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Aliases for PRPS2 Gene

Aliases for PRPS2 Gene

  • Phosphoribosyl Pyrophosphate Synthetase 2 2 3 5
  • Phosphoribosyl Pyrophosphate Synthase II 3 4
  • Ribose-Phosphate Diphosphokinase 2 2 3
  • EC 2.7.6.1 4 61
  • PRS-II 3 4
  • Ribose-Phosphate Pyrophosphokinase 2 3
  • Testicular Secretory Protein Li 41 3
  • PPRibP Synthetase 3
  • PPRibP 4
  • PRS II 2
  • PRSII 3

External Ids for PRPS2 Gene

Previous GeneCards Identifiers for PRPS2 Gene

  • GC0XP012002
  • GC0XP011575
  • GC0XP012105
  • GC0XP012170
  • GC0XP012569
  • GC0XP010576

Summaries for PRPS2 Gene

Entrez Gene Summary for PRPS2 Gene

  • This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

GeneCards Summary for PRPS2 Gene

PRPS2 (Phosphoribosyl Pyrophosphate Synthetase 2) is a Protein Coding gene. Diseases associated with PRPS2 include Sertoli Cell-Only Syndrome. Among its related pathways are Pentose phosphate pathway and Glycosaminoglycan metabolism. GO annotations related to this gene include protein homodimerization activity and carbohydrate binding. An important paralog of this gene is PRPS1.

UniProtKB/Swiss-Prot for PRPS2 Gene

  • Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRPS2 Gene

Genomics for PRPS2 Gene

Regulatory Elements for PRPS2 Gene

Enhancers for PRPS2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG012969 2 FANTOM5 Ensembl ENCODE dbSUPER 5.3 +187.4 187385 17.7 HDGF FOXA2 PKNOX1 AGO1 WRNIP1 SIN3A YY1 ZNF207 FOS DEK FAM9C TLR8-AS1 PRPS2 TMSB4X TLR7 TLR8 LOC105373133
GH0XG012790 0.9 ENCODE 7.6 +0.4 370 1.9 HDGF GLIS2 KDM4B ZNF263 SP3 SP5 ZNF610 SMARCA4 GLIS1 SP7 TLR8 TLR8-AS1 PRPS2 PSMA6P2
GH0XG012779 0.5 ENCODE 5.4 -11.6 -11617 1.2 HNF1A ATF3 GATA2 ATF2 YY1 PRPS2 RN7SKP290
GH0XG012992 0.2 dbSUPER 5 +201.4 201445 1.3 FAM9C TLR8-AS1 TLR8 PRPS2 TMSB4X LOC105373133
GH0XG012771 0.7 ENCODE 0.4 -19.7 -19719 0.2 CTCF RB1 TEAD4 ZIC2 ZNF2 RAD21 ZFHX2 EGR1 ZNF143 SMC3 PRPS2 RN7SKP290
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRPS2 on UCSC Golden Path with GeneCards custom track

Promoters for PRPS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000244508 445 2001 HDGF GLIS2 KDM4B ZNF263 SP3 SP5 MAFF ZNF610 SMARCA4 GLIS1

Genomic Location for PRPS2 Gene

Chromosome:
X
Start:
12,791,355 bp from pter
End:
12,824,227 bp from pter
Size:
32,873 bases
Orientation:
Plus strand

Genomic View for PRPS2 Gene

Genes around PRPS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRPS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRPS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRPS2 Gene

Proteins for PRPS2 Gene

  • Protein details for PRPS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11908-PRPS2_HUMAN
    Recommended name:
    Ribose-phosphate pyrophosphokinase 2
    Protein Accession:
    P11908
    Secondary Accessions:
    • Q0VDH9
    • Q0VDI0
    • Q15245
    • Q2TAK7

    Protein attributes for PRPS2 Gene

    Size:
    318 amino acids
    Molecular mass:
    34769 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer. The active form is probably a hexamer composed of 3 homodimers (By similarity).
    SequenceCaution:
    • Sequence=AAH30019.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PRPS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRPS2 Gene

Selected DME Specific Peptides for PRPS2 Gene

P11908:
  • IVSPDAGGAKRVTSIA
  • DVYIIQSGCG
  • DRVAILVDDMADTC
  • GLELGKV
  • KDKSRAPI
  • PISAKLVAN
  • FSGSSHQDLSQ
  • QSGCGEIND
  • PVDNLYAEP
  • QIQGFFD
  • KLVANML
  • LMELLIM
  • LAEAIRRTHNGES
  • THGIFSG
  • GFFDIPVD
  • YARQDKK
  • NDNLMEL
  • IHKERKKANEV
  • GADHIITMDLH
  • FEAVVVTNTIPQ
  • AADKLLSAGAT
  • ESVRGEDVYI
  • QGFFDIP

