Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PRPF38A Gene

Aliases for PRPF38A Gene

  • Pre-MRNA Processing Factor 38A 2 3 5
  • PRP38 Pre-MRNA Processing Factor 38 (Yeast) Domain Containing A 2
  • PRP38 Pre-MRNA Processing Factor 38 Domain Containing A 3
  • Prp38 3

External Ids for PRPF38A Gene

Previous GeneCards Identifiers for PRPF38A Gene

  • GC01P052583
  • GC01P052642
  • GC01P052870
  • GC01P050986

Summaries for PRPF38A Gene

GeneCards Summary for PRPF38A Gene

PRPF38A (Pre-MRNA Processing Factor 38A) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for PRPF38A Gene

  • May be required for pre-mRNA splicing.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRPF38A Gene

Genomics for PRPF38A Gene

Regulatory Elements for PRPF38A Gene

Promoters for PRPF38A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRPF38A on UCSC Golden Path with GeneCards custom track

Genomic Location for PRPF38A Gene

Chromosome:
1
Start:
52,404,547 bp from pter
End:
52,420,839 bp from pter
Size:
16,293 bases
Orientation:
Plus strand

Genomic View for PRPF38A Gene

Genes around PRPF38A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRPF38A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRPF38A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRPF38A Gene

Proteins for PRPF38A Gene

  • Protein details for PRPF38A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NAV1-PR38A_HUMAN
    Recommended name:
    Pre-mRNA-splicing factor 38A
    Protein Accession:
    Q8NAV1
    Secondary Accessions:
    • Q96JW1
    • Q9BVZ8

    Protein attributes for PRPF38A Gene

    Size:
    312 amino acids
    Molecular mass:
    37477 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB55405.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PRPF38A Gene

    Alternative splice isoforms for PRPF38A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRPF38A Gene

Proteomics data for PRPF38A Gene at MOPED

Post-translational modifications for PRPF38A Gene

  • Ubiquitination at Lys 23 and Lys 118
  • Modification sites at PhosphoSitePlus

Other Protein References for PRPF38A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PRPF38A Gene

Domains & Families for PRPF38A Gene

Protein Domains for PRPF38A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRPF38A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NAV1

UniProtKB/Swiss-Prot:

PR38A_HUMAN :
  • Belongs to the PRP38 family.
Family:
  • Belongs to the PRP38 family.
genes like me logo Genes that share domains with PRPF38A: view

No data available for Gene Families for PRPF38A Gene

Function for PRPF38A Gene

Molecular function for PRPF38A Gene

UniProtKB/Swiss-Prot Function:
May be required for pre-mRNA splicing.
genes like me logo Genes that share phenotypes with PRPF38A: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRPF38A Gene

Localization for PRPF38A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRPF38A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRPF38A Gene COMPARTMENTS Subcellular localization image for PRPF38A gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for PRPF38A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071011 precatalytic spliceosome IBA --
genes like me logo Genes that share ontologies with PRPF38A: view

Pathways & Interactions for PRPF38A Gene

SuperPathways for PRPF38A Gene

Superpath Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with PRPF38A: view

Pathways by source for PRPF38A Gene

1 KEGG pathway for PRPF38A Gene

Gene Ontology (GO) - Biological Process for PRPF38A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with PRPF38A: view

No data available for SIGNOR curated interactions for PRPF38A Gene

Drugs & Compounds for PRPF38A Gene

No Compound Related Data Available

Transcripts for PRPF38A Gene

Unigene Clusters for PRPF38A Gene

PRP38 pre-mRNA processing factor 38 (yeast) domain containing A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRPF38A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - -
SP2: - - - - -
SP3:
SP4: -

Relevant External Links for PRPF38A Gene

GeneLoc Exon Structure for
PRPF38A
ECgene alternative splicing isoforms for
PRPF38A

Expression for PRPF38A Gene

mRNA expression in normal human tissues for PRPF38A Gene

Protein differential expression in normal tissues from HIPED for PRPF38A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.9), Heart (6.9), and CD8 Tcells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRPF38A Gene



SOURCE GeneReport for Unigene cluster for PRPF38A Gene Hs.5301

genes like me logo Genes that share expression patterns with PRPF38A: view

Protein tissue co-expression partners for PRPF38A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PRPF38A Gene

Orthologs for PRPF38A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRPF38A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRPF38A 35
  • 99.68 (n)
  • 100 (a)
PRPF38A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRPF38A 36
  • 100 (a)
OneToOne
PRPF38A 35
  • 92.84 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia PRPF38A 35
  • 93.38 (n)
  • 100 (a)
PRPF38A 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prpf38a 36
  • 99 (a)
OneToOne
Prpf38a 16
Prpf38a 35
  • 88.46 (n)
  • 98.72 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 84 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PRPF38A 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prpf38a 35
  • 89.32 (n)
  • 99.36 (a)
chicken
(Gallus gallus)
Aves PRPF38A 36
  • 98 (a)
OneToOne
PRPF38A 35
  • 79.59 (n)
  • 97.76 (a)
lizard
(Anolis carolinensis)
Reptilia PRPF38A 36
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1823 35
tropical clawed frog
(Silurana tropicalis)
Amphibia prpf38a 35
  • 74.06 (n)
  • 88.75 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3597 35
zebrafish
(Danio rerio)
Actinopterygii prpf38a 36
  • 88 (a)
OneToOne
-- 35
prpf38a 35
  • 70.51 (n)
  • 82.05 (a)
fruit fly
(Drosophila melanogaster)
Insecta Prp38 36
  • 54 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea prp-38 36
  • 49 (a)
OneToOne
barley
(Hordeum vulgare)
Liliopsida Hv.10890 35
rice
(Oryza sativa)
Liliopsida Os.6813 35
wheat
(Triticum aestivum)
Liliopsida Ta.25546 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00662 35
  • 54.97 (n)
  • 46.78 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes prp38 35
  • 52.61 (n)
  • 46.49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6867 36
  • 65 (a)
OneToOne
Species with no ortholog for PRPF38A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PRPF38A Gene

ENSEMBL:
Gene Tree for PRPF38A (if available)
TreeFam:
Gene Tree for PRPF38A (if available)

Paralogs for PRPF38A Gene

Pseudogenes.org Pseudogenes for PRPF38A Gene

genes like me logo Genes that share paralogs with PRPF38A: view

No data available for Paralogs for PRPF38A Gene

Variants for PRPF38A Gene

Sequence variations from dbSNP and Humsavar for PRPF38A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs6684344 -- 52,412,975(+) CCAGC(C/T)TGGGC intron-variant
rs10127490 -- 52,409,115(+) TATAA(A/G)ACTAC intron-variant
rs10128030 -- 52,411,458(+) GTTCA(C/G)GTGCA intron-variant
rs12024709 -- 52,413,057(+) GCACC(G/T)CAGCT intron-variant
rs12038084 -- 52,415,679(+) GATTG(C/T)AGCTT intron-variant

Variation tolerance for PRPF38A Gene

Residual Variation Intolerance Score: 25.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRPF38A Gene

HapMap Linkage Disequilibrium report
PRPF38A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PRPF38A Gene

Disorders for PRPF38A Gene

Relevant External Links for PRPF38A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRPF38A

No disorders were found for PRPF38A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRPF38A Gene

Publications for PRPF38A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3

Products for PRPF38A Gene

Sources for PRPF38A Gene

Back to Top

Content