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Aliases for PRRG1 Gene

Aliases for PRRG1 Gene

  • Proline Rich And Gla Domain 1 2 3 5
  • Proline-Rich Gla (G-Carboxyglutamic Acid) Polypeptide 1 2 3
  • PRGP1 3 4
  • Transmembrane Gamma-Carboxyglutamic Acid Protein 1 3
  • Proline-Rich Gamma-Carboxyglutamic Acid Protein 1 4
  • Proline Rich Gla (G-Carboxyglutamic Acid) 1 3
  • Proline-Rich Gla Protein 1 4
  • TMG1 4

External Ids for PRRG1 Gene

Previous GeneCards Identifiers for PRRG1 Gene

  • GC0XP035313
  • GC0XP035496
  • GC0XP036053
  • GC0XP036239
  • GC0XP036964
  • GC0XP037093
  • GC0XP037209
  • GC0XP034955

Summaries for PRRG1 Gene

Entrez Gene Summary for PRRG1 Gene

  • This gene encodes a vitamin K-dependent, gamma-carboxyglutamic acid (Gla)-containing, single-pass transmembrane protein. This protein contains a Gla domain at the N-terminus, preceded by a propeptide sequence required for post-translational gamma-carboxylation of specific glutamic acid residues by a vitamin K-dependent gamma-carboxylase. The C-terminus is proline-rich containing PPXY and PXXP motifs found in a variety of signaling and cytoskeletal proteins. This gene is highly expressed in the spinal cord. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010]

GeneCards Summary for PRRG1 Gene

PRRG1 (Proline Rich And Gla Domain 1) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PRRG3.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRRG1 Gene

Genomics for PRRG1 Gene

Regulatory Elements for PRRG1 Gene

Enhancers for PRRG1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG036963 0.6 FANTOM5 3.2 -385.8 -385815 0.4 HNF4G MAX HNF4A RAD21 YY1 PRRG1 LOC441488 LOC105373154
GH0XG037346 1.2 Ensembl ENCODE 0.7 -0.7 -703 4.5 SIN3A ZNF2 YY1 NFYC SMARCB1 SMARCA4 ZIC2 TEAD3 ZFHX2 CTBP1 PRRG1 MOB1AP2
GH0XG037314 0.8 Ensembl ENCODE 0.3 -32.7 -32670 3.9 STAT1 GATA2 JUN ZNF384 FOS MOB1AP2 PRRG1
GH0XG037320 0.4 ENCODE 0.3 -28.3 -28293 0.2 HLF MOB1AP2 PRRG1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRRG1 on UCSC Golden Path with GeneCards custom track

Promoters for PRRG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000245649 525 2400 KLF17 SIN3A ZNF2 EGR1 ZNF366 FOS EGR2 ZNF362 SMAD5 ZEB2

Genomic Location for PRRG1 Gene

37,349,275 bp from pter
37,457,295 bp from pter
108,021 bases
Plus strand

Genomic View for PRRG1 Gene

Genes around PRRG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRRG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRRG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRRG1 Gene

Proteins for PRRG1 Gene

  • Protein details for PRRG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane gamma-carboxyglutamic acid protein 1
    Protein Accession:
    Secondary Accessions:
    • B2R7A3
    • C9JXL7
    • D3DWA9
    • Q5JT66

    Protein attributes for PRRG1 Gene

    218 amino acids
    Molecular mass:
    24947 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PRRG1 Gene


neXtProt entry for PRRG1 Gene

Post-translational modifications for PRRG1 Gene

  • Gla residues are produced after subsequent post-translational modifications of glutamate by a vitamin K-dependent gamma-carboxylase.
  • Ubiquitination at Lys10 and isoforms=66
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PRRG1 Gene

Domains & Families for PRRG1 Gene

Gene Families for PRRG1 Gene

Suggested Antigen Peptide Sequences for PRRG1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRRG1: view

No data available for UniProtKB/Swiss-Prot for PRRG1 Gene

Function for PRRG1 Gene

Gene Ontology (GO) - Molecular Function for PRRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PRRG1: view
genes like me logo Genes that share phenotypes with PRRG1: view

