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PRPF40B Gene

protein-coding   GIFtS: 49
GCID: GC12P049963

PRP40 Pre-MRNA Processing Factor 40 Homolog B (S. Cerevisiae)

(Previous name: PRP40 pre-mRNA processing factor 40 homolog B (yeast))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
PRP40 Pre-MRNA Processing Factor 40 Homolog B (S. Cerevisiae)1 2     PRP40 Pre-MRNA Processing Factor 40 Homolog B (Yeast)1
Huntingtin Interacting Protein C1 2     Pre-MRNA-Processing Factor 40 Homolog B2
Huntingtin Yeast Partner C2 3     Huntingtin-Interacting Protein C3
HYPC2 3     

External Ids:    HGNC: 250311   Entrez Gene: 257662   Ensembl: ENSG000001108447   UniProtKB: Q6NWY93   

Export aliases for PRPF40B gene to outside databases

Previous GC identifers: GC12P048304 GC12P050017 GC12P047049


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRPF40B Gene:
This gene encodes a WW-domain containing protein similar to yeast splicing factor PRP40. This protein has been
shown to interact with Huntingtin and MeCP2. Alternative splicing results in different transcriptional variants.
(provided by RefSeq, Jun 2012)

GeneCards Summary for PRPF40B Gene:
PRPF40B (PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)) is a protein-coding gene. Diseases associated with PRPF40B include rett syndrome, and huntington's disease. An important paralog of this gene is PRPF40A.

UniProtKB/Swiss-Prot: PR40B_HUMAN, Q6NWY9
Function: May be involved in pre-mRNA splicing




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the PRPF40B gene promoter:
         POU2F1   Egr-1   AP-2beta   AP-2gamma   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRPF40B promoter sequence
   Search Chromatin IP Primers for PRPF40B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRPF40B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13.12

PRPF40B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRPF40B gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P049963:  view genomic region     (about GC identifiers)

Start:
49,962,001 bp from pter      End:
50,038,449 bp from pter
Size:
76,449 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PR40B_HUMAN, Q6NWY9 (See protein sequence)
Recommended Name: Pre-mRNA-processing factor 40 homolog B  
Size: 871 amino acids; 99358 Da
Subunit: Interacts with the N-terminus of HD
Sequence caution: Sequence=AAH50398.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=BAB15662.1; Type=Frameshift; Positions=537, 851;
Secondary accessions: O75401 Q6PI09 Q6ZWB3 Q8NCZ1 Q9H5G4 Q9NT95
Alternative splicing: 4 isoforms:  Q6NWY9-1   Q6NWY9-2   Q6NWY9-3   Q6NWY9-4   

Explore the universe of human proteins at neXtProt for PRPF40B: NX_Q6NWY9

Explore proteomics data for PRPF40B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PRPF40B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001026868.2  
    ENSEMBL proteins: 
     ENSP00000449569   ENSP00000448073   ENSP00000261897   ENSP00000369634   ENSP00000449485  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR002713 FF_domain
     IPR001202 WW_dom

    Graphical View of Domain Structure for InterPro Entry Q6NWY9

    ProtoNet protein and cluster: Q6NWY9

    UniProtKB/Swiss-Prot: PR40B_HUMAN, Q6NWY9
    Similarity: Belongs to the PRPF40 family
    Similarity: Contains 6 FF domains
    Similarity: Contains 2 WW domains


    PRPF40B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PR40B_HUMAN, Q6NWY9
    Function: May be involved in pre-mRNA splicing

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    PRPF40B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PRPF40B:
     Decreased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRPF40B
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    miRNA
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    hsa-mir-335-5p (MIRT017362), hsa-mir-193b-3p (MIRT016390)

    Block miRNA regulation of human, mouse, rat PRPF40B using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate PRPF40B:
    hsa-miR-21* hsa-miR-185* hsa-miR-1288 hsa-miR-3138 hsa-miR-340 hsa-miR-1827 hsa-miR-3616-3p hsa-miR-4308
    SwitchGear 3'UTR luciferase reporter plasmidPRPF40B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PRPF40B

