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Aliases for PRR5L Gene

Aliases for PRR5L Gene

  • Proline Rich 5 Like 2 3
  • Protein Observed With Rictor-2 2 3 4
  • PROTOR2 3 4 6
  • Protor-2 3 4
  • Proline-Rich Protein 5-Like 3
  • FLJ14213 6

External Ids for PRR5L Gene

Summaries for PRR5L Gene

GeneCards Summary for PRR5L Gene

PRR5L (Proline Rich 5 Like) is a Protein Coding gene. Among its related pathways are PI3K / Akt Signaling and Insulin receptor signalling cascade. An important paralog of this gene is PRR5.

UniProtKB/Swiss-Prot for PRR5L Gene

  • Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton. Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRR5L Gene

Genomics for PRR5L Gene

Genomic Location for PRR5L Gene

Start:
36,296,175 bp from pter
End:
36,465,204 bp from pter
Size:
169,030 bases
Orientation:
Plus strand

Genomic View for PRR5L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRR5L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRR5L Gene

No data available for Regulatory Elements for PRR5L Gene

Proteins for PRR5L Gene

  • Protein details for PRR5L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6MZQ0-PRR5L_HUMAN
    Recommended name:
    Proline-rich protein 5-like
    Protein Accession:
    Q6MZQ0
    Secondary Accessions:
    • A4QN22
    • E9PKY1
    • Q96H46
    • Q9H7V4

    Protein attributes for PRR5L Gene

    Size:
    368 amino acids
    Molecular mass:
    40836 Da
    Quaternary structure:
    • Interacts with the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Interacts with RFFL.
    SequenceCaution:
    • Sequence=AAI25123.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PRR5L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRR5L Gene

Proteomics data for PRR5L Gene at MOPED

Post-translational modifications for PRR5L Gene

  • Ubiquitinated. Ubiquitination by RFFL promotes proteasomal degradation of PRR5L thereby modifying the substrate-specific activity of the mTORC2 complex. Ubiquitination by RFFL is stimulated by LPA/lysophosphatidic acid.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PRR5L Gene

Domains for PRR5L Gene

Protein Domains for PRR5L Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

PRR5L_HUMAN
Family:
  • Belongs to the PROTOR family.:
    • Q6MZQ0
genes like me logo Genes that share domains with PRR5L: view

No data available for Gene Families for PRR5L Gene

Function for PRR5L Gene

Molecular function for PRR5L Gene

UniProtKB/Swiss-Prot Function: Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton. Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration.

Gene Ontology (GO) - Molecular Function for PRR5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031625 ubiquitin protein ligase binding IPI 22609986
genes like me logo Genes that share ontologies with PRR5L: view

Phenotypes for PRR5L Gene

GenomeRNAi human phenotypes for PRR5L:
genes like me logo Genes that share phenotypes with PRR5L: view

miRNA for PRR5L Gene

miRTarBase miRNAs that target PRR5L

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PRR5L Gene

Localization for PRR5L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRR5L Gene COMPARTMENTS Subcellular localization image for PRR5L gene
Compartment Confidence
mitochondrion 3
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for PRR5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0031932 TORC2 complex IDA 22609986
genes like me logo Genes that share ontologies with PRR5L: view

Pathways for PRR5L Gene

genes like me logo Genes that share pathways with PRR5L: view

Pathways by source for PRR5L Gene

1 Cell Signaling Technology pathway for PRR5L Gene
1 BioSystems pathway for PRR5L Gene

Gene Ontology (GO) - Biological Process for PRR5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IMP 22609986
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0009968 negative regulation of signal transduction IEA --
GO:0010762 regulation of fibroblast migration IMP 22609986
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA --
genes like me logo Genes that share ontologies with PRR5L: view

Transcripts for PRR5L Gene

Unigene Clusters for PRR5L Gene

Proline rich 5 like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRR5L Gene

No ASD Table

Relevant External Links for PRR5L Gene

GeneLoc Exon Structure for
PRR5L
ECgene alternative splicing isoforms for
PRR5L

Expression for PRR5L Gene

mRNA expression in normal human tissues for PRR5L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRR5L Gene

This gene is overexpressed in Colon - Transverse (7.1), Spleen (6.2), and Brain - Spinal cord (cervical c-1) (5.4).