Post-translational modifications for PRPS2 Gene

  • Ubiquitination at Lys34 and isoforms=2235
  • Modification sites at PhosphoSitePlus

Other Protein References for PRPS2 Gene

Antibody Products

  • Abcam antibodies for PRPS2

Domains & Families for PRPS2 Gene

Suggested Antigen Peptide Sequences for PRPS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P11908

UniProtKB/Swiss-Prot:

PRPS2_HUMAN :
  • Belongs to the ribose-phosphate pyrophosphokinase family.
Family:
  • Belongs to the ribose-phosphate pyrophosphokinase family.
genes like me logo Genes that share domains with PRPS2: view

No data available for Gene Families for PRPS2 Gene

Function for PRPS2 Gene

Molecular function for PRPS2 Gene

GENATLAS Biochemistry:
phosphoribosyl pyrophosphate synthetase 2
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by magnesium and inorganic phosphate. Competitively or non-competitively inhibited by ADP, 2,3-bisphosphoglyceride or GDP.
UniProtKB/Swiss-Prot Function:
Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.

Enzyme Numbers (IUBMB) for PRPS2 Gene

Gene Ontology (GO) - Molecular Function for PRPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004749 ribose phosphate diphosphokinase activity ISS,IEA --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding ISS --
GO:0016208 AMP binding IEA --
genes like me logo Genes that share ontologies with PRPS2: view
genes like me logo Genes that share phenotypes with PRPS2: view

Animal Models for PRPS2 Gene

MGI Knock Outs for PRPS2:

Animal Model Products

  • Taconic Biosciences Mouse Models for PRPS2

miRNA for PRPS2 Gene

miRTarBase miRNAs that target PRPS2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PRPS2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRPS2 Gene

Localization for PRPS2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRPS2 gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 2
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PRPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002189 ribose phosphate diphosphokinase complex IEA --
GO:0043234 protein complex IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PRPS2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PRPS2 Gene

Pathways & Interactions for PRPS2 Gene

genes like me logo Genes that share pathways with PRPS2: view

Pathways by source for PRPS2 Gene

UniProtKB/Swiss-Prot P11908-PRPS2_HUMAN

  • Pathway: Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.

Gene Ontology (GO) - Biological Process for PRPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process IEA --
GO:0006139 nucleobase-containing compound metabolic process TAS 2538352
GO:0006167 AMP biosynthetic process IEA --
GO:0009116 nucleoside metabolic process IEA --
GO:0009156 ribonucleoside monophosphate biosynthetic process IEA --
genes like me logo Genes that share ontologies with PRPS2: view

No data available for SIGNOR curated interactions for PRPS2 Gene

Drugs & Compounds for PRPS2 Gene

(4) Drugs for PRPS2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(6) Additional Compounds for PRPS2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
D-Ribose 5-phosphate
  • D-Ribose 5-phosphate
  • D-Ribose-5-P
  • D-Ribose-5-phosphate
  • D-Ribose-5-phosphorate
  • D-Ribose-5-phosphoric acid
3615-55-2
D-Ribulose 5-phosphate
  • alpha-D-Ribose 5-phosphate
  • D-Ribulose 5-phosphate
  • Erythro-Pentulose 5-phosphate
  • Ribulose 5-phosphate
  • Ribulose phosphate
4151-19-3
Phosphoribosyl pyrophosphate
  • 5-Phospho-a-D-ribose-1-diphosphate
  • 5-Phospho-a-D-ribosyl pyrophosphate
  • 5-Phospho-alpha-D-ribose 1-diphosphate
  • 5-Phospho-alpha-D-ribose-1-diphosphate
  • 5-Phospho-alpha-D-ribosyl pyrophosphate
7540-64-9
Phosphoribosyl-ATP
  • 1-(5-Phospho-D-ribofuranosyl)adenosine 5'-(tetrahydrogen triphosphate)
  • 1-(5-Phospho-D-ribosyl)-ATP
  • 1-(5-Phosphoribosyl)-ATP
  • N1-(5-Phospho-D-ribosyl)-ATP
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with PRPS2: view

Transcripts for PRPS2 Gene

Unigene Clusters for PRPS2 Gene

Phosphoribosyl pyrophosphate synthetase 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PRPS2

Alternative Splicing Database (ASD) splice patterns (SP) for PRPS2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: -
SP2:

Relevant External Links for PRPS2 Gene

GeneLoc Exon Structure for
PRPS2
ECgene alternative splicing isoforms for
PRPS2

Expression for PRPS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRPS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRPS2 Gene

This gene is overexpressed in Ovary (x8.3) and Testis (x5.2).

