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Aliases for PRR4 Gene

Aliases for PRR4 Gene

  • Proline Rich 4 (Lacrimal) 2 3 5
  • Nasopharyngeal Carcinoma-Associated Proline-Rich Protein 4 3 4
  • Lacrimal Proline-Rich Protein 3 4
  • PROL4 3 4
  • LPRP 3 4
  • Proline-Rich Polypeptide 4 3
  • Proline-Rich Protein 4 3

External Ids for PRR4 Gene

Previous HGNC Symbols for PRR4 Gene

  • PROL4

Previous GeneCards Identifiers for PRR4 Gene

  • GC12M010890
  • GC12M010891
  • GC12M010998
  • GC12M010727
  • GC12M010978
  • GC12M010892

Summaries for PRR4 Gene

Entrez Gene Summary for PRR4 Gene

  • This gene encodes a member of the proline-rich protein family that lacks a conserved repetitive domain. This protein may play a role in protective functions in the eye. Alternative splicing result in multiple transcript variants. Read-through transcription also exists between this gene and the upstream PRH1 (proline-rich protein HaeIII subfamily 1) gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for PRR4 Gene

PRR4 (Proline Rich 4 (Lacrimal)) is a Protein Coding gene. Diseases associated with PRR4 include Ectodermal Dysplasia-Syndactyly Syndrome 1 and Dry Eye Syndrome.

Gene Wiki entry for PRR4 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRR4 Gene

Genomics for PRR4 Gene

Regulatory Elements for PRR4 Gene

Enhancers for PRR4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around PRR4 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRR4 Gene

10,845,849 bp from pter
11,171,613 bp from pter
325,765 bases
Minus strand

Genomic View for PRR4 Gene

Genes around PRR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRR4 Gene

Proteins for PRR4 Gene

  • Protein details for PRR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proline-rich protein 4
    Protein Accession:
    Secondary Accessions:
    • A8KA69
    • F5H0D7
    • Q8NFB3

    Protein attributes for PRR4 Gene

    134 amino acids
    Molecular mass:
    15097 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PRR4 Gene


neXtProt entry for PRR4 Gene

Post-translational modifications for PRR4 Gene

No Post-translational modifications

Other Protein References for PRR4 Gene

No data available for DME Specific Peptides for PRR4 Gene

Domains & Families for PRR4 Gene

Protein Domains for PRR4 Gene


Suggested Antigen Peptide Sequences for PRR4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRR4: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PRR4 Gene

Function for PRR4 Gene

genes like me logo Genes that share phenotypes with PRR4: view

Animal Model Products

CRISPR Products

miRNA for PRR4 Gene

miRTarBase miRNAs that target PRR4

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRR4 Gene

Localization for PRR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRR4 Gene


Subcellular locations from

Jensen Localization Image for PRR4 Gene COMPARTMENTS Subcellular localization image for PRR4 gene
Compartment Confidence
extracellular 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for PRR4 Gene

Pathways & Interactions for PRR4 Gene

SuperPathways for PRR4 Gene

No Data Available

Interacting Proteins for PRR4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000228811 Q16378-PROL4_HUMAN for PRR4 Gene via STRING IID

Gene Ontology (GO) - Biological Process for PRR4 Gene


No data available for Pathways by source and SIGNOR curated interactions for PRR4 Gene

Drugs & Compounds for PRR4 Gene

No Compound Related Data Available

Transcripts for PRR4 Gene

Unigene Clusters for PRR4 Gene

Proline rich 4 (lacrimal):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRR4 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP5: - - -
SP6: - -

Relevant External Links for PRR4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRR4 Gene

mRNA expression in normal human tissues for PRR4 Gene

mRNA differential expression in normal tissues according to GTEx for PRR4 Gene

This gene is overexpressed in Minor Salivary Gland (x41.4).

Protein differential expression in normal tissues from HIPED for PRR4 Gene

This gene is overexpressed in Skin (34.4) and Salivary gland (27.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRR4 Gene

Protein tissue co-expression partners for PRR4 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRR4 Gene:


SOURCE GeneReport for Unigene cluster for PRR4 Gene:


mRNA Expression by UniProt/SwissProt for PRR4 Gene:

Tissue specificity: Abundantly expressed in lacrimal gland where it is found in the acinar cells but not in the intralobular ducts. Also found in the submandibular gland, the parotid and sublingual glands.
genes like me logo Genes that share expression patterns with PRR4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PRR4 Gene

Orthologs for PRR4 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PRR4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRR4 34
  • 99.5 (n)
  • 99.25 (a)
Species where no ortholog for PRR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRR4 Gene

Gene Tree for PRR4 (if available)
Gene Tree for PRR4 (if available)

Paralogs for PRR4 Gene

No data available for Paralogs for PRR4 Gene

Variants for PRR4 Gene

Sequence variations from dbSNP and Humsavar for PRR4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_027926 -
VAR_027927 -

Structural Variations from Database of Genomic Variants (DGV) for PRR4 Gene

Variant ID Type Subtype PubMed ID
esv2759879 CNV loss 17122850
esv3628543 CNV gain 21293372

Variation tolerance for PRR4 Gene

Residual Variation Intolerance Score: 54.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRR4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRR4 Gene

Disorders for PRR4 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PRR4 Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
ectodermal dysplasia-syndactyly syndrome 1
  • ectodermal dysplasia-syndactyly syndrome
dry eye syndrome
  • xerophthalmia
lacrimal apparatus disease
  • lacrimal apparatus diseases
- elite association - COSMIC cancer census association via MalaCards
Search PRR4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRR4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PRR4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRR4 Gene

Publications for PRR4 Gene

  1. A major human lacrimal gland mRNA encodes a new proline-rich protein family member. (PMID: 7544782) Dickinson D.P. … Thiesse M. (Invest. Ophthalmol. Vis. Sci. 1995) 2 3 4 22 65
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4 65
  5. Characterization of human reflex tear proteome reveals high expression of lacrimal proline-rich protein 4 (PRR4). (PMID: 26173177) Perumal N. … Grus F.H. (Proteomics 2015) 3 65

Products for PRR4 Gene

Sources for PRR4 Gene

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