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PRR5L Gene

protein-coding   GIFtS: 49
GCID: GC11P036355

Proline Rich 5 Like

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Proline Rich 5 Like1 2     protor-22
Protein Observed With Rictor-21 2 3     Protor-23
PROTOR22 3 5     FLJ142135
Proline-Rich Protein 5-Like2     

External Ids:    HGNC: 258781   Entrez Gene: 798992   Ensembl: ENSG000001353627   OMIM: 6117285   UniProtKB: Q6MZQ03   

Export aliases for PRR5L gene to outside databases

Previous GC identifer: GC11P036017


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PRR5L Gene:
PRR5L (proline rich 5 like) is a protein-coding gene. Diseases associated with PRR5L include tuberous sclerosis. An important paralog of this gene is PRR5.

UniProtKB/Swiss-Prot: PRR5L_HUMAN, Q6MZQ0
Function: Associates with the mTORC2 complex that regulates cellular processes including survival and organization
of the cytoskeleton. Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for
instance the specific phosphorylation of PKCs and thereby controlling cell migration




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_009237.19  
Regulatory elements:
   Search for regulatory transcription factor binding sites for PRR5L
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for PRR5L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRR5L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13-p12   Ensembl cytogenetic band:  11p13   HGNC cytogenetic band: 11p13-p12

PRR5L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRR5L gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P036355:  view genomic region     (about GC identifiers)

Start:
36,317,725 bp from pter      End:
36,486,754 bp from pter
Size:
169,030 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PRR5L_HUMAN, Q6MZQ0 (See protein sequence)
Recommended Name: Proline-rich protein 5-like  
Size: 368 amino acids; 40836 Da
Subunit: Interacts with the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5,
RICTOR, MAPKAP1 and DEPTOR. Interacts with RFFL
Sequence caution: Sequence=AAI25123.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A4QN22 E9PKY1 Q96H46 Q9H7V4
Alternative splicing: 4 isoforms:  Q6MZQ0-1   Q6MZQ0-2   Q6MZQ0-3   Q6MZQ0-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PRR5L: NX_Q6MZQ0

Explore proteomics data for PRR5L at MOPED

Post-translational modifications: 

  • Ubiquitinated. Ubiquitination by RFFL promotes proteasomal degradation of PRR5L thereby modifying the
    substrate-specific activity of the mTORC2 complex. Ubiquitination by RFFL is stimulated by LPA/lysophosphatidic
    acid1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PRR5L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001153639.1  NP_001153640.1  NP_001153641.1  NP_079117.3  

    ENSEMBL proteins: 
     ENSP00000435050   ENSP00000433708   ENSP00000433893   ENSP00000431610   ENSP00000368144  
     ENSP00000433305   ENSP00000436485   ENSP00000431475   ENSP00000432203   ENSP00000436402  
     ENSP00000435241   ENSP00000310103  

    PRR5L Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for PRR5L
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    Novus Biologicals PRR5L Protein
    Novus Biologicals PRR5L Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PRR5L

    PRR5L Antibody Products:

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    LSBio Antibodies in human, mouse, rat for PRR5L

    PRR5L Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for PRR5L
    Cloud-Clone Corp. CLIAs for PRR5L


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR013745 HbrB

    Graphical View of Domain Structure for InterPro Entry Q6MZQ0

    ProtoNet protein and cluster: Q6MZQ0

    UniProtKB/Swiss-Prot: PRR5L_HUMAN, Q6MZQ0
    Similarity: Belongs to the PROTOR family


    PRR5L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRR5L_HUMAN, Q6MZQ0
    Function: Associates with the mTORC2 complex that regulates cellular processes including survival and organization
    of the cytoskeleton. Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for
    instance the specific phosphorylation of PKCs and thereby controlling cell migration

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031625ubiquitin protein ligase binding IPI--
         
    PRR5L for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PRR5L:
     Decreased viability with pacli  Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRR5L
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRR5L
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRR5L

    miRNA
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    miRTarBase miRNAs that target PRR5L:
    hsa-mir-26b-5p (MIRT029915)

    Block miRNA regulation of human, mouse, rat PRR5L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRR5L (see all 22):
    hsa-miR-148b hsa-miR-301a hsa-miR-1297 hsa-miR-205* hsa-miR-26b hsa-miR-548c-3p hsa-miR-450b-5p hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidPRR5L 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat PRR5L