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRPF40B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PR40B_HUMAN, Q6NWY9: Nucleus speckle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    endoplasmic reticulum2
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016607nuclear speck IEA--

    PRPF40B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRPF40B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Spliceosome
    Spliceosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for PRPF40B):
        Spliceosome


    PRPF40B for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRPF40B
    Interactions:

        Search GeneGlobe Interaction Network for PRPF40B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRPF40B (Q6NWY93 ENSP000003696344) via UniProtKB, MINT, STRING, and/or I2D (see all 88)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HLA-DRAP019033, ENSP000003787864I2D: score=1 STRING: ENSP00000378786
    ENSG00000206308P019033I2D: score=1 
    ENSG00000226260P019033I2D: score=1 
    ENSG00000227993P019033I2D: score=1 
    ENSG00000228987P019033I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IEA--

    PRPF40B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRPF40B (PR40B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PRPF40B gene (2 alternative transcripts): 
    NM_001031698.2  NM_012272.1  

    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000552301 ENST00000547764 ENST00000551063 ENST00000527253 ENST00000508736
    ENST00000551418 ENST00000548825 ENST00000548436 ENST00000261897(uc001ruq.1)
    ENST00000551111 ENST00000380281(uc001rup.1 uc001rur.1 uc001rus.1)
    ENST00000551320 ENST00000548399 ENST00000549547 ENST00000546626 ENST00000551269

    miRNA
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    Block miRNA regulation of human, mouse, rat PRPF40B using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate PRPF40B:
    hsa-miR-21* hsa-miR-185* hsa-miR-1288 hsa-miR-3138 hsa-miR-340 hsa-miR-1827 hsa-miR-3616-3p hsa-miR-4308
    SwitchGear 3'UTR luciferase reporter plasmidPRPF40B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PRPF40B
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    OriGene ORF clones in mouse, rat for PRPF40B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PRPF40B (NM_001031698)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRPF40B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRPF40B
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRPF40B
      QuantiTect SYBR Green Assays in human, mouse, rat PRPF40B
      QuantiFast Probe-based Assays in human, mouse, rat PRPF40B

    Selected AceView cDNA sequences (see all 112):

    BC031917 AF049525 BM713416 BU557290 BQ877673 BU854888 BQ082554 NM_012272 
    BI966155 BM906064 BF747904 BI916965 BC067364 BQ719821 BU855235 AI916686 
    BM725642 BU553353 BU782786 BE392926 BU846157 AK123353 BM053144 BM715151 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PRPF40B (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b · 17c ^
    SP1:                                                                                                                                                            
    SP2:                                                                                -                                                                           
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 18 ^ 19 ^ 20a · 20b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for PRPF40B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRPF40B expression in normal human tissues (normalized intensities)      PRPF40B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTTCGGAA
    PRPF40B Expression
    About this image


    PRPF40B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    PRPF40B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRPF40B Protein Expression

    UniProtKB/Swiss-Prot: PR40B_HUMAN, Q6NWY9
    Tissue specificity: Expressed in the striatum and cortex of the brain (at protein level). Highly expressed in
    testis, fetal kidney and fetal brain. Moderately expressed in pancreas, skeletal muscle, placenta, brain and
    heart. Weakly expressed in colon, ileum, ovary, prostate, spleen, kidney and fetal lung

