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Aliases for PRR12 Gene

Aliases for PRR12 Gene

  • Proline Rich 12 2 3 5
  • KIAA1205 2 3 4

External Ids for PRR12 Gene

Previous HGNC Symbols for PRR12 Gene

  • KIAA1205

Previous GeneCards Identifiers for PRR12 Gene

  • GC19P054787
  • GC19P054788
  • GC19P050094
  • GC19P046472

Summaries for PRR12 Gene

GeneCards Summary for PRR12 Gene

PRR12 (Proline Rich 12) is a Protein Coding gene. An important paralog of this gene is QSER1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRR12 Gene

Genomics for PRR12 Gene

Regulatory Elements for PRR12 Gene

Promoters for PRR12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRR12 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRR12 Gene

Chromosome:
19
Start:
49,591,643 bp from pter
End:
49,626,439 bp from pter
Size:
34,797 bases
Orientation:
Plus strand

Genomic View for PRR12 Gene

Genes around PRR12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRR12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRR12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRR12 Gene

Proteins for PRR12 Gene

  • Protein details for PRR12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULL5-PRR12_HUMAN
    Recommended name:
    Proline-rich protein 12
    Protein Accession:
    Q9ULL5
    Secondary Accessions:
    • E9PB06
    • Q8N4J6

    Protein attributes for PRR12 Gene

    Size:
    1215 amino acids
    Molecular mass:
    129991 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA86519.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PRR12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRR12 Gene

Proteomics data for PRR12 Gene at MOPED

Post-translational modifications for PRR12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRR12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRR12 Gene

Domains & Families for PRR12 Gene

Protein Domains for PRR12 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRR12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULL5

UniProtKB/Swiss-Prot:

PRR12_HUMAN :
  • Contains 2 A.T hook DNA-binding domains.
Domain:
  • Contains 2 A.T hook DNA-binding domains.
genes like me logo Genes that share domains with PRR12: view

No data available for Gene Families for PRR12 Gene

Function for PRR12 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRR12 Gene

Localization for PRR12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRR12 Gene COMPARTMENTS Subcellular localization image for PRR12 gene
Compartment Confidence
nucleus 4
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PRR12 Gene

Pathways & Interactions for PRR12 Gene

SuperPathways for PRR12 Gene

No Data Available

Interacting Proteins for PRR12 Gene

Gene Ontology (GO) - Biological Process for PRR12 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PRR12 Gene

Drugs & Compounds for PRR12 Gene

No Compound Related Data Available

Transcripts for PRR12 Gene

mRNA/cDNA for PRR12 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRR12 Gene

Proline rich 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRR12 Gene

No ASD Table

Relevant External Links for PRR12 Gene

GeneLoc Exon Structure for
PRR12
ECgene alternative splicing isoforms for
PRR12

Expression for PRR12 Gene

mRNA expression in normal human tissues for PRR12 Gene

Protein differential expression in normal tissues from HIPED for PRR12 Gene

This gene is overexpressed in Fetal gut (21.9), CD8 Tcells (12.8), and Blymphocyte (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRR12 Gene



SOURCE GeneReport for Unigene cluster for PRR12 Gene Hs.590971

genes like me logo Genes that share expression patterns with PRR12: view

Protein tissue co-expression partners for PRR12 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PRR12 Gene

Orthologs for PRR12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRR12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRR12 35
  • 89.12 (n)
  • 97.37 (a)
PRR12 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRR12 35
  • 89.53 (n)
  • 97.3 (a)
PRR12 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prr12 35
  • 85.43 (n)
  • 95.24 (a)
Prr12 16
Prr12 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRR12 35
  • 98.55 (n)
  • 98.72 (a)
PRR12 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prr12 35
  • 84.78 (n)
  • 94.52 (a)
oppossum
(Monodelphis domestica)
Mammalia PRR12 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRR12 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prr12 35
  • 59.78 (n)
  • 62.49 (a)
zebrafish
(Danio rerio)
Actinopterygii wufj88e10 35
prr12b 36
  • 33 (a)
OneToOne
Species with no ortholog for PRR12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRR12 Gene

ENSEMBL:
Gene Tree for PRR12 (if available)
TreeFam:
Gene Tree for PRR12 (if available)

Paralogs for PRR12 Gene

Paralogs for PRR12 Gene

Pseudogenes.org Pseudogenes for PRR12 Gene

genes like me logo Genes that share paralogs with PRR12: view

Variants for PRR12 Gene

Sequence variations from dbSNP and Humsavar for PRR12 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2116921 -- 49,600,048(-) cttac(A/C)ccatg intron-variant
rs2116922 -- 49,599,995(-) TGTTA(C/T)CTAGT intron-variant
rs2116923 -- 49,599,088(-) GACCA(A/G)GAACT intron-variant
rs1052829 -- 49,626,205(+) CTTTT(C/T)TACGG utr-variant-3-prime
rs1052833 -- 49,626,301(+) CCTCC(G/T)CCCCG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PRR12 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv833863 CNV Loss 17160897
nsv833864 CNV Gain 17160897
nsv828578 CNV Loss 20364138
nsv469715 CNV Complex 16826518
nsv833865 CNV Gain+Loss 17160897
nsv912266 CNV Loss 21882294
dgv3972n71 CNV Loss 21882294
nsv912269 CNV Loss 21882294
nsv817854 CNV Gain 17921354
nsv470150 CNV Gain 18288195
esv21818 CNV Gain 19812545

Variation tolerance for PRR12 Gene

Residual Variation Intolerance Score: 1.32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.89; 59.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRR12 Gene

HapMap Linkage Disequilibrium report
PRR12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRR12 Gene

Disorders for PRR12 Gene

Relevant External Links for PRR12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRR12

No disorders were found for PRR12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRR12 Gene

Publications for PRR12 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 67
  2. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3
  3. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3

Products for PRR12 Gene

Sources for PRR12 Gene

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