Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRR5L Gene

protein-coding   GIFtS: 48
GCID: GC11P036355

proline rich 5 like
 Explore 1 disease affiliated with
PRR5L via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PRR5L    

Aliases
for PRR5L gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Proline Rich 5 Like1 2     PROTOR-21
PROTOR22 3 5     Proline-Rich Protein 5-Like2
Protein Observed With Rictor-22 3     Protor-23
FLJ142131 5     Protor-23

External Ids:    HGNC: 258781   Entrez Gene: 798992   Ensembl: ENSG000001353627   OMIM: 6117285   UniProtKB: Q6MZQ03   

Export aliases for PRR5L gene to outside databases

Previous GC identifer: GC11P036017


Summaries
for PRR5L gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: PRR5L_HUMAN, Q6MZQ0
Function: May be part of the TORC2 complex which plays a critical role in AKT1 'Ser-473' phosphorylation, and may
modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization




Genomic Views
for PRR5L gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for PRR5L
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for PRR5L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRR5L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13-p12   Ensembl cytogenetic band:  11p13   HGNC cytogenetic band: 11p13-p12

PRR5L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRR5L gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P036355:  view genomic region     (about GC identifiers)

Start:
 36,317,725 bp from pter      End:
 36,486,754 bp from pter
Size:
 169,030 bases      Orientation:
 plus strand

Proteins
for PRR5L gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PRR5L_HUMAN, Q6MZQ0 (See protein sequence)
Recommended Name: Proline-rich protein 5-like  
Size: 368 amino acids; 40836 Da
Subunit: May replace PRR5 in the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5,
RICTOR, MAPKAP1 and DEPTOR
Sequence caution: Sequence=AAI25123.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A4QN22 E9PKY1 Q96H46 Q9H7V4
Alternative splicing: 4 isoforms:  Q6MZQ0-1   Q6MZQ0-2   Q6MZQ0-3   Q6MZQ0-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PRR5L: NX_Q6MZQ0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6MZQ0

    • PRR5L Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001153639.1  NP_001153640.1  NP_001153641.1  NP_079117.3  

    ENSEMBL proteins: 
     ENSP00000435050   ENSP00000433708   ENSP00000433893   ENSP00000431610   ENSP00000368144  
     ENSP00000433305   ENSP00000436485   ENSP00000431475   ENSP00000432203   ENSP00000436402  
     ENSP00000435241   ENSP00000310103  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 2): PRR5L
    OriGene Custom Protein Services for PRR5L 
    GenScript Custom Purified and Recombinant Proteins Services for PRR5L
    Novus Biologicals PRR5L Protein
    Novus Biologicals PRR5L Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PRR5L

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--


    PRR5L for ontologies           About GeneDecksing



    PRR5L Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for PRR5L  (PROTOR2)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PRR5L 
    GenScript Custom Superior Antibodies Services for PRR5L
    Novus Biologicals PRR5L Antibodies
    Search for Antibodies for PRR5L at Abcam  
    Uscn Antibodies for PRR5L
    ThermoFisher Antibodies for PRR5L

    Assay Products for PRR5L: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PRR5L
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PRR5L

    Protein Domains /
    Families
    for PRR5L gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PRR5L for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR013745 HbrB

    Graphical View of Domain Structure for InterPro Entry Q6MZQ0

    ProtoNet protein and cluster: Q6MZQ0

    UniProtKB/Swiss-Prot: PRR5L_HUMAN, Q6MZQ0
    Similarity: Belongs to the PROTOR family


    Function
    for PRR5L gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PRR5L_HUMAN, Q6MZQ0
    Function: May be part of the TORC2 complex which plays a critical role in AKT1 'Ser-473' phosphorylation, and may
    modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 4): PRR5L
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRR5L
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate PRR5L (see all 22):
    hsa-miR-148b hsa-miR-301a hsa-miR-1297 hsa-miR-205* hsa-miR-26b hsa-miR-548c-3p hsa-miR-450b-5p hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmid: PRR5L 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRR5L (see all 4)
    OriGene shRNA RFP: PRR5L
    OriGene siRNA: PRR5L
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRR5L

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PRR5L

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRR5L (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRR5L (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): PRR5L (NM_024841)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRR5L
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat PRR5L 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for PRR5L
    Search LifeMap BioReagents cell lines for PRR5L

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRR5L

    2 GenomeRNAi human phenotypes for PRR5L:
     Decreased viability with pacli  Increased S DNA content 


    Pathways & Interactions
    for PRR5L gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PI3K / Akt Signaling
    		PI3K / Akt Signaling1.00
    2mTOR signalling
    		TOR signaling0.33

