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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRPSAP1 Gene

protein-coding   GIFtS: 53
GCID: GC17M074306

phosphoribosyl pyrophosphate synthetase-associated protein...

 Explore 6 diseases affiliated with
PRPSAP1 via our new
 Human Malady Compendium 
Biological research products
for PRPSAP1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Phosphoribosyl Pyrophosphate Synthetase-Associated Protein 11 2
PAP391 2 3
39 KDa Phosphoribosypyrophosphate Synthase-Associated Protein2 3
PRPP Synthase-Associated Protein 12 3
Phosphoribosyl Pyrophosphate Synthase-Associated Protein 12

External Ids:    HGNC: 94661   Entrez Gene: 56352   Ensembl: ENSG000001615427   OMIM: 6012495   UniProtKB: Q145583   

Export aliases for PRPSAP1 gene to outside databases

Previous GC identifers: GC17M074165 GC17M077298 GC17M074771 GC17M074904 GC17M071818 GC17M069735


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: KPRA_HUMAN, Q14558
Function: Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis

Gene Wiki entry for PRPSAP1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRPSAP1 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 4   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): PRPSAP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PRPSAP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRPSAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q24-q25   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q24-q25

PRPSAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRPSAP1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M074306:  view genomic region     (about GC identifiers)

Start:
74,305,567 bp from pter      End:
74,380,602 bp from pter
Size:
75,036 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KPRA_HUMAN, Q14558 (See protein sequence)
Recommended Name: Phosphoribosyl pyrophosphate synthase-associated protein 1  
Size: 356 amino acids; 39394 Da
Subunit: Binds to PRPS1 and PRPS2
Sequence caution: Sequence=BAG35521.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for PRPSAP1:
2C4K (3D)    
Secondary accessions: B2R6M4 Q96H06
Alternative splicing: 2 isoforms:  Q14558-1   Q14558-2   

Explore the universe of human proteins at neXtProt for PRPSAP1: NX_Q14558

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14558

  • PRPSAP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002757.2  
    ENSEMBL proteins: 
     ENSP00000414624   ENSP00000314973   ENSP00000392838   ENSP00000387494   ENSP00000409190  
     ENSP00000402126  

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    Novus Biologicals PRPSAP1 Proteins
    Novus Biologicals PRPSAP1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PRPSAP1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002189ribose phosphate diphosphokinase complex IEA--
    GO:0043234protein complex ----


    PRPSAP1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for PRPSAP1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PRPSAP1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR005946 Rib-P_diPkinase

    Graphical View of Domain Structure for InterPro Entry Q14558

    ProtoNet protein and cluster: Q14558

    UniProtKB/Swiss-Prot: KPRA_HUMAN, Q14558
    Similarity: Belongs to the ribose-phosphate pyrophosphokinase family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: KPRA_HUMAN, Q14558
    Function: Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis

         Genatlas biochemistry entry for PRPSAP1:
    phosphoribosylpyrophosphate synthetase-associated protein,39kDa

    miRNA
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    hsa-miR-450b-5p hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidPRPSAP1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRPSAP1

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0004749ribose phosphate diphosphokinase activity IEA--
    GO:0004857enzyme inhibitor activity TAS8132556
    GO:0019900kinase binding IEA--
    GO:0030234enzyme regulator activity ----


    PRPSAP1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for PRPSAP1:
     Increased S DNA content 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRPSAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/33 Interacting proteins for PRPSAP1 (Q145582, 3 ENSP000004146244) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLEKHF2Q9H8W42, 3, ENSP000003223734MINT-68170 I2D: score=5 STRING: ENSP00000322373
    PRPS1P608913, ENSP000003615124I2D: score=5 STRING: ENSP00000361512
    DDX19BQ9UMR23, ENSP000002880714I2D: score=3 STRING: ENSP00000288071
    PRPS2P119083, ENSP000003815044I2D: score=3 STRING: ENSP00000381504
    NUAK1O602853, ENSP000002614024I2D: score=2 STRING: ENSP00000261402
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006139nucleobase-containing compound metabolic process TAS8611620
    GO:0009165nucleotide biosynthetic process IEA--
    GO:0033673negative regulation of kinase activity IEA--
    GO:0043086negative regulation of catalytic activity ----
    GO:0050790regulation of catalytic activity ----


    PRPSAP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PRPSAP1
    Search CenterWatch for drugs/clinical trials and news about PRPSAP1 / KPRA 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PRPSAP1 gene: 
    NM_002766.2  

    Unigene Cluster for PRPSAP1:

    Phosphoribosyl pyrophosphate synthetase-associated protein 1
    Hs.77498  [show with all ESTs]
    Unigene Representative Sequence: NM_002766
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000446526(uc010wta.1) ENST00000324684(uc010wtb.1) ENST00000588364
    ENST00000592474 ENST00000488339 ENST00000435555 ENST00000472686 ENST00000586137
    ENST00000436498 ENST00000494662 ENST00000423915 ENST00000442767

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate PRPSAP1:
    hsa-miR-450b-5p hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidPRPSAP1 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRPSAP1
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    Additional cDNA sequence: 

    AK092626.1 AK131332.1 AK298171.1 AK312637.1 BC009012.1 D61391.1 

    10 DOTS entries:

    DT.446627  DT.99968566  DT.91759025  DT.121009346  DT.86856931  DT.86854893  DT.95073686  DT.91759029 
    DT.100830844  DT.95119243 

    24/297 AceView cDNA sequences (see all 297):