SOURCE GeneReport for Unigene cluster for PRR5L Gene Hs.19987

genes like me logo Genes that share expressions with PRR5L: view

Orthologs for PRR5L Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRR5L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRR5L 36
  • 99.28 (n)
  • 99.46 (a)
PRR5L 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRR5L 36
  • 90.04 (n)
  • 92.66 (a)
PRR5L 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRR5L 36
  • 87.86 (n)
  • 88.86 (a)
PRR5L 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prr5l 36
  • 89.13 (n)
  • 91.58 (a)
Prr5l 16
Prr5l 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRR5L 37
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRR5L 37
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prr5l 36
  • 88.22 (n)
  • 90.22 (a)
chicken
(Gallus gallus)
Aves PRR5L 36
  • 73.55 (n)
  • 77.13 (a)
PRR5L 37
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRR5L 37
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prr5l 36
  • 69.03 (n)
  • 68.44 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC557634 36
  • 58.06 (n)
  • 56.68 (a)
PRR5L 37
  • 54 (a)
OneToOne
Species with no ortholog for PRR5L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRR5L Gene

ENSEMBL:
Gene Tree for PRR5L (if available)
TreeFam:
Gene Tree for PRR5L (if available)

Paralogs for PRR5L Gene

Paralogs for PRR5L Gene

Selected SIMAP similar genes for PRR5L Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with PRR5L: view

Variants for PRR5L Gene

Sequence variations from dbSNP and Humsavar for PRR5L Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs44883 -- 36,454,471(+) TGGGT(C/T)GGGGG intron-variant
rs191318 -- 36,350,084(+) ttctt(A/G)ctgta intron-variant
rs230484 -- 36,425,614(+) ACCGA(A/G)TTTCC intron-variant
rs230485 -- 36,460,362(-) GGAGG(A/C)AGCTT intron-variant
rs230486 -- 36,458,171(-) TGCTA(C/G)ACAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRR5L Gene

Variant ID Type Subtype PubMed ID
esv2422305 CNV Duplication 17116639
nsv467791 CNV Gain 19166990
nsv526434 CNV Loss 19592680
esv2475332 CNV Insertion 19546169
esv3692 OTHER Inversion 18987735
esv9649 OTHER Inversion 19470904
esv32924 CNV Loss 17666407
esv273811 CNV Insertion 20981092
esv268359 CNV Insertion 20981092
esv33552 CNV Gain 17666407
esv32890 CNV Gain 17666407
esv8636 CNV Gain 19470904
esv27622 CNV Loss 19812545
nsv518499 CNV Loss 19592680

Relevant External Links for PRR5L Gene

HapMap Linkage Disequilibrium report
PRR5L

Disorders for PRR5L Gene

Relevant External Links for PRR5L

Genetic Association Database (GAD)
PRR5L
Human Genome Epidemiology (HuGE) Navigator
PRR5L
genes like me logo Genes that share disorders with PRR5L: view

No data available for UniProtKB/Swiss-Prot for PRR5L Gene

Publications for PRR5L Gene

  1. Identification of Protor as a novel Rictor-binding component of mTOR complex-2. (PMID: 17461779) Pearce L.R. … Alessi D.R. (Biochem. J. 2007) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12. (PMID: 22609986) Gan X. … Wu D. (Nat. Cell Biol. 2012) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  5. Protor-2 interacts with tristetraprolin to regulate mRNA stability during stress. (PMID: 21964062) Holmes B. … Gera J. (Cell. Signal. 2012) 3

Products for PRR5L Gene

Sources for PRR5L Gene

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