Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PRRG3 Gene

Aliases for PRRG3 Gene

  • Proline Rich And Gla Domain 3 2 3 5
  • Proline Rich Gla (G-Carboxyglutamic Acid) 3 (Transmembrane) 2 3
  • Proline-Rich Gamma-Carboxyglutamic Acid Protein 3 3 4
  • Proline-Rich Gla Protein 3 3 4
  • PRGP3 3 4
  • TMG3 3 4
  • Transmembrane Gamma-Carboxyglutamic Acid Protein 3 3

External Ids for PRRG3 Gene

Previous GeneCards Identifiers for PRRG3 Gene

  • GC0XP150537
  • GC0XP150863
  • GC0XP139720

Summaries for PRRG3 Gene

Entrez Gene Summary for PRRG3 Gene

  • This gene encodes a protein which contains a vitamin K-dependent carboxylation/gamma-carboxyglutamic domain. The encoded protein is a member of a family of vitamin K-dependent transmembrane proteins which contain a glutamate-rich extracellular domain. [provided by RefSeq, Aug 2011]

GeneCards Summary for PRRG3 Gene

PRRG3 (Proline Rich And Gla Domain 3) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PRRG1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRRG3 Gene

Genomics for PRRG3 Gene

Regulatory Elements for PRRG3 Gene

Enhancers for PRRG3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF151695 0.2 ENCODE 30.2 +2.2 2208 2.6 RFX1 ZNF366 BHLHE40 ZNF512 MAFG FOS NFE2 PRRG3 FATE1
GH0XF151702 0.9 Ensembl ENCODE 9.8 +9.2 9163 3.1 BACH1 MAFG DPF2 ARID1B ZNF316 JUND SMARCA4 IKZF1 NFE2 KDM1A PRRG3 FATE1
GH0XF151696 0.2 ENCODE 0.8 +0.8 809 0.0 PRRG3 FATE1
GH0XF151711 0.2 ENCODE 0.3 +17.2 17152 0.7 ZNF146 CBX5 ZNF407 ZNF384 NFE2 MAFK EMSY ZNF7 FATE1 PRRG3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PRRG3 on UCSC Golden Path with GeneCards custom track

Promoters for PRRG3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001919469 424 1001

Genomic Location for PRRG3 Gene

151,694,676 bp from pter
151,705,924 bp from pter
11,249 bases
Plus strand

Genomic View for PRRG3 Gene

Genes around PRRG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRRG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRRG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRRG3 Gene

Proteins for PRRG3 Gene

  • Protein details for PRRG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane gamma-carboxyglutamic acid protein 3
    Protein Accession:
    Secondary Accessions:
    • A1A523
    • A1A575
    • Q8N2N6

    Protein attributes for PRRG3 Gene

    231 amino acids
    Molecular mass:
    25875 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRRG3 Gene

Post-translational modifications for PRRG3 Gene

  • Gla residues are produced after subsequent post-translational modifications of glutamate by a vitamin K-dependent gamma-carboxylase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRRG3 Gene

No data available for DME Specific Peptides for PRRG3 Gene

Domains & Families for PRRG3 Gene

Gene Families for PRRG3 Gene

Suggested Antigen Peptide Sequences for PRRG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Gla (gamma-carboxy-glutamate) domain.
  • Contains 1 Gla (gamma-carboxy-glutamate) domain.
genes like me logo Genes that share domains with PRRG3: view

Function for PRRG3 Gene

Gene Ontology (GO) - Molecular Function for PRRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PRRG3: view
genes like me logo Genes that share phenotypes with PRRG3: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRRG3 Gene

Localization for PRRG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRRG3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for PRRG3 Gene COMPARTMENTS Subcellular localization image for PRRG3 gene
Compartment Confidence
extracellular 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PRRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 11171957
genes like me logo Genes that share ontologies with PRRG3: view

