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Aliases for PRR7 Gene

Aliases for PRR7 Gene

  • Proline Rich 7, Synaptic 2 3 5
  • Synaptic Proline-Rich Membrane Protein 4
  • Proline Rich 7 (Synaptic) 2

External Ids for PRR7 Gene

Previous GeneCards Identifiers for PRR7 Gene

  • GC05P176807
  • GC05P176873
  • GC05P171794

Summaries for PRR7 Gene

GeneCards Summary for PRR7 Gene

PRR7 (Proline Rich 7, Synaptic) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRR7 Gene

Genomics for PRR7 Gene

Regulatory Elements for PRR7 Gene

Enhancers for PRR7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F177443 0.6 ENCODE 7.2 +0.0 20 6.1 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 FOS PAF1 ENSG00000248484 LOC105377752 OR1X5P LOC105377753 GMCL1P1 F12 GRK6 PFN3 SLC34A1 DBN1
GH05F177453 0.5 Ensembl ENCODE 6.8 +10.4 10400 7.1 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 ZNF346-IT1 ZNF346 SLC34A1 F12 GRK6 PFN3 MXD3 B4GALT7 PRR7 DBN1
GH05F177476 0.2 ENCODE 6.5 +32.5 32450 3.7 NFRKB ZNF76 ARID4B RARA SCRT2 EGR2 SMARCA5 ZNF362 CEBPB REST HNRNPAB PRR7 FGFR4 ENSG00000279821 PIR32965
GH05F177425 1 FANTOM5 ENCODE 6.4 -17.0 -16973 8.6 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 GRK6 DOK3 FAF2 UIMC1 PFN3 DBN1 SLC34A1 ENSG00000248996 LOC202181 MXD3
GH05F177461 0.9 Ensembl ENCODE 6.1 +16.2 16157 1.8 CTCF ZNF263 ZBTB11 NCOA1 ZBTB40 ZBTB7A GABPA NR2F2 ZFHX2 POLR2A SLC34A1 F12 GRK6 PFN3 MXD3 PRR7 DBN1 PIR32965 ENSG00000279821
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PRR7 on UCSC Golden Path with GeneCards custom track

Promoters for PRR7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001297873 656 1201 HDGF PKNOX1 SIN3A ZNF2 GLIS2 ELK1 ZNF263 REST MIER3 RFX3

Genomic Location for PRR7 Gene

Chromosome:
5
Start:
177,446,344 bp from pter
End:
177,456,701 bp from pter
Size:
10,358 bases
Orientation:
Plus strand

Genomic View for PRR7 Gene

Genes around PRR7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRR7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRR7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRR7 Gene

Proteins for PRR7 Gene

  • Protein details for PRR7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TB68-PRR7_HUMAN
    Recommended name:
    Proline-rich protein 7
    Protein Accession:
    Q8TB68
    Secondary Accessions:
    • Q8WU53
    • Q9BTA7

    Protein attributes for PRR7 Gene

    Size:
    274 amino acids
    Molecular mass:
    30930 Da
    Quaternary structure:
    • Found in a postsynaptic membrane complex with DLG4 and GRIN1. Interacts with DLG4. Interacts preferentially to the PDZ3 domain of DLG4 and to lesser degree to PDZ2 but not to the PDZ1 (By similarity).

    Alternative splice isoforms for PRR7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRR7 Gene

Post-translational modifications for PRR7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PRR7 Gene

Domains & Families for PRR7 Gene

Protein Domains for PRR7 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for PRR7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRR7: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PRR7 Gene

Function for PRR7 Gene

genes like me logo Genes that share phenotypes with PRR7: view

Animal Model Products

miRNA for PRR7 Gene

miRTarBase miRNAs that target PRR7

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRR7 Gene

Localization for PRR7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRR7 Gene

Membrane; Single-pass type III membrane protein. Cell junction, synapse, postsynaptic cell membrane. Note=Enriched in postsynaptic plasma membrane and postsynaptic densities (PSD). Accumulates in spines along with synapse maturation and colocalizes with DLG4 in a punctate pattern (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRR7 Gene COMPARTMENTS Subcellular localization image for PRR7 gene
Compartment Confidence
plasma membrane 4
extracellular 3
cytosol 2
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PRR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
GO:0045202 synapse IEA --
GO:0045211 postsynaptic membrane IEA --
genes like me logo Genes that share ontologies with PRR7: view