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PRPF40B gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prpf40b1 , 5 PRP40 pre-mRNA processing factor 40 homolog B (yeast)1, 5 90.36(n)1
    94.96(a)1
      15 (56.13 cM)5
    546141  NM_018786.21  NP_061256.11 
     992950875 
    lizard
    (Anolis carolinensis)
    Reptilia PRPF40B6
    PRP40 pre-mRNA processing factor 40 homolog B (S. ...
    65(a)
    1 ↔ 1
    2(94821606-94845923)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia prpf40b1 PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) 64.55(n)
    64.99(a)
      100493450  XM_002935117.2  XP_002935163.2 
    zebrafish
    (Danio rerio)
    Actinopterygii CR855359.16
    Uncharacterized protein
    20(a)
    many ↔ many
    21(40245253-40251340) ENSDARG00000087882
    fruit fly
    (Drosophila melanogaster)
    Insecta CG35421 CG3542 53.93(n)
    48.69(a)
      33513  NM_134894.4  NP_608738.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ZK1098.16
    Protein ZK1098.1, isoform a
    36(a)
    1 → many
    III(9522075-9525454) WBGene00014218
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRP40(YKL012W)4
    PRP401
    U1 snRNP protein involved in splicing, interacts with more4
    PRP401
    44.44(n)1
    30.3(a)1
      11(418310-420061)4
    8538571, 4  NP_012913.31  NP_012913.14 


    ENSEMBL Gene Tree for PRPF40B (if available)
    TreeFam Gene Tree for PRPF40B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRPF40B gene
    PRPF40A2  TCERG12  TCERG1L2  
    2 SIMAP similar genes for PRPF40B using alignment to 3 protein entries:     PR40B_HUMAN (see all proteins):
    FNBP3    PRPF40A

    PRPF40B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRPF40B (see all 513)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1889950851,2
    --49848552(+) CTCCAA/GCAGTG 1 -- us2k10--------
    rs1478791231,2
    C--49848800(+) GGTCCC/TAGGTA 2 -- us2k10--------
    rs1179453111,2
    C,F--49849170(+) TGAAAA/TTCGCC 2 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1815058551,2
    --49849183(+) AGCTGC/TGCTGG 2 -- us2k10--------
    rs740869111,2
    C,F--49849205(+) CCCCCG/AGGGGA 2 -- us2k12Minor allele frequency- A:0.07WA NA 122
    rs1874573881,2
    --49849727(+) TCTCCC/GGAGTT 2 -- us2k10--------
    rs1415146511,2
    --49849938(+) CTCAGC/GCGCAC 2 -- us2k10--------
    rs1902118791,2
    --49849952(+) AAGCAC/TGTACC 2 -- us2k10--------
    rs1808992371,2
    C--49849979(+) TGTCAA/GAGAGT 2 -- us2k10--------
    rs1472532201,2
    --49850099(+) TTTGT-/CTTTTT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for PRPF40B (49962001 - 50038449 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PRPF40B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832406CNV Loss17160897

    1 Site Specific Mutation Identification with PCR Assay for PRPF40B:
    Cosmic IdAA Change
    98000017P540S
    SeqTarget long-range PCR primers for resequencing PRPF40B
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    6 diseases for PRPF40B:    About MalaCards
    rett syndrome    huntington's disease    tonsillitis    cerebritis
    thyroiditis    prostatitis


    PRPF40B for disorders           About GeneDecksing

    Genetic Association Database (GAD): PRPF40B

    Export disorders for PRPF40B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRPF40B gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with PRPF40B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Huntingtin interacts with a family of WW domain proteins. (PubMed id 9700202)1, 2, 3, 9 Faber P.W....MacDonald M.E. (Hum. Mol. Genet. 1998)
    2. Huntingtin's WW domain partners in Huntington's disease post-mortem brain fulfill genetic criteria for direct involvement in Huntington's disease pathogenesis. (PubMed id 10958656)1, 2 Passani L.A.... MacDonald M.E. (Hum. Mol. Genet. 2000)
    3. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    4. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    5. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (Science 2009)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. A WW domain binding region in methyl-CpG-binding protein MeCP2: impact on Rett syndrome. (PubMed id 14618241)1 Buschdorf J.P. and StrAotling W.H. (J. Mol. Med. 2004)
    10. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25766 HGNC: 25031 AceView: HYPC Ensembl:ENSG00000110844 euGenes: HUgn25766
    ECgene: PRPF40B Kegg: 25766 H-InvDB: PRPF40B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PRPF40B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PRPF40B gene:
    Search GeneIP for patents involving PRPF40B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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