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Aliases for PRRC2C Gene

Aliases for PRRC2C Gene

  • Proline Rich Coiled-Coil 2C 2 3
  • Proline-Rich Coiled-Coil 2C 2 3 5
  • Proline-Rich And Coiled-Coil-Containing Protein 2C 3 4
  • HLA-B Associated Transcript 2-Like 2 2 3
  • HLA-B-Associated Transcript 2-Like 2 3 4
  • HBV X-Transactivated Gene 2 Protein 3 4
  • BAT2 Domain-Containing Protein 1 3 4
  • HBV XAg-Transactivated Protein 2 3 4
  • BAT2 Domain Containing 1 2 3
  • BAT2D1 3 4
  • BAT2L2 3 4
  • XTP2 3 4
  • HBxAg Transactivated Protein 2 3
  • Protein BAT2-Like 2 3
  • BAT2-Iso 3
  • KIAA1096 4

External Ids for PRRC2C Gene

Previous HGNC Symbols for PRRC2C Gene

  • BAT2D1
  • BAT2L2

Summaries for PRRC2C Gene

GeneCards Summary for PRRC2C Gene

PRRC2C (Proline Rich Coiled-Coil 2C) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and protein C-terminus binding. An important paralog of this gene is PRRC2B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRRC2C Gene

Genomics for PRRC2C Gene

Regulatory Elements for PRRC2C Gene

Enhancers for PRRC2C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRRC2C on UCSC Golden Path with GeneCards custom track

Promoters for PRRC2C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRRC2C on UCSC Golden Path with GeneCards custom track

Genomic Location for PRRC2C Gene

Chromosome:
1
Start:
171,485,513 bp from pter
End:
171,593,511 bp from pter
Size:
107,999 bases
Orientation:
Plus strand

Genomic View for PRRC2C Gene

Genes around PRRC2C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRRC2C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRRC2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRRC2C Gene

Proteins for PRRC2C Gene

  • Protein details for PRRC2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y520-PRC2C_HUMAN
    Recommended name:
    Protein PRRC2C
    Protein Accession:
    Q9Y520
    Secondary Accessions:
    • Q05DM8
    • Q49A39
    • Q6PD54
    • Q9H2N2
    • Q9HA05
    • Q9NSM8
    • Q9NXL3
    • Q9UF29
    • Q9UPQ6

    Protein attributes for PRRC2C Gene

    Size:
    2896 amino acids
    Molecular mass:
    316911 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH06090.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH45713.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH58930.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA90997.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for PRRC2C Gene

neXtProt entry for PRRC2C Gene

Proteomics data for PRRC2C Gene at MOPED

Post-translational modifications for PRRC2C Gene

  • Ubiquitination at Lys 665, Lys 873, and Lys 2709
  • Modification sites at PhosphoSitePlus

Other Protein References for PRRC2C Gene

No data available for DME Specific Peptides for PRRC2C Gene

Domains & Families for PRRC2C Gene

Protein Domains for PRRC2C Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRRC2C: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PRRC2C Gene

Function for PRRC2C Gene

genes like me logo Genes that share phenotypes with PRRC2C: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRRC2C Gene

Localization for PRRC2C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRRC2C Gene COMPARTMENTS Subcellular localization image for PRRC2C gene
Compartment Confidence
cytosol 4
nucleus 3
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PRRC2C Gene

Pathways & Interactions for PRRC2C Gene

SuperPathways for PRRC2C Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRRC2C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PRRC2C Gene

Drugs & Compounds for PRRC2C Gene

No Compound Related Data Available

Transcripts for PRRC2C Gene

Unigene Clusters for PRRC2C Gene

Proline-rich coiled-coil 2C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRRC2C Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^
SP1: -
SP2: -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

ExUns: 24a · 24b ^ 25 ^ 26 ^ 27a · 27b · 27c · 27d · 27e · 27f
SP1:
SP2:
SP3:
SP4: - -
SP5: -
SP6: - -
SP7: -
SP8:
SP9:
SP10: -
SP11:
SP12:

