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Aliases for PRRC2C Gene

Aliases for PRRC2C Gene

  • Proline Rich Coiled-Coil 2C 2 3 5
  • Proline-Rich And Coiled-Coil-Containing Protein 2C 3 4
  • HLA-B-Associated Transcript 2-Like 2 3 4
  • HBV X-Transactivated Gene 2 Protein 3 4
  • BAT2 Domain-Containing Protein 1 3 4
  • HBV XAg-Transactivated Protein 2 3 4
  • BAT2 Domain Containing 1 2 3
  • BAT2D1 3 4
  • BAT2L2 3 4
  • XTP2 3 4
  • HLA-B Associated Transcript 2-Like 2 2
  • HBxAg Transactivated Protein 2 3
  • Proline-Rich Coiled-Coil 2C 2
  • Protein BAT2-Like 2 3
  • Protein PRRC2C 3
  • BAT2-Iso 3
  • KIAA1096 4

External Ids for PRRC2C Gene

Previous HGNC Symbols for PRRC2C Gene

  • BAT2D1
  • BAT2L2

Summaries for PRRC2C Gene

GeneCards Summary for PRRC2C Gene

PRRC2C (Proline Rich Coiled-Coil 2C) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein C-terminus binding. An important paralog of this gene is PRRC2B.

Additional gene information for PRRC2C Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRRC2C Gene

Genomics for PRRC2C Gene

GeneHancer (GH) Regulatory Elements for PRRC2C Gene

Promoters and enhancers for PRRC2C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I171483 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 558.2 +0.3 276 3.6 HDGF PKNOX1 SMAD1 ARNT MLX ARID4B SIN3A DMAP1 ZNF2 IRF4 PRRC2C MYOC GC01P171492
GH01I171738 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 46.5 +255.9 255916 6.2 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 VAMP4 PRRC2C METTL13 PIGC FMO4 SUCO MYOC PIR43253
GH01I171779 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 49 +295.9 295887 2.9 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 METTL13 PRRC2C PIGC MYOC DNM3 LOC105371614
GH01I170530 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 16.1 -953.1 -953141 3.2 HDGF PKNOX1 CLOCK SMAD1 ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 GORAB LOC101928650 C1orf112 SCYL3 PRRC2C METTL18 RN7SL333P ENSG00000271811
GH01I170660 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13 -819.4 -819357 10.3 RB1 GLI4 RAD21 ZNF335 GLIS2 ZNF366 ZNF143 IKZF2 EGR2 SMARCA5 ENSG00000271811 PRRX1 PRRC2C SCYL3 RN7SL333P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRRC2C on UCSC Golden Path with GeneCards custom track

Genomic Locations for PRRC2C Gene

Genomic Locations for PRRC2C Gene
chr1:171,485,513-171,593,511
(GRCh38/hg38)
Size:
107,999 bases
Orientation:
Plus strand
chr1:171,454,651-171,562,650
(GRCh37/hg19)

Genomic View for PRRC2C Gene

Genes around PRRC2C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRRC2C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRRC2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRRC2C Gene

Proteins for PRRC2C Gene

  • Protein details for PRRC2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y520-PRC2C_HUMAN
    Recommended name:
    Protein PRRC2C
    Protein Accession:
    Q9Y520
    Secondary Accessions:
    • Q05DM8
    • Q49A39
    • Q6PD54
    • Q9H2N2
    • Q9HA05
    • Q9NSM8
    • Q9NXL3
    • Q9UF29
    • Q9UPQ6

    Protein attributes for PRRC2C Gene

    Size:
    2896 amino acids
    Molecular mass:
    316911 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH06090.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH45713.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH58930.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA90997.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for PRRC2C Gene

neXtProt entry for PRRC2C Gene

Post-translational modifications for PRRC2C Gene

  • Ubiquitination at Lys665, isoforms=2, 3, 4, 5, 6, 7873, and Lys2709

No data available for DME Specific Peptides for PRRC2C Gene

Domains & Families for PRRC2C Gene

Gene Families for PRRC2C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PRRC2C Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRRC2C: view

No data available for UniProtKB/Swiss-Prot for PRRC2C Gene

Function for PRRC2C Gene

Phenotypes From GWAS Catalog for PRRC2C Gene

Gene Ontology (GO) - Molecular Function for PRRC2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,HDA 22658674
GO:0008022 protein C-terminus binding IPI 17577209
genes like me logo Genes that share ontologies with PRRC2C: view
genes like me logo Genes that share phenotypes with PRRC2C: view

Animal Model Products

miRNA for PRRC2C Gene

miRTarBase miRNAs that target PRRC2C

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRRC2C Gene

Localization for PRRC2C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRRC2C gene
Compartment Confidence
cytosol 4
nucleus 3
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PRRC2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
GO:0016020 membrane HDA,IDA 19946888
genes like me logo Genes that share ontologies with PRRC2C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PRRC2C Gene

