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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRR7 Gene

protein-coding   GIFtS: 44
GCID: GC05P176873

Proline Rich 7 (Synaptic)

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Proline Rich 7 (Synaptic)1 2
Synaptic Proline-Rich Membrane Protein2 3
Proline-Rich Protein 72

External Ids:    HGNC: 281301   Entrez Gene: 807582   Ensembl: ENSG000001311887   UniProtKB: Q8TB683   

Export aliases for PRR7 gene to outside databases

Previous GC identifers: GC05P176807 GC05P171794


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PRR7 Gene: 
PRR7 (proline rich 7 (synaptic)) is a protein-coding gene. Diseases associated with PRR7 include kidney disease.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRR7 gene promoter:
         AhR   POU2F2 (Oct-2.1)   Oct-B1   oct-B2   oct-B3   POU2F2   Arnt   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRR7 promoter sequence
   Search SABiosciences Chromatin IP Primers for PRR7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRR7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35.3

PRR7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRR7 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P176873:  view genomic region     (about GC identifiers)

Start:
176,873,446 bp from pter      End:
176,883,287 bp from pter
Size:
9,842 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PRR7_HUMAN, Q8TB68 (See protein sequence)
Recommended Name: Proline-rich protein 7  
Size: 274 amino acids; 30930 Da
Subunit: Found in a postsynaptic membrane complex with DLG4 and GRIN1. Interacts with DLG4. Interacts
preferentially to the PDZ3 domain of DLG4 and to lesser degree to PDZ2 but not to the PDZ1 (By similarity)
Subcellular location: Membrane; Single-pass type III membrane protein (Potential). Cell junction, synapse,
postsynaptic cell membrane (By similarity). Note=Enriched in postsynaptic plasma membrane and postsynaptic
densities (PSD). Accumulates in spines along with synapse maturation and colocalizes with DLG4 in a punctate
pattern (By similarity)
Secondary accessions: Q8WU53 Q9BTA7
Alternative splicing: 2 isoforms:  Q8TB68-1   Q8TB68-2   

Explore the universe of human proteins at neXtProt for PRR7: NX_Q8TB68

Explore proteomics data for PRR7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TB68

  • PRR7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PRR7 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001167572.1  NP_001167573.1  NP_085044.2  

    ENSEMBL proteins: 
     ENSP00000426601   ENSP00000327168   ENSP00000420872   ENSP00000421039  

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    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--
    GO:0030054cell junction IEA--
    GO:0045211postsynaptic membrane IEA--

    PRR7 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR021684 Uncharacterised_WW-bd

    Graphical View of Domain Structure for InterPro Entry Q8TB68

    ProtoNet protein and cluster: Q8TB68


    PRR7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 GenomeRNAi human phenotype for PRR7:
     High actin ratio cells 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PRR7 
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    SwitchGear 3'UTR luciferase reporter plasmidPRR7 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PRR7

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for PRR7 (ENSP000003271684) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    --ENSP000003180904STRING: ENSP00000318090
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PRR7

    Search CenterWatch for drugs/clinical trials and news about PRR7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PRR7 gene (3 alternative transcripts): 
    NM_001174101.1  NM_001174102.1  NM_030567.4  

    Unigene Cluster for PRR7:

    Proline rich 7 (synaptic)
    Hs.534492  [show with all ESTs]
    Unigene Representative Sequence: AK125417
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000507881 ENST00000323249(uc003mgu.2 uc003mgv.2) ENST00000502922
    ENST00000510492(uc003mgw.2)
    miRNA
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    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate PRR7 (see all 11):
    hsa-miR-411* hsa-miR-362-3p hsa-miR-495 hsa-miR-379* hsa-miR-7-2* hsa-miR-373* hsa-miR-329 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidPRR7 3' UTR sequence
    Inhib. RNA
    Products:
         
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRR7
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): PRR7 (NM_030567)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRR7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRR7
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRR7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRR7

    Additional mRNA sequence: 

    AK125417.1 BC021240.1 BC024233.2 BC033649.1 

    10 DOTS entries:

    DT.97844144  DT.91759568  DT.100690998  DT.100023615  DT.91811542  DT.91759570  DT.97813619  DT.100737458 
    DT.91759567  DT.95173554 

    24/72 AceView cDNA sequences (see all 72):

