Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRPF4B Gene

protein-coding   GIFtS: 62
GCID: GC06P004021

Pre-MRNA Processing Factor 4B

(Previous name: PRP4 pre-mRNA processing factor 4 homolog B (yeast))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Pre-MRNA Processing Factor 4B1     EC 2.7.11.13 8
PRP42 3 5     PR4H2
PRP4 Pre-MRNA Processing Factor 4 Homolog B (Yeast)1 2     dJ1013A10.12
PRP4H2 3     DJ1013A10.1 (PRP4 Protein Kinase Homolog)2
PRP4K2 3     Protein-Serine/Threonine Kinase2
PRP4 Kinase2 3     Serine/Threonine-Protein Kinase PRP4 Homolog2
PRP4 Pre-MRNA-Processing Factor 4 Homolog2 3     KIAA05363

External Ids:    HGNC: 173461   Entrez Gene: 88992   Ensembl: ENSG000001127397   OMIM: 6023385   UniProtKB: Q135233   

Export aliases for PRPF4B gene to outside databases

Previous GC identifers: GC06P004006 GC06P003966 GC06P003898


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PRPF4B Gene:
Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is
thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family
that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is
regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). (provided by
RefSeq, Jul 2008)

GeneCards Summary for PRPF4B Gene: 
PRPF4B (pre-mRNA processing factor 4B) is a protein-coding gene. Diseases associated with PRPF4B include ovarian cancer, and breast cancer, and among its related super-pathways are Processing of Capped Intron-Containing Pre-mRNA. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is CLK3.

UniProtKB/Swiss-Prot: PRP4B_HUMAN, Q13523
Function: Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF

Gene Wiki entry for PRPF4B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRPF4B gene promoter:
         HSF1 (long)   FOXD3   Nkx2-5   GATA-1   YY1   FAC1   E2F-1   E2F   HSF1short   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRPF4B promoter sequence
   Search SABiosciences Chromatin IP Primers for PRPF4B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRPF4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p25.2   Ensembl cytogenetic band:  6p25.2   HGNC cytogenetic band: 6p24.2

PRPF4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRPF4B gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P004021:  view genomic region     (about GC identifiers)

Start:
4,021,501 bp from pter      End:
4,065,217 bp from pter
Size:
43,717 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PRP4B_HUMAN, Q13523 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase PRP4 homolog  
Size: 1007 amino acids; 116987 Da
Subunit: Identified in the spliceosome C complex. Interacts with Clk1 C-terminus
Subcellular location: Nucleus
Sequence caution: Sequence=AAH09844.1; Type=Frameshift; Positions=432; Sequence=BAA25462.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8K5C9 Q5D0F6 Q5TAY8 Q8IVC3 Q8TDP2 Q96QT7 Q9UEE6

Explore the universe of human proteins at neXtProt for PRPF4B: NX_Q13523

Explore proteomics data for PRPF4B at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by Clk1
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13523

  • 4/11 DME Specific Peptides for PRPF4B (Q13523) (see all 11)
     GCTLYEL  DIKPDNI  KIIRNNE  RRSRSPL 

    PRPF4B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PRPF4B Protein Expression
    REFSEQ proteins: NP_003904.3  
    ENSEMBL proteins: 
     ENSP00000433547   ENSP00000337194   ENSP00000433714   ENSP00000439331  

    Human Recombinant Protein Products for PRPF4B: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PRPF4B
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for PRPF4B
    GenScript Custom Purified and Recombinant Proteins Services for PRPF4B
    Novus Biologicals PRPF4B Proteins
    Novus Biologicals PRPF4B Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PRPF4B 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005694chromosome IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0071013catalytic step 2 spliceosome IDA11991638

    PRPF4B for ontologies           About GeneDecksing



    PRPF4B Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for PRPF4B  (PRP4)
    OriGene Antibodies for PRPF4B
    OriGene Custom Antibody Services for PRPF4B
    GenScript Custom Superior Antibodies Services for PRPF4B
    Novus Biologicals PRPF4B Antibodies
    Abcam antibodies for PRPF4B
    Cloud-Clone Corp. Antibodies for PRPF4B 
    ThermoFisher Antibody for PRPF4B
    LSBio Antibodies in human, mouse, rat for PRPF4B 

    Assay Products for PRPF4B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PRPF4B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PRPF4B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PRPF4B 
    Cloud-Clone Corp. CLIAs for PRPF4B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: PRP4 pre-mRNA processing factor 4 homolog B (yeast) 
    PRP4 subfamily

    4 InterPro protein domains:
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q13523

    ProtoNet protein and cluster: Q13523

    UniProtKB/Swiss-Prot: PRP4B_HUMAN, Q13523
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    PRPF4B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRP4B_HUMAN, Q13523
    Function: Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Number (IUBMB): EC 2.7.11.11 2

