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PRRC2A Gene

protein-coding   GIFtS: 48
GCID: GC06P031761

Proline-Rich Coiled-Coil 2A

(Previous name: HLA-B associated transcript 2)
(Previous symbol: BAT2)
  See PRRC2A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Proline-Rich Coiled-Coil 2A1 2     G22 3
BAT21 2 3 5     HLA-B-Associated Transcript 22 3
HLA-B Associated Transcript 21 2     D6S51E2 5
Large Proline-Rich Protein BAT22 3     D6S512
Proline-Rich And Coiled-Coil-Containing Protein 2A2 3     Protein PRRC2A2
Protein G22 3     

External Ids:    HGNC: 139181   Entrez Gene: 79162   Ensembl: ENSG000002044697   OMIM: 1425805   UniProtKB: P486343   

Export aliases for PRRC2A gene to outside databases

Previous GC identifers: GC06P031374 GC06P031592 GC06P031594 GC06P031600 GC06P031719


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRRC2A Gene:
A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These
genes are all within the human major histocompatibility complex class III region. This gene has microsatellite
repeats which are associated with the age-at-onset of insulin-dependent diabetes mellitus (IDDM) and possibly
thought to be involved with the inflammatory process of pancreatic beta-cell destruction during the development
of IDDM. This gene is also a candidate gene for the development of rheumatoid arthritis. Two transcript variants
encoding the same protein have been found for this gene. (provided by RefSeq, Dec 2010)

GeneCards Summary for PRRC2A Gene:
PRRC2A (proline-rich coiled-coil 2A) is a protein-coding gene. Diseases associated with PRRC2A include coronary artery aneurysm, and rheumatoid arthritis. An important paralog of this gene is PRRC2C.

UniProtKB/Swiss-Prot: PRC2A_HUMAN, P48634
Function: May play a role in the regulation of pre-mRNA splicing

Gene Wiki entry for PRRC2A (BAT2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NT_113891.3  NT_167245.2  NT_167246.2  NT_167247.2  NT_167248.2  NT_167249.2  
NC_018917.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for PRRC2A
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRRC2A promoter sequence
   Search Chromatin IP Primers for PRRC2A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRRC2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

PRRC2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRRC2A gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P031761:  view genomic region     (about GC identifiers)

Start:
31,588,450 bp from pter      End:
31,605,554 bp from pter
Size:
17,105 bases      Orientation:
plus strand

6 alternative locations:
Chr6+,NT_167247 2,968,140-2,985,242      Chr6+,NT_167246 2,931,334-2,948,438      Chr6+,NT_167248 2,882,091-2,899,191     
Chr6+,NT_167249 2,919,253-2,936,356      Chr6+,NT_167245 2,874,022-2,891,126      Chr6+,NT_113891.2 3,098,067-3,115,170     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PRC2A_HUMAN, P48634 (See protein sequence)
Recommended Name: Protein PRRC2A  
Size: 2157 amino acids; 228863 Da
Developmental stage: Broadly expressed during the 11th week of gestation, with highest levels in the central
nervous system, spinal ganglia, osteoblasts and osteocytes (at protein level)
Sequence caution: Sequence=AAA35585.1; Type=Frameshift; Positions=38, 58; Sequence=AAA35586.1; Type=Frameshift;
Positions=38, 58; Sequence=BAE06116.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAA78744.1; Type=Frameshift; Positions=38, 58;
Secondary accessions: B0UX77 B0UZE9 B0UZL3 O95875 Q05BK4 Q4LE37 Q5SQ29 Q5SQ30 Q5ST84 Q5STX6
Q5STX7 Q68DW9 Q6P9P7 Q6PIN1 Q8MGQ9 Q96QC6
Alternative splicing: 4 isoforms:  P48634-1   P48634-2   P48634-3   P48634-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PRRC2A: NX_P48634

Explore proteomics data for PRRC2A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PRRC2A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004629.3  NP_542417.2  

    ENSEMBL proteins: 
     ENSP00000365175   ENSP00000365201  

    PRRC2A Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PRRC2A 

     
    antibodies-online proteins for PRRC2A (2 products) 

     
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    antibodies-online kits for PRRC2A (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009738 BAT2_N

    Graphical View of Domain Structure for InterPro Entry P48634

    ProtoNet protein and cluster: P48634


    Find genes that share domains with PRRC2A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRC2A_HUMAN, P48634
    Function: May play a role in the regulation of pre-mRNA splicing