    CA447711 BQ676931 BU186175 BM547340 AI081984 BQ014476 BU187094 AI538110 
    AA284525 BQ677842 AW269480 BQ680871 BU689612 AA548855 AI289298 N44997 
    CN482681 BQ681429 BQ683561 BQ430183 BQ684538 CB852654 CF131042 BM752722 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRPSAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGTTACATC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See PRPSAP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRPSAP1

    SOURCE GeneReport for Unigene cluster: Hs.77498

    UniProtKB/Swiss-Prot: KPRA_HUMAN, Q14558
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for PRPSAP1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRPSAP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for PRPSAP1 gene from 9/33 species (see all 33)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves PRPSAP11 phosphoribosyl pyrophosphate synthetase-associated more 86.05(n)
    97.47(a)
      417360  XM_415620.3  XP_415620.2 
    lizard
    (Anolis carolinensis)
    Reptilia PRPSAP16
    --
    95(a)
    1 ↔ 1
    2(112397200-112428826)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC043887.12   -- 78.52(n)    BC043887.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:918451 zgc:91845 77.24(n)
    90.08(a)
      431746  NM_001002199.1  NP_001002199.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG22463 ribose-phosphate pyrophosphokinase 64(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea W04G3.53 ribose-phosphate pyrophosphokinase 59(a)   X(11108892-11111004)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PRS26
    AT2G353906
    (see all 5)
    ribose-phosphate pyrophosphokinase 1
    (see all 5)
    27(a)
    26(a)
    (see all 5)
    possible ortholog
    possible ortholog
    (see all 5)
    1(11681752-11684478)
    2(14895279-14897822)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 6)
    phosphoribosyl transferase, putative, expressed
    (see all 6)
    27(a)
    27(a)
    (see all 6)
    possible ortholog
    possible ortholog
    (see all 6)
    2(1437433-1441125)
    3(18106-19491)
    E. coli
    (Escherichia coli)
    Gamma proteobacteria prs6
    phosphoribosylpyrophosphate synthase
    38(a)
    possible ortholog
    Chromosome(1260151-1261098)


    ENSEMBL Gene Tree for PRPSAP1 (if available)
    TreeFam Gene Tree for PRPSAP1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRPSAP1 gene
    PRPS12  PRPS22  PRPSAP22  PRPS1L12  
    4 SIMAP similar genes for PRPSAP1 using alignment to 6 protein entries:     KPRA_HUMAN (see all proteins):
    PRPSAP2    PRPS2    PRPS1L1    PRPS1

    PRPSAP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/881 NCBI SNPs in PRPSAP1 are shown (see all 881    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1396330401,2
    --74306503(+) GCCTCA/GGCCTC 1 -- ds50010--------
    rs65018841,2
    C,F,A,--74306526(+) GATTAC/AAGGCA 1 -- ds50017Minor allele frequency- A:0.29NA CSA WA EA 366
    rs1443328971,2
    --74306533(+) GGCATA/GAGACA 1 -- ds50010--------
    rs1451756471,2
    --74306588(+) GTCACC/GCAGGA 1 -- ds50010--------
    rs1923662701,2
    --74306701(+) TGCTAC/TCAATG 1 -- ds50010--------
    rs4216121,2
    C,A,H,--74306830(-) CTCACA/GCCTAT 1 -- ds50018Minor allele frequency- G:0.33WA NA CSA EA 367
    rs126013811,2
    H--74306945(+) GTTTGT/GGTCCA 1 -- ut314Minor allele frequency- G:0.00NS EA 400
    rs1491511801,2
    --74306985(+) ATGGTC/TTTCTG 1 -- ut310--------
    rs1156054181,2
    C,F,--74307102(+) AAGATG/ATAACA 1 -- ut311Minor allele frequency- A:0.02WA 118
    rs1433897631,2
    --74307111(+) CAACAC/TGAATG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PRPSAP1 (74305567 - 74380602 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for PRPSAP1
         2 CNVs: 67264 5032

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRPSAP1
    DNA2.0 Custom Variant and Variant Library Synthesis for PRPSAP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PRPSAP1 for disorders           About GeneDecksing

    OMIM gene information: 601249    OMIM disorders: --

    6 diseases for PRPSAP1:    About MalaCards
    mitral valve stenosis    osteogenesis imperfecta    pneumonia    tuberculosis
    malaria    mycobacterium tuberculosis

    1 disease from the University of Copenhagen DISEASES database for PRPSAP1:
    Hyperuricemia

    Export disorders for PRPSAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRPSAP1 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with PRPSAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human phosphoribosylpyrophosphate synthetase-associated protein 39 gene (PRPSAP1) is located in the chromosome region 17q24-q25. (PubMed id 8660991)1, 3, 9 Ishizuka T....Tatibana M. (1996)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Cloning and sequencing of human complementary DNA for the phosphoribosylpyrophosphate synthetase-associated protein 39. (PubMed id 8611620)1, 2 Ishizuka T....Tatibana M. (1996)
    4. Mammalian phosphoribosyl-pyrophosphate synthetase. (PubMed id 7572345)1, 9 Tatibana M....Ahmad I. (1995)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    7. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5635 HGNC: 9466 AceView: PRPSAP1 Ensembl:ENSG00000161542 euGenes: HUgn5635
    ECgene: PRPSAP1 H-InvDB: PRPSAP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRPSAP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PRPSAP1 gene:
    Search GeneIP for patents involving PRPSAP1

    GeneCards and IP:
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