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Aliases for PRRG4 Gene

Aliases for PRRG4 Gene

  • Proline Rich And Gla Domain 4 2 3
  • Proline Rich Gla (G-Carboxyglutamic Acid) 4 (Transmembrane) 2 3 5
  • Proline-Rich Gamma-Carboxyglutamic Acid Protein 4 3 4
  • Proline-Rich Gla Protein 4 3 4
  • PRGP4 3 4
  • TMG4 3 4
  • Proline Rich Gla 4 (Transmembrane) Isoform 1 3
  • Proline Rich Gla 4 (Transmembrane) Isoform 2 3
  • Proline Rich Gla 4 (Transmembrane) Isoform 3 3

External Ids for PRRG4 Gene

Previous GeneCards Identifiers for PRRG4 Gene

  • GC11P032808
  • GC11P032545

Summaries for PRRG4 Gene

GeneCards Summary for PRRG4 Gene

PRRG4 (Proline Rich And Gla Domain 4) is a Protein Coding gene. Diseases associated with PRRG4 include Wagr Syndrome. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PRRG1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRRG4 Gene

Genomics for PRRG4 Gene

Regulatory Elements for PRRG4 Gene

Enhancers for PRRG4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRRG4 on UCSC Golden Path with GeneCards custom track

Promoters for PRRG4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRRG4 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRRG4 Gene

32,829,774 bp from pter
32,858,123 bp from pter
28,350 bases
Plus strand

Genomic View for PRRG4 Gene

Genes around PRRG4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRRG4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRRG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRRG4 Gene

Proteins for PRRG4 Gene

  • Protein details for PRRG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane gamma-carboxyglutamic acid protein 4
    Protein Accession:

    Protein attributes for PRRG4 Gene

    226 amino acids
    Molecular mass:
    25403 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRRG4 Gene

Proteomics data for PRRG4 Gene at MOPED

Post-translational modifications for PRRG4 Gene

  • Gla residues are produced after subsequent post-translational modifications of glutamate by a vitamin K-dependent gamma-carboxylase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRRG4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRRG4 Gene

Domains & Families for PRRG4 Gene

Gene Families for PRRG4 Gene

Suggested Antigen Peptide Sequences for PRRG4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Gla (gamma-carboxy-glutamate) domain.
  • Contains 1 Gla (gamma-carboxy-glutamate) domain.
genes like me logo Genes that share domains with PRRG4: view

Function for PRRG4 Gene

genes like me logo Genes that share phenotypes with PRRG4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PRRG4

miRNA for PRRG4 Gene

miRTarBase miRNAs that target PRRG4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRRG4 Gene

Localization for PRRG4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRRG4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for PRRG4 Gene COMPARTMENTS Subcellular localization image for PRRG4 gene
Compartment Confidence
extracellular 3
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for PRRG4 Gene

Pathways & Interactions for PRRG4 Gene

SuperPathways for PRRG4 Gene

No Data Available

Interacting Proteins for PRRG4 Gene

Gene Ontology (GO) - Biological Process for PRRG4 Gene


No data available for Pathways by source and SIGNOR curated interactions for PRRG4 Gene

Drugs & Compounds for PRRG4 Gene

No Compound Related Data Available

Transcripts for PRRG4 Gene

mRNA/cDNA for PRRG4 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRRG4 Gene

Proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRRG4 Gene

No ASD Table

Relevant External Links for PRRG4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRRG4 Gene

mRNA expression in normal human tissues for PRRG4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRRG4 Gene

This gene is overexpressed in Esophagus - Mucosa (x7.4) and Nerve - Tibial (x4.2).

