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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRR12 Gene

protein-coding   GIFtS: 38
GCID: GC19P050094

proline rich 12

(Previous name: KIAA1205 )
(Previous symbol: KIAA1205)
  Search for PRR12
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PRR12    

Aliases
for PRR12 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Proline Rich 121 2
KIAA12051 2 3
Proline-Rich Protein 122

External Ids:    HGNC: 292171   Entrez Gene: 574792   Ensembl: ENSG000001264647   UniProtKB: Q9ULL53   

Export aliases for PRR12 gene to outside databases

Previous GC identifers: GC19P054787 GC19P054788 GC19P046472


Summaries
for PRR12 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for PRR12 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRR12 gene promoter:
         p53   STAT5A   RelA   NF-kappaB   Egr-4   Egr-2   HOXA5   c-Myb   Zic3   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for PRR12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRR12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.33

PRR12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRR12 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P050094:  view genomic region     (about GC identifiers)

Start:
 50,094,912 bp from pter      End:
 50,129,696 bp from pter
Size:
 34,785 bases      Orientation:
 plus strand

Proteins
for PRR12 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PRR12_HUMAN, Q9ULL5 (See protein sequence)
Recommended Name: Proline-rich protein 12  
Size: 1215 amino acids; 129991 Da
Sequence caution: Sequence=BAA86519.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: E9PB06 Q8N4J6
Alternative splicing: 3 isoforms:  Q9ULL5-1   Q9ULL5-2   Q9ULL5-3   (No experimental confirmation available. Prediction based on ortholog sequences. Ref.3 (BF805116) sequence differs from that shown due to a frameshift in position 10. Contains a phosphoserine at position 651. Contains a phosphothreonine at position 738)

Explore the universe of human proteins at neXtProt for PRR12: NX_Q9ULL5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9ULL5

    • PRR12 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_065770.1  
    ENSEMBL proteins: 
     ENSP00000394510  

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    Protein Domains /
    Families
    for PRR12 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PRR12 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR017956 AT_hook_DNA-bd_motif
     IPR025451 DUF4211

    Graphical View of Domain Structure for InterPro Entry Q9ULL5

    ProtoNet protein and cluster: Q9ULL5

    UniProtKB/Swiss-Prot: PRR12_HUMAN, Q9ULL5
    Similarity: Contains 2 A.T hook DNA-binding domains


    Function
    for PRR12 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate PRR12 (see all 37):
    hsa-miR-3685 hsa-miR-323-3p hsa-miR-300 hsa-miR-128 hsa-miR-765 hsa-let-7a-2* hsa-miR-624 hsa-miR-486-3p
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    Inhib. RNA
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--


    PRR12 for ontologies           About GeneDecksing



    Pathways & Interactions
    for PRR12 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PRR12

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for PRR12 (ENSP000003945104) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FASNENSP000003045924STRING: ENSP00000304592
    PUM1ENSP000003917234STRING: ENSP00000391723
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Drugs & Compounds
    for PRR12 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PRR12
    Search CenterWatch for drugs/clinical trials and news about PRR12 

    Transcripts
    for PRR12 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PRR12 gene: 
    NM_020719.1  

    Unigene Cluster for PRR12:

    Proline rich 12
    Hs.590971  [show with all ESTs]
    Unigene Representative Sequence: NM_020719
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000418929(uc002poo.4)

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    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate PRR12 (see all 37):
    hsa-miR-3685 hsa-miR-323-3p hsa-miR-300 hsa-miR-128 hsa-miR-765 hsa-let-7a-2* hsa-miR-624 hsa-miR-486-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRR12 (see all 4)
    OriGene shRNA RFP: PRR12
    OriGene siRNA: PRR12
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRR12
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRR12
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRR12

    Additional cDNA sequence: 

    AB033031.1 BC034003.1 

    6 DOTS entries:

    DT.453962  DT.92470742  DT.97858979  DT.121408963  DT.97815244  DT.92067109 

    3 AceView cDNA sequences:

    CR593436 BC034003 AB033031 

    GeneLoc Exon Structure


    Expression
    for PRR12 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRR12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGTCAGGGTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See PRR12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRR12

    SOURCE GeneReport for Unigene cluster: Hs.590971
        SABiosciences Custom PCR Arrays for PRR12
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRR12

    Orthologs
    for PRR12 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for PRR12 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Prr121 , 5 proline rich 121, 5 84.67(n)1
    93.83(a)1    		   7 (29.08 cM)5
    2332101  NM_175022.21  NP_778187.21 
     450277075 
    lizard
    (Anolis carolinensis)    		 Reptilia PRR126
    		 --
    		 59(a)
    		 1 ↔ 1
    		 6(80526222-80553001)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia 1377132142   -- 75.91(n)    137713214 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufj88e102 Transcribed sequence with weak similarity to protein more 77.92(n)    BI888447.1 


    ENSEMBL Gene Tree for PRR12 (if available)
    TreeFam Gene Tree for PRR12 (if available) 

    Paralogs
    for PRR12 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRR12 gene
    QSER12  

    PRR12 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PRR12
    PGOHUM00000247663


    Genomic Variants
    for PRR12 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/677 NCBI SNPs in PRR12 are shown (see all 677)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1464154051,2
    		C,--50095048(+) GCCCA-/GCCGG 
                GCCGG     		1 -- int10--------
    rs1912134721,2
    		--50095051(+) CAGCCA/GGGCCG 1 -- int10--------
    rs2009187081,2
    		--50095072(+) GGCCG-/GGCCC 
                GCCCG     		1 -- int10--------
    rs1819282931,2
    		--50095191(+) GCCAGC/TTCCGG 1 -- int10--------
    rs1466020011,2
    		--50095370(+) AAGGTG/TGGAAG 1 -- int10--------
    rs741820601,2
    		C,--50095527(+) GGGGTTG/-TGTGT 1 -- int11Minor allele frequency- -:0.50NA 2
    rs1874316571,2
    		--50095576(+) CCTTTA/GATGCC 1 -- int10--------
    rs1425626121,2
    		--50095663(+) GGTGCC/TGTTGC 1 -- int10--------
    rs1176139971,2
    		C,F,--50095702(+) TGTGTT/GTNNNN 1 -- int11Minor allele frequency- G:0.03NA 120
    rs1905057001,2
    		--50095711(+) GTGTCC/TGAGCG 1 -- int10--------

    HapMap Linkage Disequilibrium report for PRR12 (50094912 - 50129696 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 8 variations for PRR12
         8 CNVs: 30912 2246 5112 73399 9803 5113 5110 32261

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for PRR12

    Disorders / Diseases
    for PRR12 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for PRR12 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRR12 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with PRR12)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2, 3 Nagase T.... Ohara O. (1999)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1, 2 Dias Neto E....Simpson A.J.G. (2000)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    9. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    10. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)

    External Searches for PRR12 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PRR12 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57479 HGNC: 29217 AceView: KIAA1205 Ensembl:ENSG00000126464 euGenes: HUgn57479
    ECgene: PRR12 H-InvDB: PRR12

    Other Databases showing PRR12 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1205

    Specialized Databases showing PRR12 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRR12 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PRR12 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PRR12 gene:
    Search GeneIP for patents involving PRR12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for PRR12 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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