Pathways & Interactions for PRRC2C Gene

SuperPathways for PRRC2C Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRRC2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IBA --
genes like me logo Genes that share ontologies with PRRC2C: view

No data available for Pathways by source and SIGNOR curated interactions for PRRC2C Gene

Drugs & Compounds for PRRC2C Gene

No Compound Related Data Available

Transcripts for PRRC2C Gene

Unigene Clusters for PRRC2C Gene

Proline-rich coiled-coil 2C:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRRC2C Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^
SP1: -
SP2: -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

ExUns: 24a · 24b ^ 25 ^ 26 ^ 27a · 27b · 27c · 27d · 27e · 27f
SP1:
SP2:
SP3:
SP4: - -
SP5: -
SP6: - -
SP7: -
SP8:
SP9:
SP10: -
SP11:
SP12:

Relevant External Links for PRRC2C Gene

GeneLoc Exon Structure for
PRRC2C
ECgene alternative splicing isoforms for
PRRC2C

Expression for PRRC2C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRRC2C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PRRC2C Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.3), CD8 Tcells (7.0), and Adrenal (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRRC2C Gene



Protein tissue co-expression partners for PRRC2C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRRC2C Gene:

PRRC2C

SOURCE GeneReport for Unigene cluster for PRRC2C Gene:

Hs.494614

mRNA Expression by UniProt/SwissProt for PRRC2C Gene:

Q9Y520-PRC2C_HUMAN
Tissue specificity: Overexpressed in bladder cancer.

Evidence on tissue expression from TISSUES for PRRC2C Gene

  • Nervous system(4.8)
  • Intestine(4.7)
  • Liver(4.7)
  • Skin(4.3)
  • Lung(4)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with PRRC2C: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRRC2C Gene

Orthologs for PRRC2C Gene

This gene was present in the common ancestor of animals.

Orthologs for PRRC2C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRRC2C 33 34
  • 99.41 (n)
cow
(Bos Taurus)
Mammalia PRRC2C 33 34
  • 89.84 (n)
dog
(Canis familiaris)
Mammalia PRRC2C 33 34
  • 89.7 (n)
mouse
(Mus musculus)
Mammalia Prrc2c 33 16 34
  • 85.36 (n)
oppossum
(Monodelphis domestica)
Mammalia PRRC2C 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRRC2C 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRRC2C 33 34
  • 73.76 (n)
lizard
(Anolis carolinensis)
Reptilia PRRC2C 34
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75934 33
African clawed frog
(Xenopus laevis)
Amphibia LOC398535 33
zebrafish
(Danio rerio)
Actinopterygii prrc2c 34
  • 50 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F52G3.1 34
  • 25 (a)
OneToMany
Species where no ortholog for PRRC2C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRRC2C Gene

ENSEMBL:
Gene Tree for PRRC2C (if available)
TreeFam:
Gene Tree for PRRC2C (if available)

Paralogs for PRRC2C Gene

Paralogs for PRRC2C Gene

(1) SIMAP similar genes for PRRC2C Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for PRRC2C Gene

genes like me logo Genes that share paralogs with PRRC2C: view

Variants for PRRC2C Gene

Sequence variations from dbSNP and Humsavar for PRRC2C Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000004630 -- 171,526,986(+) T/G intron_variant
rs1000068548 -- 171,511,663(+) T/A intron_variant
rs1000077374 -- 171,592,935(+) G/T 3_prime_UTR_variant, non_coding_transcript_variant
rs1000130173 -- 171,510,652(+) A/G intron_variant
rs1000179307 -- 171,487,783(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRRC2C Gene

Variant ID Type Subtype PubMed ID
esv2230348 CNV deletion 18987734
esv2719518 CNV deletion 23290073
esv28731 CNV gain+loss 19812545
esv3578271 CNV loss 25503493
nsv3498 CNV insertion 18451855
nsv465639 CNV loss 19166990
nsv548190 CNV loss 21841781

Variation tolerance for PRRC2C Gene

Residual Variation Intolerance Score: 3.64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.20; 84.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRRC2C Gene

Human Gene Mutation Database (HGMD)
PRRC2C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRRC2C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRRC2C Gene

Disorders for PRRC2C Gene

Additional Disease Information for PRRC2C

No disorders were found for PRRC2C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRRC2C Gene

Publications for PRRC2C Gene

  1. KIAA1096, a gene on chromosome 1q, is amplified and overexpressed in bladder cancer. (PMID: 12443540) Huang WC … McGarvey TW (DNA and cell biology 2002) 2 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for PRRC2C Gene

Sources for PRRC2C Gene

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