Protein differential expression in normal tissues from HIPED for PRRG4 Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRRG4 Gene

SOURCE GeneReport for Unigene cluster for PRRG4 Gene Hs.471695

mRNA Expression by UniProt/SwissProt for PRRG4 Gene

Tissue specificity: Expressed in lung, liver, kidney, pancreas and placenta.
genes like me logo Genes that share expression patterns with PRRG4: view

Protein tissue co-expression partners for PRRG4 Gene

Primer Products

Orthologs for PRRG4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRRG4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PRRG4 35
  • 87.91 (n)
  • 83.19 (a)
PRRG4 36
  • 82 (a)
(Canis familiaris)
Mammalia PRRG4 35
  • 88 (n)
  • 85.78 (a)
PRRG4 36
  • 85 (a)
(Mus musculus)
Mammalia Prrg4 35
  • 80.59 (n)
  • 75.11 (a)
Prrg4 16
Prrg4 36
  • 74 (a)
(Pan troglodytes)
Mammalia PRRG4 35
  • 99.56 (n)
  • 99.12 (a)
PRRG4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Prrg4 35
  • 80.74 (n)
  • 76.44 (a)
(Ornithorhynchus anatinus)
Mammalia PRRG4 36
  • 72 (a)
(Gallus gallus)
Aves PRRG4 35
  • 61.21 (n)
  • 53.18 (a)
PRRG4 36
  • 48 (a)
(Anolis carolinensis)
Reptilia PRRG4 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486092 35
  • 57.09 (n)
  • 54.79 (a)
(Danio rerio)
Actinopterygii prrg4 35
  • 56.63 (n)
  • 53.76 (a)
prrg4 36
  • 47 (a)
Species with no ortholog for PRRG4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRRG4 Gene

Gene Tree for PRRG4 (if available)
Gene Tree for PRRG4 (if available)

Paralogs for PRRG4 Gene

Paralogs for PRRG4 Gene

(1) SIMAP similar genes for PRRG4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PRRG4: view

Variants for PRRG4 Gene

Sequence variations from dbSNP and Humsavar for PRRG4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs33962176 - 32,830,626(+) CGGGA(A/G)AAGAA reference, missense
rs34736080 - 32,840,217(-) ATTAC(A/G)CTTAG intron-variant, reference, missense
rs34139105 - 32,853,373(-) GCAAT(G/T)GAGAC reference, missense
rs761283 -- 32,857,180(-) AGTGA(A/G)ACTCC utr-variant-3-prime
rs761284 -- 32,856,316(-) TTAGA(A/G)CAACT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PRRG4 Gene

Variant ID Type Subtype PubMed ID
essv7540 CNV CNV 17122850
essv6421 CNV CNV 17122850
esv34742 CNV Gain 17911159
nsv897190 CNV Gain 21882294
nsv897191 CNV Gain 21882294
dgv1064n71 CNV Gain 21882294
nsv825818 CNV Loss 20364138
esv2659576 CNV Deletion 23128226

Variation tolerance for PRRG4 Gene

Residual Variation Intolerance Score: 77.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.40; 71.13% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PRRG4 Gene

Disorders for PRRG4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRRG4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
wagr syndrome
  • 11p partial monosomy syndrome
- elite association - COSMIC cancer census association via MalaCards
Search PRRG4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRRG4

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PRRG4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRRG4 Gene

Publications for PRRG4 Gene

  1. Identification of two novel transmembrane gamma-carboxyglutamic acid proteins expressed broadly in fetal and adult tissues. (PMID: 11171957) Kulman J.D. … Davie E.W. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4 23 67
  2. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Cellular localization and characterization of cytosolic binding partners for Gla domain-containing proteins PRRG4 and PRRG2. (PMID: 23873930) Yazicioglu M.N. … High K.A. (J. Biol. Chem. 2013) 3
  5. Narrowing of the responsible region for severe developmental delay and autistic behaviors in WAGR syndrome down to 1.6a88Mb including PAX6, WT1, and PRRG4. (PMID: 24357251) Yamamoto T. … Okamoto N. (Am. J. Med. Genet. A 2013) 3

Products for PRRG4 Gene

Sources for PRRG4 Gene