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PRPF4B Gene

protein-coding   GIFtS: 63
GCID: GC06P004021

Pre-MRNA Processing Factor 4B

(Previous name: PRP4 pre-mRNA processing factor 4 homolog B (yeast))
  Search for PRPF4B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Pre-MRNA Processing Factor 4B1 2     PR4H2
PRP42 3 5     dJ1013A10.12
PRP4H2 3     DJ1013A10.1 (PRP4 Protein Kinase Homolog)2
PRP4K2 3     Protein-Serine/Threonine Kinase2
PRP4 Kinase2 3     PRP4 Pre-MRNA Processing Factor 4 Homolog B2
PRP4 Pre-MRNA-Processing Factor 4 Homolog2 3     Serine/Threonine-Protein Kinase PRP4 Homolog2
EC 2.7.11.13 8     KIAA05363
PRP4 Pre-MRNA Processing Factor 4 Homolog B (Yeast)1     

External Ids:    HGNC: 173461   Entrez Gene: 88992   Ensembl: ENSG000001127397   OMIM: 6023385   UniProtKB: Q135233   

Export aliases for PRPF4B gene to outside databases

Previous GC identifers: GC06P004006 GC06P003966 GC06P003898


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRPF4B Gene:
Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is
thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family
that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is
regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). (provided by
RefSeq, Jul 2008)

GeneCards Summary for PRPF4B Gene:
PRPF4B (pre-mRNA processing factor 4B) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is CLK3.

UniProtKB/Swiss-Prot: PRP4B_HUMAN, Q13523
Function: Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF

Gene Wiki entry for PRPF4B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRPF4B gene promoter:
         HSF1 (long)   FOXD3   Nkx2-5   GATA-1   YY1   FAC1   E2F-1   E2F   HSF1short   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRPF4B promoter sequence
   Search Chromatin IP Primers for PRPF4B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRPF4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p25.2   Ensembl cytogenetic band:  6p25.2   HGNC cytogenetic band: 6p24.2

PRPF4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRPF4B gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P004021:  view genomic region     (about GC identifiers)

Start:
4,021,501 bp from pter      End:
4,065,217 bp from pter
Size:
43,717 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PRP4B_HUMAN, Q13523 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase PRP4 homolog  
Size: 1007 amino acids; 116987 Da
Subunit: Identified in the spliceosome C complex. Interacts with Clk1 C-terminus
Sequence caution: Sequence=AAH09844.1; Type=Frameshift; Positions=432; Sequence=BAA25462.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
4 PDB 3D structures from and Proteopedia for PRPF4B:
4IAN (3D)        4IFC (3D)        4IIR (3D)        4IJP (3D)    
Secondary accessions: A8K5C9 Q5D0F6 Q5TAY8 Q8IVC3 Q8TDP2 Q96QT7 Q9UEE6

Explore the universe of human proteins at neXtProt for PRPF4B: NX_Q13523

Explore proteomics data for PRPF4B at MOPED

Post-translational modifications: 

  • Phosphorylated by Clk11
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PRPF4B (Q13523) (see all 11)
     GCTLYEL  DIKPDNI  KIIRNNE  RRSRSPL 


    See PRPF4B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003904.3  
    ENSEMBL proteins: 
     ENSP00000433547   ENSP00000337194   ENSP00000433714   ENSP00000439331  

    PRPF4B Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for PRPF4B

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: PRP4 pre-mRNA processing factor 4 homolog B (yeast)
    PRP4 subfamily

    4 InterPro protein domains:
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q13523

    ProtoNet protein and cluster: Q13523

    UniProtKB/Swiss-Prot: PRP4B_HUMAN, Q13523
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with PRPF4B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRP4B_HUMAN, Q13523
    Function: Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Number (IUBMB): EC 2.7.11.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS9102632
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI15452250
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with PRPF4B           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for PRPF4B:
     Decreased CYP1A1 activity afte  Decreased focal adhesion (FA)   Decreased viability with pacli  Gemcitabine induced cell-death 
     Increased cell death in HCT116  Upregulation of Wnt/beta-caten 

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target PRPF4B:
    hsa-mir-30a-5p (MIRT028664)

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    Selected qRT-PCR Assays for microRNAs that regulate PRPF4B (see all 78):
    hsa-miR-579 hsa-miR-323-3p hsa-miR-607 hsa-miR-3653 hsa-miR-371-5p hsa-miR-4275 hsa-miR-525-3p hsa-miR-130a*
    SwitchGear 3'UTR luciferase reporter plasmidPRPF4B 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for PRPF4B 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PRP4B_HUMAN, Q13523: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton2
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005694chromosome IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0071013catalytic step 2 spliceosome IDA11991638

    Find genes that share ontologies with PRPF4B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRPF4B About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA processing0.44
    2Translational Control
    Translational Control


    Find genes that share SuperPaths with PRPF4B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for PRPF4B
        Translational Control