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 4): PRR5L (NM_024841)
    Browse Sino Biological Human cDNA Clones
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat PRR5L

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRR5L


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion3
    cytosol2
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0031932TORC2 complex IDA--

    PRR5L for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRR5L About    
    See pathways by source

    SuperPathContained pathways About
    1Insulin receptor signalling cascade
    TOR signaling0.32
    2PI3K / Akt Signaling
    PI3K / Akt Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for PRR5L
        PI3K / Akt Signaling

    1 BioSystems Pathway for PRR5L
        TOR signaling



    PRR5L for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRR5L
    Interactions:

        Search GeneGlobe Interaction Network for PRR5L

    4 Interacting proteins for PRR5L (Q6MZQ03) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RICTORQ6R3273I2D: score=3 
    MAPKAP1Q9BPZ73I2D: score=2 
    MLST8Q9BVC43I2D: score=2 
    MTORP423453I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001933negative regulation of protein phosphorylation IMP--
    GO:0001934positive regulation of protein phosphorylation IEA--
    GO:0009968negative regulation of signal transduction IEA--
    GO:0010762regulation of fibroblast migration IMP--
    GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling IEA--

    PRR5L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRR5L



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PRR5L gene (4 alternative transcripts): 
    NM_001160167.1  NM_001160168.1  NM_001160169.1  NM_024841.4  

    Unigene Cluster for PRR5L:

    Proline rich 5 like
    Hs.19987  [show with all ESTs]
    Unigene Representative Sequence: NM_001160167
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000531269 ENST00000529034 ENST00000530639 ENST00000527172 ENST00000532121
    ENST00000526728 ENST00000378867(uc001mwo.4 uc001mwp.3 uc010rfc.2)
    ENST00000389693 ENST00000524380 ENST00000526682 ENST00000532843 ENST00000527751
    ENST00000530252 ENST00000532578 ENST00000530050 ENST00000526679 ENST00000527487
    ENST00000525672
    miRNA
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    Block miRNA regulation of human, mouse, rat PRR5L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRR5L (see all 22):
    hsa-miR-148b hsa-miR-301a hsa-miR-1297 hsa-miR-205* hsa-miR-26b hsa-miR-548c-3p hsa-miR-450b-5p hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidPRR5L 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PRR5L
    Predesigned siRNA for gene silencing in human, mouse, rat PRR5L
    Clone
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    OriGene ORF clones in mouse, rat for PRR5L
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): PRR5L (NM_024841)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRR5L
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat PRR5L
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PRR5L
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat PRR5L
      QuantiTect SYBR Green Assays in human, mouse, rat PRR5L
      QuantiFast Probe-based Assays in human, mouse, rat PRR5L

    Additional mRNA sequence: 

    AK024275.1 AK055042.1 BC008922.2 BC125122.1 BX640959.1 

    20 DOTS entries:

    DT.97795024  DT.91680631  DT.120719849  DT.308171  DT.120719944  DT.100739788  DT.91676606  DT.92414829 
    DT.120719860  DT.120719999  DT.95168337  DT.120720029  DT.97813477  DT.102825199  DT.120719880  DT.120720010 
    DT.91884244  DT.95074932  DT.40220837  DT.92052689 

    Selected AceView cDNA sequences (see all 62):

    AI811432 T39395 BX479617 AI924247 BM824457 AU131980 AI732355 BC008922 
    BM457495 AI738715 NM_024841 BG122846 BQ919225 AK055042 AA573376 BI600625 
    BG283215 BI602384 BM764639 BM765128 BF570179 BG117238 BF569194 N45568 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRR5L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTCCTATG
    PRR5L Expression
    About this image


    PRR5L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Lung (Respiratory System)
             Basal Cells Trachea
     
