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Aliases for PRR13 Gene

Aliases for PRR13 Gene

  • Proline Rich 13 2 3 5
  • Taxane-Resistance Protein 3 4
  • TXR1 3 4
  • Proline-Rich Protein 13 3

External Ids for PRR13 Gene

Previous GeneCards Identifiers for PRR13 Gene

  • GC12P052125
  • GC12P053835
  • GC12P050875

Summaries for PRR13 Gene

GeneCards Summary for PRR13 Gene

PRR13 (Proline Rich 13) is a Protein Coding gene.

UniProtKB/Swiss-Prot for PRR13 Gene

  • Negatively regulates TSP1 expression at the level of transcription. This down-regulation was shown to reduce taxane-induced apoptosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRR13 Gene

Genomics for PRR13 Gene

Regulatory Elements for PRR13 Gene

Enhancers for PRR13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F053440 0.2 ENCODE 26.6 +1.0 980 4.7 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 FOS SP1 PRR13 AAAS ENSG00000257379 PCBP2
GH12F053423 0.9 Ensembl ENCODE 24.9 -16.5 -16483 2.6 HDAC1 TBL1XR1 BMI1 GLIS2 GATA2 SCRT2 CREM EGR2 USF2 ZEB2 PRR13 SP1 NFE2 AAAS AMHR2
GH12F053378 1.1 ENCODE 22.7 -60.7 -60678 5.6 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 SIN3A FEZF1 DMAP1 ZNF2 YY1 SP1 PRR13 AAAS HOXC8 HOXC9 MAP3K12 ENSG00000258086 AMHR2 SP7 HOXC5
GH12F053498 0.2 ENCODE 21.3 +59.0 59002 5.0 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF740 SP1 IGFBP6 ENSG00000258344 LOC100652999 PRR13 AAAS ATP5G2 MAP3K12 LOC105378250
GH12F053492 1 ENCODE 20.9 +51.8 51822 2.6 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF2 GLIS2 ZNF207 SP3 PRR13 AMHR2 AAAS ATF7 SP1 MAP3K12 ENSG00000273658
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PRR13 on UCSC Golden Path with GeneCards custom track

Promoters for PRR13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000430841 495 2201 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 FOS

Genomic Location for PRR13 Gene

Chromosome:
12
Start:
53,441,605 bp from pter
End:
53,446,645 bp from pter
Size:
5,041 bases
Orientation:
Plus strand

Genomic View for PRR13 Gene

Genes around PRR13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRR13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRR13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRR13 Gene

Proteins for PRR13 Gene

  • Protein details for PRR13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZ81-PRR13_HUMAN
    Recommended name:
    Proline-rich protein 13
    Protein Accession:
    Q9NZ81
    Secondary Accessions:
    • Q0V8U0
    • Q6FIG7
    • Q6MZP8
    • Q6NXQ6
    • Q6PKF9

    Protein attributes for PRR13 Gene

    Size:
    148 amino acids
    Molecular mass:
    15385 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PRR13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRR13 Gene

Post-translational modifications for PRR13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PRR13 Gene

Domains & Families for PRR13 Gene

Protein Domains for PRR13 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for PRR13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRR13: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PRR13 Gene

Function for PRR13 Gene

Molecular function for PRR13 Gene

UniProtKB/Swiss-Prot Function:
Negatively regulates TSP1 expression at the level of transcription. This down-regulation was shown to reduce taxane-induced apoptosis.

Gene Ontology (GO) - Molecular Function for PRR13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with PRR13: view
genes like me logo Genes that share phenotypes with PRR13: view

Animal Model Products

miRNA for PRR13 Gene

miRTarBase miRNAs that target PRR13

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRR13 Gene

Localization for PRR13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRR13 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRR13 Gene COMPARTMENTS Subcellular localization image for PRR13 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PRR13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with PRR13: view

Pathways & Interactions for PRR13 Gene

SuperPathways for PRR13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRR13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with PRR13: view

No data available for Pathways by source and SIGNOR curated interactions for PRR13 Gene

Transcripts for PRR13 Gene

Unigene Clusters for PRR13 Gene

Proline rich 13:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRR13 Gene

No ASD Table

Relevant External Links for PRR13 Gene

GeneLoc Exon Structure for
PRR13
ECgene alternative splicing isoforms for
PRR13

Expression for PRR13 Gene

mRNA expression in normal human tissues for PRR13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRR13 Gene

This gene is overexpressed in Whole Blood (x9.0).

NURSA nuclear receptor signaling pathways regulating expression of PRR13 Gene:

PRR13

SOURCE GeneReport for Unigene cluster for PRR13 Gene:

Hs.744894
genes like me logo Genes that share expression patterns with PRR13: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PRR13 Gene

Orthologs for PRR13 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PRR13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRR13 34 35
  • 99.55 (n)
cow
(Bos Taurus)
Mammalia PRR13 35
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRR13 35
  • 80 (a)
OneToOne
Species where no ortholog for PRR13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRR13 Gene

ENSEMBL:
Gene Tree for PRR13 (if available)
TreeFam:
Gene Tree for PRR13 (if available)

Paralogs for PRR13 Gene

genes like me logo Genes that share paralogs with PRR13: view

No data available for Paralogs for PRR13 Gene

Variants for PRR13 Gene

Sequence variations from dbSNP and Humsavar for PRR13 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs111235514 -- 53,445,105(+) CCAGC(A/G)CTTTG intron-variant
rs11170557 -- 53,440,396(+) TCTTT(C/T)TTTTT upstream-variant-2KB
rs11170558 -- 53,441,251(+) GGAGA(G/T)ATTAT upstream-variant-2KB
rs112934088 -- 53,445,891(+) CTGAC(C/G)TTCTT intron-variant
rs113942405 -- 53,445,986(+) ATCTT(-/CTTTCCC)CTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRR13 Gene

Variant ID Type Subtype PubMed ID
nsv975495 CNV duplication 23825009

Variation tolerance for PRR13 Gene

Residual Variation Intolerance Score: 68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRR13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRR13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRR13 Gene

Disorders for PRR13 Gene

Relevant External Links for PRR13

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRR13

No disorders were found for PRR13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRR13 Gene

Publications for PRR13 Gene

  1. Txr1: a transcriptional regulator of thrombospondin-1 that modulates cellular sensitivity to taxanes. (PMID: 16847352) Lih C.-J. … Cohen S.N. (Genes Dev. 2006) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 64
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4 64
  5. Txr1: an important factor in oxaliplatin resistance in gastric cancer. (PMID: 24362794) Bi J. … Zhang Z. (Med. Oncol. 2014) 3 64

Products for PRR13 Gene

Sources for PRR13 Gene

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