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for PRR5L
        PI3K / Akt Signaling

    1 BioSystems Pathway for PRR5L 
        TOR signaling



    PRR5L for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PRR5L

    4 Interacting proteins for PRR5L (Q6MZQ03) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RICTORQ6R3273I2D: score=3 
    MAPKAP1Q9BPZ73I2D: score=2 
    MLST8Q9BVC43I2D: score=2 
    MTORP423453I2D: score=2 
    About this table

    Drugs & Compounds
    for PRR5L gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PRR5L
    Search CenterWatch for drugs/clinical trials and news about PRR5L 

    Transcripts
    for PRR5L gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PRR5L gene (4 alternative transcripts): 
    NM_001160167.1  NM_001160168.1  NM_001160169.1  NM_024841.4  

    Unigene Cluster for PRR5L:

    Proline rich 5 like
    Hs.19987  [show with all ESTs]
    Unigene Representative Sequence: NM_001160167
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000531269 ENST00000529034 ENST00000530639 ENST00000527172 ENST00000532121
    ENST00000526728 ENST00000378867(uc001mwo.4 uc001mwp.3 uc010rfc.2)
    ENST00000389693 ENST00000524380 ENST00000526682 ENST00000532843 ENST00000527751
    ENST00000530252 ENST00000532578 ENST00000530050 ENST00000526679 ENST00000527487
    ENST00000525672

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 4): PRR5L
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRR5L
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate PRR5L (see all 22):
    hsa-miR-148b hsa-miR-301a hsa-miR-1297 hsa-miR-205* hsa-miR-26b hsa-miR-548c-3p hsa-miR-450b-5p hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmid: PRR5L 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRR5L (see all 4)
    OriGene shRNA RFP: PRR5L
    OriGene siRNA: PRR5L
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRR5L
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRR5L (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRR5L (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): PRR5L (NM_024841)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRR5L
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat PRR5L 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRR5L
    Browse OriGene validated miRNA SYBR primer pairs
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat PRR5L
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRR5L
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRR5L

    Additional cDNA sequence: 

    AK024275.1 AK055042.1 BC008922.2 BC125122.1 BX640959.1 

    20 DOTS entries:

    DT.97795024  DT.91680631  DT.120719849  DT.308171  DT.120719944  DT.100739788  DT.91676606  DT.92414829 
    DT.120719860  DT.120719999  DT.95168337  DT.120720029  DT.97813477  DT.102825199  DT.120719880  DT.120720010 
    DT.91884244  DT.95074932  DT.40220837  DT.92052689 

    24/62 AceView cDNA sequences (see all 62):

    AU131980 T39395 AI811432 BX479617 BM824457 AI924247 BC008922 BI602384 
    BE744094 AW473414 BG122846 AI732355 AK055042 AA573376 BM765128 BG117238 
    BQ927099 BI822067 T40553 BG545687 BX956829 BM798151 BQ951066 AK024275 

    GeneLoc Exon Structure


    Expression
    for PRR5L gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRR5L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTTTCCTATG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PRR5L expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyRenal VesicleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

    See PRR5L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRR5L

    SOURCE GeneReport for Unigene cluster: Hs.19987
        SABiosciences Custom PCR Arrays for PRR5L
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRR5L
    Browse OriGene validated miRNA SYBR primer pairs
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat PRR5L
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRR5L
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRR5L
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRR5L

    Orthologs
    for PRR5L gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for PRR5L gene from 3/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PRR5L1 proline rich 5 like 74.66(n)
    78.51(a)    		   423162  XM_003641383.1  XP_003641431.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PRR5L6
    		 --
    		 69(a)
    		 1 ↔ 1
    		 1(53593730-53648942)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5576341 proline-rich protein 5-like 56.7(n)
    55.43(a)    		   557634  XM_680728.4  XP_685820.3 


    ENSEMBL Gene Tree for PRR5L (if available)
    TreeFam Gene Tree for PRR5L (if available) 

    Paralogs
    for PRR5L gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRR5L gene
    PRR52  
    1 SIMAP similar gene for PRR5L using alignment to 10 protein entries:     PRR5L_HUMAN (see all proteins):
    PRR5

