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Aliases for PRR11 Gene

Aliases for PRR11 Gene

  • Proline Rich 11 2 3 5

External Ids for PRR11 Gene

Previous GeneCards Identifiers for PRR11 Gene

  • GC17P054588
  • GC17P057233
  • GC17P052593

Summaries for PRR11 Gene

GeneCards Summary for PRR11 Gene

PRR11 (Proline Rich 11) is a Protein Coding gene.

UniProtKB/Swiss-Prot for PRR11 Gene

  • Plays a critical role in cell cycle progression.

Additional gene information for PRR11 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRR11 Gene

Genomics for PRR11 Gene

GeneHancer (GH) Regulatory Elements for PRR11 Gene

Promoters and enhancers for PRR11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I059151 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE 550.8 +0.8 791 9.6 CLOCK ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 SP3 NFYC PRR11 SKA2 GC17M059154 MKS1 NDUFB8P2 TUBD1 TRIM37 RPS6KB1 SMG8 RNFT1
GH17I059616 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.8 +464.2 464176 6.8 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 CLTC ENSG00000273702 TUBD1 RPS6KB1 HEATR6 SKA2 PPM1D DHX40 RNFT1 NDUFB8P2
GH17I059641 Enhancer 1.2 Ensembl ENCODE dbSUPER 4.8 +487.3 487266 1.9 PKNOX1 NFRKB ZSCAN4 BATF IRF4 RFX5 ZNF207 ATF7 ETV6 RCOR1 NDUFB8P2 RPS6KB1 PPM1D TUBD1 HEATR6 DHX40 PRR11 ENSG00000274378 CLTC ENSG00000273702
GH17I059110 Enhancer 0.5 dbSUPER 11.1 -43.5 -43467 2.7 PKNOX1 ZNF362 PRDM6 ZNF157 ZNF384 TRIM37 MIR301A MIR454 SKA2 PRR11 GC17M059110 ENSG00000224738
GH17I059633 Enhancer 1.1 Ensembl ENCODE dbSUPER 4.8 +479.3 479316 1.9 ZNF449 NFRKB NEUROD1 NFXL1 COPS2 YBX1 CEBPG GATA3 ZNF316 FOSL2 ENSG00000224738 RPS6KB1 DHX40 PRR11 ENSG00000273702 CLTC GC17M059649
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRR11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRR11 gene promoter:

Genomic Locations for PRR11 Gene

Genomic Locations for PRR11 Gene
chr17:59,155,499-59,206,709
(GRCh38/hg38)
Size:
51,211 bases
Orientation:
Plus strand
chr17:57,232,860-57,284,070
(GRCh37/hg19)

Genomic View for PRR11 Gene

Genes around PRR11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRR11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRR11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRR11 Gene

Proteins for PRR11 Gene

  • Protein details for PRR11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HE9-PRR11_HUMAN
    Recommended name:
    Proline-rich protein 11
    Protein Accession:
    Q96HE9
    Secondary Accessions:
    • Q9NUZ7
    • Q9NXE9

    Protein attributes for PRR11 Gene

    Size:
    360 amino acids
    Molecular mass:
    40085 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91064.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for PRR11 Gene

Post-translational modifications for PRR11 Gene

  • Ubiquitinated (Probable). Rapidly degraded by the proteasome; degradation may involve FBXW7-specific phosphorylated phosphodegron motifs.

No data available for DME Specific Peptides for PRR11 Gene

Domains & Families for PRR11 Gene

Gene Families for PRR11 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PRR11 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for PRR11 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRR11: view

No data available for UniProtKB/Swiss-Prot for PRR11 Gene

Function for PRR11 Gene

Molecular function for PRR11 Gene

UniProtKB/Swiss-Prot Function:
Plays a critical role in cell cycle progression.
UniProtKB/Swiss-Prot Induction:
Expression increases from G1 to G2/M phase.

