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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRPF4 Gene

protein-coding   GIFtS: 60
GCID: GC09P116037

Pre-MRNA Processing Factor 4

(Previous name: PRP4 pre-mRNA processing factor 4 homolog (yeast))
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Pre-MRNA Processing Factor 41     WD Splicing Factor Prp42 3
PRP42 3 5     HPRP42 5
PRP4 Pre-MRNA Processing Factor 4 Homolog (Yeast)1 2     HPRP4P2
PRP4/STK/WD Splicing Factor1 2     Prp4p2
U4/U6 Small Nuclear Ribonucleoprotein Prp41 2     SNRNP602
PRP4 Homolog2 3     hPrp43
U4/U6 SnRNP 60 KDa Protein2 3     

External Ids:    HGNC: 173491   Entrez Gene: 91282   Ensembl: ENSG000001368757   OMIM: 6077955   UniProtKB: O431723   

Export aliases for PRPF4 gene to outside databases

Previous GC identifers: GC09P106836 GC09P107770 GC09P109491 GC09P111414 GC09P113117 GC09P115077 GC09P085645


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PRPF4 Gene:
The protein encoded by this gene is part of a heteromeric complex that binds U4, U5, and U6 small nuclear RNAs and
is involved in pre-mRNA splicing. The encoded protein also is a mitotic checkpoint protein and a regulator of
chemoresistance in human ovarian cancer. Two transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for PRPF4 Gene: 
PRPF4 (pre-mRNA processing factor 4) is a protein-coding gene. Diseases associated with PRPF4 include ovarian cancer, and among its related super-pathways are mRNA Processing and Generic Transcription Pathway. GO annotations related to this gene include protein binding. An important paralog of this gene is WDR83.

UniProtKB/Swiss-Prot: PRP4_HUMAN, O43172
Function: Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of
the spliceosome

Gene Wiki entry for PRPF4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRPF4 gene promoter:
         E47   NF-AT   MEF-2A   NF-AT4   Nkx6-1   NF-AT2   NF-AT3   Hand1   aMEF-2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRPF4 promoter sequence
   Search SABiosciences Chromatin IP Primers for PRPF4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRPF4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q31-q33   Ensembl cytogenetic band:  9q32   HGNC cytogenetic band: 9q31-q33

PRPF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRPF4 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P116037:  view genomic region     (about GC identifiers)

Start:
116,037,623 bp from pter      End:
116,055,185 bp from pter
Size:
17,563 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PRP4_HUMAN, O43172 (See protein sequence)
Recommended Name: U4/U6 small nuclear ribonucleoprotein Prp4  
Size: 522 amino acids; 58449 Da
Subunit: Interacts directly with PRPF18, PPIH and PRPF3. Part of a heteromeric complex containing PPIH, PRPF3 and
PRPF4 that is stable in the absence of RNA. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6
and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2,
PPIH, NHP2L1, EFTUD2, SART1 and USP39
Subcellular location: Nucleus speckle (By similarity). Note=Colocalizes with spliceosomal snRNPs (By similarity)
1 PDB 3D structure from and Proteopedia for PRPF4:
1MZW (3D)    
Secondary accessions: O43445 O43864 Q5T1M8 Q96DG2 Q96IK4
Alternative splicing: 2 isoforms:  O43172-1   O43172-2   

Explore the universe of human proteins at neXtProt for PRPF4: NX_O43172

Explore proteomics data for PRPF4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43172

  • PRPF4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PRPF4 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001231855.1  NP_004688.2  

    ENSEMBL proteins: 
     ENSP00000363315   ENSP00000363313  
    Reactome Protein details: O43172
    Human Recombinant Protein Products for PRPF4: 
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    Cloud-Clone Corp. Proteins for PRPF4 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex NAS9328476
    GO:0005730NOT nucleolus IDA--
    GO:0015030Cajal body IDA15257298

    PRPF4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    5/8 InterPro protein domains (see all 8):
     IPR019775 WD40_repeat_CS
     IPR014906 PRP4
     IPR003648 SFM
     IPR027106 Prp4/Asa1
     IPR001680 WD40_repeat

    Graphical View of Domain Structure for InterPro Entry O43172

    ProtoNet protein and cluster: O43172

    2 Blocks protein domains:
    IPB001680 G-protein beta WD-40 repeat signature
    IPB003648 Splicing factor motif


    UniProtKB/Swiss-Prot: PRP4_HUMAN, O43172
    Similarity: Contains 7 WD repeats


    PRPF4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRP4_HUMAN, O43172
    Function: Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of
    the spliceosome

