA9B   SRF   AML1a   SRF (504 AA)   FOXD3   Meis-1   Meis-1b   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for PRRX2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRRX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.1   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.11

PRRX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRRX2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P132427:  view genomic region     (about GC identifiers)

Start:
132,427,920 bp from pter      End:
132,484,953 bp from pter
Size:
57,034 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PRRX2_HUMAN, Q99811 (See protein sequence)
Recommended Name: Paired mesoderm homeobox protein 2  
Size: 253 amino acids; 27079 Da
Developmental stage: Higher expression in fetus than in adult
Secondary accessions: Q5SZB5 Q9UIB3

Explore the universe of human proteins at neXtProt for PRRX2: NX_Q99811

Explore proteomics data for PRRX2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PRRX2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057391.1  
    ENSEMBL proteins: 
     ENSP00000361547  

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    antibodies-online peptides for PRRX2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PRD: Homeoboxes / PRD class

    4 InterPro protein domains:
     IPR003654 OAR_dom
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q99811

    ProtoNet protein and cluster: Q99811

    2 Blocks protein domains:
    IPB000047 Lambda and other repressor helix-turn-helix signature
    IPB003654 Paired-like homeodomain protein


    UniProtKB/Swiss-Prot: PRRX2_HUMAN, Q99811
    Similarity: Belongs to the paired homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Find genes that share domains with PRRX2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRRX2_HUMAN, Q99811
    Function: May play a role in the scarless healing of cutaneous wounds during the first two trimesters of
    development

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity NAS11063257
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with PRRX2           About GenesLikeMe


    Phenotypes:
         15 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Prrx2):
     behavior/neurological  cardiovascular system  craniofacial  digestive/alimentary  embryogenesis 
     growth/size/body  hearing/vestibular/ear  homeostasis/metabolism  limbs/digits/tail  mortality/aging 
     nervous system  normal  respiratory system  skeleton  vision/eye 

    Find genes that share phenotypes with PRRX2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Prrx2tm1Mjk for PRRX2

       genOway: Develop your customized and physiologically relevant rodent model for PRRX2

    miRNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PRRX2_HUMAN, Q99811: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000228nuclear chromosome ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with PRRX2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRRX2
    Interactions:

        Search GeneGlobe Interaction Network for PRRX2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for PRRX2 (Q998113 ENSP000003615474) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SOX10P566933, ENSP000003541304I2D: score=1 STRING: ENSP00000354130
    IFI16ENSP000003571134STRING: ENSP00000357113
    MNDAENSP000003571234STRING: ENSP00000357123
    CHEK2ENSP000003720234STRING: ENSP00000372023
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002053positive regulation of mesenchymal cell proliferation IEA--
    GO:0006355regulation of transcription, DNA-templated NAS9665387
    GO:0030326embryonic limb morphogenesis IEA--
    GO:0042472inner ear morphogenesis IEA--
    GO:0042474middle ear morphogenesis IEA--

    Find genes that share ontologies with PRRX2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRRX2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRRX2 gene: 
    NM_016307.3  

    Unigene Cluster for PRRX2:

    Paired related homeobox 2
    Hs.660115  [show with all ESTs]
    Unigene Representative Sequence: BM909706
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000372469(uc004byh.3)
    miRNA
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    Additional mRNA sequence: 

    AF061970.1 BC014645.1 U81600.1 

    2 DOTS entries:

    DT.203595  DT.121156198 

    Selected AceView cDNA sequences (see all 43):

    BM694729 AI917607 BX097188 NM_016307 AI821507 BC014645 AI923085 BF939198 
    AI420043 AA548667 AI674514 BE645185 BU731241 BM716252 AI203915 AI751739 
    AI808278 AW167940 AI697307 BM800161 U81600 BG055248 BU624928 AI936570 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRRX2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCAACAGCA
    PRRX2 Expression
    About this image


    PRRX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Fibroblasts (Uncategorized)    fully expand to see all 10 entries
             Human Dermal Fibroblasts-adult (HDF-a)   
     
     Dermis (Integumentary System)    fully expand to see all 5 entries
             Human Dermal Fibroblasts-adult (HDF-a)   
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Mandibular Process
             HyStem+BMP4-induced SK11 cells
     
     Head Mesenchyme (Muscoskeletal System)    fully expand to see all 4 entries
             Dental Mesenchymal Cells Branchial Arch 1
             Branchial Arch 1
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+BMP4-induced E15 cells
    PRRX2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRRX2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.660115

    UniProtKB/Swiss-Prot: PRRX2_HUMAN, Q99811
    Tissue specificity: In fetal skin, highest expression found in cells of mesodermal origin within the dermal
    papilla of the developing hair shaft. Not detected in epidermis or dermis. In adult skin, weakly expressed within
    the basal layers of the epidermis. Not expressed in dermis

