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Aliases for PRRG3 Gene

Aliases for PRRG3 Gene

  • Proline Rich Gla (G-Carboxyglutamic Acid) 3 (Transmembrane) 2 3
  • PRGP3 3 4 6
  • TMG3 3 4 6
  • Proline-Rich Gamma-Carboxyglutamic Acid Protein 3 3 4
  • Proline-Rich Gla Protein 3 3 4
  • Transmembrane Gamma-Carboxyglutamic Acid Protein 3 3

External Ids for PRRG3 Gene

Previous GeneCards Identifiers for PRRG3 Gene

  • GC0XP150537
  • GC0XP150863
  • GC0XP139720

Summaries for PRRG3 Gene

Entrez Gene Summary for PRRG3 Gene

  • This gene encodes a protein which contains a vitamin K-dependent carboxylation/gamma-carboxyglutamic domain. The encoded protein is a member of a family of vitamin K-dependent transmembrane proteins which contain a glutamate-rich extracellular domain. [provided by RefSeq, Aug 2011]

GeneCards Summary for PRRG3 Gene

PRRG3 (Proline Rich Gla (G-Carboxyglutamic Acid) 3 (Transmembrane)) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PRRG1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRRG3 Gene

Genomics for PRRG3 Gene

Regulatory Elements for PRRG3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PRRG3 Gene

151,695,124 bp from pter
151,705,924 bp from pter
10,801 bases
Plus strand

Genomic View for PRRG3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRRG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRRG3 Gene

Proteins for PRRG3 Gene

  • Protein details for PRRG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane gamma-carboxyglutamic acid protein 3
    Protein Accession:
    Secondary Accessions:
    • A1A523
    • A1A575
    • Q8N2N6

    Protein attributes for PRRG3 Gene

    231 amino acids
    Molecular mass:
    25875 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRRG3 Gene

Proteomics data for PRRG3 Gene at MOPED

Post-translational modifications for PRRG3 Gene

  • Gla residues are produced after subsequent post-translational modifications of glutamate by a vitamin K-dependent gamma-carboxylase
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRRG3 Gene

No data available for DME Specific Peptides for PRRG3 Gene

Domains for PRRG3 Gene

Suggested Antigen Peptide Sequences for PRRG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Gla (gamma-carboxy-glutamate) domain.
  • Contains 1 Gla (gamma-carboxy-glutamate) domain.
genes like me logo Genes that share domains with PRRG3: view

No data available for Gene Families for PRRG3 Gene

Function for PRRG3 Gene

Gene Ontology (GO) - Molecular Function for PRRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PRRG3: view

Animal Model Products

miRNA for PRRG3 Gene

miRTarBase miRNAs that target PRRG3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for PRRG3 Gene

Localization for PRRG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRRG3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for PRRG3 Gene COMPARTMENTS Subcellular localization image for PRRG3 gene
Compartment Confidence
extracellular 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PRRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016021 integral component of membrane NAS 11171957
genes like me logo Genes that share ontologies with PRRG3: view

Pathways for PRRG3 Gene

SuperPathways for PRRG3 Gene

No Data Available

Interacting Proteins for PRRG3 Gene

Gene Ontology (GO) - Biological Process for PRRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with PRRG3: view

No data available for Pathways by source for PRRG3 Gene

Transcripts for PRRG3 Gene

Unigene Clusters for PRRG3 Gene

Proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRRG3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b
SP1: -
SP2: - -

Relevant External Links for PRRG3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRRG3 Gene

mRNA expression in normal human tissues for PRRG3 Gene

mRNA differential expression in normal tissues according to GTEx for PRRG3 Gene

This gene is overexpressed in Nerve - Tibial (5.7), Brain - Frontal Cortex (BA9) (4.6), Brain - Cortex (4.4), and Brain - Anterior cingulate cortex (BA24) (4.0).

Protein differential expression in normal tissues for PRRG3 Gene

This gene is overexpressed in Heart (54.7) and Testis (14.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for PRRG3 Gene

SOURCE GeneReport for Unigene cluster for PRRG3 Gene Hs.592236

mRNA Expression by UniProt/SwissProt for PRRG3 Gene

Tissue specificity: Expressed in brain, lung, kidney and heart.
genes like me logo Genes that share expressions with PRRG3: view

Expression partners for PRRG3 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PRRG3 Gene

Orthologs for PRRG3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRRG3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PRRG3 35
  • 90.62 (n)
  • 94.37 (a)
PRRG3 36
  • 94 (a)
(Canis familiaris)
Mammalia PRRG3 35
  • 89.75 (n)
  • 94.37 (a)
PRRG3 36
  • 94 (a)
(Mus musculus)
Mammalia Prrg3 35
  • 87.3 (n)
  • 94.37 (a)
Prrg3 16
Prrg3 36
  • 94 (a)
(Pan troglodytes)
Mammalia PRRG3 35
  • 99.13 (n)
  • 99.57 (a)
PRRG3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia LOC102546678 35
  • 87.88 (n)
  • 93.51 (a)
(Ornithorhynchus anatinus)
Mammalia PRRG3 36
  • 65 (a)
(Gallus gallus)
Aves PRRG3 35
  • 75.92 (n)
  • 77.53 (a)
PRRG3 36
  • 63 (a)
(Anolis carolinensis)
Reptilia PRRG3 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia prrg3 35
  • 65.37 (n)
  • 63.11 (a)
(Danio rerio)
Actinopterygii LOC563290 35
  • 60.85 (n)
  • 57.55 (a)
PRRG3 36
  • 49 (a)
Species with no ortholog for PRRG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRRG3 Gene

Gene Tree for PRRG3 (if available)
Gene Tree for PRRG3 (if available)

Paralogs for PRRG3 Gene

Paralogs for PRRG3 Gene

(12) SIMAP similar genes for PRRG3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PRRG3: view

Variants for PRRG3 Gene

Sequence variations from dbSNP and Humsavar for PRRG3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1106194 -- 151,701,022(+) CTGGC(A/G)CTGAC missense, reference, nc-transcript-variant, intron-variant
rs3827429 -- 151,698,597(+) GAGAA(C/G)AGCTT intron-variant, nc-transcript-variant
rs4265328 -- 151,702,241(+) GCCTG(C/G)GTCTA intron-variant
rs4323608 - 151,700,795(+) AGCGA(A/G)CAGCC reference, missense, nc-transcript-variant, intron-variant
rs4347102 -- 151,701,871(+) TTTGC(A/G)AATGG downstream-variant-500B, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRRG3 Gene

Variant ID Type Subtype PubMed ID
nsv7156 CNV Insertion 18451855

Relevant External Links for PRRG3 Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRRG3 Gene

Disorders for PRRG3 Gene

No disorders were found for PRRG3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for PRRG3 Gene

Publications for PRRG3 Gene

  1. Identification of two novel transmembrane gamma-carboxyglutamic acid proteins expressed broadly in fetal and adult tissues. (PMID: 11171957) Kulman J.D. … Davie E.W. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. (PMID: 15203218) Fu G.K. … Stuve L.L. (Genomics 2004) 3
  4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for PRRG3 Gene

Sources for PRRG3 Gene

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