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Aliases for PRR4 Gene

Aliases for PRR4 Gene

  • Proline Rich 4 (Lacrimal) 2 3 5
  • Nasopharyngeal Carcinoma-Associated Proline-Rich Protein 4 3 4
  • Lacrimal Proline-Rich Protein 3 4
  • PROL4 3 4
  • LPRP 3 4
  • Proline-Rich Polypeptide 4 3
  • Proline-Rich Protein 4 3

External Ids for PRR4 Gene

Previous HGNC Symbols for PRR4 Gene

  • PROL4

Previous GeneCards Identifiers for PRR4 Gene

  • GC12M010890
  • GC12M010891
  • GC12M010998
  • GC12M010727
  • GC12M010978
  • GC12M010892
  • GC12M011046
  • GC12M011337

Summaries for PRR4 Gene

Entrez Gene Summary for PRR4 Gene

  • This gene encodes a member of the proline-rich protein family that lacks a conserved repetitive domain. This protein may play a role in protective functions in the eye. Alternative splicing result in multiple transcript variants. Read-through transcription also exists between this gene and the upstream PRH1 (proline-rich protein HaeIII subfamily 1) gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for PRR4 Gene

PRR4 (Proline Rich 4 (Lacrimal)) is a Protein Coding gene. Diseases associated with PRR4 include Ectodermal Dysplasia-Syndactyly Syndrome 1 and Dry Eye Syndrome.

Gene Wiki entry for PRR4 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRR4 Gene

Genomics for PRR4 Gene

Regulatory Elements for PRR4 Gene

Enhancers for PRR4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G010891 1 ENCODE 40.3 +279.4 279445 1.2 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 SLC30A9 SP5 NFYC MIER2 PRR4 LINC01252 TAS2R8 TAS2R7 TAS2R12P GC12P010842
GH12G011169 1.1 ENCODE 36.2 +0.2 172 3.0 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 LINC01252 TAS2R64P PRR4 TAS2R15P TAS2R14 ENSG00000256712
GH12G010939 0.7 ENCODE 24.8 +230.0 229975 3.5 MAFG CEBPB ZEB2 JUND GATA3 ZNF316 MAFF GLIS1 NFE2 EMSY PRR4 LINC01252 GC12M011739 GC12M011732
GH12G011085 0.7 ENCODE 17 +86.0 85957 0.2 MTA2 NR2F1 JUNB DPF2 TBX21 EP300 ARID3A IKZF1 RELB IKZF2 PRR4 LINC01252 TAS2R64P TAS2R43
GH12G010969 0.5 Ensembl 20.4 +202.5 202513 0.2 JUND HNF4A RAD21 PRR4 TAS2R15P TAS2R50
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRR4 on UCSC Golden Path with GeneCards custom track

Promoters for PRR4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000048765 -187 2001 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1

Genomic Location for PRR4 Gene

Chromosome:
12
Start:
10,845,849 bp from pter
End:
11,171,613 bp from pter
Size:
325,765 bases
Orientation:
Minus strand

Genomic View for PRR4 Gene

Genes around PRR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRR4 Gene

Proteins for PRR4 Gene

  • Protein details for PRR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16378-PROL4_HUMAN
    Recommended name:
    Proline-rich protein 4
    Protein Accession:
    Q16378
    Secondary Accessions:
    • A8KA69
    • F5H0D7
    • Q8NFB3

    Protein attributes for PRR4 Gene

    Size:
    134 amino acids
    Molecular mass:
    15097 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PRR4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRR4 Gene

Post-translational modifications for PRR4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRR4 Gene

No data available for DME Specific Peptides for PRR4 Gene

Domains & Families for PRR4 Gene

Protein Domains for PRR4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRR4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRR4: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PRR4 Gene

