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Aliases for PRPF40B Gene

Aliases for PRPF40B Gene

  • PRP40 Pre-MRNA Processing Factor 40 Homolog B (S. Cerevisiae) 2 3
  • Huntingtin Interacting Protein C 2 3
  • Huntingtin Yeast Partner C 3 4
  • HYPC 3 4
  • PRP40 Pre-MRNA Processing Factor 40 Homolog B (Yeast) 2
  • Pre-MRNA-Processing Factor 40 Homolog B 3
  • Huntingtin-Interacting Protein C 4

External Ids for PRPF40B Gene

Previous GeneCards Identifiers for PRPF40B Gene

  • GC12P048304
  • GC12P050017
  • GC12P047049
  • GC12P049963

Summaries for PRPF40B Gene

Entrez Gene Summary for PRPF40B Gene

  • This gene encodes a WW-domain containing protein similar to yeast splicing factor PRP40. This protein has been shown to interact with Huntingtin and methyl CpG binding protein 2 (MeCP2). Alternative splicing results in different transcript variants. [provided by RefSeq, Aug 2014]

GeneCards Summary for PRPF40B Gene

PRPF40B (PRP40 Pre-MRNA Processing Factor 40 Homolog B (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Spliceosome. An important paralog of this gene is PRPF40A.

UniProtKB/Swiss-Prot for PRPF40B Gene

  • May be involved in pre-mRNA splicing.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRPF40B Gene

Genomics for PRPF40B Gene

Regulatory Elements for PRPF40B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PRPF40B Gene

49,568,218 bp from pter
49,645,129 bp from pter
76,912 bases
Plus strand

Genomic View for PRPF40B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRPF40B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRPF40B Gene

Proteins for PRPF40B Gene

  • Protein details for PRPF40B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pre-mRNA-processing factor 40 homolog B
    Protein Accession:
    Secondary Accessions:
    • O75401
    • Q6PI09
    • Q6ZWB3
    • Q8NCZ1
    • Q9H5G4
    • Q9NT95

    Protein attributes for PRPF40B Gene

    871 amino acids
    Molecular mass:
    99358 Da
    Quaternary structure:
    • Interacts with the N-terminus of HD.
    • Sequence=AAH50398.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB15662.1; Type=Frameshift; Positions=537, 851; Evidence={ECO:0000305};

    Alternative splice isoforms for PRPF40B Gene


neXtProt entry for PRPF40B Gene

Proteomics data for PRPF40B Gene at MOPED

Post-translational modifications for PRPF40B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRPF40B Gene

Antibody Products

No data available for DME Specific Peptides for PRPF40B Gene

Domains for PRPF40B Gene

Protein Domains for PRPF40B Gene


Suggested Antigen Peptide Sequences for PRPF40B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 6 FF domains.
  • Belongs to the PRPF40 family.
  • Contains 6 FF domains.
  • Contains 2 WW domains.
  • Belongs to the PRPF40 family.
genes like me logo Genes that share domains with PRPF40B: view

No data available for Gene Families for PRPF40B Gene

Function for PRPF40B Gene

Molecular function for PRPF40B Gene

UniProtKB/Swiss-Prot Function:
May be involved in pre-mRNA splicing.

Gene Ontology (GO) - Molecular Function for PRPF40B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with PRPF40B: view

Phenotypes for PRPF40B Gene

GenomeRNAi human phenotypes for PRPF40B:
genes like me logo Genes that share phenotypes with PRPF40B: view

Animal Model Products

CRISPR Products

miRNA for PRPF40B Gene

miRTarBase miRNAs that target PRPF40B

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PRPF40B Gene

Localization for PRPF40B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRPF40B Gene

Nucleus speckle.

Subcellular locations from

Jensen Localization Image for PRPF40B Gene COMPARTMENTS Subcellular localization image for PRPF40B gene
Compartment Confidence
nucleus 5
cytosol 2
endoplasmic reticulum 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PRPF40B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with PRPF40B: view

Pathways for PRPF40B Gene

SuperPathways for PRPF40B Gene

Superpath Contained pathways
1 Spliceosome
genes like me logo Genes that share pathways with PRPF40B: view

Pathways by source for PRPF40B Gene

1 KEGG pathway for PRPF40B Gene

Gene Ontology (GO) - Biological Process for PRPF40B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with PRPF40B: view

Transcripts for PRPF40B Gene

Unigene Clusters for PRPF40B Gene

PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRPF40B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b · 17c ^
SP2: -
SP6: -
SP7: -

