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Aliases for PRR27 Gene

Aliases for PRR27 Gene

  • Proline Rich 27 2 3 5
  • C4orf40 3 4
  • Chromosome 4 Open Reading Frame 40 2
  • Proline-Rich Protein 27 3

External Ids for PRR27 Gene

Previous HGNC Symbols for PRR27 Gene

  • C4orf40

Previous GeneCards Identifiers for PRR27 Gene

  • GC04P071000

Summaries for PRR27 Gene

GeneCards Summary for PRR27 Gene

PRR27 (Proline Rich 27) is a Protein Coding gene.

Additional gene information for PRR27 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRR27 Gene

Genomics for PRR27 Gene

Regulatory Elements for PRR27 Gene

Enhancers for PRR27 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H070180 1 dbSUPER 11.3 +49.7 49675 5 FOXA2 ATF1 MLX ARNT ZFP64 DMAP1 ZNF143 ATF7 MIER2 PPARG PRR27 STATH ODAM SULT1E1 LOC105377270
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRR27 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRR27 Gene

Chromosome:
4
Start:
70,133,616 bp from pter
End:
70,176,799 bp from pter
Size:
43,184 bases
Orientation:
Plus strand

Genomic View for PRR27 Gene

Genes around PRR27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRR27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRR27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRR27 Gene

Proteins for PRR27 Gene

  • Protein details for PRR27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6MZM9-PRR27_HUMAN
    Recommended name:
    Proline-rich protein 27
    Protein Accession:
    Q6MZM9
    Secondary Accessions:
    • A8MXP0
    • Q6MZR6

    Protein attributes for PRR27 Gene

    Size:
    219 amino acids
    Molecular mass:
    22720 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRR27 Gene

Post-translational modifications for PRR27 Gene

No Post-translational modifications

Other Protein References for PRR27 Gene

No data available for DME Specific Peptides for PRR27 Gene

Domains & Families for PRR27 Gene

Gene Families for PRR27 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for PRR27 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRR27: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for PRR27 Gene

Function for PRR27 Gene

Phenotypes for PRR27 Gene

genes like me logo Genes that share phenotypes with PRR27: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PRR27
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRR27 Gene

Localization for PRR27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRR27 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRR27 gene
Compartment Confidence
extracellular 5
plasma membrane 1
mitochondrion 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PRR27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with PRR27: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRR27 Gene

Pathways & Interactions for PRR27 Gene

SuperPathways for PRR27 Gene

No Data Available

Interacting Proteins for PRR27 Gene

Gene Ontology (GO) - Biological Process for PRR27 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PRR27 Gene

Drugs & Compounds for PRR27 Gene

No Compound Related Data Available

Transcripts for PRR27 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PRR27
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PRR27 Gene

No ASD Table

Relevant External Links for PRR27 Gene

GeneLoc Exon Structure for
PRR27
ECgene alternative splicing isoforms for
PRR27

Expression for PRR27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRR27 Gene

mRNA differential expression in normal tissues according to GTEx for PRR27 Gene

This gene is overexpressed in Minor Salivary Gland (x44.7) and Testis (x6.5).

Protein differential expression in normal tissues from HIPED for PRR27 Gene

This gene is overexpressed in Skin (38.1) and Salivary gland (25.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRR27 Gene



Protein tissue co-expression partners for PRR27 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRR27 Gene:

PRR27

Evidence on tissue expression from TISSUES for PRR27 Gene

  • Muscle(2.9)
genes like me logo Genes that share expression patterns with PRR27: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRR27 Gene

Orthologs for PRR27 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PRR27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRR27 33
  • 98.93 (n)
C4orf40 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C4orf40 34
  • 40 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4930432K09Rik 34
  • 28 (a)
OneToOne
Species where no ortholog for PRR27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRR27 Gene

ENSEMBL:
Gene Tree for PRR27 (if available)
TreeFam:
Gene Tree for PRR27 (if available)

Paralogs for PRR27 Gene

No data available for Paralogs for PRR27 Gene

Variants for PRR27 Gene

Sequence variations from dbSNP and Humsavar for PRR27 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000050339 -- 70,154,703(+) GGATC(A/C)CACGT intron-variant
rs1000218659 -- 70,157,539(+) TTTTG(-/A)GACAG intron-variant
rs1000346997 -- 70,163,588(+) AATAC(A/G)GGCGT utr-variant-3-prime
rs1000382811 -- 70,163,311(+) ATAGC(C/G)TCTTT utr-variant-3-prime
rs1000654272 -- 70,157,357(+) AGAAC(C/T)TCCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRR27 Gene

Variant ID Type Subtype PubMed ID
dgv5319n100 CNV loss 25217958
dgv9126n54 CNV loss 21841781
esv2760880 CNV loss 21179565
esv3600930 CNV loss 21293372
nsv1012495 CNV gain 25217958
nsv461553 CNV loss 19166990
nsv517703 CNV loss 19592680
nsv594643 CNV loss 21841781
nsv829963 CNV gain 17160897

Variation tolerance for PRR27 Gene

Residual Variation Intolerance Score: 89.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.86; 58.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRR27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRR27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRR27 Gene

Disorders for PRR27 Gene

Relevant External Links for PRR27

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRR27

No disorders were found for PRR27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRR27 Gene

Publications for PRR27 Gene

  1. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). (PMID: 19199708) Gonzalez-Begne M … Yates JR (Journal of proteome research 2009) 3 60
  2. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 60
  3. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A … Wiemann S (Nucleic acids research 2006) 3 60
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 60
  5. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S … Poustka A (Genome research 2004) 3 60

Products for PRR27 Gene

Sources for PRR27 Gene

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