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Aliases for PRR35 Gene

Aliases for PRR35 Gene

  • Proline Rich 35 2 3 5
  • C16orf11 3 4
  • Chromosome 16 Open Reading Frame 11 2
  • Uncharacterized Protein RJD1 4
  • Proline-Rich Protein 35 3
  • LA16c-366D1.2 3

External Ids for PRR35 Gene

Previous HGNC Symbols for PRR35 Gene

  • C16orf11

Summaries for PRR35 Gene

GeneCards Summary for PRR35 Gene

PRR35 (Proline Rich 35) is a Protein Coding gene. An important paralog of this gene is ZNF750.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRR35 Gene

Genomics for PRR35 Gene

Regulatory Elements for PRR35 Gene

Enhancers for PRR35 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F000550 1.6 FANTOM5 Ensembl ENCODE 25.5 -3.9 -3930 11.8 MLX ZFP64 ARID4B ZNF2 ZNF48 ZNF121 GLIS2 ZNF202 SP3 SP5 GNG13 LOC105371038 PRR35 WASH4P ENSG00000262528 ENSG00000268836 HBZP1 PRSS29P JMJD8 ENSG00000261505
GH16F000523 1.5 FANTOM5 ENCODE 13 -32.6 -32631 7.6 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 NHLRC4 JMJD8 PRR35 PIGQ ENSG00000261505 MPG LOC105371038 TPSG1 ENSG00000260022 ENSG00000260051
GH16F000586 1.5 FANTOM5 ENCODE 12.5 +30.7 30710 8.4 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 WFIKKN1 RAB40C LOC105371038 ENSG00000261505 HBZP1 PRSS29P ENSG00000260051 ENSG00000260022 ENSG00000260954 NHLRC4
GH16F000456 1.4 FANTOM5 Ensembl ENCODE 11.2 -102.7 -102666 2.3 HDAC1 TBL1XR1 GATA2 SCRT2 EGR2 ZNF263 PPARG KLF16 SMARCA4 PBX2 DECR2 NME4 NHLRC4 PRR35 PIGQ ENSG00000230428 GC16P000492
GH16F000533 1.2 Ensembl ENCODE 13 -25.5 -25521 3.2 PKNOX1 ZFP64 ARID4B DMAP1 ZNF2 ZNF48 YY1 GLIS2 KLF7 FOS CAPN15 PRR35 NHLRC4 PIGQ NME4 DECR2 MIR5587 GC16M000522
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRR35 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRR35 Gene

560,422 bp from pter
565,529 bp from pter
5,108 bases
Plus strand

Genomic View for PRR35 Gene

Genes around PRR35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRR35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRR35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRR35 Gene

Proteins for PRR35 Gene

  • Protein details for PRR35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proline-rich protein 35
    Protein Accession:
    Secondary Accessions:
    • B8ZZ27
    • Q8N233
    • Q96AX3
    • Q96S23

    Protein attributes for PRR35 Gene

    571 amino acids
    Molecular mass:
    59354 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAK61234.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for PRR35 Gene

Post-translational modifications for PRR35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRR35 Gene

No data available for DME Specific Peptides for PRR35 Gene

Domains & Families for PRR35 Gene

Protein Domains for PRR35 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRR35: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for PRR35 Gene

Function for PRR35 Gene

genes like me logo Genes that share phenotypes with PRR35: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRR35 Gene

Localization for PRR35 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRR35 gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PRR35 Gene

Pathways & Interactions for PRR35 Gene

SuperPathways for PRR35 Gene

No Data Available

Interacting Proteins for PRR35 Gene

Gene Ontology (GO) - Biological Process for PRR35 Gene


No data available for Pathways by source and SIGNOR curated interactions for PRR35 Gene

Transcripts for PRR35 Gene

mRNA/cDNA for PRR35 Gene

(4) REFSEQ mRNAs :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRR35 Gene

No ASD Table

Relevant External Links for PRR35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRR35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRR35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PRR35 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRR35 Gene

Protein tissue co-expression partners for PRR35 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRR35 Gene:

genes like me logo Genes that share expression patterns with PRR35: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PRR35 Gene

Orthologs for PRR35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRR35 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C16H16orf11 34
  • 98.48 (n)
C16orf11 35
  • 97 (a)
(Canis familiaris)
Mammalia C6H16orf11 34
  • 77.8 (n)
C16orf11 35
  • 70 (a)
(Bos Taurus)
Mammalia C25H16orf11 34
  • 77.23 (n)
C16orf11 35
  • 67 (a)
(Rattus norvegicus)
Mammalia LOC302999 34
  • 74.72 (n)
(Mus musculus)
Mammalia A930017K11Rik 35
  • 65 (a)
(Monodelphis domestica)
Mammalia C16orf11 35
  • 29 (a)
(Gallus gallus)
Aves C16orf11 35
  • 34 (a)
(Anolis carolinensis)
Reptilia C16orf11 35
  • 38 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13681 34
(Danio rerio)
Actinopterygii C24H16orf11 35
  • 25 (a)
Species where no ortholog for PRR35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRR35 Gene

Gene Tree for PRR35 (if available)
Gene Tree for PRR35 (if available)

Paralogs for PRR35 Gene

Paralogs for PRR35 Gene Pseudogenes for PRR35 Gene

genes like me logo Genes that share paralogs with PRR35: view

Variants for PRR35 Gene

Sequence variations from dbSNP and Humsavar for PRR35 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1010761 -- 564,821(+) ACCCG(A/G)GCCCT upstream-variant-2KB, reference, synonymous-codon
rs10581998 -- 562,586(+) ACATG(-/CACA)CACAC intron-variant, utr-variant-5-prime
rs10581999 -- 562,602(+) ACACA(-/CACA)GGCAC intron-variant, utr-variant-5-prime
rs10582000 -- 562,621(+) CACAC(-/AC)GCAGC intron-variant, utr-variant-5-prime
rs111468365 -- 560,479(+) CGGAC(C/G)CGGGA intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PRR35 Gene

Variant ID Type Subtype PubMed ID
nsv471064 CNV gain 18288195
nsv526903 CNV loss 19592680
nsv528354 CNV loss 19592680
nsv570988 CNV gain 21841781
nsv571006 CNV gain 21841781
nsv833113 CNV loss 17160897
nsv833114 CNV gain+loss 17160897
nsv952898 CNV deletion 24416366
nsv471063 CNV loss 18288195
nsv457304 CNV gain 19166990
nsv1160325 CNV duplication 26073780
nsv1143795 CNV deletion 24896259
nsv1070731 CNV deletion 25765185
esv25069 CNV loss 19812545
esv2422427 CNV duplication 17116639
dgv4823n54 CNV loss 21841781
dgv4822n54 CNV loss 21841781
dgv4821n54 CNV gain 21841781
dgv4819n54 CNV gain+loss 21841781
dgv4818n54 CNV loss 21841781
dgv4817n54 CNV gain 21841781

Variation tolerance for PRR35 Gene

Gene Damage Index Score: 3.92; 59.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRR35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRR35 Gene

Disorders for PRR35 Gene

Relevant External Links for PRR35

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PRR35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRR35 Gene

Publications for PRR35 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  2. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
  4. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 4 64

Products for PRR35 Gene

Sources for PRR35 Gene

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