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Aliases for PRRC2C Gene

Aliases for PRRC2C Gene

  • Proline Rich Coiled-Coil 2C 2 3 5
  • Proline-Rich And Coiled-Coil-Containing Protein 2C 3 4
  • HLA-B-Associated Transcript 2-Like 2 3 4
  • HBV X-Transactivated Gene 2 Protein 3 4
  • BAT2 Domain-Containing Protein 1 3 4
  • HBV XAg-Transactivated Protein 2 3 4
  • BAT2 Domain Containing 1 2 3
  • BAT2D1 3 4
  • BAT2L2 3 4
  • XTP2 3 4
  • HLA-B Associated Transcript 2-Like 2 2
  • HBxAg Transactivated Protein 2 3
  • Proline-Rich Coiled-Coil 2C 2
  • Protein BAT2-Like 2 3
  • Protein PRRC2C 3
  • BAT2-Iso 3
  • KIAA1096 4

External Ids for PRRC2C Gene

Previous HGNC Symbols for PRRC2C Gene

  • BAT2D1
  • BAT2L2

Summaries for PRRC2C Gene

GeneCards Summary for PRRC2C Gene

PRRC2C (Proline Rich Coiled-Coil 2C) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and protein C-terminus binding. An important paralog of this gene is PRRC2B.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRRC2C Gene

Genomics for PRRC2C Gene

Regulatory Elements for PRRC2C Gene

Enhancers for PRRC2C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G171511 1.1 dbSUPER 19.7 +29.4 29413 6.7 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 PRRC2C METTL13 MYOC GC01P171514 GC01P171492
GH01G171434 1.3 FANTOM5 Ensembl ENCODE 14.2 -50.5 -50516 2.2 CTCF TAF1 JUN ETV1 MAX CEBPG ZIC2 RAD21 GTF3C2 DIDO1 PRRC2C FMO4 MIR214 CYCSP53 GC01M171420
GH01G171437 1.2 FANTOM5 Ensembl ENCODE 14.5 -46.7 -46732 2.4 ELK4 JUN MAX USF2 EP300 ZBTB40 JUND MAFF SMC3 RCOR1 PRRC2C FMO4 CYCSP53 GC01M171420
GH01G171644 1.5 Ensembl ENCODE dbSUPER 9.6 +160.2 160189 1.8 HDGF PKNOX1 ATF1 CREB3L1 ARID4B ZNF2 ZNF48 YY1 TCF12 GTF3C2 PIGC PRRC2C MYOC VAMP4 GC01P171602
GH01G171483 1.4 ENCODE dbSUPER 8.1 +0.3 276 3.6 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 PRRC2C MYOC GC01P171492
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRRC2C on UCSC Golden Path with GeneCards custom track

Promoters for PRRC2C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000015685 387 2201 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766

Genomic Location for PRRC2C Gene

Chromosome:
1
Start:
171,485,513 bp from pter
End:
171,593,511 bp from pter
Size:
107,999 bases
Orientation:
Plus strand

Genomic View for PRRC2C Gene

Genes around PRRC2C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRRC2C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRRC2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRRC2C Gene

Proteins for PRRC2C Gene

  • Protein details for PRRC2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y520-PRC2C_HUMAN
    Recommended name:
    Protein PRRC2C
    Protein Accession:
    Q9Y520
    Secondary Accessions:
    • Q05DM8
    • Q49A39
    • Q6PD54
    • Q9H2N2
    • Q9HA05
    • Q9NSM8
    • Q9NXL3
    • Q9UF29
    • Q9UPQ6

    Protein attributes for PRRC2C Gene

    Size:
    2896 amino acids
    Molecular mass:
    316911 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH06090.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH45713.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH58930.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA90997.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for PRRC2C Gene

neXtProt entry for PRRC2C Gene

Post-translational modifications for PRRC2C Gene

  • Ubiquitination at Lys665, isoforms=2, 3, 4, 5, 6, 7873, and Lys2709
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PRRC2C Gene

Domains & Families for PRRC2C Gene

Protein Domains for PRRC2C Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRRC2C: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PRRC2C Gene

Function for PRRC2C Gene

Gene Ontology (GO) - Molecular Function for PRRC2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0008022 protein C-terminus binding IPI 17577209
genes like me logo Genes that share ontologies with PRRC2C: view
genes like me logo Genes that share phenotypes with PRRC2C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRRC2C Gene

Localization for PRRC2C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRRC2C gene
Compartment Confidence
cytosol 4
nucleus 3
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PRRC2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with PRRC2C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PRRC2C Gene

Pathways & Interactions for PRRC2C Gene

SuperPathways for PRRC2C Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRRC2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IBA --
genes like me logo Genes that share ontologies with PRRC2C: view