    1 BioSystems Pathway for PRPF4B
        mRNA processing



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRPF4B
    Interactions:

        GeneGlobe Interaction Network for PRPF4B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRPF4B (Q135231, 2, 3 ENSP000003371944) via UniProtKB, MINT, STRING, and/or I2D (see all 580)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619812, 3, ENSP000003063304MINT-50834 I2D: score=4 STRING: ENSP00000306330
    KLF13Q9Y2Y91, 3, ENSP000003024564EBI-395940,EBI-1255893 I2D: score=2 STRING: ENSP00000302456
    ARRB1P494071, 3EBI-395940,EBI-743313 I2D: score=1 
    ARRB2P321211, 3EBI-395940,EBI-714559 I2D: score=1 
    POLR3FQ9H1D91, 2, 3, ENSP000003668284EBI-395940,EBI-710067 MINT-65454 I2D: score=5 STRING: ENSP00000366828
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome IC11991638
    GO:0006468protein phosphorylation TAS9102632
    GO:0008380RNA splicing TAS9102632

    Find genes that share ontologies with PRPF4B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRPF4B (PRP4B)

    2 HMDB Compounds for PRPF4B    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRPF4B gene (2 alternative transcripts): 
    NM_003913.4  NM_176800.2  

    Unigene Cluster for PRPF4B:

    PRP4 pre-mRNA processing factor 4 homolog B (yeast)
    Hs.159014  [show with all ESTs]
    Unigene Representative Sequence: NM_003913
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000480058(uc003mvv.3) ENST00000337659 ENST00000481109(uc003mvw.3)
    ENST00000490399 ENST00000463634 ENST00000466185 ENST00000494674 ENST00000490653
    ENST00000461612 ENST00000538861(uc011dhv.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat PRPF4B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRPF4B (see all 78):
    hsa-miR-579 hsa-miR-323-3p hsa-miR-607 hsa-miR-3653 hsa-miR-371-5p hsa-miR-4275 hsa-miR-525-3p hsa-miR-130a*
    SwitchGear 3'UTR luciferase reporter plasmidPRPF4B 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for PRPF4B 
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRPF4B
      QuantiTect SYBR Green Assays in human, mouse, rat PRPF4B
      QuantiFast Probe-based Assays in human, mouse, rat PRPF4B

    Additional mRNA sequence: 

    AK291244.1 AK303047.1 AY029347.1 BC009844.2 BC034969.1 U48736.1 Z25435.1 

    20 DOTS entries:

    DT.100797428  DT.117361  DT.121332576  DT.40132399  DT.70104916  DT.117363  DT.100026989  DT.100666856 
    DT.121332605  DT.95173765  DT.97847711  DT.99948453  DT.121332556  DT.75100975  DT.95087620  DT.95173770 
    DT.97769287  DT.91837011  DT.92441503  DT.97803041 

    Selected AceView cDNA sequences (see all 332):

    BQ181919 AY029347 AI432598 R72647 BC009844 BG168246 AB011108 AI634867 
    BQ218559 AI225148 BF062482 AI968269 BU616536 AA478565 AW519008 AA678675 
    AA343904 AU123782 AA773346 AA251478 BE796197 BE077181 R72726 AI216759 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PRPF4B (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19a · 19b ·
    SP1:                                                                                -                             -     -     -                 -     -     -   
    SP2:                                                                                -                                                                           
    SP3:                                                                                                                                            -     -     -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19c ^ 20a · 20b · 20c ^ 21a · 21b · 21c ^ 22a · 22b
    SP1:              -     -           -     -               
    SP2:        -     -     -                                 
    SP3:                    -                                 
    SP4:              -     -           -     -               
    SP5:                                                      


    ECgene alternative splicing isoforms for PRPF4B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRPF4B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGATTTCTG
    PRPF4B Expression
    About this image


    PRPF4B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Bone (Muscoskeletal System)
             Bone Marrow
    PRPF4B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRPF4B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.159014

    UniProtKB/Swiss-Prot: PRP4B_HUMAN, Q13523
    Tissue specificity: Ubiquitous

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRPF4B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PRPF4B gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prpf4b1 , 5 PRP4 pre-mRNA processing factor 4 homolog B (yeast)1, 5 89.1(n)1
    95.23(a)1
      13 (14.21 cM)5
    191341  NM_013830.21  NP_038858.21 
     348754945 
    chicken
    (Gallus gallus)
    Aves PRPF4B1 PRP4 pre-mRNA processing factor 4 homolog B (yeast) 82.02(n)
    89.93(a)
      420879  XM_001232308.3  XP_001232309.2 
    lizard
    (Anolis carolinensis)
    Reptilia PRPF4B6
    pre-mRNA processing factor 4B
    88(a)
    1 ↔ 1
    GL343247.1(1577593-1601856)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.100662 Xenopus laevis transcribed sequences 85.88(n)    CF549086.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.48912 Danio rerio mRNA similar to PRP4 pre-mRNA processing more 76.65(n)    BC048879.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG70286
    --
    45(a)
    1 ↔ 1
    3L(207887-211457)
    worm
    (Caenorhabditis elegans)
    Secernentea prpf-46
    Protein PRPF-4, isoform b (prpf-4) mRNA, complete ...
    46(a)
    1 ↔ 1
    I(7091317-7094748) WBGene00004186
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KNS16
    Nonessential putative protein kinase of unknown ce...
    18(a)
    1 → many
    XII(105686-107899) YLL019C
    rice
    (Oryza sativa)
    Liliopsida Os.173762 Oryza sativa (japonica cultivar-group) cDNA clone0 more 73.48(n)    AK060641.1 