Protein differential expression in normal tissues from HIPED for PRPS2 Gene

This gene is overexpressed in Testis (28.9), Lymph node (8.6), and Ovary (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRPS2 Gene



Protein tissue co-expression partners for PRPS2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRPS2 Gene:

PRPS2

SOURCE GeneReport for Unigene cluster for PRPS2 Gene:

Hs.654581

Evidence on tissue expression from TISSUES for PRPS2 Gene

  • Blood(4.3)
  • Nervous system(2.6)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with PRPS2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRPS2 Gene

Orthologs for PRPS2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRPS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRPS2 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRPS2 35
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRPS2 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRPS2 34 35
  • 90.34 (n)
cow
(Bos Taurus)
Mammalia PRPS2 34 35
  • 89.62 (n)
mouse
(Mus musculus)
Mammalia Prps2 34 16 35
  • 89.1 (n)
rat
(Rattus norvegicus)
Mammalia Prps2 34
  • 88.47 (n)
chicken
(Gallus gallus)
Aves PRPS2 34 35
  • 84.22 (n)
lizard
(Anolis carolinensis)
Reptilia PRPS2 35
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prps2 34
  • 80.4 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6767 36 35
  • 87 (a)
worm
(Caenorhabditis elegans)
Secernentea R151.2a 36
  • 80 (a)
R151.2b 36
  • 80 (a)
R151.2c 36
  • 80 (a)
R151.2 34 35
  • 68.97 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRS2 35
  • 62 (a)
ManyToMany
PRS4 35
  • 61 (a)
ManyToMany
PRS3 34 35 37
  • 57.94 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F25718g 34
  • 59.68 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL080C 34
  • 59.66 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2559 35
  • 85 (a)
OneToMany
Species where no ortholog for PRPS2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for PRPS2 Gene

ENSEMBL:
Gene Tree for PRPS2 (if available)
TreeFam:
Gene Tree for PRPS2 (if available)

Paralogs for PRPS2 Gene

Paralogs for PRPS2 Gene

(4) SIMAP similar genes for PRPS2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PRPS2: view

Variants for PRPS2 Gene

Sequence variations from dbSNP and Humsavar for PRPS2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000033968 -- 12,800,638(+) AACTC(A/G)GTGCA intron-variant
rs1000074318 -- 12,810,696(+) GAAGG(A/G)AGTTA intron-variant
rs1000121268 -- 12,794,162(+) GAAAG(C/T)TTGTT intron-variant
rs1000140580 -- 12,800,820(+) GGTTT(C/G)CATTC intron-variant
rs1000367946 -- 12,805,186(+) TAATG(A/G)TGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRPS2 Gene

Variant ID Type Subtype PubMed ID
esv3573585 CNV loss 25503493
nsv520250 CNV gain 19592680

Variation tolerance for PRPS2 Gene

Residual Variation Intolerance Score: 15.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.11; 2.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRPS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRPS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRPS2 Gene

Disorders for PRPS2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRPS2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
sertoli cell-only syndrome
  • del castillo syndrome
- elite association - COSMIC cancer census association via MalaCards
Search PRPS2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRPS2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRPS2
genes like me logo Genes that share disorders with PRPS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRPS2 Gene

Publications for PRPS2 Gene

  1. Promoter regions of the human X-linked housekeeping genes PRPS1 and PRPS2 encoding phosphoribosylpyrophosphate synthetase subunit I and II isoforms. (PMID: 1314091) Ishizuka T. … Tatibana M. (Biochim. Biophys. Acta 1992) 3 4 22 64
  2. Cloning of cDNAs for human phosphoribosylpyrophosphate synthetases 1 and 2 and X chromosome localization of PRPS1 and PRPS2 genes. (PMID: 1962753) Becker M.A. … Roessler B.J. (Genomics 1990) 2 3 22 64
  3. Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells. (PMID: 18677108) Mannava S. … Nikiforov M.A. (Cell Cycle 2008) 3 22 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Molecular cloning and sequencing of human cDNA for phosphoribosyl pyrophosphate synthetase subunit II. (PMID: 2538352) Iizasa T. … Tatibana M. (FEBS Lett. 1989) 3 4 64

Products for PRPS2 Gene

  • Addgene plasmids for PRPS2

Sources for PRPS2 Gene

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