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Aliases for PRR5L Gene

Aliases for PRR5L Gene

  • Proline Rich 5 Like 2 3 5
  • Protein Observed With Rictor-2 2 3 4
  • Protor-2 3 4
  • PROTOR2 3 4

External Ids for PRR5L Gene

Previous GeneCards Identifiers for PRR5L Gene

  • GC11P036017

Summaries for PRR5L Gene

GeneCards Summary for PRR5L Gene

PRR5L (Proline Rich 5 Like) is a Protein Coding gene. Among its related pathways are PI3K / Akt Signaling and mTOR signalling. GO annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is PRR5.

UniProtKB/Swiss-Prot for PRR5L Gene

  • Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton. Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRR5L Gene

Genomics for PRR5L Gene

Regulatory Elements for PRR5L Gene

Enhancers for PRR5L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRR5L on UCSC Golden Path with GeneCards custom track

Genomic Location for PRR5L Gene

Chromosome:
11
Start:
36,296,175 bp from pter
End:
36,465,204 bp from pter
Size:
169,030 bases
Orientation:
Plus strand

Genomic View for PRR5L Gene

Genes around PRR5L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRR5L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRR5L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRR5L Gene

Proteins for PRR5L Gene

  • Protein details for PRR5L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6MZQ0-PRR5L_HUMAN
    Recommended name:
    Proline-rich protein 5-like
    Protein Accession:
    Q6MZQ0
    Secondary Accessions:
    • A4QN22
    • E9PKY1
    • Q96H46
    • Q9H7V4

    Protein attributes for PRR5L Gene

    Size:
    368 amino acids
    Molecular mass:
    40836 Da
    Quaternary structure:
    • Interacts with the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Interacts with RFFL.
    SequenceCaution:
    • Sequence=AAI25123.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PRR5L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRR5L Gene

Proteomics data for PRR5L Gene at MOPED

Post-translational modifications for PRR5L Gene

  • Ubiquitinated. Ubiquitination by RFFL promotes proteasomal degradation of PRR5L thereby modifying the substrate-specific activity of the mTORC2 complex. Ubiquitination by RFFL is stimulated by LPA/lysophosphatidic acid.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRR5L (PROTOR2)

No data available for DME Specific Peptides for PRR5L Gene

Domains & Families for PRR5L Gene

Protein Domains for PRR5L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRR5L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6MZQ0

UniProtKB/Swiss-Prot:

PRR5L_HUMAN :
  • Belongs to the PROTOR family.
Family:
  • Belongs to the PROTOR family.
genes like me logo Genes that share domains with PRR5L: view

No data available for Gene Families for PRR5L Gene

Function for PRR5L Gene

Molecular function for PRR5L Gene

UniProtKB/Swiss-Prot Function:
Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton. Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration.

Phenotypes for PRR5L Gene

GenomeRNAi human phenotypes for PRR5L:
genes like me logo Genes that share phenotypes with PRR5L: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRR5L Gene

Localization for PRR5L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRR5L Gene COMPARTMENTS Subcellular localization image for PRR5L gene
Compartment Confidence
mitochondrion 4
cytosol 2
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PRR5L Gene

Pathways & Interactions for PRR5L Gene

SuperPathways for PRR5L Gene

genes like me logo Genes that share pathways with PRR5L: view

Pathways by source for PRR5L Gene

1 Cell Signaling Technology pathway for PRR5L Gene
1 BioSystems pathway for PRR5L Gene

Gene Ontology (GO) - Biological Process for PRR5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IMP 22609986
GO:0009968 negative regulation of signal transduction IEA --
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA --
genes like me logo Genes that share ontologies with PRR5L: view

No data available for SIGNOR curated interactions for PRR5L Gene

Drugs & Compounds for PRR5L Gene

No Compound Related Data Available

Transcripts for PRR5L Gene

Unigene Clusters for PRR5L Gene

Proline rich 5 like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRR5L Gene

No ASD Table

Relevant External Links for PRR5L Gene

GeneLoc Exon Structure for
PRR5L
ECgene alternative splicing isoforms for
PRR5L

Expression for PRR5L Gene

mRNA expression in normal human tissues for PRR5L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRR5L Gene

This gene is overexpressed in Colon - Transverse (x7.1), Spleen (x6.2), and Brain - Spinal cord (cervical c-1) (x5.4).