ExUns: 18 ^ 19 ^ 20a · 20b

Relevant External Links for PRPF40B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRPF40B Gene

mRNA expression in normal human tissues for PRPF40B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for PRPF40B Gene

This gene is overexpressed in Heart (38.3), Retina (14.2), and Testis (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRPF40B Gene

SOURCE GeneReport for Unigene cluster for PRPF40B Gene Hs.706827

mRNA Expression by UniProt/SwissProt for PRPF40B Gene

Tissue specificity: Expressed in the striatum and cortex of the brain (at protein level). Highly expressed in testis, fetal kidney and fetal brain. Moderately expressed in pancreas, skeletal muscle, placenta, brain and heart. Weakly expressed in colon, ileum, ovary, prostate, spleen, kidney and fetal lung.
genes like me logo Genes that share expressions with PRPF40B: view

Expression partners for PRPF40B Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PRPF40B Gene

Orthologs for PRPF40B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRPF40B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PRPF40B 35
  • 93.59 (n)
  • 97.06 (a)
PRPF40B 36
  • 97 (a)
(Canis familiaris)
Mammalia PRPF40B 35
  • 93.68 (n)
  • 97.43 (a)
PRPF40B 36
  • 85 (a)
(Mus musculus)
Mammalia Prpf40b 35
  • 90.36 (n)
  • 94.96 (a)
Prpf40b 16
Prpf40b 36
  • 95 (a)
(Pan troglodytes)
Mammalia PRPF40B 35
  • 99.55 (n)
  • 99.78 (a)
PRPF40B 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Prpf40b 35
  • 90.82 (n)
  • 95.49 (a)
(Ornithorhynchus anatinus)
Mammalia PRPF40B 36
  • 49 (a)
(Anolis carolinensis)
Reptilia PRPF40B 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia prpf40b 35
  • 64.55 (n)
  • 64.99 (a)
(Danio rerio)
Actinopterygii CR855359.1 36
  • 20 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008263 35
  • 57.47 (n)
  • 51.49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3542 35
  • 53.93 (n)
  • 48.69 (a)
CG3542 36
  • 44 (a)
(Caenorhabditis elegans)
Secernentea ZK1098.1 36
  • 36 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR159C 35
  • 45.62 (n)
  • 26.54 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E18239g 35
  • 47.98 (n)
  • 40.91 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP40 35
  • 44.44 (n)
  • 30.3 (a)
PRP40 36
  • 25 (a)
PRP40 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11107 36
  • 47 (a)
Species with no ortholog for PRPF40B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRPF40B Gene

Gene Tree for PRPF40B (if available)
Gene Tree for PRPF40B (if available)

Paralogs for PRPF40B Gene

Paralogs for PRPF40B Gene

(2) SIMAP similar genes for PRPF40B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PRPF40B: view

Variants for PRPF40B Gene

Sequence variations from dbSNP and Humsavar for PRPF40B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1902328 -- 49,632,587(+) TCTTT(C/T)TTCGG intron-variant
rs4898526 -- 49,632,759(+) CCAGG(C/G)GACTA intron-variant
rs7294970 -- 49,635,663(+) GAGGA(A/G)GAGTC intron-variant
rs7299609 -- 49,631,143(+) TAAAC(C/T)TCCCT intron-variant
rs7980832 -- 49,633,562(+) CCTAC(A/G)GGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRPF40B Gene

Variant ID Type Subtype PubMed ID
nsv832406 CNV Loss 17160897

Relevant External Links for PRPF40B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRPF40B Gene

Disorders for PRPF40B Gene

Relevant External Links for PRPF40B

Genetic Association Database (GAD)

No disorders were found for PRPF40B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for PRPF40B Gene

Publications for PRPF40B Gene

  1. Huntingtin interacts with a family of WW domain proteins. (PMID: 9700202) Faber P.W. … MacDonald M.E. (Hum. Mol. Genet. 1998) 2 3 4 23
  2. Huntingtin's WW domain partners in Huntington's disease post-mortem brain fulfill genetic criteria for direct involvement in Huntington's disease pathogenesis. (PMID: 10958656) Passani L.A. … MacDonald M.E. (Hum. Mol. Genet. 2000) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. A WW domain binding region in methyl-CpG-binding protein MeCP2: impact on Rett syndrome. (PMID: 14618241) Buschdorf J.P. … StrAotling W.H. (J. Mol. Med. 2004) 3
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3

Products for PRPF40B Gene

Sources for PRPF40B Gene

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