Phenotypes From GWAS Catalog for PRR11 Gene

genes like me logo Genes that share phenotypes with PRR11: view

miRNA for PRR11 Gene

miRTarBase miRNAs that target PRR11

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRR11 Gene

Localization for PRR11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRR11 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRR11 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRR11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 23246489
GO:0005737 cytoplasm IDA,IEA 23246489
GO:0016020 membrane IDA,HDA 19946888
genes like me logo Genes that share ontologies with PRR11: view

Pathways & Interactions for PRR11 Gene

SuperPathways for PRR11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRR11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007050 cell cycle arrest IBA --
GO:0051726 regulation of cell cycle IDA 23246489
genes like me logo Genes that share ontologies with PRR11: view

No data available for Pathways by source and SIGNOR curated interactions for PRR11 Gene

Drugs & Compounds for PRR11 Gene

No Compound Related Data Available

Transcripts for PRR11 Gene

Unigene Clusters for PRR11 Gene

Proline rich 11:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRR11 Gene

No ASD Table

Relevant External Links for PRR11 Gene

GeneLoc Exon Structure for
PRR11
ECgene alternative splicing isoforms for
PRR11

Expression for PRR11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRR11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRR11 Gene



NURSA nuclear receptor signaling pathways regulating expression of PRR11 Gene:

PRR11

SOURCE GeneReport for Unigene cluster for PRR11 Gene:

Hs.631750

mRNA Expression by UniProt/SwissProt for PRR11 Gene:

Q96HE9-PRR11_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for PRR11 Gene

  • Eye(4.1)
genes like me logo Genes that share expression patterns with PRR11: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRR11 Gene

Orthologs for PRR11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRR11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRR11 33 34
  • 99.17 (n)
dog
(Canis familiaris)
Mammalia PRR11 33 34
  • 87.04 (n)
cow
(Bos Taurus)
Mammalia PRR11 33 34
  • 85 (n)
rat
(Rattus norvegicus)
Mammalia Prr11 33
  • 81.2 (n)
mouse
(Mus musculus)
Mammalia Prr11 33 16 34
  • 79.63 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PRR11 34
  • 55 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRR11 34
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRR11 33 34
  • 60.13 (n)
lizard
(Anolis carolinensis)
Reptilia PRR11 34
  • 33 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prr11 33
  • 52.58 (n)
zebrafish
(Danio rerio)
Actinopterygii prr11 34
  • 31 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
OneToOne
Species where no ortholog for PRR11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRR11 Gene

ENSEMBL:
Gene Tree for PRR11 (if available)
TreeFam:
Gene Tree for PRR11 (if available)

Paralogs for PRR11 Gene

Pseudogenes.org Pseudogenes for PRR11 Gene

genes like me logo Genes that share paralogs with PRR11: view

No data available for Paralogs for PRR11 Gene

Variants for PRR11 Gene

Sequence variations from dbSNP and Humsavar for PRR11 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000025106 -- 59,160,834(+) C/T intron_variant
rs1000067031 -- 59,175,965(+) A/C intron_variant
rs1000079762 -- 59,191,649(+) C/G intron_variant
rs1000309334 -- 59,158,373(+) G/A intron_variant
rs1000359436 -- 59,207,179(+) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PRR11 Gene

Variant ID Type Subtype PubMed ID
dgv3270n100 CNV gain 25217958
dgv3271n100 CNV gain 25217958
dgv38n82 CNV duplication 23825009
esv25721 CNV gain 19812545
esv2662575 CNV deletion 23128226
esv2667720 CNV deletion 23128226
esv2716081 CNV deletion 23290073
esv2758699 CNV gain 17122850
esv28194 CNV loss 19812545
esv3573764 CNV gain 25503493
esv3640902 CNV loss 21293372
nsv1057152 CNV gain 25217958
nsv1062736 CNV gain 25217958
nsv1065063 CNV gain 25217958
nsv1065442 CNV gain 25217958
nsv1109092 CNV deletion 24896259
nsv575802 CNV loss 21841781
nsv833499 CNV loss 17160897

Variation tolerance for PRR11 Gene

Residual Variation Intolerance Score: 86.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRR11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRR11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRR11 Gene

Disorders for PRR11 Gene

Additional Disease Information for PRR11

No disorders were found for PRR11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRR11 Gene

Publications for PRR11 Gene

  1. PRR11 is a novel gene implicated in cell cycle progression and lung cancer. (PMID: 23246489) Ji Y … Bu Y (The international journal of biochemistry & cell biology 2013) 3 4 58
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis. (PMID: 11799066) Weinmann AS … Farnham PJ (Genes & development 2002) 2 3 58

Products for PRR11 Gene

Sources for PRR11 Gene

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