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS9102632
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI15452250
    GO:0005524ATP binding IEA--
         
    PRPF4B for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for PRPF4B:
     Decreased CYP1A1 activity afte  Decreased focal adhesion (FA)   Decreased viability with pacli  Gemcitabine induced cell-death 
     Increased cell death in HCT116  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PRPF4B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PRPF4B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRPF4B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRPF4B 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRPF4B
    8/78 QIAGEN miScript miRNA Assays for microRNAs that regulate PRPF4B (see all 78):
    hsa-miR-579 hsa-miR-323-3p hsa-miR-607 hsa-miR-3653 hsa-miR-371-5p hsa-miR-4275 hsa-miR-525-3p hsa-miR-130a*
    SwitchGear 3'UTR luciferase reporter plasmidPRPF4B 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PRPF4B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRPF4B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PRPF4B
    Sirion Biotech Customized adenovirus for overexpression of PRPF4B

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PRPF4B (see all 8)
    OriGene ORF clones in mouse, rat for PRPF4B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRPF4B (NM_003913)
    Sino Biological Human cDNA Clone for PRPF4B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRPF4B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRPF4B
    Sirion Biotech Customized lentivirus for stable overexpression of PRPF4B 
                         Customized lentivirus expression plasmids for stable overexpression of PRPF4B 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PRPF4B
    Search LifeMap BioReagents cell lines for PRPF4B
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRPF4B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PRPF4B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA processing0.46
    2Translational Control
    Translational Control

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for PRPF4B
        Translational Control

    1 BioSystems Pathway for PRPF4B
        mRNA processing




    PRPF4B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRPF4B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/571 Interacting proteins for PRPF4B (Q135231, 2, 3 ENSP000003371944) via UniProtKB, MINT, STRING, and/or I2D (see all 571)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619812, 3, ENSP000003063304MINT-50834 I2D: score=4 STRING: ENSP00000306330
    KLF13Q9Y2Y91, 3, ENSP000003024564EBI-395940,EBI-1255893 I2D: score=2 STRING: ENSP00000302456
    ARRB1P494071, 3EBI-395940,EBI-743313 I2D: score=1 
    ARRB2P321211, 3EBI-395940,EBI-714559 I2D: score=1 
    POLR3FQ9H1D91, 2, 3, ENSP000003668284EBI-395940,EBI-710067 MINT-65454 I2D: score=5 STRING: ENSP00000366828
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome IC11991638
    GO:0006468protein phosphorylation TAS9102632
    GO:0008380RNA splicing TAS9102632

    PRPF4B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PRPF4B (PRP4B)

    2 HMDB Compounds for PRPF4B    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Search CenterWatch for drugs/clinical trials and news about PRPF4B / PRP4B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PRPF4B gene (2 alternative transcripts): 
    NM_003913.4  NM_176800.2  

    Unigene Cluster for PRPF4B:

    PRP4 pre-mRNA processing factor 4 homolog B (yeast)
    Hs.159014  [show with all ESTs]
    Unigene Representative Sequence: NM_003913
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000480058(uc003mvv.3) ENST00000337659 ENST00000481109(uc003mvw.3)
    ENST00000490399 ENST00000463634 ENST00000466185 ENST00000494674 ENST00000490653
    ENST00000461612 ENST00000538861(uc011dhv.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRPF4B
    8/78 QIAGEN miScript miRNA Assays for microRNAs that regulate PRPF4B (see all 78):
    hsa-miR-579 hsa-miR-323-3p hsa-miR-607 hsa-miR-3653 hsa-miR-371-5p hsa-miR-4275 hsa-miR-525-3p hsa-miR-130a*
    SwitchGear 3'UTR luciferase reporter plasmidPRPF4B 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PRPF4B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRPF4B
    Clone
    Products:
         
    OriGene clones in human, mouse for PRPF4B (see all 8)
    OriGene ORF clones in mouse, rat for PRPF4B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRPF4B (NM_003913)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRPF4B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRPF4B
    Sirion Biotech Customized lentivirus for stable overexpression of PRPF4B 
                         Customized lentivirus expression plasmids for stable overexpression of PRPF4B 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PRPF4B
    OriGene qSTAR qPCR primer pairs in human, mouse for PRPF4B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PRPF4B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRPF4B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRPF4B

    Additional mRNA sequence: 

    AK291244.1 AK303047.1 AY029347.1 BC009844.2 BC034969.1 U48736.1 Z25435.1 

    20 DOTS entries:

    DT.100797428  DT.117361  DT.121332576  DT.40132399  DT.70104916  DT.117363  DT.100026989  DT.100666856 
    DT.121332605  DT.95173765  DT.97847711  DT.99948453  DT.121332556  DT.75100975  DT.95087620  DT.95173770 
    DT.97769287  DT.91837011  DT.92441503  DT.97803041 

