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Aliases for PRR7 Gene

Aliases for PRR7 Gene

  • Proline Rich 7 (Synaptic) 2 3
  • Synaptic Proline-Rich Membrane Protein 4

External Ids for PRR7 Gene

Previous GeneCards Identifiers for PRR7 Gene

  • GC05P176807
  • GC05P176873
  • GC05P171794

Summaries for PRR7 Gene

GeneCards Summary for PRR7 Gene

PRR7 (Proline Rich 7 (Synaptic)) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRR7 Gene

Genomics for PRR7 Gene

Regulatory Elements for PRR7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PRR7 Gene

177,446,344 bp from pter
177,456,701 bp from pter
10,358 bases
Plus strand

Genomic View for PRR7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRR7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRR7 Gene

Proteins for PRR7 Gene

  • Protein details for PRR7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proline-rich protein 7
    Protein Accession:
    Secondary Accessions:
    • Q8WU53
    • Q9BTA7

    Protein attributes for PRR7 Gene

    274 amino acids
    Molecular mass:
    30930 Da
    Quaternary structure:
    • Found in a postsynaptic membrane complex with DLG4 and GRIN1. Interacts with DLG4. Interacts preferentially to the PDZ3 domain of DLG4 and to lesser degree to PDZ2 but not to the PDZ1 (By similarity).

    Alternative splice isoforms for PRR7 Gene


neXtProt entry for PRR7 Gene

Proteomics data for PRR7 Gene at MOPED

Post-translational modifications for PRR7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRR7 Gene

No data available for DME Specific Peptides for PRR7 Gene

Domains & Families for PRR7 Gene

Protein Domains for PRR7 Gene


Suggested Antigen Peptide Sequences for PRR7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRR7: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PRR7 Gene

Function for PRR7 Gene

genes like me logo Genes that share phenotypes with PRR7: view

Animal Model Products

miRNA for PRR7 Gene

miRTarBase miRNAs that target PRR7

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for PRR7 Gene

Localization for PRR7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRR7 Gene

Membrane; Single-pass type III membrane protein. Cell junction, synapse, postsynaptic cell membrane. Note=Enriched in postsynaptic plasma membrane and postsynaptic densities (PSD). Accumulates in spines along with synapse maturation and colocalizes with DLG4 in a punctate pattern (By similarity). {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for PRR7 Gene COMPARTMENTS Subcellular localization image for PRR7 gene
Compartment Confidence
plasma membrane 3
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for PRR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
GO:0045211 postsynaptic membrane IEA --
genes like me logo Genes that share ontologies with PRR7: view

Pathways & Interactions for PRR7 Gene

SuperPathways for PRR7 Gene

No Data Available

Interacting Proteins for PRR7 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000327168 for PRR7 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for PRR7 Gene


No data available for Pathways by source and SIGNOR curated interactions for PRR7 Gene

Drugs & Compounds for PRR7 Gene

No Compound Related Data Available

Transcripts for PRR7 Gene

Unigene Clusters for PRR7 Gene

Proline rich 7 (synaptic):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRR7 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP2: -

Relevant External Links for PRR7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRR7 Gene

mRNA expression in normal human tissues for PRR7 Gene

mRNA differential expression in normal tissues according to GTEx for PRR7 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x4.4) and Brain - Nucleus accumbens (basal ganglia) (x4.0).

SOURCE GeneReport for Unigene cluster for PRR7 Gene Hs.534492

genes like me logo Genes that share expression patterns with PRR7: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PRR7 Gene

Orthologs for PRR7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRR7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PRR7 35
  • 88.6 (n)
  • 92.19 (a)
PRR7 36
  • 98 (a)
(Canis familiaris)
Mammalia PRR7 35
  • 87.01 (n)
  • 88.97 (a)
PRR7 36
  • 97 (a)
(Mus musculus)
Mammalia Prr7 35
  • 88.97 (n)
  • 91.82 (a)
Prr7 16
Prr7 36
  • 97 (a)
(Pan troglodytes)
Mammalia PRR7 35
  • 95.71 (n)
  • 95 (a)
PRR7 36
  • 93 (a)
(Rattus norvegicus)
Mammalia Prr7 35
  • 89.34 (n)
  • 92.19 (a)
(Monodelphis domestica)
Mammalia PRR7 36
  • 72 (a)
(Anolis carolinensis)
Reptilia PRR7 36
  • 68 (a)
(Danio rerio)
Actinopterygii BX927237.2 36
  • 44 (a)
Species with no ortholog for PRR7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRR7 Gene

Gene Tree for PRR7 (if available)
Gene Tree for PRR7 (if available)

Paralogs for PRR7 Gene

No data available for Paralogs for PRR7 Gene

Variants for PRR7 Gene

Sequence variations from dbSNP and Humsavar for PRR7 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_042437 -

Structural Variations from Database of Genomic Variants (DGV) for PRR7 Gene

Variant ID Type Subtype PubMed ID
dgv6379n71 CNV Loss 21882294
nsv471057 CNV Loss 18288195
nsv883163 CNV Loss 21882294
nsv883164 CNV Loss 21882294
dgv733n27 CNV Loss 19166990
dgv6381n71 CNV Loss 21882294
nsv883172 CNV Loss 21882294
dgv6383n71 CNV Loss 21882294
nsv515805 CNV Loss 19592680
nsv883177 CNV Loss 21882294
nsv883178 CNV Loss 21882294
esv2822 CNV Deletion 18987735
esv2731192 CNV Deletion 23290073
esv2677804 CNV Deletion 23128226
esv999663 CNV Deletion 20482838
esv2731193 CNV Deletion 23290073
nsv329248 CNV Loss 16902084

Relevant External Links for PRR7 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PRR7 Gene

Disorders for PRR7 Gene

Relevant External Links for PRR7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PRR7: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRR7 Gene

Publications for PRR7 Gene

  1. Proteomic analysis revealed a novel synaptic proline-rich membrane protein (PRR7) associated with PSD-95 and NMDA receptor. (PMID: 15629447) Murata Y. … Fujiyoshi Y. (Biochem. Biophys. Res. Commun. 2005) 2 67
  2. Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease. (PMID: 22703881) Tang W. … Folsom A.R. (Am. J. Hum. Genet. 2012) 67
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 67
  4. PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis. (PMID: 21460222) Hrdinka M. … Drbal K. (J. Biol. Chem. 2011) 67
  5. New loci associated with kidney function and chronic kidney disease. (PMID: 20383146) KAPttgen A. … Fox C.S. (Nat. Genet. 2010) 67

Products for PRR7 Gene

Sources for PRR7 Gene

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