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19615732
         
    PRPF4 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for PRPF4:
     Decreased TP53 protein express  Decreased viability of wild-ty  Increased circadian period len  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PRPF4 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PRPF4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA0.85
    mRNA Splicing0.82
    mRNA Processing0.85
    mRNA processing0.46
    mRNA Splicing - Major Pathway0.82
    Spliceosome0.31
    2Generic Transcription Pathway
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for PRPF4
        mRNA processing

    5        Reactome Pathways for PRPF4
        mRNA Splicing - Major Pathway
    mRNA Splicing
    Gene Expression
    mRNA Processing
    Processing of Capped Intron-Containing Pre-mRNA


    1         Kegg Pathway  (Kegg details for PRPF4):
        Spliceosome


    PRPF4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRPF4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/280 Interacting proteins for PRPF4 (O431722, 3 ENSP000003633134) via UniProtKB, MINT, STRING, and/or I2D (see all 280)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP5J2P561342, 3MINT-63889 I2D: score=5 
    ENSG00000224979Q9Y3333, ENSP000004140064I2D: score=7 STRING: ENSP00000414006
    ENSG00000236826Q9Y3333, ENSP000004146344I2D: score=7 STRING: ENSP00000414634
    ENSG00000172850Q9Y3333I2D: score=7 
    ENSG00000225998Q9Y3333I2D: score=7 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000375RNA splicing, via transesterification reactions NAS9328476
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006396RNA processing TAS9328476
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--

    PRPF4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for PRPF4 (PRP4)

    2 HMDB Compounds for PRPF4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Search CenterWatch for drugs/clinical trials and news about PRPF4 / PRP4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for PRPF4 gene (2 alternative transcripts): 
    NM_001244926.1  NM_004697.4  

    Unigene Cluster for PRPF4:

    PRP4 pre-mRNA processing factor 4 homolog (yeast)
    Hs.744014  [show with all ESTs]
    Unigene Representative Sequence: NM_004697
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374199(uc004bgy.3) ENST00000374198(uc004bgx.3) ENST00000488937

    miRNA
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    hsa-miR-3618 hsa-miR-3915 hsa-miR-1207-5p
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    Inhib. RNA
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    Additional mRNA sequence: 

    AB209797.1 AF016369.1 AK225056.1 AK313131.1 AY572489.1 BC001588.2 BC007424.2 CR457105.1 
    U82756.1 

    17 DOTS entries:

    DT.92441511  DT.452994  DT.100020528  DT.121172873  DT.121172895  DT.121172847  DT.100825038  DT.100825044 
    DT.121172882  DT.99965298  DT.100825036  DT.121172930  DT.95374874  DT.97819356  DT.121172850  DT.40310529 
    DT.447359 

    24/231 AceView cDNA sequences (see all 231):

    CF135075 BU166023 AW516397 AI139266 AA961714 BU191932 AA700055 BF056244 
    AA179511 AF016369 BC001588 AA341821 BF433055 AU137968 BI756186 NM_004697 
    BX956400 BE467594 CR603092 AI081204 AI800163 AA359040 AA772596 CA422310 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PRPF4 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c
    SP1:                                      -                                               -                                             
    SP2:                                      -                                               -                                             
    SP3:                                                                                      -                                             
    SP4:                                                                                                                                    
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for PRPF4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRPF4 expression in normal human tissues (normalized intensities)      PRPF4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACGTCTCTAT
    PRPF4 Expression
    About this image


    PRPF4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See PRPF4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRPF4

    SOURCE GeneReport for Unigene cluster: Hs.744014
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRPF4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PRPF4 gene from 9/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prpf41 , 5 PRP4 pre-mRNA processing factor 4 homolog (yeast)1, 5 90.91(n)1
    99.04(a)1
      4 (33.13 cM)5
    700521  NM_027297.31  NP_081573.11 
     624087975 
    chicken
    (Gallus gallus)
    Aves PRPF41 PRP4 pre-mRNA processing factor 4 homolog (yeast) 78.75(n)
    89.67(a)
      417270  XM_415544.3  XP_415544.3 
    lizard
    (Anolis carolinensis)
    Reptilia PRPF46
    Uncharacterized protein
    90(a)
    1 ↔ 1
    GL344086.1(7614-32751)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.68852 Xenopus laevis transcribed sequence with moderate similarity more 76.4(n)    BX853387.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mgab03a022 mgab03a02 73.14(n)   326944  BC056720.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG63223
    U4-U6-60K1
    RNA splicing pre-mRNA splicing factor3
    U4-U6 small nuclear riboprotein factor 60K1
    56(a)3
    55.87(n)1
    55.2(a)1
      74D23
    399551  NM_140733.21  NP_648990.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C36B1.53
    prp-41
    U4/U6 small nuclear ribonucleoprotein3
    Protein PRP-41
    45(a)3
    49.43(n)1
    46.01(a)1
      I(8741588-8743767)3
    1832501  NM_059962.21  NP_492363.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRP4(YPR178W)4
    PRP41
    Splicing factor, component of the U4/U6-U5 snRNP complex4
    Prp4p1
    46.73(n)1
    35.51(a)1
      16(892332-893729)4
    8563071, 4  NP_015504.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons LIS1 U4/U6 small nuclear ribonucleoprotein PRP4-like protein 53.71(n)
    46.36(a)
      818748  NM_129713.3  NP_181681.1 