Pathways & Interactions for PRR7 Gene

SuperPathways for PRR7 Gene

No Data Available

Interacting Proteins for PRR7 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000327168%0d%0a9606.ENSP00000378642%0d%0a
Selected Interacting proteins: ENSP00000327168 Q8TB68-PRR7_HUMAN for PRR7 Gene via STRING IID

Gene Ontology (GO) - Biological Process for PRR7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PRR7 Gene

Transcripts for PRR7 Gene

Unigene Clusters for PRR7 Gene

Proline rich 7 (synaptic):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRR7 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for PRR7 Gene

GeneLoc Exon Structure for
PRR7
ECgene alternative splicing isoforms for
PRR7

Expression for PRR7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRR7 Gene

mRNA differential expression in normal tissues according to GTEx for PRR7 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x4.4) and Brain - Nucleus accumbens (basal ganglia) (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of PRR7 Gene:

PRR7

SOURCE GeneReport for Unigene cluster for PRR7 Gene:

Hs.534492
genes like me logo Genes that share expression patterns with PRR7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PRR7 Gene

Orthologs for PRR7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRR7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRR7 34 35
  • 95.71 (n)
rat
(Rattus norvegicus)
Mammalia Prr7 34
  • 89.34 (n)
mouse
(Mus musculus)
Mammalia Prr7 34 16 35
  • 88.97 (n)
cow
(Bos Taurus)
Mammalia PRR7 34 35
  • 88.6 (n)
dog
(Canis familiaris)
Mammalia PRR7 34 35
  • 87.01 (n)
oppossum
(Monodelphis domestica)
Mammalia PRR7 35
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRR7 35
  • 68 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii BX927237.2 35
  • 44 (a)
OneToOne
Species where no ortholog for PRR7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRR7 Gene

ENSEMBL:
Gene Tree for PRR7 (if available)
TreeFam:
Gene Tree for PRR7 (if available)

Paralogs for PRR7 Gene

No data available for Paralogs for PRR7 Gene

Variants for PRR7 Gene

Sequence variations from dbSNP and Humsavar for PRR7 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10038437 -- 177,450,960(+) GCAGC(A/G)TAGTG intron-variant, utr-variant-5-prime
rs10055093 -- 177,449,022(+) ccaat(C/G)tttgt intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1061378 -- 177,456,890(-) CCTGT(C/T)TGGCC downstream-variant-500B, utr-variant-3-prime
rs1061379 -- 177,456,863(-) CCCAG(C/T)TGGGG downstream-variant-500B, utr-variant-3-prime
rs10713910 -- 177,449,518(+) CCCCA(-/C)CAGGG intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PRR7 Gene

Variant ID Type Subtype PubMed ID
dgv10184n54 CNV loss 21841781
dgv733n27 CNV loss 19166990
esv2677804 CNV deletion 23128226
esv2731192 CNV deletion 23290073
esv2731193 CNV deletion 23290073
esv2822 CNV loss 18987735
esv999663 CNV deletion 20482838
nsv1119054 CNV deletion 24896259
nsv1161311 CNV duplication 26073780
nsv1161313 CNV duplication 26073780
nsv329248 CNV deletion 16902084
nsv471057 CNV loss 18288195
nsv515805 CNV loss 19592680

Relevant External Links for PRR7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRR7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PRR7 Gene

Disorders for PRR7 Gene

Relevant External Links for PRR7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRR7

No disorders were found for PRR7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRR7 Gene

Publications for PRR7 Gene

  1. Proteomic analysis revealed a novel synaptic proline-rich membrane protein (PRR7) associated with PSD-95 and NMDA receptor. (PMID: 15629447) Murata Y. … Fujiyoshi Y. (Biochem. Biophys. Res. Commun. 2005) 2 3 64
  2. Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease. (PMID: 22703881) Tang W. … Folsom A.R. (Am. J. Hum. Genet. 2012) 3 64
  3. PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis. (PMID: 21460222) Hrdinka M. … Drbal K. (J. Biol. Chem. 2011) 3 64
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3 64
  5. New loci associated with kidney function and chronic kidney disease. (PMID: 20383146) KAPttgen A. … Fox C.S. (Nat. Genet. 2010) 3 64

Products for PRR7 Gene

Sources for PRR7 Gene

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