Aliases for PRRC2C Gene
Aliases for PRRC2C Gene
External Ids for PRRC2C Gene
- HGNC: 24903
- Entrez Gene: 23215
- Ensembl: ENSG00000117523
- OMIM: 617373
- UniProtKB: Q9Y520
Previous HGNC Symbols for PRRC2C Gene
- BAT2D1
- BAT2L2
Summaries for PRRC2C Gene
GeneCards Summary for PRRC2C Gene
PRRC2C (Proline Rich Coiled-Coil 2C) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and protein C-terminus binding. An important paralog of this gene is PRRC2B.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRRC2C Gene
Genomics for PRRC2C Gene
Regulatory Elements for PRRC2C Gene
Enhancers for PRRC2C Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH01G171511 | 1.1 | dbSUPER | 19.7 | +29.4 | 29413 | 6.7 | HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 | PRRC2C METTL13 MYOC GC01P171514 GC01P171492 |
| GH01G171434 | 1.3 | FANTOM5 Ensembl ENCODE | 14.2 | -50.5 | -50516 | 2.2 | CTCF TAF1 JUN ETV1 MAX CEBPG ZIC2 RAD21 GTF3C2 DIDO1 | PRRC2C FMO4 MIR214 CYCSP53 GC01M171420 |
| GH01G171437 | 1.2 | FANTOM5 Ensembl ENCODE | 14.5 | -46.7 | -46732 | 2.4 | ELK4 JUN MAX USF2 EP300 ZBTB40 JUND MAFF SMC3 RCOR1 | PRRC2C FMO4 CYCSP53 GC01M171420 |
| GH01G171644 | 1.5 | Ensembl ENCODE dbSUPER | 9.6 | +160.2 | 160189 | 1.8 | HDGF PKNOX1 ATF1 CREB3L1 ARID4B ZNF2 ZNF48 YY1 TCF12 GTF3C2 | PIGC PRRC2C MYOC VAMP4 GC01P171602 |
| GH01G171483 | 1.4 | ENCODE dbSUPER | 8.1 | +0.3 | 276 | 3.6 | HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 | PRRC2C MYOC GC01P171492 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around PRRC2C on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for PRRC2C Gene
- Chromosome:
- 1
- Start:
- 171,485,513 bp from pter
- End:
- 171,593,511 bp from pter
- Size:
- 107,999 bases
- Orientation:
- Plus strand
Genomic View for PRRC2C Gene
Genes around PRRC2C on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q24.3 by Ensembl
- 1q24.3 by Entrez Gene
- 1q24.3 by HGNC
PRRC2C Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PRRC2C Gene
Proteins for PRRC2C Gene
-
Protein details for PRRC2C Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y520-PRC2C_HUMAN
- Recommended name:
- Protein PRRC2C
- Protein Accession:
- Q9Y520
- Q05DM8
- Q49A39
- Q6PD54
- Q9H2N2
- Q9HA05
- Q9NSM8
- Q9NXL3
- Q9UF29
- Q9UPQ6
Protein attributes for PRRC2C Gene
- Size:
- 2896 amino acids
- Molecular mass:
- 316911 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH06090.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH45713.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH58930.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA90997.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Protein Expression for PRRC2C Gene
Post-translational modifications for PRRC2C Gene
Other Protein References for PRRC2C Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for PRRC2C
- Invitrogen Antibodies for PRRC2C
- Search GeneTex for Antibodies for PRRC2C
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for PRRC2C
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- Novus Biologicals proteins for PRRC2C
- Search GeneTex for Proteins for PRRC2C
Assay Products
No data available for DME Specific Peptides for PRRC2C Gene
Domains & Families for PRRC2C Gene
Suggested Antigen Peptide Sequences for PRRC2C Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for PRRC2C Gene
Function for PRRC2C Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IDA | 22658674 |
| GO:0008022 | protein C-terminus binding | IPI | 17577209 |
Phenotypes for PRRC2C Gene
- GenomeRNAi human phenotypes for PRRC2C:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PRRC2C
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PRRC2C gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PRRC2C gene
- Search ViGene Biosciences for PRRC2C
CRISPR Products
-
OriGene CRISPR knockouts for PRRC2C
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRRC2C