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16713569
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with PRRC2A           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PRRC2A:
     Increased cell death in breast 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PRRC2A

    miRNA
    Products:
        
    miRTarBase miRNAs that target PRRC2A:
    hsa-mir-222-3p (MIRT046673), hsa-mir-25-3p (MIRT050337), hsa-let-7b-5p (MIRT005234), hsa-mir-92b-3p (MIRT040729), hsa-mir-760 (MIRT036751), hsa-mir-296-3p (MIRT038490), hsa-mir-106a-5p (MIRT048319), hsa-mir-330-5p (MIRT038238), hsa-mir-484 (MIRT041837), hsa-mir-193b-3p (MIRT041320), hsa-mir-423-5p (MIRT038145), hsa-mir-18a-3p (MIRT040800), hsa-mir-1180-3p (MIRT035936), hsa-mir-331-3p (MIRT043314), hsa-let-7e-5p (MIRT051617), hsa-mir-93-3p (MIRT038861), hsa-mir-744-5p (MIRT037410), hsa-mir-877-3p (MIRT037162), hsa-mir-615-3p (MIRT039872), hsa-mir-1303 (MIRT035887), hsa-let-7c-5p (MIRT051744)

    Block miRNA regulation of human, mouse, rat PRRC2A using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate PRRC2A:
    hsa-miR-495 hsa-miR-300 hsa-miR-381
    SwitchGear 3'UTR luciferase reporter plasmidPRRC2A 3' UTR sequence
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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRRC2A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PRC2A_HUMAN, P48634: Cytoplasm. Nucleus

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with PRRC2A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRRC2A
    Interactions:

        Search GeneGlobe Interaction Network for PRRC2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRRC2A (P486341, 2, 3 ENSP000003651754) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542531, 2, 3, ENSP000002447694EBI-347545,EBI-930964 MINT-2864423 MINT-2856362 MINT-2864404 MINT-2864442 I2D: score=3 STRING: ENSP00000244769
    C1QBPQ070212, 3, ENSP000002256984MINT-62735 MINT-62637 MINT-62811 I2D: score=5 STRING: ENSP00000225698
    CCR10P460922, 3, ENSP000003325044MINT-62802 MINT-62628 MINT-62726 I2D: score=5 STRING: ENSP00000332504
    FGAP026712, 3, ENSP000003063614MINT-62623 MINT-62721 MINT-62797 I2D: score=5 STRING: ENSP00000306361
    IMMTQ168912, 3, ENSP000003872624MINT-62725 MINT-62627 MINT-62801 I2D: score=5 STRING: ENSP00000387262
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRRC2A (PRC2A)

    1 PharmGKB related drug/compound annotation for PRRC2A gene    About this table
    Drug/compound PharmGKB Annotation
    carbamazepineCA  



    Find genes that share compounds with PRRC2A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRRC2A gene (2 alternative transcripts): 
    NM_004638.3  NM_080686.2  

    Unigene Cluster for PRRC2A:

    Proline-rich coiled-coil 2A
    Hs.436093  [show with all ESTs]
    Unigene Representative Sequence: NM_004638
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376007(uc011dnv.1 uc003nvb.4) ENST00000469577 ENST00000376033(uc003nvc.4)
    ENST00000464079 ENST00000464890 ENST00000483470 ENST00000460302 ENST00000484787
    ENST00000469501 ENST00000487089 ENST00000487839 ENST00000492691 ENST00000462617
    ENST00000482441
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate PRRC2A:
    hsa-miR-495 hsa-miR-300 hsa-miR-381
    SwitchGear 3'UTR luciferase reporter plasmidPRRC2A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PRRC2A
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    OriGene ORF clones in mouse, rat for PRRC2A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PRRC2A (NM_080686)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRRC2A
    Primer
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    OriGene qPCR primer pairs and template standards for PRRC2A
    OriGene qSTAR qPCR primer pairs in human, mouse for PRRC2A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRRC2A
      QuantiTect SYBR Green Assays in human, mouse, rat PRRC2A
      QuantiFast Probe-based Assays in human, mouse, rat PRRC2A

    Additional mRNA sequence: 

    AB210034.1 AF075059.1 AK297210.1 AK298584.1 AK302756.1 AK309774.1 BC030127.1 BC032134.2 
    BC042295.1 BC050408.1 BC060668.1 CR749245.1 M33509.1 

    Selected DOTS entries (see all 30):

    DT.95319619  DT.95350369  DT.97763962  DT.92412731  DT.95228022  DT.100039278  DT.92453850  DT.92453852 
    DT.121406434  DT.91833257  DT.91833692  DT.92416778  DT.95173136  DT.97860787  DT.121406453  DT.121406464 
    DT.86857378  DT.95173133  DT.100811214  DT.100039277  DT.100798869  DT.100823013  DT.100823014  DT.121406444 

    5 AceView cDNA sequences:

    BE302895 BI019233 BE389143 BE278011 BG827834 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRRC2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTAGACTCAC
    PRRC2A Expression
    About this image


