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Aliases for PRPS2 Gene

Aliases for PRPS2 Gene

  • Phosphoribosyl Pyrophosphate Synthetase 2 2 3
  • Phosphoribosyl Pyrophosphate Synthase II 3 4
  • Ribose-Phosphate Diphosphokinase 2 2 3
  • EC 4 63
  • PRS-II 3 4
  • PPRibP Synthetase 3
  • PRS II 2
  • PPRibP 4
  • PRSII 3

External Ids for PRPS2 Gene

Previous GeneCards Identifiers for PRPS2 Gene

  • GC0XP012002
  • GC0XP011575
  • GC0XP012105
  • GC0XP012170
  • GC0XP012569
  • GC0XP010576

Summaries for PRPS2 Gene

Entrez Gene Summary for PRPS2 Gene

  • This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

GeneCards Summary for PRPS2 Gene

PRPS2 (Phosphoribosyl Pyrophosphate Synthetase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include protein homodimerization activity and carbohydrate binding. An important paralog of this gene is PRPS1L1.

UniProtKB/Swiss-Prot for PRPS2 Gene

  • Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRPS2 Gene

Genomics for PRPS2 Gene

Regulatory Elements for PRPS2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PRPS2 Gene

12,791,355 bp from pter
12,824,227 bp from pter
32,873 bases
Plus strand

Genomic View for PRPS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRPS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRPS2 Gene

Proteins for PRPS2 Gene

  • Protein details for PRPS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribose-phosphate pyrophosphokinase 2
    Protein Accession:
    Secondary Accessions:
    • Q0VDH9
    • Q0VDI0
    • Q15245
    • Q2TAK7

    Protein attributes for PRPS2 Gene

    318 amino acids
    Molecular mass:
    34769 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer. The active form is probably a hexamer composed of 3 homodimers (By similarity).
    • Sequence=AAH30019.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PRPS2 Gene


neXtProt entry for PRPS2 Gene

Proteomics data for PRPS2 Gene at MOPED

Post-translational modifications for PRPS2 Gene

  • Ubiquitination at Lys 34 and Lys 235
  • Modification sites at PhosphoSitePlus

Other Protein References for PRPS2 Gene

Domains & Families for PRPS2 Gene

Suggested Antigen Peptide Sequences for PRPS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribose-phosphate pyrophosphokinase family.
  • Belongs to the ribose-phosphate pyrophosphokinase family.
genes like me logo Genes that share domains with PRPS2: view

No data available for Gene Families for PRPS2 Gene

Function for PRPS2 Gene

Molecular function for PRPS2 Gene

GENATLAS Biochemistry:
phosphoribosyl pyrophosphate synthetase 2
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by magnesium and inorganic phosphate. Competitively or non-competitively inhibited by ADP, 2,3-bisphosphoglyceride or GDP
UniProtKB/Swiss-Prot Function:
Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis

Enzyme Numbers (IUBMB) for PRPS2 Gene

Gene Ontology (GO) - Molecular Function for PRPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004749 ribose phosphate diphosphokinase activity ISS --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding ISS --
GO:0016208 AMP binding IEA --
genes like me logo Genes that share ontologies with PRPS2: view

Phenotypes for PRPS2 Gene

genes like me logo Genes that share phenotypes with PRPS2: view

Animal Model Products

miRNA for PRPS2 Gene

miRTarBase miRNAs that target PRPS2

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for PRPS2 Gene

Localization for PRPS2 Gene

Subcellular locations from

Jensen Localization Image for PRPS2 Gene COMPARTMENTS Subcellular localization image for PRPS2 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for PRPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002189 ribose phosphate diphosphokinase complex IEA --
GO:0043234 protein complex --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PRPS2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PRPS2 Gene

Pathways & Interactions for PRPS2 Gene

genes like me logo Genes that share pathways with PRPS2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot P11908-PRPS2_HUMAN

  • Pathway: Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1

Gene Ontology (GO) - Biological Process for PRPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process IEA --
GO:0006139 nucleobase-containing compound metabolic process TAS 2538352
GO:0006167 AMP biosynthetic process IEA --
GO:0009156 ribonucleoside monophosphate biosynthetic process --
GO:0009165 nucleotide biosynthetic process --
genes like me logo Genes that share ontologies with PRPS2: view

No data available for SIGNOR curated interactions for PRPS2 Gene

Drugs & Compounds for PRPS2 Gene

(5) Drugs for PRPS2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0
Phosphoribosyl pyrophosphate Experimental Pharma 0
Magnesium Nutra 0

(5) Additional Compounds for PRPS2 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
D-Ribose 5-phosphate
  • D-Ribose 5-phosphate
  • D-Ribose-5-P
  • D-Ribose-5-phosphate
  • D-Ribose-5-phosphorate
  • D-Ribose-5-phosphoric acid
D-Ribulose 5-phosphate
  • alpha-D-Ribose 5-phosphate
  • D-Ribulose 5-phosphate
  • Erythro-Pentulose 5-phosphate
  • Ribulose 5-phosphate
  • Ribulose phosphate
  • 1-(5-Phospho-D-ribofuranosyl)adenosine 5'-(tetrahydrogen triphosphate)
  • 1-(5-Phospho-D-ribosyl)-ATP
  • 1-(5-Phosphoribosyl)-ATP
  • N1-(5-Phospho-D-ribosyl)-ATP
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
genes like me logo Genes that share compounds with PRPS2: view

Transcripts for PRPS2 Gene

Unigene Clusters for PRPS2 Gene

Phosphoribosyl pyrophosphate synthetase 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRPS2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRPS2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: -

Relevant External Links for PRPS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRPS2 Gene

mRNA expression in normal human tissues for PRPS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRPS2 Gene

This gene is overexpressed in Ovary (x8.3) and Testis (x5.2).

