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PRPF4 Gene

protein-coding   GIFtS: 57
GCID: GC09P116037

Pre-MRNA Processing Factor 4

(Previous name: PRP4 pre-mRNA processing factor 4 homolog (yeast))
  See PRPF4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Pre-MRNA Processing Factor 41 2     HPRP42 5
PRP42 3 5     PRP4 Pre-MRNA Processing Factor 4 Homolog (Yeast)1
PRP4/STK/WD Splicing Factor1 2     HPRP4P2
U4/U6 Small Nuclear Ribonucleoprotein Prp41 2     Prp4p2
PRP4 Homolog2 3     SNRNP602
U4/U6 SnRNP 60 KDa Protein2 3     PRP4 Pre-MRNA Processing Factor 4 Homolog2
WD Splicing Factor Prp42 3     hPrp43

External Ids:    HGNC: 173491   Entrez Gene: 91282   Ensembl: ENSG000001368757   OMIM: 6077955   UniProtKB: O431723   

Export aliases for PRPF4 gene to outside databases

Previous GC identifers: GC09P106836 GC09P107770 GC09P109491 GC09P111414 GC09P113117 GC09P115077 GC09P085645


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRPF4 Gene:
The protein encoded by this gene is part of a heteromeric complex that binds U4, U5, and U6 small nuclear RNAs and
is involved in pre-mRNA splicing. The encoded protein also is a mitotic checkpoint protein and a regulator of
chemoresistance in human ovarian cancer. Two transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for PRPF4 Gene:
PRPF4 (pre-mRNA processing factor 4) is a protein-coding gene. Diseases associated with PRPF4 include ovarian cancer, and leber congenital amaurosis. An important paralog of this gene is PRPF19.

UniProtKB/Swiss-Prot: PRP4_HUMAN, O43172
Function: Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of
the spliceosome

Gene Wiki entry for PRPF4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the PRPF4 gene promoter:
         E47   NF-AT   MEF-2A   NF-AT4   Nkx6-1   NF-AT2   NF-AT3   Hand1   aMEF-2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRPF4 promoter sequence
   Search Chromatin IP Primers for PRPF4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRPF4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q31-q33   Ensembl cytogenetic band:  9q32   HGNC cytogenetic band: 9q31-q33

PRPF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRPF4 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P116037:  view genomic region     (about GC identifiers)

Start:
116,037,623 bp from pter      End:
116,055,185 bp from pter
Size:
17,563 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PRP4_HUMAN, O43172 (See protein sequence)
Recommended Name: U4/U6 small nuclear ribonucleoprotein Prp4  
Size: 522 amino acids; 58449 Da
Subunit: Interacts directly with PRPF18, PPIH and PRPF3. Part of a heteromeric complex containing PPIH, PRPF3 and
PRPF4 that is stable in the absence of RNA. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6
and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2,
PPIH, NHP2L1, EFTUD2, SART1 and USP39
1 PDB 3D structure from and Proteopedia for PRPF4:
1MZW (3D)    
Secondary accessions: O43445 O43864 Q5T1M8 Q96DG2 Q96IK4
Alternative splicing: 2 isoforms:  O43172-1   O43172-2   

Explore the universe of human proteins at neXtProt for PRPF4: NX_O43172

Explore proteomics data for PRPF4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys159
  • Modification sites at PhosphoSitePlus

  • See PRPF4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001231855.1  NP_004688.2  

    ENSEMBL proteins: 
     ENSP00000363315   ENSP00000363313  
    Reactome Protein details: O43172

    PRPF4 Human Recombinant Protein Products:

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    antibodies-online proteins for PRPF4 (5 products) 

     
    antibodies-online peptides for PRPF4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 8):
     IPR019775 WD40_repeat_CS
     IPR014906 PRP4-like
     IPR003648 SFM
     IPR027106 Prp4
     IPR001680 WD40_repeat

    Graphical View of Domain Structure for InterPro Entry O43172

    ProtoNet protein and cluster: O43172

    2 Blocks protein domains:
    IPB001680 G-protein beta WD-40 repeat signature
    IPB003648 Splicing factor motif


    UniProtKB/Swiss-Prot: PRP4_HUMAN, O43172
    Similarity: Contains 7 WD repeats


    Find genes that share domains with PRPF4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRP4_HUMAN, O43172
    Function: Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of
    the spliceosome

