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Aliases for PRPF38A Gene

Aliases for PRPF38A Gene

  • Pre-MRNA Processing Factor 38A 2 3
  • PRP38 Pre-MRNA Processing Factor 38 (Yeast) Domain Containing A 2
  • PRP38 Pre-MRNA Processing Factor 38 Domain Containing A 3
  • Pre-MRNA-Splicing Factor 38A 3
  • Prp38 3

External Ids for PRPF38A Gene

Previous GeneCards Identifiers for PRPF38A Gene

  • GC01P052583
  • GC01P052642
  • GC01P052870
  • GC01P050986

Summaries for PRPF38A Gene

GeneCards Summary for PRPF38A Gene

PRPF38A (Pre-MRNA Processing Factor 38A) is a Protein Coding gene. Among its related pathways are Spliceosome.

UniProtKB/Swiss-Prot for PRPF38A Gene

  • May be required for pre-mRNA splicing.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRPF38A Gene

Genomics for PRPF38A Gene

Regulatory Elements for PRPF38A Gene

Genomic Location for PRPF38A Gene

Start:
52,404,547 bp from pter
End:
52,420,839 bp from pter
Size:
16,293 bases
Orientation:
Plus strand

Genomic View for PRPF38A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRPF38A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRPF38A Gene

Proteins for PRPF38A Gene

  • Protein details for PRPF38A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NAV1-PR38A_HUMAN
    Recommended name:
    Pre-mRNA-splicing factor 38A
    Protein Accession:
    Q8NAV1
    Secondary Accessions:
    • Q96JW1
    • Q9BVZ8

    Protein attributes for PRPF38A Gene

    Size:
    312 amino acids
    Molecular mass:
    37477 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB55405.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PRPF38A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRPF38A Gene

Proteomics data for PRPF38A Gene at MOPED

Post-translational modifications for PRPF38A Gene

  • Ubiquitination at Lys23 and Lys118
  • Modification sites at PhosphoSitePlus

Other Protein References for PRPF38A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRPF38A Gene

Domains for PRPF38A Gene

Protein Domains for PRPF38A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRPF38A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NAV1

UniProtKB/Swiss-Prot:

PR38A_HUMAN :
  • Q8NAV1
Family:
  • Belongs to the PRP38 family.
genes like me logo Genes that share domains with PRPF38A: view

No data available for Gene Families for PRPF38A Gene

Function for PRPF38A Gene

Molecular function for PRPF38A Gene

UniProtKB/Swiss-Prot Function: May be required for pre-mRNA splicing.

Gene Ontology (GO) - Molecular Function for PRPF38A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22365833
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with PRPF38A: view

Phenotypes for PRPF38A Gene

GenomeRNAi human phenotypes for PRPF38A:
genes like me logo Genes that share phenotypes with PRPF38A: view

Animal Model Products

CRISPR Products

miRNA for PRPF38A Gene

miRTarBase miRNAs that target PRPF38A

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PRPF38A Gene

Localization for PRPF38A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRPF38A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRPF38A Gene COMPARTMENTS Subcellular localization image for PRPF38A gene
Compartment Confidence
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for PRPF38A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005681 spliceosomal complex --
GO:0031965 nuclear membrane IDA --
GO:0071011 precatalytic spliceosome IBA --
genes like me logo Genes that share ontologies with PRPF38A: view

Pathways for PRPF38A Gene

SuperPathways for PRPF38A Gene

Superpath Contained pathways
1 Spliceosome
genes like me logo Genes that share pathways with PRPF38A: view

Pathways by source for PRPF38A Gene

1 KEGG pathway for PRPF38A Gene

Gene Ontology (GO) - Biological Process for PRPF38A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with PRPF38A: view

Transcripts for PRPF38A Gene

Unigene Clusters for PRPF38A Gene

PRP38 pre-mRNA processing factor 38 (yeast) domain containing A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRPF38A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRPF38A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - -
SP2: - - - - -
SP3:
SP4: -

Relevant External Links for PRPF38A Gene

GeneLoc Exon Structure for
PRPF38A
ECgene alternative splicing isoforms for
PRPF38A

Expression for PRPF38A Gene

mRNA expression in normal human tissues for PRPF38A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRPF38A Gene

SOURCE GeneReport for Unigene cluster for PRPF38A Gene Hs.5301

genes like me logo Genes that share expressions with PRPF38A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PRPF38A Gene

Orthologs for PRPF38A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRPF38A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRPF38A 35
  • 99.68 (n)
  • 100 (a)
PRPF38A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRPF38A 35
  • 92.84 (n)
  • 100 (a)
PRPF38A 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRPF38A 35
  • 93.38 (n)
  • 100 (a)
PRPF38A 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prpf38a 35
  • 88.46 (n)
  • 98.72 (a)
Prpf38a 16
Prpf38a 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 84 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PRPF38A 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prpf38a 35
  • 89.32 (n)
  • 99.36 (a)
chicken
(Gallus gallus)
Aves PRPF38A 35
  • 79.59 (n)
  • 97.76 (a)
PRPF38A 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRPF38A 36
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1823 35
tropical clawed frog
(Silurana tropicalis)
Amphibia prpf38a 35
  • 74.06 (n)
  • 88.75 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3597 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
prpf38a 35
  • 70.51 (n)
  • 82.05 (a)
prpf38a 36
  • 88 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Prp38 36
  • 54 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea prp-38 36
  • 49 (a)
OneToOne
barley
(Hordeum vulgare)
Liliopsida Hv.10890 35
rice
(Oryza sativa)
Liliopsida Os.6813 35
wheat
(Triticum aestivum)
Liliopsida Ta.25546 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00662 35
  • 54.97 (n)
  • 46.78 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes prp38 35
  • 52.61 (n)
  • 46.49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6867 36
  • 65 (a)
OneToOne
Species with no ortholog for PRPF38A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PRPF38A Gene

ENSEMBL:
Gene Tree for PRPF38A (if available)
TreeFam:
Gene Tree for PRPF38A (if available)

Paralogs for PRPF38A Gene

Pseudogenes.org Pseudogenes for PRPF38A Gene

genes like me logo Genes that share paralogs with PRPF38A: view

No data available for Paralogs for PRPF38A Gene

Variants for PRPF38A Gene

Sequence variations from dbSNP and Humsavar for PRPF38A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4319263 -- 52,412,628(+) AGGTC(A/T)GGCAC intron-variant
rs6665054 -- 52,408,442(+) CCTCC(A/G)CAATT intron-variant
rs6677047 -- 52,416,734(+) GATAT(A/G)AGGAT utr-variant-3-prime
rs6684344 -- 52,412,975(+) CCAGC(C/T)TGGGC intron-variant
rs10127490 -- 52,409,115(+) TATAA(A/G)ACTAC intron-variant

Relevant External Links for PRPF38A Gene

HapMap Linkage Disequilibrium report
PRPF38A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PRPF38A Gene

Disorders for PRPF38A Gene

No disorders were found for PRPF38A Gene.

No data available for UniProtKB/Swiss-Prot for PRPF38A Gene

Publications for PRPF38A Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PMID: 15302935) Beausoleil S.A. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for PRPF38A Gene

Sources for PRPF38A Gene

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