    ENSEMBL Gene Tree for PRPF4 (if available)
    TreeFam Gene Tree for PRPF4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRPF4 gene
    WDR832  POC1B2  WDR52  WDR482  ATG16L12  SNRNP402  WDR5B2  PAFAH1B12  
    SMU12  DAW12  WDR382  ATG16L22  POC1A2  
    5 SIMAP similar genes for PRPF4 using alignment to 3 protein entries:     PRP4_HUMAN (see all proteins):
    POC1B    CORO1C    DAW1    GNB2    WDR5

    PRPF4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/385 SNPs in PRPF4 are shown (see all 385)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1137023921,2
    C,F--116039908(+) TGATCC/TGCCCA 2 -- int11Minor allele frequency- T:0.50NA 2
    rs1174328441,2
    F--116039968(+) ACTGAG/ACTATC 2 -- int11Minor allele frequency- A:0.03NA 120
    rs1423321591,2
    C--116040037(+) CACTTC/TGGGAG 2 -- int10--------
    rs108174741,2
    C,F,A,H--116040440(+) ATTTTT/GCATTT 2 -- int123Minor allele frequency- G:0.23NS EA NA CSA 2536
    rs1808233911,2
    --116040538(+) TTCAGA/GCAATG 2 -- int10--------
    rs1859643401,2
    --116040587(+) CATCTA/GTCAGG 2 -- int10--------
    rs1117925951,2
    F--116040590(+) CTGTCG/AGGTTT 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs1170277241,2
    C,F--116040659(+) AACTTT/CTAATA 2 -- int11Minor allele frequency- C:0.01NA 120
    rs1112317951,2
    F--116040662(+) TTTTAA/GTACTG 2 -- int12Minor allele frequency- G:0.04CSA WA 120
    rs1483217921,2
    --116040763(+) AAATCC/GTTATA 2 -- int10--------

    HapMap Linkage Disequilibrium report for PRPF4 (116037623 - 116055185 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PRPF4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv893744CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PRPF4
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607795    OMIM disorders: --

    2 diseases for PRPF4:    About MalaCards
    ovarian cancer    


    PRPF4 for disorders           About GeneDecksing


    Export disorders for PRPF4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRPF4 gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with PRPF4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs. (PubMed id 9404889)1, 2, 3, 9 Horowitz D.S.... Krainer A.R. (1997)
    2. The human U4/U6 snRNP contains 60 and 90kD proteins that are structurally homologous to the yeast splicing factors Prp4p and Prp3p. (PubMed id 9257651)1, 2, 3 Lauber J.... Luehrmann R. (1997)
    3. Identification and characterization of human genes encoding Hprp3p and Hprp4p, interacting components of the spliceosome. (PubMed id 9328476)1, 2, 9 Wang A.... Hu J. (1997)
    4. The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP. (PubMed id 16723661)1, 2 Liu S.... Luehrmann R. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide. (PubMed id 12875835)1, 2 Reidt U....Ficner R. (2003)
    7. A human protein required for the second step of pre-mRNA splicing is functionally related to a yeast splicing factor. (PubMed id 9000057)1, 2 Horowitz D.S. and Krainer A.R. (1997)
    8. Cloning of human PRP4 reveals interaction with Clk1. (PubMed id 11418604)1, 9 Kojima T.... Hagiwara M. (2001)
    9. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (2013)
    10. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9128 HGNC: 17349 AceView: PRPF4 Ensembl:ENSG00000136875 euGenes: HUgn9128
    ECgene: PRPF4 Kegg: 9128 H-InvDB: PRPF4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRPF4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PRPF4 gene:
    Search GeneIP for patents involving PRPF4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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