Function for PRR4 Gene

genes like me logo Genes that share phenotypes with PRR4: view

Animal Model Products

CRISPR Products

miRNA for PRR4 Gene

miRTarBase miRNAs that target PRR4

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRR4 Gene

Localization for PRR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRR4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRR4 gene
Compartment Confidence
extracellular 5
cytosol 2

Gene Ontology (GO) - Cellular Components for PRR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA,TAS 22664934
genes like me logo Genes that share ontologies with PRR4: view

Pathways & Interactions for PRR4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis IEP 23580065
GO:0007601 visual perception TAS 7544782
genes like me logo Genes that share ontologies with PRR4: view

No data available for Pathways by source and SIGNOR curated interactions for PRR4 Gene

Transcripts for PRR4 Gene

Unigene Clusters for PRR4 Gene

Proline rich 4 (lacrimal):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRR4 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4:
SP5: - - -
SP6: - -
SP7:
SP8:

Relevant External Links for PRR4 Gene

GeneLoc Exon Structure for
PRR4
ECgene alternative splicing isoforms for
PRR4

Expression for PRR4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRR4 Gene

mRNA differential expression in normal tissues according to GTEx for PRR4 Gene

This gene is overexpressed in Minor Salivary Gland (x41.4).

Protein differential expression in normal tissues from HIPED for PRR4 Gene

This gene is overexpressed in Skin (34.4) and Salivary gland (27.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRR4 Gene



Protein tissue co-expression partners for PRR4 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRR4 Gene:

PRR4

SOURCE GeneReport for Unigene cluster for PRR4 Gene:

Hs.732031

mRNA Expression by UniProt/SwissProt for PRR4 Gene:

Q16378-PROL4_HUMAN
Tissue specificity: Abundantly expressed in lacrimal gland where it is found in the acinar cells but not in the intralobular ducts. Also found in the submandibular gland, the parotid and sublingual glands.

Evidence on tissue expression from TISSUES for PRR4 Gene

  • Eye(5)
  • Blood(4.3)
  • Lung(3.2)
  • Stomach(2.2)
genes like me logo Genes that share expression patterns with PRR4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRR4 Gene

Orthologs for PRR4 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PRR4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRR4 34
  • 99.5 (n)
Species where no ortholog for PRR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRR4 Gene

ENSEMBL:
Gene Tree for PRR4 (if available)
TreeFam:
Gene Tree for PRR4 (if available)

Paralogs for PRR4 Gene

No data available for Paralogs for PRR4 Gene

Variants for PRR4 Gene

Sequence variations from dbSNP and Humsavar for PRR4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1047699 --
rs1063193 --

Structural Variations from Database of Genomic Variants (DGV) for PRR4 Gene

Variant ID Type Subtype PubMed ID
esv2759879 CNV loss 17122850
esv3628543 CNV gain 21293372

Variation tolerance for PRR4 Gene

Residual Variation Intolerance Score: 54.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRR4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRR4 Gene

Disorders for PRR4 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PRR4 Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
ectodermal dysplasia-syndactyly syndrome 1
  • ectodermal dysplasia-syndactyly syndrome
dry eye syndrome
  • tear film insufficiency
lacrimal apparatus disease
  • lacrimal apparatus diseases
- elite association - COSMIC cancer census association via MalaCards
Search PRR4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRR4

Genetic Association Database (GAD)
PRR4
Human Genome Epidemiology (HuGE) Navigator
PRR4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRR4
genes like me logo Genes that share disorders with PRR4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRR4 Gene

Publications for PRR4 Gene

  1. A major human lacrimal gland mRNA encodes a new proline-rich protein family member. (PMID: 7544782) Dickinson D.P. … Thiesse M. (Invest. Ophthalmol. Vis. Sci. 1995) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4 64
  5. Characterization of human reflex tear proteome reveals high expression of lacrimal proline-rich protein 4 (PRR4). (PMID: 26173177) Perumal N. … Grus F.H. (Proteomics 2015) 3 64

Products for PRR4 Gene

Sources for PRR4 Gene

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