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Aliases for PRR7 Gene

Aliases for PRR7 Gene

  • Proline Rich 7, Synaptic 2 3 5
  • Synaptic Proline-Rich Membrane Protein 4
  • Proline Rich 7 (Synaptic) 2

External Ids for PRR7 Gene

Previous GeneCards Identifiers for PRR7 Gene

  • GC05P176807
  • GC05P176873
  • GC05P171794

Summaries for PRR7 Gene

GeneCards Summary for PRR7 Gene

PRR7 (Proline Rich 7, Synaptic) is a Protein Coding gene.

Additional gene information for PRR7 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRR7 Gene

Genomics for PRR7 Gene

Regulatory Elements for PRR7 Gene

Enhancers for PRR7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H177425 1.8 FANTOM5 ENCODE dbSUPER 6.5 -17.0 -16973 8.6 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 CBX5 NSD1 GRK6 FAF2 UIMC1 DOK3 ENSG00000247679 LOC202181 ZNF346-IT1 PFN3 FAM193B
GH05H177453 1.7 Ensembl ENCODE dbSUPER 6.8 +10.5 10521 6.9 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF346 NSD1 ZNF346-IT1 LOC202181 UIMC1 ENSG00000247679 SLC34A1 F12 GRK6 PFN3
GH05H177443 1.6 Ensembl ENCODE dbSUPER 7.2 +0.0 20 6.1 HNRNPUL1 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF207 FOS NSD1 FAF2 UIMC1 ENSG00000248484 ZNF346 LOC105377752 OR1X5P LOC105377753 GMCL1P1 ENSG00000247679
GH05H177476 1.5 Ensembl ENCODE dbSUPER 6.5 +32.4 32402 4.3 PKNOX1 ARID4B ATF7 RUNX3 NCOA1 ZNF592 MEF2D SSRP1 ATF4 SMARCA4 RPL21P60 NSD1 LOC202181 PRR7 FGFR4 ENSG00000279821 PIR32965
GH05H177467 1.3 ENCODE dbSUPER 5.7 +25.2 25168 7.1 HDGF PKNOX1 ARID4B SIN3A YBX1 GLIS2 ZNF143 FOS KLF7 RUNX3 RPL21P60 MXD3 DOK3 DDX41 FAM193B NSD1 LOC202181 DBN1 PRR7 FGFR4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRR7 on UCSC Golden Path with GeneCards custom track

Promoters for PRR7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for PRR7 Gene

Genomic Locations for PRR7 Gene
10,358 bases
Plus strand

Genomic View for PRR7 Gene

Genes around PRR7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRR7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRR7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRR7 Gene

Proteins for PRR7 Gene

  • Protein details for PRR7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proline-rich protein 7
    Protein Accession:
    Secondary Accessions:
    • Q8WU53
    • Q9BTA7

    Protein attributes for PRR7 Gene

    274 amino acids
    Molecular mass:
    30930 Da
    Quaternary structure:
    • Found in a postsynaptic membrane complex with DLG4 and GRIN1. Interacts with DLG4. Interacts preferentially to the PDZ3 domain of DLG4 and to lesser degree to PDZ2 but not to the PDZ1 (By similarity).

    Alternative splice isoforms for PRR7 Gene


neXtProt entry for PRR7 Gene

Post-translational modifications for PRR7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PRR7 Gene

Domains & Families for PRR7 Gene

Gene Families for PRR7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PRR7 Gene


Suggested Antigen Peptide Sequences for PRR7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRR7: view

No data available for UniProtKB/Swiss-Prot for PRR7 Gene

Function for PRR7 Gene

genes like me logo Genes that share phenotypes with PRR7: view

Animal Models for PRR7 Gene

MGI Knock Outs for PRR7:
  • Prr7 tm1(KOMP)Vlcg

Animal Model Products

miRNA for PRR7 Gene

miRTarBase miRNAs that target PRR7

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRR7 Gene

Localization for PRR7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRR7 Gene