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19615732
         
    Find genes that share ontologies with PRPF4           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for PRPF4:
     Decreased TP53 protein express  Decreased viability of wild-ty  Increased circadian period len  Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PRPF4

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    hsa-miR-3618 hsa-miR-3915 hsa-miR-1207-5p
    SwitchGear 3'UTR luciferase reporter plasmidPRPF4 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PRP4_HUMAN, O43172: Nucleus speckle (By similarity). Note=Colocalizes with spliceosomal snRNPs (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex NAS9328476
    GO:0005730NOT nucleolus IDA--
    GO:0015030Cajal body IDA15257298

    Find genes that share ontologies with PRPF4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRPF4 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA processing0.44
    2Gene Expression
    Gene Expression0.40
    3Spliceosome
    Spliceosome


    Find genes that share SuperPaths with PRPF4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for PRPF4
        mRNA processing


    1 Reactome Pathway for PRPF4
        mRNA Splicing - Major Pathway


    1 Kegg Pathway  (Kegg details for PRPF4):
        Spliceosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRPF4
    Interactions:

        GeneGlobe Interaction Network for PRPF4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRPF4 (O431721, 2, 3 ENSP000003633134) via UniProtKB, MINT, STRING, and/or I2D (see all 350)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPKOWQ929171, 2, ENSP000001561094EBI-718395,EBI-746309 MINT-8336496 MINT-8331745 STRING: ENSP00000156109
    ATP5J2P561342, 3MINT-63889 I2D: score=5 
    ENSG00000236826Q9Y3333, ENSP000004146344I2D: score=7 STRING: ENSP00000414634
    ENSG00000224979Q9Y3333, ENSP000004140064I2D: score=7 STRING: ENSP00000414006
    ENSG00000172850Q9Y3333I2D: score=7 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000375RNA splicing, via transesterification reactions NAS9328476
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006396RNA processing TAS9328476
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with PRPF4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for PRPF4 (PRP4)

    2 HMDB Compounds for PRPF4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRPF4 gene (2 alternative transcripts): 
    NM_001244926.1  NM_004697.4  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374199(uc004bgy.3) ENST00000374198(uc004bgx.3) ENST00000488937

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate PRPF4:
    hsa-miR-3618 hsa-miR-3915 hsa-miR-1207-5p
    SwitchGear 3'UTR luciferase reporter plasmidPRPF4 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat PRPF4
      QuantiFast Probe-based Assays in human, mouse, rat PRPF4

    Selected AceView cDNA sequences (see all 231):

    BX956400 NM_004697 AA678858 BF433055 AA992449 AI681391 AA703250 CB163865 
    BM505003 AA418960 BE467573 BU166023 AW615593 BE464994 AW516397 AI276555 
    AL513632 AA341821 BP364429 AA772596 AA700055 BC007424 BE206369 AY572489 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PRPF4 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c
    SP1:                                      -                                               -                                             
    SP2:                                      -                                               -                                             
    SP3:                                                                                      -                                             
    SP4:                                                                                                                                    
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for PRPF4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRPF4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACGTCTCTAT
    PRPF4 Expression
    About this image


    PRPF4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    PRPF4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRPF4 Protein Expression
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRPF4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PRPF4 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prpf41 , 5 PRP4 pre-mRNA processing factor 4 homolog (yeast)1, 5 90.91(n)1
    99.04(a)1
      4 (33.13 cM)5
    700521  NM_027297.31  NP_081573.11 
     624087975 
    chicken
    (Gallus gallus)
    Aves PRPF41 PRP4 pre-mRNA processing factor 4 homolog (yeast) 78.49(n)
    89.34(a)
      417270  XM_415544.4  XP_415544.3 
    lizard
    (Anolis carolinensis)
    Reptilia PRPF46
    pre-mRNA processing factor 4
    90(a)
    1 ↔ 1
    GL344086.1(7614-32751)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.68852 Xenopus laevis transcribed sequence with moderate similarity more 76.4(n)    BX853387.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mgab03a022 mgab03a02 73.14(n)   326944  BC056720.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG63223
    U4-U6-60K1
    RNA splicing pre-mRNA splicing factor3
    U4-U6 small nuclear riboprotein factor 60K1
    56(a)3
    56(n)1
    55.4(a)1
      74D23
    399551  NM_140733.31  NP_648990.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C36B1.53
    prp-41
    U4/U6 small nuclear ribonucleoprotein3
    prp-41
    45(a)3
    49.37(n)1
    45.45(a)1
      I(8741588-8743767)3
    1832501  NM_059962.31  NP_492363.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRP4(YPR178W)4
    PRP41
    Splicing factor, component of the U4/U6-U5 snRNP complex4
    PRP41
    47.12(n)1
    35.75(a)1
      16(892332-893729)4
    8563071, 4  NP_015504.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons LIS1 LIS 50.5(n)
    41.98(a)
      818748  NM_129713.3  NP_181681.1 


