Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PRR30 Gene

Aliases for PRR30 Gene

  • Proline Rich 30 2 3 5
  • C2orf53 3 4
  • Chromosome 2 Open Reading Frame 53 2
  • Proline-Rich Protein 30 3

External Ids for PRR30 Gene

Previous HGNC Symbols for PRR30 Gene

  • C2orf53

Summaries for PRR30 Gene

GeneCards Summary for PRR30 Gene

PRR30 (Proline Rich 30) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRR30 Gene

Genomics for PRR30 Gene

Regulatory Elements for PRR30 Gene

Enhancers for PRR30 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F027169 1.3 Ensembl ENCODE 12.3 -31.8 -31805 2.9 ATF1 MLX ARID4B DMAP1 ZNF48 YY1 ZNF143 ZNF263 SP5 ZHX2 ATRAID GTF3C2 TCF23 PRR30 PREB SLC5A6 ABHD1 CAD DNAJC5G SLC30A3
GH02F027091 1.3 Ensembl ENCODE 10.9 +45.4 45350 7.0 CREB3L1 MLX ZFP64 ARID4B DMAP1 YY1 SLC30A9 ZNF143 PAF1 SP5 KHK EMILIN1 ABHD1 CGREF1 ATRAID SLC5A6 CAD PRR30 TCF23 PREB
GH02F027164 0.6 ENCODE 12.2 -25.9 -25893 1.1 PKNOX1 RAD51 MTA2 IKZF1 PRDM10 SPI1 GTF3C2 PRR30 PREB ATRAID SLC5A6 ABHD1 CGREF1 CAD KHK EMILIN1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRR30 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRR30 Gene

Chromosome:
2
Start:
27,136,847 bp from pter
End:
27,139,464 bp from pter
Size:
2,618 bases
Orientation:
Minus strand

Genomic View for PRR30 Gene

Genes around PRR30 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRR30 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRR30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRR30 Gene

Proteins for PRR30 Gene

  • Protein details for PRR30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53SZ7-PRR30_HUMAN
    Recommended name:
    Proline-rich protein 30
    Protein Accession:
    Q53SZ7
    Secondary Accessions:
    • Q86UE2

    Protein attributes for PRR30 Gene

    Size:
    412 amino acids
    Molecular mass:
    44690 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRR30 Gene

Post-translational modifications for PRR30 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRR30 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRR30 Gene

Domains & Families for PRR30 Gene

Protein Domains for PRR30 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRR30: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for PRR30 Gene

Function for PRR30 Gene

genes like me logo Genes that share phenotypes with PRR30: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRR30 Gene

Localization for PRR30 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRR30 gene
Compartment Confidence
nucleus 2
peroxisome 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PRR30 Gene

Pathways & Interactions for PRR30 Gene

SuperPathways for PRR30 Gene

No Data Available

Interacting Proteins for PRR30 Gene

Gene Ontology (GO) - Biological Process for PRR30 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PRR30 Gene

Transcripts for PRR30 Gene

mRNA/cDNA for PRR30 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRR30 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c
SP1: - -
SP2: - -
SP3:

Relevant External Links for PRR30 Gene

GeneLoc Exon Structure for
PRR30
ECgene alternative splicing isoforms for
PRR30

Expression for PRR30 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRR30 Gene

Protein differential expression in normal tissues from HIPED for PRR30 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRR30 Gene



Protein tissue co-expression partners for PRR30 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRR30 Gene:

PRR30
genes like me logo Genes that share expression patterns with PRR30: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PRR30 Gene

Orthologs for PRR30 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PRR30 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C2AH2orf53 34
  • 96.75 (n)
C2orf53 35
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C11H2orf53 34
  • 79.12 (n)
C2orf53 35
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100322897 34
  • 73.25 (n)
mouse
(Mus musculus)
Mammalia 1700110M21Rik 34 35
  • 69.79 (n)
Prr30 16
platypus
(Ornithorhynchus anatinus)
Mammalia C2orf53 35
  • 29 (a)
OneToOne
Species where no ortholog for PRR30 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRR30 Gene

ENSEMBL:
Gene Tree for PRR30 (if available)
TreeFam:
Gene Tree for PRR30 (if available)

Paralogs for PRR30 Gene

No data available for Paralogs for PRR30 Gene

Variants for PRR30 Gene

Sequence variations from dbSNP and Humsavar for PRR30 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs11121 -- 27,137,019(-) TCTCG(A/G)GGAGT utr-variant-3-prime
rs111513220 -- 27,137,265(+) GTCTG(C/G)GAGGG reference, synonymous-codon
rs111711012 -- 27,136,966(+) GCAGG(-/A)GAACA utr-variant-3-prime
rs111836785 -- 27,141,178(+) TGGTC(A/T)CAAAC upstream-variant-2KB
rs111918465 -- 27,140,336(+) CAGGC(A/G)CGGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PRR30 Gene

Variant ID Type Subtype PubMed ID
dgv6744n54 CNV loss 21841781
nsv817673 CNV gain 17921354
nsv833603 CNV loss 17160897

Variation tolerance for PRR30 Gene

Residual Variation Intolerance Score: 83.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.45; 71.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRR30 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRR30

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRR30 Gene

Disorders for PRR30 Gene

Relevant External Links for PRR30

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRR30

No disorders were found for PRR30 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRR30 Gene

Publications for PRR30 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  2. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for PRR30 Gene

Sources for PRR30 Gene

Content
Loading form....