No data available for Pathways by source and SIGNOR curated interactions for PRRC2C Gene

Drugs & Compounds for PRRC2C Gene

No Compound Related Data Available

Transcripts for PRRC2C Gene

Unigene Clusters for PRRC2C Gene

Proline-rich coiled-coil 2C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRRC2C Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^
SP1: -
SP2: -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

ExUns: 24a · 24b ^ 25 ^ 26 ^ 27a · 27b · 27c · 27d · 27e · 27f
SP1:
SP2:
SP3:
SP4: - -
SP5: -
SP6: - -
SP7: -
SP8:
SP9:
SP10: -
SP11:
SP12:

Relevant External Links for PRRC2C Gene

GeneLoc Exon Structure for
PRRC2C
ECgene alternative splicing isoforms for
PRRC2C

Expression for PRRC2C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRRC2C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PRRC2C Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.3), CD8 Tcells (7.0), and Adrenal (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRRC2C Gene



Protein tissue co-expression partners for PRRC2C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRRC2C Gene:

PRRC2C

SOURCE GeneReport for Unigene cluster for PRRC2C Gene:

Hs.494614

mRNA Expression by UniProt/SwissProt for PRRC2C Gene:

Q9Y520-PRC2C_HUMAN
Tissue specificity: Overexpressed in bladder cancer.

Evidence on tissue expression from TISSUES for PRRC2C Gene

  • Nervous system(4.8)
  • Intestine(4.7)
  • Liver(4.7)
  • Skin(4.3)
  • Lung(4)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with PRRC2C: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRRC2C Gene

Orthologs for PRRC2C Gene

This gene was present in the common ancestor of animals.

Orthologs for PRRC2C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRRC2C 34 35
  • 99.41 (n)
cow
(Bos Taurus)
Mammalia PRRC2C 34 35
  • 89.84 (n)
dog
(Canis familiaris)
Mammalia PRRC2C 34 35
  • 89.7 (n)
mouse
(Mus musculus)
Mammalia Prrc2c 34 16 35
  • 85.36 (n)
oppossum
(Monodelphis domestica)
Mammalia PRRC2C 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRRC2C 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRRC2C 34 35
  • 73.76 (n)
lizard
(Anolis carolinensis)
Reptilia PRRC2C 35
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75934 34
African clawed frog
(Xenopus laevis)
Amphibia LOC398535 34
zebrafish
(Danio rerio)
Actinopterygii prrc2c 35
  • 50 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F52G3.1 35
  • 25 (a)
OneToMany
Species where no ortholog for PRRC2C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRRC2C Gene

ENSEMBL:
Gene Tree for PRRC2C (if available)
TreeFam:
Gene Tree for PRRC2C (if available)

Paralogs for PRRC2C Gene

Paralogs for PRRC2C Gene

(1) SIMAP similar genes for PRRC2C Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for PRRC2C Gene

genes like me logo Genes that share paralogs with PRRC2C: view

Variants for PRRC2C Gene

Sequence variations from dbSNP and Humsavar for PRRC2C Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000004630 -- 171,526,986(+) GTATC(G/T)TTAGT intron-variant
rs1000068548 -- 171,511,663(+) TCCTG(A/T)CATTT intron-variant
rs1000077374 -- 171,592,935(+) CCTCT(G/T)TGAAT nc-transcript-variant, utr-variant-3-prime
rs1000130173 -- 171,510,652(+) ATTGT(A/G)TTAGT intron-variant
rs1000179307 -- 171,487,783(+) AGAAT(A/G)GTAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRRC2C Gene

Variant ID Type Subtype PubMed ID
esv2230348 CNV deletion 18987734
esv2719518 CNV deletion 23290073
esv28731 CNV gain+loss 19812545
esv3578271 CNV loss 25503493
nsv3498 CNV insertion 18451855
nsv465639 CNV loss 19166990
nsv548190 CNV loss 21841781

Variation tolerance for PRRC2C Gene

Residual Variation Intolerance Score: 3.64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.20; 84.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRRC2C Gene

Human Gene Mutation Database (HGMD)
PRRC2C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRRC2C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRRC2C Gene

Disorders for PRRC2C Gene

Relevant External Links for PRRC2C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRRC2C

No disorders were found for PRRC2C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRRC2C Gene

Publications for PRRC2C Gene

  1. KIAA1096, a gene on chromosome 1q, is amplified and overexpressed in bladder cancer. (PMID: 12443540) Huang W.C. … McGarvey T.W. (DNA Cell Biol. 2002) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development. (PMID: 27542412) Cheng Y.F. … Edge A.S. (J. Biol. Chem. 2016) 3 64
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 64

Products for PRRC2C Gene

Sources for PRRC2C Gene

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