    ENSEMBL Gene Tree for PRPF4B (if available)
    TreeFam Gene Tree for PRPF4B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRPF4B gene
    CLK32  CLK12  CLK42  CLK22  
    13 SIMAP similar genes for PRPF4B using alignment to 3 protein entries:     PRP4B_HUMAN (see all proteins):
    DYRK4    MAPK14    NEK9    CDKL1    CDK7    CDKL4
    ULK1    CDK4    BRSK2    CLK1    CDC2    CLK2
    RPS6KA2

    Find genes that share paralogs with PRPF4B           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for PRPF4B
    PGOHUM00000258397 PGOHUM00000241510


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRPF4B (see all 1033)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356334
    A breast cancer sample4--see VAR_0356332 F L mis40--------
    rs1831081381,2
    --4019603(+) CCTGAA/GCTCTC 1 -- us2k10--------
    rs795024191,2
    F--4019639(+) AACAAG/AGCATT 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs126620571,2
    C,F,H--4019752(+) CTGTGA/GGGGTG 1 -- us2k115Minor allele frequency- G:0.32NS EA NA 2112
    rs1498591891,2
    --4019764(+) ATGCTC/TAACAA 1 -- us2k10--------
    rs1468770261,2
    --4019996(+) GATCTC/TTCACA 1 -- us2k10--------
    rs1881945291,2
    --4020011(+) TACTAC/TGTACA 1 -- us2k10--------
    rs1929797821,2
    --4020062(+) TATTTC/TATTTA 1 -- us2k10--------
    rs1405531521,2
    --4020152(+) ATTCTC/TTTGCC 1 -- us2k10--------
    rs1148790961,2
    C,F--4020176(+) TAGCTG/AAGACT 1 -- us2k11Minor allele frequency- A:0.03NA 120

    HapMap Linkage Disequilibrium report for PRPF4B (4021501 - 4065217 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for PRPF4B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2201190CNV Deletion18987734
    esv993339CNV Deletion20482838
    esv2731501CNV Deletion23290073
    esv2527172CNV Deletion19546169
    esv4480CNV Deletion18987735
    esv1454617CNV Deletion17803354
    nsv349965CNV Loss16902084
    nsv349483CNV Loss16902084
    esv9631CNV Loss19470904

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRPF4B
    DNA2.0 Custom Variant and Variant Library Synthesis for PRPF4B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602338    OMIM disorders: --


    Find genes that share disorders with PRPF4B           About GenesLikeMe

    Genetic Association Database (GAD): PRPF4B
    Human Genome Epidemiology (HuGE) Navigator: PRPF4B (1 document)

    Export disorders for PRPF4B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRPF4B gene, integrated from 10 sources (see all 57):
    (articles sorted by number of sources associating them with PRPF4B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of human PRP4 reveals interaction with Clk1. (PubMed id 11418604)1, 2, 3, 9 Kojima T.... Hagiwara M. (J. Biol. Chem. 2001)
    2. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2, 3 Nagase T....Ohara O. (DNA Res. 1998)
    3. Functional analysis of the fission yeast Prp4 protein kinase involved in pre-mRNA splicing and isolation of a putative mammalian homologue. (PubMed id 9102632)1, 2, 9 Gross T....Kaeufer N.F. (Nucleic Acids Res. 1997)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    6. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (RNA 2002)
    7. Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes. (PubMed id 12077342)1, 2 Dellaire G.... Bickmore W.A. (Mol. Cell. Biol. 2002)
    8. Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation. (PubMed id 20118938)1, 9 Schneider M....LA1hrmann R. (amp 2010)
    9. miR-371-5p down-regulates pre mRNA processing factor 4 homolog B (PRPF4B) and facilitates the G1/S transition in human hepatocellular carcinoma cells. (PubMed id 23466643)1 Liu R.Y....Tang H. (Cancer Lett. 2013)
    10. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8899 HGNC: 17346 AceView: PRPF4B Ensembl:ENSG00000112739 euGenes: HUgn8899
    ECgene: PRPF4B H-InvDB: PRPF4B

    (According to HUGE)
    About This Section

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    HUGE: KIAA0536

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PRPF4B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PRPF4B gene:
    Search GeneIP for patents involving PRPF4B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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