Pathways & Interactions for PRRG3 Gene

SuperPathways for PRRG3 Gene

No Data Available

Interacting Proteins for PRRG3 Gene

Gene Ontology (GO) - Biological Process for PRRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with PRRG3: view

No data available for Pathways by source and SIGNOR curated interactions for PRRG3 Gene

Transcripts for PRRG3 Gene

Unigene Clusters for PRRG3 Gene

Proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRRG3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b
SP1: -
SP2: - -

Relevant External Links for PRRG3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRRG3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRRG3 Gene

mRNA differential expression in normal tissues according to GTEx for PRRG3 Gene

This gene is overexpressed in Nerve - Tibial (x5.7), Brain - Frontal Cortex (BA9) (x4.6), Brain - Cortex (x4.4), and Brain - Anterior cingulate cortex (BA24) (x4.0).

Protein differential expression in normal tissues from HIPED for PRRG3 Gene

This gene is overexpressed in Heart (54.7) and Testis (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRRG3 Gene

Protein tissue co-expression partners for PRRG3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRRG3 Gene:


SOURCE GeneReport for Unigene cluster for PRRG3 Gene:


mRNA Expression by UniProt/SwissProt for PRRG3 Gene:

Tissue specificity: Expressed in brain, lung, kidney and heart.
genes like me logo Genes that share expression patterns with PRRG3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PRRG3 Gene

Orthologs for PRRG3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRRG3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRRG3 34 35
  • 99.13 (n)
(Bos Taurus)
Mammalia PRRG3 34 35
  • 90.62 (n)
(Canis familiaris)
Mammalia PRRG3 34 35
  • 89.75 (n)
(Rattus norvegicus)
Mammalia LOC102546678 34
  • 87.88 (n)
(Mus musculus)
Mammalia Prrg3 34 16 35
  • 87.3 (n)
(Ornithorhynchus anatinus)
Mammalia PRRG3 35
  • 65 (a)
(Gallus gallus)
Aves PRRG3 34 35
  • 75.92 (n)
(Anolis carolinensis)
Reptilia PRRG3 35
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia prrg3 34
  • 65.37 (n)
(Danio rerio)
Actinopterygii LOC563290 34
  • 60.85 (n)
PRRG3 35
  • 49 (a)
Species where no ortholog for PRRG3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRRG3 Gene

Gene Tree for PRRG3 (if available)
Gene Tree for PRRG3 (if available)

Paralogs for PRRG3 Gene

Paralogs for PRRG3 Gene

(12) SIMAP similar genes for PRRG3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PRRG3: view

Variants for PRRG3 Gene

Sequence variations from dbSNP and Humsavar for PRRG3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1106194 -- 151,701,022(+) CTGGC(A/G)CTGAC nc-transcript-variant, reference, missense
rs111325817 -- 151,699,102(+) ACATG(C/T)CAGCT intron-variant
rs111640441 -- 151,692,748(+) TGCCA(C/T)CCATA upstream-variant-2KB
rs111875902 -- 151,694,575(+) GGGTG(C/G)GGGTA upstream-variant-2KB
rs112162704 -- 151,697,136(+) TCTCC(A/C/G)TCCCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PRRG3 Gene

Variant ID Type Subtype PubMed ID
nsv7156 CNV insertion 18451855

Variation tolerance for PRRG3 Gene

Residual Variation Intolerance Score: 89.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.67; 31.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRRG3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRRG3 Gene

Disorders for PRRG3 Gene

Relevant External Links for PRRG3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PRRG3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRRG3 Gene

Publications for PRRG3 Gene

  1. Identification of two novel transmembrane gamma-carboxyglutamic acid proteins expressed broadly in fetal and adult tissues. (PMID: 11171957) Kulman J.D. … Davie E.W. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 64
  5. Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. (PMID: 15203218) Fu G.K. … Stuve L.L. (Genomics 2004) 3 64

Products for PRRG3 Gene

Sources for PRRG3 Gene

Loading form....