Animal Model Products

CRISPR Products

miRNA for PRRG1 Gene

miRTarBase miRNAs that target PRRG1

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRRG1 Gene

Localization for PRRG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRRG1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRRG1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for PRRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005887 integral component of plasma membrane TAS 9256434
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PRRG1: view

Pathways & Interactions for PRRG1 Gene

SuperPathways for PRRG1 Gene

No Data Available

Interacting Proteins for PRRG1 Gene

Selected Interacting proteins: O14668-TMG1_HUMAN for PRRG1 Gene via IID

Gene Ontology (GO) - Biological Process for PRRG1 Gene


No data available for Pathways by source and SIGNOR curated interactions for PRRG1 Gene

Drugs & Compounds for PRRG1 Gene

No Compound Related Data Available

Transcripts for PRRG1 Gene

Unigene Clusters for PRRG1 Gene

Proline rich Gla (G-carboxyglutamic acid) 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRRG1 Gene

No ASD Table

Relevant External Links for PRRG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRRG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRRG1 Gene

mRNA differential expression in normal tissues according to GTEx for PRRG1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.5) and Brain - Substantia nigra (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of PRRG1 Gene:


SOURCE GeneReport for Unigene cluster for PRRG1 Gene:


mRNA Expression by UniProt/SwissProt for PRRG1 Gene:

Tissue specificity: Highly expressed in the spinal cord.

Evidence on tissue expression from TISSUES for PRRG1 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with PRRG1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRRG1 Gene

Orthologs for PRRG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRRG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRRG1 35
  • 100 (a)
(Canis familiaris)
Mammalia LOC491821 34
  • 92.81 (n)
PRRG1 35
  • 92 (a)
(Mus musculus)
Mammalia Prrg1 34 16 35
  • 90.37 (n)
(Bos Taurus)
Mammalia PRRG1 34 35
  • 89.91 (n)
(Rattus norvegicus)
Mammalia Prrg1 34
  • 89.04 (n)
(Monodelphis domestica)
Mammalia PRRG1 35
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia PRRG1 35
  • 67 (a)
(Gallus gallus)
Aves PRRG1 34 35
  • 70.37 (n)
(Anolis carolinensis)
Reptilia PRRG1 35
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia prrg1 34
  • 64.38 (n)
Str.6489 34
African clawed frog
(Xenopus laevis)
Amphibia LOC398382 34
(Danio rerio)
Actinopterygii zgc:103657 34
  • 47.38 (n)
PRRG1 35
  • 38 (a)
Species where no ortholog for PRRG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRRG1 Gene

Gene Tree for PRRG1 (if available)
Gene Tree for PRRG1 (if available)

Paralogs for PRRG1 Gene

Paralogs for PRRG1 Gene

(9) SIMAP similar genes for PRRG1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PRRG1: view

Variants for PRRG1 Gene

Sequence variations from dbSNP and Humsavar for PRRG1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_036268 A breast cancer sample
rs1000061244 -- 37,445,462(+) TGCTT(C/T)AGCAT intron-variant
rs1000148804 -- 37,406,246(+) CAAGA(A/G)AACAT utr-variant-5-prime
rs1000175688 -- 37,444,907(+) CACCC(C/T)TAGAA intron-variant
rs1000297137 -- 37,455,356(+) ATCTA(C/T)ACTAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PRRG1 Gene

Variant ID Type Subtype PubMed ID
esv3576845 CNV gain 25503493
nsv1115858 CNV duplication 24896259
nsv1119334 CNV duplication 24896259
nsv1148646 CNV duplication 26484159
nsv6863 CNV insertion 18451855

Variation tolerance for PRRG1 Gene

Residual Variation Intolerance Score: 77.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRRG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRRG1 Gene

Disorders for PRRG1 Gene

Relevant External Links for PRRG1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PRRG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRRG1 Gene

Publications for PRRG1 Gene

  1. Primary structure and tissue distribution of two novel proline-rich gamma-carboxyglutamic acid proteins. (PMID: 9256434) Kulman J.D. … Davie E.W. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 22 64
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. (PMID: 23940030) Teixeira F.R. … Gomes M.D. (J. Biol. Chem. 2013) 3 64
  5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen J.V. … Mann M. (Sci. Signal. 2010) 4 64

Products for PRRG1 Gene

Sources for PRRG1 Gene

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