Membrane; Single-pass type III membrane protein. Cell junction, synapse, postsynaptic cell membrane. Note=Enriched in postsynaptic plasma membrane and postsynaptic densities (PSD). Accumulates in spines along with synapse maturation and colocalizes with DLG4 in a punctate pattern (By similarity). {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRR7 gene
Compartment Confidence
plasma membrane 4
extracellular 3
nucleus 2
cytosol 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
GO:0045202 synapse IEA --
GO:0045211 postsynaptic membrane IEA --
genes like me logo Genes that share ontologies with PRR7: view

Pathways & Interactions for PRR7 Gene

No Data Available

Interacting Proteins for PRR7 Gene

Gene Ontology (GO) - Biological Process for PRR7 Gene


No data available for Pathways by source and SIGNOR curated interactions for PRR7 Gene

Drugs & Compounds for PRR7 Gene

No Compound Related Data Available

Transcripts for PRR7 Gene

Unigene Clusters for PRR7 Gene

Proline rich 7 (synaptic):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRR7 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP2: -

Relevant External Links for PRR7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRR7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRR7 Gene

mRNA differential expression in normal tissues according to GTEx for PRR7 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x4.4) and Brain - Nucleus accumbens (basal ganglia) (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of PRR7 Gene:


SOURCE GeneReport for Unigene cluster for PRR7 Gene:


Evidence on tissue expression from TISSUES for PRR7 Gene

  • Skin(4.2)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with PRR7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRR7 Gene

Orthologs for PRR7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRR7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRR7 33 34
  • 95.71 (n)
(Rattus norvegicus)
Mammalia Prr7 33
  • 89.34 (n)
(Mus musculus)
Mammalia Prr7 33 16 34
  • 88.97 (n)
(Bos Taurus)
Mammalia PRR7 33 34
  • 88.6 (n)
(Canis familiaris)
Mammalia PRR7 33 34
  • 87.01 (n)
(Monodelphis domestica)
Mammalia PRR7 34
  • 72 (a)
(Anolis carolinensis)
Reptilia PRR7 34
  • 68 (a)
(Danio rerio)
Actinopterygii BX927237.2 34
  • 44 (a)
Species where no ortholog for PRR7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRR7 Gene

Gene Tree for PRR7 (if available)
Gene Tree for PRR7 (if available)

Paralogs for PRR7 Gene

No data available for Paralogs for PRR7 Gene

Variants for PRR7 Gene

Sequence variations from dbSNP and Humsavar for PRR7 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000411522 -- 177,446,552(+) TGGCC(C/T)GGGCT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000698031 -- 177,447,773(+) GGAAG(C/G)AGAGT intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1000986634 -- 177,454,742(+) GCTTT(A/C)CCCGG intron-variant, utr-variant-5-prime
rs1001025642 -- 177,447,663(+) GAAGC(C/T)TGCAT intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1001563063 -- 177,448,026(+) TGGCT(A/C)CCCTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PRR7 Gene

Variant ID Type Subtype PubMed ID
nsv515805 CNV loss 19592680
nsv471057 CNV loss 18288195
nsv329248 CNV deletion 16902084
nsv1161313 CNV duplication 26073780
nsv1161311 CNV duplication 26073780
nsv1119054 CNV deletion 24896259
esv999663 CNV deletion 20482838
esv2822 CNV loss 18987735
esv2731193 CNV deletion 23290073
esv2731192 CNV deletion 23290073
esv2677804 CNV deletion 23128226
dgv733n27 CNV loss 19166990
dgv10184n54 CNV loss 21841781

Relevant External Links for PRR7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PRR7 Gene

Disorders for PRR7 Gene

Relevant External Links for PRR7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PRR7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRR7 Gene

Publications for PRR7 Gene

  1. Proteomic analysis revealed a novel synaptic proline-rich membrane protein (PRR7) associated with PSD-95 and NMDA receptor. (PMID: 15629447) Murata Y … Fujiyoshi Y (Biochemical and biophysical research communications 2005) 2 3 60
  2. Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity. (PMID: 27458189) Kravchick DO … Jordan BA (The EMBO journal 2016) 3 60
  3. Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease. (PMID: 22703881) Tang W … Folsom AR (American journal of human genetics 2012) 3 60
  4. PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis. (PMID: 21460222) Hrdinka M … Drbal K (The Journal of biological chemistry 2011) 3 60
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3 60

Products for PRR7 Gene

Sources for PRR7 Gene

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