    ENSEMBL Gene Tree for PRPF4 (if available)
    TreeFam Gene Tree for PRPF4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRPF4 gene
    PRPF192  CSTF12  SPAG162  
    5 SIMAP similar genes for PRPF4 using alignment to 3 protein entries:     PRP4_HUMAN (see all proteins):
    POC1B    CORO1C    DAW1    GNB2    WDR5

    Find genes that share paralogs with PRPF4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRPF4 (see all 385)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1137023921,2
    C,F--116039908(+) TGATCC/TGCCCA 2 -- int11Minor allele frequency- T:0.50NA 2
    rs1174328441,2
    F--116039968(+) ACTGAG/ACTATC 2 -- int11Minor allele frequency- A:0.03NA 120
    rs1423321591,2
    C--116040037(+) CACTTC/TGGGAG 2 -- int10--------
    rs108174741,2
    C,F,A,H--116040440(+) ATTTTT/GCATTT 2 -- int123Minor allele frequency- G:0.23NS EA NA CSA 2536
    rs1808233911,2
    --116040538(+) TTCAGA/GCAATG 2 -- int10--------
    rs1859643401,2
    --116040587(+) CATCTA/GTCAGG 2 -- int10--------
    rs1117925951,2
    F--116040590(+) CTGTCG/AGGTTT 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs1170277241,2
    C,F--116040659(+) AACTTT/CTAATA 2 -- int11Minor allele frequency- C:0.01NA 120
    rs1112317951,2
    F--116040662(+) TTTTAA/GTACTG 2 -- int12Minor allele frequency- G:0.04CSA WA 120
    rs1483217921,2
    --116040763(+) AAATCC/GTTATA 2 -- int10--------

    HapMap Linkage Disequilibrium report for PRPF4 (116037623 - 116055185 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PRPF4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv893744CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRPF4
    DNA2.0 Custom Variant and Variant Library Synthesis for PRPF4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607795    OMIM disorders: --

    2 diseases for PRPF4:    
    About MalaCards
    ovarian cancer    leber congenital amaurosis


    Find genes that share disorders with PRPF4           About GenesLikeMe


    Export disorders for PRPF4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRPF4 gene, integrated from 10 sources (see all 54):
    (articles sorted by number of sources associating them with PRPF4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs. (PubMed id 9404889)1, 2, 3, 9 Horowitz D.S.... Krainer A.R. (RNA 1997)
    2. The human U4/U6 snRNP contains 60 and 90kD proteins that are structurally homologous to the yeast splicing factors Prp4p and Prp3p. (PubMed id 9257651)1, 2, 3 Lauber J.... Luehrmann R. (RNA 1997)
    3. Identification and characterization of human genes encoding Hprp3p and Hprp4p, interacting components of the spliceosome. (PubMed id 9328476)1, 2, 9 Wang A.... Hu J. (Hum. Mol. Genet. 1997)
    4. The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP. (PubMed id 16723661)1, 2 Liu S.... Luehrmann R. (RNA 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide. (PubMed id 12875835)1, 2 Reidt U....Ficner R. (J. Mol. Biol. 2003)
    7. A human protein required for the second step of pre-mRNA splicing is functionally related to a yeast splicing factor. (PubMed id 9000057)1, 2 Horowitz D.S. and Krainer A.R. (Genes Dev. 1997)
    8. Cloning of human PRP4 reveals interaction with Clk1. (PubMed id 11418604)1, 9 Kojima T.... Hagiwara M. (J. Biol. Chem. 2001)
    9. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    10. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9128 HGNC: 17349 AceView: PRPF4 Ensembl:ENSG00000136875 euGenes: HUgn9128
    ECgene: PRPF4 Kegg: 9128 H-InvDB: PRPF4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRPF4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRPF4 gene:
    Search GeneIP for patents involving PRPF4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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