    24/332 AceView cDNA sequences (see all 332):

    NM_176800 BU616536 AW517371 BG777575 BF062482 BM973138 C02527 AI298188 
    AI568157 AA478565 AI718400 AI832433 AA954720 CR610305 BE077181 CA311784 
    NM_003913 CA447276 BQ024543 BM479351 CK821317 BU738424 AI634867 BF478232 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for PRPF4B (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19a · 19b ·
    SP1:                                                                                -                             -     -     -                 -     -     -   
    SP2:                                                                                -                                                                           
    SP3:                                                                                                                                            -     -     -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19c ^ 20a · 20b · 20c ^ 21a · 21b · 21c ^ 22a · 22b
    SP1:              -     -           -     -               
    SP2:        -     -     -                                 
    SP3:                    -                                 
    SP4:              -     -           -     -               
    SP5:                                                      


    ECgene alternative splicing isoforms for PRPF4B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRPF4B expression in normal human tissues (normalized intensities)      PRPF4B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGATTTCTG
    PRPF4B Expression
    About this image


    PRPF4B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             bone marrow cd34+   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord blood-derived endothelial progenitor cells
             stem cells (umbilical cord cd34+)   
     
     Endothelium (Cardiovascular System)
             Umbilical cord blood-derived endothelial progenitor cells

    See PRPF4B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRPF4B

    SOURCE GeneReport for Unigene cluster: Hs.159014

    UniProtKB/Swiss-Prot: PRP4B_HUMAN, Q13523
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for PRPF4B
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PRPF4B
    OriGene qSTAR qPCR primer pairs in human, mouse for PRPF4B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PRPF4B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRPF4B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRPF4B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRPF4B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PRPF4B gene from 10/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prpf4b1 , 5 PRP4 pre-mRNA processing factor 4 homolog B (yeast)1, 5 89.1(n)1
    95.23(a)1
      13 (14.21 cM)5
    191341  NM_013830.21  NP_038858.21 
     348754945 
    chicken
    (Gallus gallus)
    Aves PRPF4B1 PRP4 pre-mRNA processing factor 4 homolog B (yeast) 82.12(n)
    90.11(a)
      420879  XM_001232308.2  XP_001232309.1 
    lizard
    (Anolis carolinensis)
    Reptilia PRPF4B6
    PRP4 pre-mRNA processing factor 4 homolog B (yeast...
    88(a)
    1 ↔ 1
    GL343247.1(1577593-1601856)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.100662 Xenopus laevis transcribed sequences 85.88(n)    CF549086.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.48912 Danio rerio mRNA similar to PRP4 pre-mRNA processing more 76.65(n)    BC048879.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG70281 CG7028 48.99(n)
    49.14(a)
      38032  NM_138166.3  NP_612010.1 
    worm
    (Caenorhabditis elegans)
    Secernentea prpf-41 Protein PRPF-4 50.4(n)
    46.28(a)
      172443  NM_059607.5  NP_492008.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KNS16
    Nonessential putative protein kinase of unknown ce...
    16(a)
    1 → many
    XII(105686-107899)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G536401 protein kinase family protein 51.84(n)
    46.14(a)
      824532  NM_115224.1  NP_190932.1 
    rice
    (Oryza sativa)
    Liliopsida Os.173762 Oryza sativa (japonica cultivar-group) cDNA clone0 more 73.48(n)    AK060641.1 


    ENSEMBL Gene Tree for PRPF4B (if available)
    TreeFam Gene Tree for PRPF4B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRPF4B gene
    CLK32  CLK12  CLK42  CLK22  
    14 SIMAP similar genes for PRPF4B using alignment to 3 protein entries:     PRP4B_HUMAN (see all proteins):
    DYRK4    NDUFA9    MAPK14    NEK9    CDKL1    CDK7
    CDKL4    ULK1    CDK4    BRSK2    CLK1    CDC2
    CLK2    RPS6KA2

    PRPF4B for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for PRPF4B
    PGOHUM00000258397 PGOHUM00000241510


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1033 SNPs in PRPF4B are shown (see all 1033)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356334
    A breast cancer sample4--see VAR_0356332 F L mis40--------
    VAR_0477984
    ----see VAR_0477982 I V mis40--------
    rs1831081381,2
    --4019603(+) CCTGAA/GCTCTC 1 -- us2k10--------
    rs795024191,2
    F--4019639(+) AACAAG/AGCATT 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs126620571,2
    C,F,H--4019752(+) CTGTGA/GGGGTG 1 -- us2k115Minor allele frequency- G:0.32NS EA NA 2112
    rs1498591891,2
    --4019764(+) ATGCTC/TAACAA 1 -- us2k10--------
    rs1468770261,2
    --4019996(+) GATCTC/TTCACA 1 -- us2k10--------
    rs1881945291,2
    --4020011(+) TACTAC/TGTACA 1 -- us2k10--------
    rs1929797821,2
    --4020062(+) TATTTC/TATTTA 1 -- us2k10--------
    rs1405531521,2
    --4020152(+) ATTCTC/TTTGCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PRPF4B (4021501 - 4065217 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for PRPF4B:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2201190CNV Deletion18987734
    esv993339CNV Deletion20482838
    esv2731501CNV Deletion23290073
    esv2527172CNV Deletion19546169
    esv4480CNV Deletion18987735
    esv1454617CNV Deletion17803354
    nsv349965CNV Loss16902084
    nsv349483CNV Loss16902084
    esv9631CNV Loss19470904