- GenScript: Design CRISPR guide RNA sequences for PRRC2C
miRNA for PRRC2C Gene
- miRTarBase miRNAs that target PRRC2C
-
- hsa-mir-98-5p (MIRT027663)
- hsa-mir-16-5p (MIRT031781)
- hsa-mir-877-3p (MIRT037060)
- hsa-mir-342-5p (MIRT038222)
- hsa-mir-324-3p (MIRT042975)
- hsa-mir-320a (MIRT044602)
- hsa-mir-149-5p (MIRT045460)
- hsa-mir-218-5p (MIRT046993)
- hsa-mir-10b-5p (MIRT047500)
- hsa-mir-10a-5p (MIRT047747)
- hsa-mir-100-5p (MIRT048425)
- hsa-mir-20a-5p (MIRT050592)
- hsa-mir-19a-3p (MIRT050643)
- hsa-mir-3163 (MIRT060641)
- hsa-mir-181a-5p (MIRT131427)
- hsa-mir-181b-5p (MIRT131428)
- hsa-mir-181c-5p (MIRT131429)
- hsa-mir-181d-5p (MIRT131435)
- hsa-mir-221-5p (MIRT182476)
- hsa-mir-1263 (MIRT182477)
- hsa-mir-8073 (MIRT182478)
- hsa-mir-15a-5p (MIRT246938)
- hsa-mir-15b-5p (MIRT246939)
- hsa-mir-195-5p (MIRT246940)
- hsa-mir-5579-3p (MIRT571774)
- hsa-mir-4536-5p (MIRT571775)
- hsa-mir-593-5p (MIRT571776)
- hsa-mir-7851-3p (MIRT571777)
- hsa-mir-619-3p (MIRT571778)
- hsa-mir-1277-5p (MIRT706763)
- hsa-mir-6083 (MIRT706764)
- hsa-mir-3924 (MIRT706765)
- hsa-mir-190a-3p (MIRT706766)
- hsa-mir-5011-5p (MIRT706767)
- hsa-mir-410-3p (MIRT706768)
- hsa-mir-607 (MIRT707914)
- hsa-mir-3671 (MIRT707915)
miRNA Products
- Search ViGene Biosciences for PRRC2C
Inhibitory RNA Products
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-
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Clone Products
-
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for PRRC2C
-
ViGene Biosciences adenoviral particle packaged cDNA for PRRC2C gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PRRC2C gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PRRC2C gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRRC2C Gene
Localization for PRRC2C Gene
| Compartment | Confidence |
|---|---|
| cytosol | 4 |
| nucleus | 3 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016020 | membrane | IDA | 19946888 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for PRRC2C Gene
Pathways & Interactions for PRRC2C Gene
No Data Available
Interacting Proteins for PRRC2C Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002244 | hematopoietic progenitor cell differentiation | IBA | -- |
No data available for Pathways by source and SIGNOR curated interactions for PRRC2C Gene
Transcripts for PRRC2C Gene
mRNA/cDNA for PRRC2C Gene
- (18) REFSEQ mRNAs :
- (17) Additional mRNA sequences :
- (707) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PRRC2C Gene
CRISPR Products
-
OriGene CRISPR knockouts for PRRC2C
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRRC2C
- GenScript: Design CRISPR guide RNA sequences for PRRC2C
miRNA Products
- Search ViGene Biosciences for PRRC2C
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for PRRC2C
- Browse OriGene Inhibitory RNA Products For PRRC2C
-
ViGene Biosciences ready-to-package AAV shRNAs for PRRC2C gene
Clone Products
-
OriGene ORF clones in human for PRRC2C
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for PRRC2C
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRRC2C
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22a | · | 22b | ^ | 23 | ^ |
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| ExUns: | 24a | · | 24b | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b | · | 27c | · | 27d | · | 27e | · | 27f |
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| SP12: |
Expression for PRRC2C Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Peripheral blood mononuclear cells (10.3), CD8 Tcells (7.0), and Adrenal (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRRC2C Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of PRRC2C Gene:
PRRC2CSOURCE GeneReport for Unigene cluster for PRRC2C Gene:
Hs.494614mRNA Expression by UniProt/SwissProt for PRRC2C Gene:
Q9Y520-PRC2C_HUMAN
Tissue specificity:
Overexpressed in bladder cancer.
