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Aliases for PRR5L Gene

Aliases for PRR5L Gene

  • Proline Rich 5 Like 2 3 5
  • Protein Observed With Rictor-2 2 3 4
  • Protor-2 3 4
  • PROTOR2 3 4
  • Proline-Rich Protein 5-Like 3

External Ids for PRR5L Gene

Previous GeneCards Identifiers for PRR5L Gene

  • GC11P036017

Summaries for PRR5L Gene

GeneCards Summary for PRR5L Gene

PRR5L (Proline Rich 5 Like) is a Protein Coding gene. Among its related pathways are mTOR signalling and PI3K / Akt Signaling. GO annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is PRR5.

UniProtKB/Swiss-Prot for PRR5L Gene

  • Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton (PubMed:17461779). Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration (PubMed:22609986). Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF-alpha and GM-CSF, in response to stress (PubMed:21964062). Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress (PubMed:21964062).

Additional gene information for PRR5L Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRR5L Gene

Genomics for PRR5L Gene

Regulatory Elements for PRR5L Gene

Enhancers for PRR5L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H036408 1.7 FANTOM5 Ensembl ENCODE dbSUPER 35.3 +114.8 114769 5 HDAC1 PKNOX1 ATF1 NFRKB ZBTB40 RFX5 ELK1 FOS ATF7 ETV6 PRR5L TRAF6 COMMD9 ENSG00000255060 ENSG00000255186
GH11H036360 1.2 Ensembl ENCODE dbSUPER 17.2 +66.5 66515 4 TBP KLF1 JUN TSC22D4 ZMYM3 BATF POLR2A RCOR1 ETV6 RUNX3 PRR5L ENSG00000255060 COMMD9 PIR61917 GC11P036377
GH11H036419 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12 +125.3 125343 3 HDAC1 PKNOX1 RAD21 BRCA1 RFX5 GATA2 RCOR1 FOS IKZF2 DEK PRR5L COMMD9 TRAF6 ENSG00000255060 ENSG00000255186
GH11H036499 1 Ensembl ENCODE 17.5 +205.4 205372 4 HDGF ATF1 JUN KLF17 BATF FOSL1 ZNF366 EED FOS ZNF600 PRR5L ENSG00000255060 TRAF6 GC11M036483
GH11H036349 1 Ensembl ENCODE dbSUPER 16.7 +53.7 53736 0 ZFHX2 EGR1 ZSCAN4 EGR2 PRR5L ENSG00000255060 PIR61917 ENSG00000254566
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRR5L on UCSC Golden Path with GeneCards custom track

Genomic Location for PRR5L Gene

Chromosome:
11
Start:
36,296,175 bp from pter
End:
36,465,204 bp from pter
Size:
169,030 bases
Orientation:
Plus strand

Genomic View for PRR5L Gene

Genes around PRR5L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRR5L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRR5L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRR5L Gene

Proteins for PRR5L Gene

  • Protein details for PRR5L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6MZQ0-PRR5L_HUMAN
    Recommended name:
    Proline-rich protein 5-like
    Protein Accession:
    Q6MZQ0
    Secondary Accessions:
    • A4QN22
    • E9PKY1
    • Q96H46
    • Q9H7V4

    Protein attributes for PRR5L Gene

    Size:
    368 amino acids
    Molecular mass:
    40836 Da
    Quaternary structure:
    • Interacts with the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR (PubMed:17461779). Interacts with RFFL (PubMed:22609986). Interacts (via C-terminus) with ZFP36 (via C-terminus); this interaction may accelerate ZFP36-mediated mRNA decay during stress (PubMed:21964062). Interacts with RICTOR (PubMed:21964062).
    SequenceCaution:
    • Sequence=AAI25123.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PRR5L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRR5L Gene

Post-translational modifications for PRR5L Gene

  • Ubiquitinated. Ubiquitination by RFFL promotes proteasomal degradation of PRR5L thereby modifying the substrate-specific activity of the mTORC2 complex. Ubiquitination by RFFL is stimulated by LPA/lysophosphatidic acid.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PRR5L Gene

Domains & Families for PRR5L Gene

Gene Families for PRR5L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PRR5L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRR5L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6MZQ0

UniProtKB/Swiss-Prot:

PRR5L_HUMAN :
  • Belongs to the PROTOR family.
Family:
  • Belongs to the PROTOR family.
genes like me logo Genes that share domains with PRR5L: view

Function for PRR5L Gene

Molecular function for PRR5L Gene

UniProtKB/Swiss-Prot Function:
Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton (PubMed:17461779). Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration (PubMed:22609986). Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF-alpha and GM-CSF, in response to stress (PubMed:21964062). Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress (PubMed:21964062).