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PRRX2 gene from 10 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia PRRX21 paired related homeobox 2 99.74(n)
    100(a)
      464792  XM_520310.4  XP_520310.2 
    mouse
    (Mus musculus)
    Mammalia Prrx21 , 5 paired related homeobox 21, 5 85.09(n)1
    92.28(a)1
      2 (21.74 cM)5
    202041  NM_009116.21  NP_033142.21 
     308349725 
    rat
    (Rattus norvegicus)
    Mammalia Prrx21 paired related homeobox 2 84.95(n)
    91.53(a)
      113931  NM_001105739.1  NP_001099209.1 
    cow
    (Bos taurus)
    Mammalia PRRX21 paired related homeobox 2 90.39(n)
    94.59(a)
      534258  XM_002691674.3  XP_002691720.3 
    dog
    (Canis familiaris)
    Mammalia PRRX21 paired related homeobox 2 89.19(n)
    91.35(a)
      491298  XM_548419.4  XP_548419.3 
    oppossum
    (Monodelphis domestica)
    Mammalia PRRX26
    paired related homeobox 2
    77(a)
    1 ↔ 1
    1(455898361-455964292)
    chicken
    (Gallus gallus)
    Aves PRRX21 paired related homeobox 2 78.44(n)
    86.24(a)
      396314  XM_415476.4  XP_415476.3 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia prrx21 paired related homeobox 2 67.28(n)
    67.43(a)
      100488907  XM_002940757.2  XP_002940803.1 
    zebrafish
    (Danio rerio)
    Actinopterygii phox2ba6
    paired-like homeobox 2ba
    36(a)
    many ↔ many
    1(17816221-17821852) ENSDARG00000075330
    fruit fly
    (Drosophila melanogaster)
    Insecta CG98766
    --
    29(a)
    1 → many
    2R(18977626-18981785)
            Species with no ortholog for PRRX2

    ENSEMBL Gene Tree for PRRX2 (if available)
    TreeFam Gene Tree for PRRX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRRX2 gene
    ALX12  PHOX2B2  ARX2  RAX2  DRGX2  SHOX22  PRRX12  PHOX2A2  
    ALX42  ISX2  RAX22  ALX32  SHOX2  OTP2  
    10 SIMAP similar genes for PRRX2 using alignment to 1 protein entry:     PRRX2_HUMAN:
    PRRX1    PHOX2A    SHOX2    POU6F1    PHOX2B    RAX
    RAX2    PAX6    ARX    OTP

    Find genes that share paralogs with PRRX2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRRX2 (see all 1323)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1399179221,2
    C--132425940(+) GTAGTA/GGCCCT 1 -- us2k10--------
    rs78647171,2
    C,F--132426059(+) ACTGGC/TGCCTC 1 -- us2k11Minor allele frequency- T:0.16WA 118
    rs1494099041,2
    --132426160(+) CACCTA/GCACGG 1 -- us2k10--------
    rs107397561,2
    C,A,H--132426231(+) TATTTT/AATTTA 1 -- us2k19Minor allele frequency- A:0.27NA WA CSA EA 371
    rs1817809151,2
    --132426242(+) ATTTAC/TATATA 1 -- us2k10--------
    rs1861638191,2
    --132426256(+) TTTGAA/GATGGA 1 -- us2k10--------
    rs1909306491,2
    --132426327(+) CGCCTC/TCCAGG 1 -- us2k10--------
    rs1474973391,2
    --132426382(+) CAGGCA/GCCTGC 1 -- us2k10--------
    rs1478543051,2
    --132426411(+) TTTTTA/TATTAT 1 -- us2k10--------
    rs132912281,2
    C,F--132426773(+) GGCCAA/GCATGG 1 -- us2k17Minor allele frequency- G:0.16NA WA CSA EA 131

    HapMap Linkage Disequilibrium report for PRRX2 (132427920 - 132484953 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for PRRX2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv893919CNV Loss21882294
    nsv466589CNV Loss19166990
    nsv469901CNV Loss18288195
    nsv893924CNV Loss21882294
    nsv893909CNV Loss21882294
    nsv893927CNV Loss21882294
    nsv893925CNV Gain21882294
    nsv893926CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604675    OMIM disorders: --


    Find genes that share disorders with PRRX2           About GenesLikeMe

    Genetic Association Database (GAD): PRRX2
    Human Genome Epidemiology (HuGE) Navigator: PRRX2 (1 document)

    Export disorders for PRRX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRRX2 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with PRRX2)
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    1. Human PRRX1 and PRRX2 genes: cloning, expression, genomic localization, and exclusion as disease genes for Nager syndrome. (PubMed id 11063257)1, 2, 3, 9 Norris R.A.... Kern M.J. (Mamm. Genome 2000)
    2. Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds. (PubMed id 9665387)1, 2, 9 Stelnicki E.J....Largman C. (J. Invest. Dermatol. 1998)
    3. Web-based, participant-driven studies yield novel genetic associations for common traits. (PubMed id 20585627)1, 4 Eriksson N....Mountain J. (PLoS Genet. 2010)
    4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. GeneChip microarrays facilitate identification of Protease Nexin-1 as a target gene of the Prx2 (S8) homeoprotein. (PubMed id 12713735)1, 9 Scott K.K....Kern M.J. (DNA Cell Biol. 2003)
    7. Model for the exceptional reactivity of peroxiredoxins 2 and 3 with hydrogen peroxide: a kinetic and computational study. (PubMed id 21385867)1 Nagy P....Winterbourn C.C. (J. Biol. Chem. 2011)
    8. Oxidation of Prx2 and phosphorylation of GRP58 by angiotensin II in human coronary smooth muscle cells identified by 2D-DIGE analysis. (PubMed id 17964282)1 Tokutomi Y....Kim-Mitsuyama S. (Biochem. Biophys. Res. Commun. 2007)
    9. The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. (PubMed id 16582099)1 WissmA1ller S....Wegner M. (Nucleic Acids Res. 2006)
    10. A new translocation t(9;11)(q34;p15) fuses NUP98 to a novel homeobox partner gene, PRRX2, in a therapy-related acute myeloid leukemia. (PubMed id 15496970)1 Gervais C.... Lessard M. (Leukemia 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51450 HGNC: 21338 AceView: PRRX2 Ensembl:ENSG00000167157 euGenes: HUgn51450
    ECgene: PRRX2 H-InvDB: PRRX2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRRX2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRRX2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRRX2 gene:
    Search GeneIP for patents involving PRRX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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