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Aliases for PRRG4 Gene

Aliases for PRRG4 Gene

  • Proline Rich And Gla Domain 4 2 3 5
  • Proline Rich Gla (G-Carboxyglutamic Acid) 4 (Transmembrane) 2 3
  • Proline-Rich Gamma-Carboxyglutamic Acid Protein 4 3 4
  • Proline-Rich Gla Protein 4 3 4
  • PRGP4 3 4
  • TMG4 3 4
  • Transmembrane Gamma-Carboxyglutamic Acid Protein 4 3
  • Proline Rich Gla 4 (Transmembrane) Isoform 1 3
  • Proline Rich Gla 4 (Transmembrane) Isoform 2 3
  • Proline Rich Gla 4 (Transmembrane) Isoform 3 3

External Ids for PRRG4 Gene

Previous GeneCards Identifiers for PRRG4 Gene

  • GC11P032808
  • GC11P032545

Summaries for PRRG4 Gene

GeneCards Summary for PRRG4 Gene

PRRG4 (Proline Rich And Gla Domain 4) is a Protein Coding gene. Diseases associated with PRRG4 include Aniridia 1. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is PRRG2.

Additional gene information for PRRG4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRRG4 Gene

Genomics for PRRG4 Gene

GeneHancer (GH) Regulatory Elements for PRRG4 Gene

Promoters and enhancers for PRRG4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I032828 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +0.3 312 2.4 FOXA2 ARID4B SIN3A ZNF48 YY1 ATF7 RUNX3 RXRA REST SMARCB1 PRRG4 QSER1
GH11I032809 Enhancer 0.7 ENCODE 12.8 -20.4 -20384 0.1 SMARCA5 CTCF ZNF654 RXRA RB1 TRIM22 REST RAD21 JUND SMC3 PRRG4 GC11P032801 GC11P032824
GH11I032851 Enhancer 0.6 Ensembl ENCODE 12.2 +22.6 22603 1 CEBPB ZMYM3 TCF7L2 PRRG4 QSER1 TCP11L1 CCDC73
GH11I032838 Enhancer 0.7 ENCODE 0.4 +9.2 9236 0.2 ZFP37 CEBPB ZNF501 CEBPG EP300 IRF9 HIC1 ZNF664 GATA3 PRDM6 QSER1 TCP11L1 PRRG4
GH11I032839 Enhancer 0.7 ENCODE 0.4 +9.0 8976 0.2 JUN EBF1 CEBPG HIC1 ZFHX2 ZNF366 PRDM10 FOS EGR2 ZNF10 QSER1 TCP11L1 PRRG4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRRG4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRRG4 gene promoter:

Genomic Locations for PRRG4 Gene

Genomic Locations for PRRG4 Gene
28,350 bases
Plus strand

Genomic View for PRRG4 Gene

Genes around PRRG4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRRG4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRRG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRRG4 Gene

Proteins for PRRG4 Gene

  • Protein details for PRRG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane gamma-carboxyglutamic acid protein 4
    Protein Accession:

    Protein attributes for PRRG4 Gene

    226 amino acids
    Molecular mass:
    25403 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRRG4 Gene

Post-translational modifications for PRRG4 Gene

  • Gla residues are produced after subsequent post-translational modifications of glutamate by a vitamin K-dependent gamma-carboxylase.

Other Protein References for PRRG4 Gene

No data available for DME Specific Peptides for PRRG4 Gene

Domains & Families for PRRG4 Gene

Gene Families for PRRG4 Gene

Suggested Antigen Peptide Sequences for PRRG4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRRG4: view

No data available for UniProtKB/Swiss-Prot for PRRG4 Gene

Function for PRRG4 Gene

Phenotypes From GWAS Catalog for PRRG4 Gene

Gene Ontology (GO) - Molecular Function for PRRG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PRRG4: view
genes like me logo Genes that share phenotypes with PRRG4: view

Animal Model Products

CRISPR Products

miRNA for PRRG4 Gene

miRTarBase miRNAs that target PRRG4

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRRG4 Gene

Localization for PRRG4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRRG4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRRG4 gene
Compartment Confidence
extracellular 3
plasma membrane 2
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRRG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 11171957
genes like me logo Genes that share ontologies with PRRG4: view