Phenotypes From GWAS Catalog for PRR5L Gene

Gene Ontology (GO) - Molecular Function for PRR5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21964062
GO:0031625 ubiquitin protein ligase binding IPI 22609986
genes like me logo Genes that share ontologies with PRR5L: view

Phenotypes for PRR5L Gene

GenomeRNAi human phenotypes for PRR5L:
genes like me logo Genes that share phenotypes with PRR5L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRR5L Gene

Localization for PRR5L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRR5L gene
Compartment Confidence
mitochondrion 4
cytosol 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRR5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0031932 TORC2 complex IDA 22609986
genes like me logo Genes that share ontologies with PRR5L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PRR5L Gene

Pathways & Interactions for PRR5L Gene

genes like me logo Genes that share pathways with PRR5L: view

Pathways by source for PRR5L Gene

1 Cell Signaling Technology pathway for PRR5L Gene
1 BioSystems pathway for PRR5L Gene

Gene Ontology (GO) - Biological Process for PRR5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IMP 22609986
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0009968 negative regulation of signal transduction IEA --
GO:0010762 regulation of fibroblast migration IMP 22609986
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA --
genes like me logo Genes that share ontologies with PRR5L: view

No data available for SIGNOR curated interactions for PRR5L Gene

Drugs & Compounds for PRR5L Gene

No Compound Related Data Available

Transcripts for PRR5L Gene

Unigene Clusters for PRR5L Gene

Proline rich 5 like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRR5L Gene

No ASD Table

Relevant External Links for PRR5L Gene

GeneLoc Exon Structure for
PRR5L
ECgene alternative splicing isoforms for
PRR5L

Expression for PRR5L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRR5L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRR5L Gene

This gene is overexpressed in Colon - Transverse (x7.1), Spleen (x6.2), and Brain - Spinal cord (cervical c-1) (x5.4).

NURSA nuclear receptor signaling pathways regulating expression of PRR5L Gene:

PRR5L

SOURCE GeneReport for Unigene cluster for PRR5L Gene:

Hs.19987

Evidence on tissue expression from TISSUES for PRR5L Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with PRR5L: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRR5L Gene

Orthologs for PRR5L Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRR5L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRR5L 33 34
  • 99.28 (n)
cow
(Bos Taurus)
Mammalia PRR5L 33 34
  • 90.04 (n)
mouse
(Mus musculus)
Mammalia Prr5l 33 16 34
  • 89.13 (n)
rat
(Rattus norvegicus)
Mammalia Prr5l 33
  • 88.22 (n)
dog
(Canis familiaris)
Mammalia PRR5L 33 34
  • 87.86 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PRR5L 34
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRR5L 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRR5L 33 34
  • 73.55 (n)
lizard
(Anolis carolinensis)
Reptilia PRR5L 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prr5l 33
  • 69.03 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC557634 33
  • 58.06 (n)
PRR5L 34
  • 54 (a)
OneToOne
Species where no ortholog for PRR5L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRR5L Gene

ENSEMBL:
Gene Tree for PRR5L (if available)
TreeFam:
Gene Tree for PRR5L (if available)

Paralogs for PRR5L Gene

Paralogs for PRR5L Gene

(1) SIMAP similar genes for PRR5L Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with PRR5L: view

Variants for PRR5L Gene

Sequence variations from dbSNP and Humsavar for PRR5L Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000024820 -- 36,427,670(+) CCCCA(C/T)AGATG intron-variant
rs1000026773 -- 36,387,930(+) TTTTT(C/G)GACTT intron-variant
rs1000033104 -- 36,341,600(+) CTCCC(A/G)ATTCT intron-variant
rs1000047848 -- 36,410,881(+) GCACT(C/G)ACCAG intron-variant
rs1000065678 -- 36,347,372(+) ACCAT(A/C)AGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRR5L Gene

Variant ID Type Subtype PubMed ID
dgv341e212 CNV loss 25503493
esv2422305 CNV duplication 17116639
esv2475332 CNV insertion 19546169
esv2761662 CNV loss 21179565
esv27622 CNV loss 19812545
esv2762906 CNV loss 21179565
esv32890 CNV gain 17666407
esv32924 CNV loss 17666407
esv3304080 CNV mobile element insertion 20981092
esv3309539 CNV mobile element insertion 20981092
esv33552 CNV gain 17666407
esv3385094 OTHER inversion 20981092
esv3414530 CNV duplication 20981092
esv3421257 CNV duplication 20981092
esv3425565 CNV insertion 20981092
esv3578616 CNV gain 25503493
esv3692 OTHER inversion 18987735
esv8636 CNV gain 19470904
esv9649 OTHER inversion 19470904
nsv1042014 CNV loss 25217958
nsv1046452 CNV gain 25217958
nsv1111054 CNV tandem duplication 24896259
nsv1119419 CNV insertion 24896259
nsv1140474 CNV tandem duplication 24896259
nsv1145515 CNV deletion 24896259
nsv467791 CNV gain 19166990
nsv518499 CNV loss 19592680
nsv526434 CNV loss 19592680
nsv554003 CNV gain 21841781

Variation tolerance for PRR5L Gene

Residual Variation Intolerance Score: 81.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.05; 68.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRR5L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRR5L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRR5L Gene

Disorders for PRR5L Gene

Relevant External Links for PRR5L

Genetic Association Database (GAD)
PRR5L
Human Genome Epidemiology (HuGE) Navigator
PRR5L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRR5L

No disorders were found for PRR5L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRR5L Gene

Publications for PRR5L Gene

  1. Identification of Protor as a novel Rictor-binding component of mTOR complex-2. (PMID: 17461779) Pearce LR … Alessi DR (The Biochemical journal 2007) 2 3 4 60
  2. PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12. (PMID: 22609986) Gan X … Wu D (Nature cell biology 2012) 3 4 60
  3. Protor-2 interacts with tristetraprolin to regulate mRNA stability during stress. (PMID: 21964062) Holmes B … Gera J (Cellular signalling 2012) 3 4 60
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for PRR5L Gene

Sources for PRR5L Gene

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