Protein differential expression in normal tissues from HIPED for PRPS2 Gene

This gene is overexpressed in Testis (28.9), Lymph node (8.6), and Ovary (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRPS2 Gene

SOURCE GeneReport for Unigene cluster for PRPS2 Gene Hs.654581

genes like me logo Genes that share expression patterns with PRPS2: view

Protein tissue co-expression partners for PRPS2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PRPS2 Gene

Orthologs for PRPS2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRPS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PRPS2 35
  • 89.62 (n)
  • 98.13 (a)
PRPS2 36
  • 99 (a)
(Canis familiaris)
Mammalia PRPS2 35
  • 90.34 (n)
  • 99.07 (a)
PRPS2 36
  • 99 (a)
(Mus musculus)
Mammalia Prps2 35
  • 89.1 (n)
  • 98.74 (a)
Prps2 16
Prps2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Prps2 35
  • 88.47 (n)
  • 99.06 (a)
(Monodelphis domestica)
Mammalia PRPS2 36
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia PRPS2 36
  • 98 (a)
(Pan troglodytes)
Mammalia PRPS2 36
  • 100 (a)
(Gallus gallus)
Aves PRPS2 35
  • 84.22 (n)
  • 97.2 (a)
PRPS2 36
  • 96 (a)
(Anolis carolinensis)
Reptilia PRPS2 36
  • 96 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia prps2 35
  • 80.4 (n)
  • 98.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6767 37
  • 87 (a)
CG6767 36
  • 72 (a)
(Caenorhabditis elegans)
Secernentea R151.2a 37
  • 80 (a)
R151.2b 37
  • 80 (a)
R151.2c 37
  • 80 (a)
R151.2 35
  • 68.97 (n)
  • 80.82 (a)
R151.2 36
  • 58 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL080C 35
  • 59.66 (n)
  • 64.01 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F25718g 35
  • 59.68 (n)
  • 61.9 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRS3 35
  • 57.94 (n)
  • 62.15 (a)
PRS2 36
  • 62 (a)
PRS3 36
  • 61 (a)
PRS4 36
  • 61 (a)
PRS3 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2559 36
  • 85 (a)
Species with no ortholog for PRPS2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for PRPS2 Gene

Gene Tree for PRPS2 (if available)
Gene Tree for PRPS2 (if available)

Paralogs for PRPS2 Gene

Paralogs for PRPS2 Gene

(4) SIMAP similar genes for PRPS2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PRPS2: view

Variants for PRPS2 Gene

Sequence variations from dbSNP and Humsavar for PRPS2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs764646 -- 12,803,731(-) aatcc(C/T)tggaa intron-variant
rs917580 -- 12,820,815(+) TCTAT(A/C/G)CACCA intron-variant
rs1062629 -- 12,823,176(+) CTTCA(C/G)ATTAA utr-variant-3-prime
rs1266347 -- 12,809,516(+) AGTCA(A/G)TTTTG intron-variant
rs1266348 -- 12,812,664(+) AATAC(A/G)TACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRPS2 Gene

Variant ID Type Subtype PubMed ID
nsv520250 CNV Gain 19592680

Variation tolerance for PRPS2 Gene

Residual Variation Intolerance Score: 15.53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.11; 2.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRPS2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRPS2 Gene

Disorders for PRPS2 Gene

Relevant External Links for PRPS2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PRPS2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRPS2 Gene

Publications for PRPS2 Gene

  1. Cloning of cDNAs for human phosphoribosylpyrophosphate synthetases 1 and 2 and X chromosome localization of PRPS1 and PRPS2 genes. (PMID: 1962753) Becker M.A. … Roessler B.J. (Genomics 1990) 2 23 67
  2. Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells. (PMID: 18677108) Mannava S. … Nikiforov M.A. (Cell Cycle 2008) 23 67
  3. Transcriptional targets of hepatocyte growth factor signaling and Ki-ras oncogene activation in colorectal cancer. (PMID: 16158056) Seiden-Long I.M. … Tsao M.S. (Oncogene 2006) 23 67
  4. Promoter regions of the human X-linked housekeeping genes PRPS1 and PRPS2 encoding phosphoribosylpyrophosphate synthetase subunit I and II isoforms. (PMID: 1314091) Ishizuka T. … Tatibana M. (Biochim. Biophys. Acta 1992) 23 67
  5. Physical mapping of loci in the distal half of the short arm of the human X chromosome: implications for the spreading of X-chromosome inactivation. (PMID: 1315458) Wang J.C. … Mohandas T.K. (Somat. Cell Mol. Genet. 1992) 23 67

Products for PRPS2 Gene

Sources for PRPS2 Gene

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