Pathways & Interactions for PRRG4 Gene

SuperPathways for PRRG4 Gene

No Data Available

Interacting Proteins for PRRG4 Gene

Gene Ontology (GO) - Biological Process for PRRG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with PRRG4: view

No data available for Pathways by source and SIGNOR curated interactions for PRRG4 Gene

Drugs & Compounds for PRRG4 Gene

No Compound Related Data Available

Transcripts for PRRG4 Gene

mRNA/cDNA for PRRG4 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRRG4 Gene

Proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRRG4 Gene

No ASD Table

Relevant External Links for PRRG4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRRG4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRRG4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRRG4 Gene

This gene is overexpressed in Esophagus - Mucosa (x7.4) and Nerve - Tibial (x4.2).

Protein differential expression in normal tissues from HIPED for PRRG4 Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRRG4 Gene

Protein tissue co-expression partners for PRRG4 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRRG4 Gene:


SOURCE GeneReport for Unigene cluster for PRRG4 Gene:


mRNA Expression by UniProt/SwissProt for PRRG4 Gene:

Tissue specificity: Expressed in lung, liver, kidney, pancreas and placenta.

Evidence on tissue expression from TISSUES for PRRG4 Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with PRRG4: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PRRG4 Gene

Orthologs for PRRG4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRRG4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRRG4 34 33
  • 99.56 (n)
(Canis familiaris)
Mammalia PRRG4 34 33
  • 88 (n)
(Bos Taurus)
Mammalia PRRG4 33 34
  • 87.91 (n)
(Rattus norvegicus)
Mammalia Prrg4 33
  • 80.74 (n)
(Mus musculus)
Mammalia Prrg4 33 16 34
  • 80.59 (n)
(Ornithorhynchus anatinus)
Mammalia PRRG4 34
  • 72 (a)
(Gallus gallus)
Aves PRRG4 33 34
  • 61.21 (n)
(Anolis carolinensis)
Reptilia PRRG4 34
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486092 33
  • 57.09 (n)
(Danio rerio)
Actinopterygii prrg4 33 34
  • 56.63 (n)
Species where no ortholog for PRRG4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRRG4 Gene

Gene Tree for PRRG4 (if available)
Gene Tree for PRRG4 (if available)

Paralogs for PRRG4 Gene

Paralogs for PRRG4 Gene

(1) SIMAP similar genes for PRRG4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PRRG4: view

Variants for PRRG4 Gene

Sequence variations from dbSNP and Humsavar for PRRG4 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000025177 -- 32,845,946(+) C/T intron_variant
rs1000068152 -- 32,831,198(+) T/C intron_variant
rs1000264218 -- 32,837,651(+) G/A intron_variant
rs1000378397 -- 32,830,728(+) G/A intron_variant
rs1000471726 -- 32,830,433(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRRG4 Gene

Variant ID Type Subtype PubMed ID
esv2659576 CNV deletion 23128226
esv2759815 CNV gain 17122850
esv34742 CNV gain 17911159
esv3547553 CNV deletion 23714750
esv3547554 CNV deletion 23714750
esv3625867 CNV loss 21293372
nsv825818 CNV loss 20364138

Variation tolerance for PRRG4 Gene

Residual Variation Intolerance Score: 77.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.40; 71.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRRG4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRRG4 Gene

Disorders for PRRG4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRRG4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
aniridia 1
  • an1
- elite association - COSMIC cancer census association via MalaCards
Search PRRG4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PRRG4

genes like me logo Genes that share disorders with PRRG4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRRG4 Gene

Publications for PRRG4 Gene

  1. Identification of two novel transmembrane gamma-carboxyglutamic acid proteins expressed broadly in fetal and adult tissues. (PMID: 11171957) Kulman JD … Davie EW (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 4 22 58
  2. Genomewide association study for onset age in Parkinson disease. (PMID: 19772629) Latourelle JC … GenePD Investigators, Coordinators and Molecular Genetic Laboratories (BMC medical genetics 2009) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The WAGR syndrome gene PRRG4 is a functional homologue of the commissureless axon guidance gene. (PMID: 28859078) Justice ED … Kidd T (PLoS genetics 2017) 3 58

Products for PRRG4 Gene

Sources for PRRG4 Gene

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