Evidence on tissue expression from TISSUES for PRRC2C Gene
- Nervous system(4.8)
- Intestine(4.7)
- Liver(4.7)
- Skin(4.3)
- Lung(4)
- Spleen(2.1)
Primer Products
-
OriGene qPCR primer pairs for PRRC2C
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRRC2C Gene
Orthologs for PRRC2C Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PRRC2C 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | PRRC2C 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | PRRC2C 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Prrc2c 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PRRC2C 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PRRC2C 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PRRC2C 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | PRRC2C 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | MGC75934 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398535 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | prrc2c 35 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | F52G3.1 35 |
|
OneToMany |
- Species where no ortholog for PRRC2C was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for PRRC2C Gene
(1) SIMAP similar genes for PRRC2C Gene using alignment to 3 proteins:
Pseudogenes.org Pseudogenes for PRRC2C Gene
Variants for PRRC2C Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000004630 | -- | 171,526,986(+) | GTATC(G/T)TTAGT | intron-variant | |
| rs1000068548 | -- | 171,511,663(+) | TCCTG(A/T)CATTT | intron-variant | |
| rs1000077374 | -- | 171,592,935(+) | CCTCT(G/T)TGAAT | nc-transcript-variant, utr-variant-3-prime | |
| rs1000130173 | -- | 171,510,652(+) | ATTGT(A/G)TTAGT | intron-variant | |
| rs1000179307 | -- | 171,487,783(+) | AGAAT(A/G)GTAGG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2230348 | CNV | deletion | 18987734 |
| esv2719518 | CNV | deletion | 23290073 |
| esv28731 | CNV | gain+loss | 19812545 |
| esv3578271 | CNV | loss | 25503493 |
| nsv3498 | CNV | insertion | 18451855 |
| nsv465639 | CNV | loss | 19166990 |
| nsv548190 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
3.64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.20;
84.86% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for PRRC2C Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRRC2C Gene
Disorders for PRRC2C Gene
Relevant External Links for PRRC2C
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- PRRC2C
No disorders were found for PRRC2C Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRRC2C Gene
Publications for PRRC2C Gene
- KIAA1096, a gene on chromosome 1q, is amplified and overexpressed in bladder cancer. (PMID: 12443540) Huang W.C. … McGarvey T.W. (DNA Cell Biol. 2002) 2 3 4 64
- Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development. (PMID: 27542412) Cheng Y.F. … Edge A.S. (J. Biol. Chem. 2016) 3 64
- Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 64
Products for PRRC2C Gene
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- OriGene qPCR primer pairs for PRRC2C
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- GenScript: Design CRISPR guide RNA sequences for PRRC2C
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- CloneReady with Over 120,000 Genes
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- Browse Sino Biological cDNA Clones
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- Novus Biologicals Antibodies for PRRC2C
- Novus Biologicals proteins for PRRC2C
- Novus Biologicals
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- Invitrogen Antibodies for PRRC2C
- ViGene Biosciences adenoviral particle packaged cDNA for PRRC2C gene
- ViGene Biosciences lentiviral particle packaged cDNA for PRRC2C gene
- ViGene Biosciences ready-to-package AAV shRNAs for PRRC2C gene
- Search ViGene Biosciences for PRRC2C
- Horizon Cell Lines for PRRC2C
- Cyagen custom Knockout/knockin (KOKI) mouse models for PRRC2C
- VectorBuilder custom plasmid, inducible vectors for PRRC2C
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRRC2C
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for PRRC2C Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
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