     Blood (Hematopoietic System)
             pre Conventional Dendritic Cells Peripheral Blood
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
    PRR5L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRR5L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.19987
        Custom PCR Arrays for PRR5L
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRR5L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PRR5L gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prr5l1 , 5 proline rich 5 like1, 5 89.13(n)1
    91.58(a)1
      2 (53.93 cM)5
    724461  NM_001083810.21  NP_001077279.11 
     1017162415 
    chicken
    (Gallus gallus)
    Aves PRR5L1 proline rich 5 like 73.55(n)
    77.13(a)
      423162  XM_004941549.1  XP_004941606.1 
    lizard
    (Anolis carolinensis)
    Reptilia PRR5L6
    proline rich 5 like
    71(a)
    1 ↔ 1
    1(53593730-53678229)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia prr5l1 proline rich 5 like 69.03(n)
    68.44(a)
      100380146  XM_004913347.1  XP_004913404.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5576341 proline-rich protein 5-like 58.06(n)
    56.68(a)
      557634  XM_680728.5  XP_685820.3 


    ENSEMBL Gene Tree for PRR5L (if available)
    TreeFam Gene Tree for PRR5L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRR5L gene
    PRR52  
    1 SIMAP similar gene for PRR5L using alignment to 10 protein entries:     PRR5L_HUMAN (see all proteins):
    PRR5

    PRR5L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRR5L (see all 3831)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1828175391,2
    C--36315772(+) GCTTAA/TATAAA 1 -- us2k10--------
    rs1863089181,2
    --36315783(+) CTCCTA/CTTCTC 1 -- us2k10--------
    rs1129575741,2
    C--36315871(+) TCCTGC/TAGTCC 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs679472691,2
    C,F--36315898(+) GCCACC/TCTCCT 1 -- us2k12Minor allele frequency- T:0.15NA EA 240
    rs127964051,2
    C,F,H--36315922(+) TTTCCC/TTTTTC 1 -- us2k1 trp322Minor allele frequency- T:0.18NS EA NA WA 2522
    rs127969831,2
    C,F,H--36316021(+) TTGACG/ATGGCC 1 -- us2k1 tfbs37Minor allele frequency- A:0.01NS EA NA 426
    rs110335361,2
    C,F,H--36316044(+) CAGTCG/Atctta 1 -- us2k16Minor allele frequency- A:0.03NS EA WA 538
    rs1829285391,2
    --36316060(+) TATGGA/GCTAAT 1 -- us2k10--------
    rs113560551,2
    C--36316093(+) GTGGC-/TTTATC 1 -- us2k12Minor allele frequency- T:0.25NA CSA 4
    rs64848341,2
    C,F,A,H--36316168(+) ATTCTG/ATGTTT 1 -- us2k129Minor allele frequency- A:0.44NS EA NA WA CSA 2906

    HapMap Linkage Disequilibrium report for PRR5L (36317725 - 36486754 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PRR5L (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422305CNV Duplication17116639
    esv268359CNV Insertion20981092
    esv2475332CNV Insertion19546169
    esv273811CNV Insertion20981092
    esv27622CNV Loss19812545
    nsv518499CNV Loss19592680
    esv32924CNV Loss17666407
    nsv526434CNV Loss19592680
    esv33552CNV Gain17666407
    esv32890CNV Gain17666407

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRR5L
    DNA2.0 Custom Variant and Variant Library Synthesis for PRR5L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611728    OMIM disorders: --

    1 disease for PRR5L:    
    About MalaCards
    tuberous sclerosis


    PRR5L for disorders           About GeneDecksing

    Genetic Association Database (GAD): PRR5L
    Human Genome Epidemiology (HuGE) Navigator: PRR5L (1 document)

    Export disorders for PRR5L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRR5L gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with PRR5L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of Protor as a novel Rictor-binding component of mTOR complex-2. (PubMed id 17461779)1, 2, 3 Pearce L.R.... Alessi D.R. (Biochem. J. 2007)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Protor-2 interacts with tristetraprolin to regulate mRNA stability during stress. (PubMed id 21964062)1 Holmes B....Gera J. (Cell. Signal. 2012)
    5. PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12. (PubMed id 22609986)2 Gan X.... Wu D. (Nat. Cell Biol. 2012)
    6. Hsp70 associates with Rictor and is required for mTORC2 formation and activity. (PubMed id 18505677)1 Martin J....Gera J. (Biochem. Biophys. Res. Commun. 2008)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79899 HGNC: 25878 AceView: FLJ14213 Ensembl:ENSG00000135362 euGenes: HUgn79899
    ECgene: PRR5L H-InvDB: PRR5L

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRR5L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRR5L gene:
    Search GeneIP for patents involving PRR5L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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