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Aliases for PRR4 Gene

Aliases for PRR4 Gene

  • Proline Rich 4 (Lacrimal) 2 3 5
  • Nasopharyngeal Carcinoma-Associated Proline-Rich Protein 4 3 4
  • Lacrimal Proline-Rich Protein 3 4
  • PROL4 3 4
  • LPRP 3 4
  • Proline-Rich Polypeptide 4 3

External Ids for PRR4 Gene

Previous HGNC Symbols for PRR4 Gene

  • PROL4

Previous GeneCards Identifiers for PRR4 Gene

  • GC12M010890
  • GC12M010891
  • GC12M010998
  • GC12M010727
  • GC12M010978

Summaries for PRR4 Gene

Entrez Gene Summary for PRR4 Gene

  • This gene encodes a member of the proline-rich protein family that lacks a conserved repetitive domain. This protein may play a role in protective functions in the eye. Alternative splicing result in multiple transcript variants. Read-through transcription also exists between this gene and the upstream PRH1 (proline-rich protein HaeIII subfamily 1) gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for PRR4 Gene

PRR4 (Proline Rich 4 (Lacrimal)) is a Protein Coding gene. Diseases associated with PRR4 include ectodermal dysplasia-syndactyly syndrome 1 and dry eye syndrome.

Gene Wiki entry for PRR4 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRR4 Gene

Genomics for PRR4 Gene

Regulatory Elements for PRR4 Gene

Promoters for PRR4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRR4 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRR4 Gene

Chromosome:
12
Start:
10,845,849 bp from pter
End:
11,171,613 bp from pter
Size:
325,765 bases
Orientation:
Minus strand

Genomic View for PRR4 Gene

Genes around PRR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRR4 Gene

Proteins for PRR4 Gene

  • Protein details for PRR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16378-PROL4_HUMAN
    Recommended name:
    Proline-rich protein 4
    Protein Accession:
    Q16378
    Secondary Accessions:
    • A8KA69
    • F5H0D7
    • Q8NFB3

    Protein attributes for PRR4 Gene

    Size:
    134 amino acids
    Molecular mass:
    15097 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PRR4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRR4 Gene

Proteomics data for PRR4 Gene at MOPED

Post-translational modifications for PRR4 Gene

No Post-translational modifications

Other Protein References for PRR4 Gene

No data available for DME Specific Peptides for PRR4 Gene

Domains & Families for PRR4 Gene

Protein Domains for PRR4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRR4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRR4: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PRR4 Gene

Function for PRR4 Gene

genes like me logo Genes that share phenotypes with PRR4: view

Animal Model Products

CRISPR Products

miRNA for PRR4 Gene

miRTarBase miRNAs that target PRR4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRR4 Gene

Localization for PRR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRR4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRR4 Gene COMPARTMENTS Subcellular localization image for PRR4 gene
Compartment Confidence
extracellular 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for PRR4 Gene

Pathways & Interactions for PRR4 Gene

SuperPathways for PRR4 Gene

No Data Available

Interacting Proteins for PRR4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000228811%0d%0a9606.ENSP00000302021%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000228811 Q16378-PROL4_HUMAN for PRR4 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for PRR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007601 visual perception TAS 7544782
genes like me logo Genes that share ontologies with PRR4: view

No data available for Pathways by source and SIGNOR curated interactions for PRR4 Gene

Drugs & Compounds for PRR4 Gene

No Compound Related Data Available

Transcripts for PRR4 Gene

Unigene Clusters for PRR4 Gene

Proline rich 4 (lacrimal):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRR4 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4:
SP5: - - -
SP6: - -
SP7:
SP8:

Relevant External Links for PRR4 Gene

GeneLoc Exon Structure for
PRR4
ECgene alternative splicing isoforms for
PRR4

Expression for PRR4 Gene

mRNA expression in normal human tissues for PRR4 Gene

mRNA differential expression in normal tissues according to GTEx for PRR4 Gene

This gene is overexpressed in Minor Salivary Gland (x41.4).

Protein differential expression in normal tissues from HIPED for PRR4 Gene

This gene is overexpressed in Skin (34.4) and Salivary gland (27.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRR4 Gene



SOURCE GeneReport for Unigene cluster for PRR4 Gene Hs.732031

mRNA Expression by UniProt/SwissProt for PRR4 Gene

Q16378-PROL4_HUMAN
Tissue specificity: Abundantly expressed in lacrimal gland where it is found in the acinar cells but not in the intralobular ducts. Also found in the submandibular gland, the parotid and sublingual glands.
genes like me logo Genes that share expression patterns with PRR4: view

Protein tissue co-expression partners for PRR4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PRR4 Gene

Orthologs for PRR4 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PRR4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRR4 35
  • 99.5 (n)
  • 99.25 (a)
Species with no ortholog for PRR4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRR4 Gene

ENSEMBL:
Gene Tree for PRR4 (if available)
TreeFam:
Gene Tree for PRR4 (if available)

Paralogs for PRR4 Gene

No data available for Paralogs for PRR4 Gene

Variants for PRR4 Gene

Sequence variations from dbSNP and Humsavar for PRR4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_027926 -
VAR_027927 -

Structural Variations from Database of Genomic Variants (DGV) for PRR4 Gene

Variant ID Type Subtype PubMed ID
nsv898776 CNV Loss 21882294
dgv475e1 CNV Complex 17122850

Variation tolerance for PRR4 Gene

Residual Variation Intolerance Score: 54.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRR4 Gene

HapMap Linkage Disequilibrium report
PRR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRR4 Gene

Disorders for PRR4 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PRR4 Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
ectodermal dysplasia-syndactyly syndrome 1
  • edss1
dry eye syndrome
  • xerophthalmia
lacrimal apparatus disease
  • lacrimal apparatus diseases
- elite association - COSMIC cancer census association via MalaCards
Search PRR4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRR4

Genetic Association Database (GAD)
PRR4
Human Genome Epidemiology (HuGE) Navigator
PRR4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRR4
genes like me logo Genes that share disorders with PRR4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRR4 Gene

Publications for PRR4 Gene

  1. A major human lacrimal gland mRNA encodes a new proline-rich protein family member. (PMID: 7544782) Dickinson D.P. … Thiesse M. (Invest. Ophthalmol. Vis. Sci. 1995) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Characterization of lacrimal proline-rich protein 4 (PRR4) in human tear proteome. (PMID: 24782455) Perumal N. … Grus F.H. (Proteomics 2014) 3
  4. Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naA^ve to therapy. (PMID: 23580065) Pieragostino D. … Del Boccio P. (Mol Biosyst 2013) 3
  5. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. (PMID: 22664934) BAPhm D. … Grus F.H. (Oncol. Rep. 2012) 3

Products for PRR4 Gene

Sources for PRR4 Gene

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