    PRRC2A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract
    PRRC2A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRRC2A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436093

    UniProtKB/Swiss-Prot: PRC2A_HUMAN, P48634
    Tissue specificity: Limited to cell-lines of leukemic origin

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRRC2A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PRRC2A gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prrc2a1 , 5 proline-rich coiled-coil 2A1, 5 87.88(n)1
    89.61(a)1
      17 (18.59 cM)5
    537611  NM_001199044.11  NP_001185973.11 
     351490765 
    lizard
    (Anolis carolinensis)
    Reptilia PRRC2A6
    proline-rich coiled-coil 2A
    58(a)
    1 ↔ 1
    2(193947910-193978099)
    African clawed frog
    (Xenopus laevis)
    Amphibia bat2-prov2 HLA-B associated transcript 2 78.47(n)    BC051009.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nfkbil12 nuclear factor of kappa light polypeptide gene enhancer more 81.03(n)   394248  BC055180.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F52G3.16
    Protein F52G3.1 (F52G3.1) mRNA, complete cds
    19(a)
    1 → many
    X(16963871-16972820) WBGene00018710


    ENSEMBL Gene Tree for PRRC2A (if available)
    TreeFam Gene Tree for PRRC2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRRC2A gene
    PRRC2C2  PRRC2B2  
    1 SIMAP similar gene for PRRC2A using alignment to 2 protein entries:     PRC2A_HUMAN (see all proteins):
    BAT2L

    Find genes that share paralogs with PRRC2A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRRC2A (see all 669)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357974
    A breast cancer sample4--see VAR_0357972 R H mis40--------
    VAR_0357964
    A breast cancer sample4--see VAR_0357962 T I mis40--------
    rs1909528121,2
    --31586529(+) GTGGCA/GTGATC 2 -- us2k10--------
    rs93917301,2
    C,F--31586603(+) gctgaG/Aactac 2 -- us2k12Minor allele frequency- A:0.50NA 4
    rs30912801,2
    C--31586742(+) ctacaG/Agcata 2 -- us2k14Minor allele frequency- A:0.45NA CSA EA 244
    rs69347191,2
    C--31586761(+) cgcccA/GgccTC 2 -- us2k10--------
    rs1831591691,2
    --31586777(+) TCTTAA/GTAAGA 2 -- us2k10--------
    rs779153891,2
    C--31586783(+) TAAGAG/ATTTTT 2 -- us2k12Minor allele frequency- A:0.05WA 120
    rs556930601,2
    C--31586827(+) CATATC/TTTATT 2 -- us2k10--------
    rs2018390111,2
    C--31586840(+) TCTAC-/TTCT  
            
    TTCTT
    2 -- us2k10--------

    HapMap Linkage Disequilibrium report for PRRC2A (31588450 - 31605554 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PRRC2A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830627CNV Loss17160897
    dgv6581n71CNV Loss21882294
    nsv884423CNV Loss21882294
    nsv462871CNV Loss19166990
    nsv884418CNV Gain21882294

    Human Gene Mutation Database (HGMD): PRRC2A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRRC2A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142580    OMIM disorders: --

    2 diseases for PRRC2A:    
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    coronary artery aneurysm    rheumatoid arthritis


    Find genes that share disorders with PRRC2A           About GenesLikeMe


    Export disorders for PRRC2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRRC2A gene, integrated from 10 sources (see all 69):
    (articles sorted by number of sources associating them with PRRC2A)
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    1. A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain. (PubMed id 2156268)1, 2, 3, 9 Banerji J.... Spies T. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    2. Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment. (PubMed id 8499947)1, 2, 3 Iris F.J.M....Cohen D. (Nat. Genet. 1993)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. Antibodies generated by a novel DNA vaccination identify the MHC class III encoded BAT2 polypeptide. (PubMed id 15752841)1, 2 Schneiders A.... Koch N. (Vaccine 2005)
    5. Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. (PubMed id 14667819)1, 2 Lehner B....Sanderson C.M. (Genomics 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PubMed id 14656967)1, 2 Xie T.... Hood L. (Genome Res. 2003)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    9. A comprehensive family-based replication study of schizophrenia genes. (PubMed id 23894747)1 Aberg K.A....van den Oord E.J. (JAMA Psychiatry 2013)
    10. Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans. (PubMed id 23221128)1 Walsh K.M....Amos C.I. (amp 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7916 HGNC: 13918 AceView: BAT2.5 Ensembl:ENSG00000204469 euGenes: HUgn7916
    ECgene: PRRC2A H-InvDB: PRRC2A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRRC2A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRRC2A gene:
    Search GeneIP for patents involving PRRC2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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