    PRR5L for paralogs           About GeneDecksing



    Genomic Variants
    for PRR5L gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3347 NCBI SNPs in PRR5L are shown (see all 3347)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1828175391,2
    		--36315772(+) GCTTAA/TATAAA 1 -- us2k10--------
    rs1863089181,2
    		--36315783(+) CTCCTA/CTTCTC 1 -- us2k10--------
    rs679472691,2
    		C,F,--36315898(+) GCCACC/TCTCCT 1 -- us2k12Minor allele frequency- T:0.15NA EA 240
    rs127964051,2
    		C,F,H,--36315922(+) TTTCCC/TTTTTC 1 -- us2k1 trp322Minor allele frequency- T:0.18NS EA NA WA 2522
    rs127969831,2
    		C,F,H,--36316021(+) TTGACG/ATGGCC 1 -- us2k1 tfbs37Minor allele frequency- A:0.01NS EA NA 426
    rs110335361,2
    		C,F,H,--36316044(+) CAGTCG/Atctta 1 -- us2k16Minor allele frequency- A:0.03NS EA WA 538
    rs1829285391,2
    		--36316060(+) TATGGA/GCTAAT 1 -- us2k10--------
    rs113560551,2
    		C,--36316093(+) GTGGC-/TTTATC 1 -- us2k12Minor allele frequency- T:0.25NA CSA 4
    rs64848341,2
    		C,F,A,H,--36316168(+) ATTCTG/ATGTTT 1 -- us2k129Minor allele frequency- A:0.44NS EA NA WA CSA 2906
    rs64848351,2
    		C,F,A,H,--36316183(+) AGGACG/AGTTTC 1 -- us2k132Minor allele frequency- A:0.24NS EA NA WA CSA 3330

    HapMap Linkage Disequilibrium report for PRR5L (36317725 - 36486754 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 21 variations for PRR5L
         14 CNVs: 75597 85724 75602 75603 75600 75595 75596 75601 5274 75599 71309 85723 85722 75598
         5 Indels: 11049 11048 101183 11050 60043
         2 Inversions: 43708 59692

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRR5L
    DNA2.0 Custom Variant and Variant Library Synthesis for PRR5L

    Disorders / Diseases
    for PRR5L gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PRR5L for disorders           About GeneDecksing

    OMIM gene information: 611728    OMIM disorders: --

    1 disease for PRR5L:    About MalaCards
    tuberous sclerosis

    Human Genome Epidemiology (HuGE) Navigator: PRR5L (1 document)

    Export disorders for PRR5L gene to outside databases

    Publications
    for PRR5L gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRR5L gene integrated from 9 sources:
    (articles sorted by number of sources associating them with PRR5L)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of Protor as a novel Rictor-binding component of mTOR complex-2. (PubMed id 17461779)1, 2, 3 Pearce L.R.... Alessi D.R. (2007)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Protor-2 interacts with tristetraprolin to regulate mR NA stability during stress. (PubMed id 21964062)1 Holmes B....Gera J. (2012)
    4. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    7. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for PRR5L gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PRR5L gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79899 HGNC: 25878 AceView: FLJ14213 Ensembl:ENSG00000135362 euGenes: HUgn79899
    ECgene: PRR5L H-InvDB: PRR5L

    Other Databases showing PRR5L gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PRR5L gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRR5L Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PRR5L gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PRR5L gene:
    Search GeneIP for patents involving PRR5L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for PRR5L gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for PRR5L  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRR5L   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRR5L  
     OriGene Protein Over-expression Lysate for PRR5L   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for PRR5L   OriGene 3'-UTR Clone for PRR5L  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRR5L   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRR5L  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PRR5L   OriGene Custom Protein Services for PRR5L  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PRR5L
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRR5L
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRR5L
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRR5L
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRR5L
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRR5L
     GenScript Custom Purified and Recombinant Proteins Services for PRR5L GenScript cDNA clones with any tag delivered in your preferred vector for PRR5L
     GenScript Custom Assay Services for PRR5L GenScript Custom Superior Antibodies Services for PRR5L
     GenScript Custom overexpressing Cell Line Services for PRR5L CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for PRR5L  (PROTOR2)

     Search Regulatory tfbs for PRR5L
     Search Chromatin IP Primers for PRR5L
     Search RT2 qPCR Primer Assays in human, mouse, rat PRR5L
     Search GNC Networks for PRR5L
     SABiosciences Custom PCR Arrays for PRR5L
     Search Tocris compounds for PRR5L
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PRR5L antibodies
     PRR5L proteins
     PRR5L lysates
     Search for Antibodies for PRR5L at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for PRR5L
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     PRR5L Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for PRR5L
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRR5L
     SwitchGear 3'UTR luciferase reporter plasmids for PRR5L
     Browse SwitchGear Promoter luciferase reporter plasmids for PRR5L
     ThermoFisher Antibodies for PRR5L
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat PRR5L
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      PRR5L gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4