    CA432376 BM790061 BE383140 BM852111 CN479297 BQ945746 BG056212 CR611394 
    BI756019 BC004261 BM823010 AW874052 CR624103 BG033579 BG030490 BQ675160 
    AA921357 BI195829 BU168122 BV179861 BI196544 NM_030567 BC024233 BM023413 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for PRR7    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:              -               


    ECgene alternative splicing isoforms for PRR7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRR7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCAAACCAC
    PRR7 Expression
    About this image


    See PRR7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRR7

    SOURCE GeneReport for Unigene cluster: Hs.534492
        SABiosciences Custom PCR Arrays for PRR7
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRR7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PRR7 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prr71 , 5 proline rich 7 (synaptic)1, 5 91.57(n)1
    97.4(a)1
      13 (30.06 cM)5
    4327631  NM_001030296.41  NP_001025467.11 
     554642675 
    lizard
    (Anolis carolinensis)
    Reptilia PRR76
    Uncharacterized protein
    68(a)
    1 ↔ 1
    2(145770978-145772565)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD361645.12   -- 77.42(n)    CD361645.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BX927237.26
    Uncharacterized protein
    42(a)
    1 ↔ 1
    21(36100499-36105769)


    ENSEMBL Gene Tree for PRR7 (if available)
    TreeFam Gene Tree for PRR7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/121 SNPs in PRR7 are shown (see all 121)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3760464331,2
    C--176876965(+) GGTGTA/CCCAGT 3 -- int10--------
    rs745763911,2
    F--176877105(+) GCAGCC/TACCTC 3 -- int11Minor allele frequency- T:0.02WA 118
    rs4612641,2
    C,F,A,H--176877110(+) CACCTC/TCTGAG 3 -- int114Minor allele frequency- T:0.11MN NS NA WA CSA 1775
    rs1916200461,2
    --176877318(+) CACCCC/TCCAGA 3 -- int10--------
    rs772176561,2
    C,F--176877350(+) CAGCCT/CTTTCC 3 -- int11Minor allele frequency- C:0.08EA 120
    rs784525961,2
    F--176877378(+) CATGGG/AGTCTC 3 -- int11Minor allele frequency- A:0.02NA 120
    rs1505554841,2
    --176877407(+) CCTGCC/TAGGCG 3 -- int10--------
    rs1806936271,2
    --176877471(+) TCCCAA/GGAATG 3 -- int10--------
    rs1163522321,2
    F--176877512(+) TCCCCC/TGGTCC 3 -- int11Minor allele frequency- T:0.01WA 118
    rs1395791881,2
    --176877513(+) CCCCCA/GGTCCC 3 -- int10--------

    HapMap Linkage Disequilibrium report for PRR7 (176873446 - 176883287 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/17 variations for PRR7 (see all 17):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2731193CNV Deletion23290073
    esv2822CNV Deletion18987735
    esv2677804CNV Deletion23128226
    esv2731192CNV Deletion23290073
    esv999663CNV Deletion20482838
    nsv471057CNV Loss18288195
    dgv6383n71CNV Loss21882294
    nsv883172CNV Loss21882294
    nsv883164CNV Loss21882294
    nsv329248CNV Loss16902084

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for PRR7:    About MalaCards
    kidney disease    


    PRR7 for disorders           About GeneDecksing


    Export disorders for PRR7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRR7 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with PRR7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Proteomic analysis revealed a novel synaptic proline-rich membrane protein (PRR7) associated with PSD-95 and NMDA receptor. (PubMed id 15629447)1, 3 Murata Y....Fujiyoshi Y. (2005)
    2. Genetic associations for activated partial thromboplas tin time and prothrombin time, their gene expression profiles, and risk of coron ary artery disease. (PubMed id 22703881)1 Tang W....Folsom A.R. (2012)
    3. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    4. PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apopt osis. (PubMed id 21460222)1 Hrdinka M....Drbal K. (2011)
    5. New loci associated with kidney function and chronic kidney disease. (PubMed id 20383146)1 KAPttgen A....Fox C.S. (2010)
    6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80758 HGNC: 28130 AceView: MGC10772 Ensembl:ENSG00000131188 euGenes: HUgn80758
    ECgene: PRR7 H-InvDB: PRR7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRR7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PRR7 gene:
    Search GeneIP for patents involving PRR7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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