Relevant External Links for PRRC2C Gene

GeneLoc Exon Structure for
PRRC2C
ECgene alternative splicing isoforms for
PRRC2C

Expression for PRRC2C Gene

mRNA expression in normal human tissues for PRRC2C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PRRC2C Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.3), CD8 Tcells (7.0), and Adrenal (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRRC2C Gene



SOURCE GeneReport for Unigene cluster for PRRC2C Gene Hs.494614

mRNA Expression by UniProt/SwissProt for PRRC2C Gene

Q9Y520-PRC2C_HUMAN
Tissue specificity: Overexpressed in bladder cancer.
genes like me logo Genes that share expression patterns with PRRC2C: view

Protein tissue co-expression partners for PRRC2C Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for PRRC2C Gene

Orthologs for PRRC2C Gene

This gene was present in the common ancestor of animals.

Orthologs for PRRC2C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRRC2C 35
  • 89.84 (n)
  • 90.58 (a)
PRRC2C 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRRC2C 35
  • 89.7 (n)
  • 90.74 (a)
PRRC2C 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prrc2c 35
  • 85.36 (n)
  • 86 (a)
Prrc2c 16
Prrc2c 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRRC2C 35
  • 99.41 (n)
  • 99.08 (a)
PRRC2C 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRRC2C 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRRC2C 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRRC2C 35
  • 73.76 (n)
  • 74.92 (a)
PRRC2C 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRRC2C 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75934 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398535 35
zebrafish
(Danio rerio)
Actinopterygii prrc2c 36
  • 50 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F52G3.1 36
  • 25 (a)
OneToMany
Species with no ortholog for PRRC2C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRRC2C Gene

ENSEMBL:
Gene Tree for PRRC2C (if available)
TreeFam:
Gene Tree for PRRC2C (if available)

Paralogs for PRRC2C Gene

Paralogs for PRRC2C Gene

(1) SIMAP similar genes for PRRC2C Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for PRRC2C Gene

genes like me logo Genes that share paralogs with PRRC2C: view

Variants for PRRC2C Gene

Sequence variations from dbSNP and Humsavar for PRRC2C Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10913157 - 171,517,773(+) AGCAG(A/G)CTGCT reference, missense
rs36013361 - 171,523,502(+) AGTAA(C/G)AGTCC reference, missense
rs704839 - 171,532,497(+) TGAAG(A/G/T)GGAAG reference, missense
rs760644 - 171,540,188(+) TATCC(A/G)CTCCT reference, missense
rs34269512 - 171,540,347(+) AAGAA(C/T)CAATA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PRRC2C Gene

Variant ID Type Subtype PubMed ID
esv28731 CNV Gain+Loss 19812545
esv2230348 CNV Deletion 18987734
esv2719518 CNV Deletion 23290073
nsv465639 CNV Loss 19166990
nsv3498 CNV Insertion 18451855

Variation tolerance for PRRC2C Gene

Residual Variation Intolerance Score: 3.64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.20; 84.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRRC2C Gene

HapMap Linkage Disequilibrium report
PRRC2C
Human Gene Mutation Database (HGMD)
PRRC2C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRRC2C Gene

Disorders for PRRC2C Gene

Relevant External Links for PRRC2C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRRC2C

No disorders were found for PRRC2C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRRC2C Gene

Publications for PRRC2C Gene

  1. KIAA1096, a gene on chromosome 1q, is amplified and overexpressed in bladder cancer. (PMID: 12443540) Huang W.C. … McGarvey T.W. (DNA Cell Biol. 2002) 2 3 4 67
  2. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 3
  3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  4. Analysis of HIV-1 Gag protein interactions via biotin ligase tagging. (PMID: 25631074) Ritchie C. … Barklis E. (J. Virol. 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for PRRC2C Gene

Sources for PRRC2C Gene

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