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PRPF4B
    DNA2.0 Custom Variant and Variant Library Synthesis for PRPF4B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602338    OMIM disorders: --

    2 diseases for PRPF4B:    About MalaCards
    ovarian cancer    breast cancer


    PRPF4B for disorders           About GeneDecksing

    Genetic Association Database (GAD): PRPF4B
    Human Genome Epidemiology (HuGE) Navigator: PRPF4B (1 document)

    Export disorders for PRPF4B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRPF4B gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with PRPF4B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of human PRP4 reveals interaction with Clk1. (PubMed id 11418604)1, 2, 3, 9 Kojima T.... Hagiwara M. (2001)
    2. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2, 3 Nagase T....Ohara O. (1998)
    3. Functional analysis of the fission yeast Prp4 protein kinase involved in pre-mRNA splicing and isolation of a putative mammalian homologue. (PubMed id 9102632)1, 2, 9 Gross T....Kaeufer N.F. (1997)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    6. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (2002)
    7. Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes. (PubMed id 12077342)1, 2 Dellaire G.... Bickmore W.A. (2002)
    8. Human PRP4 kinase is required for stable tri-snRNP as sociation during spliceosomal B complex formation. (PubMed id 20118938)1, 9 Schneider M....LA1hrmann R. (2010)
    9. miR-371-5p down-regulates pre mRNA processing factor 4 homolog B (PRPF4B) and facilitates the G1/S transition in human hepatocellular carcinoma cells. (PubMed id 23466643)1 Liu R.Y....Tang H. (2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8899 HGNC: 17346 AceView: PRPF4B Ensembl:ENSG00000112739 euGenes: HUgn8899
    ECgene: PRPF4B H-InvDB: PRPF4B

    (According to HUGE)
    About This Section
    HUGE: KIAA0536

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRPF4B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PRPF4B gene:
    Search GeneIP for patents involving PRPF4B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PRPF4B   OriGene RNAi products in human, mouse, rat for PRPF4B  
     OriGene qPCR primer pairs and template standards for PRPF4B   OriGene Protein Over-expression Lysate for PRPF4B  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PRPF4B  
     OriGene qSTAR qPCR primer pairs in human, mouse for PRPF4B   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PRPF4B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PRPF4B   OriGene Custom Protein Services for PRPF4B  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PRPF4B
     QIAGEN SeqTarget long-range PCR primers for resequencing PRPF4B
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRPF4B
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRPF4B
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRPF4B
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRPF4B
     GenScript Custom Purified and Recombinant Proteins Services for PRPF4B GenScript cDNA clones with any tag delivered in your preferred vector for PRPF4B
     GenScript Custom Assay Services for PRPF4B GenScript Custom Superior Antibodies Services for PRPF4B
     GenScript Custom overexpressing Cell Line Services for PRPF4B CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for PRPF4B  (PRP4)

     Regulatory tfbs in PRPF4B promoter
     Search Chromatin IP Primers for PRPF4B
     RT2 qPCR Primer Assay in human, mouse, rat PRPF4B
     GNC Network for PRPF4B
     SABiosciences Custom PCR Arrays for PRPF4B
     Search Tocris compounds for PRPF4B (PRP4B)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for PRPF4B
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PRPF4B antibodies
     PRPF4B proteins
     PRPF4B lysates
     Antibodies for PRPF4B
     See all of Abcam's Antibodies, Kits and Proteins for PRPF4B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for PRPF4B
     Antibodies for PRPF4B
     ELISAs for PRPF4B
     CLIAs for PRPF4B
     Search LifeMap BioReagents cell lines for PRPF4B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRPF4B
     SwitchGear 3'UTR luciferase reporter plasmids for PRPF4B
     SwitchGear Promoter luciferase reporter plasmids for PRPF4B
     ThermoFisher Antibody for PRPF4B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRPF4B
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PRPF4B
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PRPF4B
    Customized:
     lentivirus for stable overexpression of PRPF4B
     lentivirus expression plasmids for stable overexpression of PRPF4B
     adenovirus for overexpression of PRPF4B
     LSBio Antibodies in human, mouse, rat for PRPF4B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PRPF4B gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4