SOURCE GeneReport for Unigene cluster for PRR5L Gene Hs.19987

genes like me logo Genes that share expression patterns with PRR5L: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PRR5L Gene

Orthologs for PRR5L Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRR5L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRR5L 35
  • 90.04 (n)
  • 92.66 (a)
PRR5L 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRR5L 35
  • 87.86 (n)
  • 88.86 (a)
PRR5L 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prr5l 35
  • 89.13 (n)
  • 91.58 (a)
Prr5l 16
Prr5l 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRR5L 35
  • 99.28 (n)
  • 99.46 (a)
PRR5L 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prr5l 35
  • 88.22 (n)
  • 90.22 (a)
oppossum
(Monodelphis domestica)
Mammalia PRR5L 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRR5L 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRR5L 35
  • 73.55 (n)
  • 77.13 (a)
PRR5L 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRR5L 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prr5l 35
  • 69.03 (n)
  • 68.44 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC557634 35
  • 58.06 (n)
  • 56.68 (a)
PRR5L 36
  • 54 (a)
OneToOne
Species with no ortholog for PRR5L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRR5L Gene

ENSEMBL:
Gene Tree for PRR5L (if available)
TreeFam:
Gene Tree for PRR5L (if available)

Paralogs for PRR5L Gene

Paralogs for PRR5L Gene

(1) SIMAP similar genes for PRR5L Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with PRR5L: view

Variants for PRR5L Gene

Sequence variations from dbSNP and Humsavar for PRR5L Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs330261 - 36,401,242(-) CCGAG(C/T)TGCTT intron-variant, reference, missense
rs11033639 - 36,462,617(+) GCTTC(C/T)CCCCG reference, missense, utr-variant-3-prime
rs525634 -- 36,370,332(-) tttac(A/C)taggg intron-variant
rs559243 -- 36,389,542(-) CCTCT(A/G)CAGCT intron-variant
rs563010 -- 36,389,118(-) TGCAG(C/T)CTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRR5L Gene

Variant ID Type Subtype PubMed ID
esv2422305 CNV Duplication 17116639
nsv467791 CNV Gain 19166990
nsv526434 CNV Loss 19592680
esv2475332 CNV Insertion 19546169
esv3692 OTHER Inversion 18987735
esv9649 OTHER Inversion 19470904
esv32924 CNV Loss 17666407
esv273811 CNV Insertion 20981092
esv268359 CNV Insertion 20981092
esv33552 CNV Gain 17666407
esv32890 CNV Gain 17666407
esv8636 CNV Gain 19470904
esv27622 CNV Loss 19812545
nsv518499 CNV Loss 19592680

Variation tolerance for PRR5L Gene

Residual Variation Intolerance Score: 81.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.05; 68.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRR5L Gene

HapMap Linkage Disequilibrium report
PRR5L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRR5L Gene

Disorders for PRR5L Gene

Relevant External Links for PRR5L

Genetic Association Database (GAD)
PRR5L
Human Genome Epidemiology (HuGE) Navigator
PRR5L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRR5L

No disorders were found for PRR5L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRR5L Gene

Publications for PRR5L Gene

  1. Identification of Protor as a novel Rictor-binding component of mTOR complex-2. (PMID: 17461779) Pearce L.R. … Alessi D.R. (Biochem. J. 2007) 2 3 4 67
  2. Protor-2 interacts with tristetraprolin to regulate mRNA stability during stress. (PMID: 21964062) Holmes B. … Gera J. (Cell. Signal. 2012) 3
  3. PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12. (PMID: 22609986) Gan X. … Wu D. (Nat. Cell Biol. 2012) 3
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3
  5. Hsp70 associates with Rictor and is required for mTORC2 formation and activity. (PMID: 18505677) Martin J. … Gera J. (Biochem. Biophys. Res. Commun. 2008) 3

Products for PRR5L Gene

Sources for PRR5L Gene

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