PRPF31 Gene
protein-coding GIFtS: 62
GCID: GC19P054618
|
|
PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae)(Previous name: PRP31 pre-mRNA processing factor 31 homolog (yeast) )
(Previous symbol: RP11)
| |
Aliases
for PRPF31 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| PRP31 Pre-MRNA Processing Factor 31 Homolog (S. Cerevisiae)1 2 | | Serologically Defined Breast Cancer Antigen NY-BR-992 3 | | PRP311 2 3 5 | | HPrp311 | | RP111 2 5 | | U4/U6 SnRNP 61 KDa Protein2 3 | | NY-BR-991 2 | | PRP31 Pre-MRNA Processing Factor 31 Homolog (Yeast)1 | | Pre-MRNA-Processing Factor 312 3 | | U4/U6 Small Nuclear Ribonucleoprotein Prp312 | | Protein 61K2 3 | | |
Export aliases for PRPF31 gene to outside databasesPrevious GC identifers: GC19P055264 GC19P055043 GC19P059294 GC19P059310 GC19P050934 |
Summaries
for PRPF31 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PRPF31:
This gene encodes a component of the spliceosome complex and is one of several retinitis pigmentosa-causing genes. Whenthe gene product is added to the spliceosome complex, activation occurs.(provided by RefSeq, Jan 2009)
UniProtKB/Swiss-Prot: PRP31_HUMAN, Q8WWY3Function: Involved in pre-mRNA splicing. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of thebuilding blocks of the spliceosome
Gene Wiki entry for PRPF31
|
Genomic Views
for PRPF31 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PRPF31 gene promoter:
AML1a Pax-2 Pax-2a c-Ets-1 YY1 AREB6 PPAR-gamma1 COMP1 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for PRPF31
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRPF31 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.42 Ensembl cytogenetic band: 19q13.42 HGNC cytogenetic band: 19q13.4PRPF31 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P054618: view genomic region
(about GC identifiers)
Start:
|
54,618,790 bp from pter |
End:
|
54,635,150 bp from pter |
Size:
|
16,361 bases |
Orientation:
|
plus strand |
|
Proteins
for PRPF31 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PRP31_HUMAN, Q8WWY3 (See
protein sequence)Recommended Name: U4/U6 small nuclear ribonucleoprotein Prp31 Size: 499 amino acids; 55456 Da
Subunit: Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4,PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39. Interacts witha complex formed by NHP2L1 and U4 snRNA, but not with NHP2L1 or U4 snRNA alone. Interacts with PRPF6/U5snRNP-associated 102 kDa protein. Component of some MLL1/MLL complex, at least composed of the core components MLL,ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1,LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6,TAF7, TAF9 and TEX10. Interacts (via its NLS) with CTNNBL1
Subcellular location: Nucleus speckle. Nucleus, Cajal body. Note=Predominantly found in speckles and in Cajal bodies
3 PDB 3D structures from  and Proteopedia  for PRPF31:2OZB (3D)
3SIU (3D)
3SIV (3D)
Secondary accessions: Q17RB4 Q8N7F9 Q9H271 Q9Y439Alternative splicing: 3 isoforms: Q8WWY3-1 Q8WWY3-2 Q8WWY3-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for PRPF31: NX_Q8WWY3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WWY3
PRPF31 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056444.3
ENSEMBL proteins: ENSP00000324122 ENSP00000395894 ENSP00000408980 ENSP00000395089 ENSP00000375635 ENSP00000405166
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
PRPF31 for ontologies About GeneDecksing
PRPF31 Antibody Products:
Assay Products for PRPF31: |
Protein
Domains /
Families
for PRPF31 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PRPF31 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WWY3ProtoNet protein and cluster: Q8WWY3 2 Blocks protein families: IPB002687 Pre-mRNA processing ribonucleoprotein IPB012976 NOSIC
UniProtKB/Swiss-Prot: PRP31_HUMAN, Q8WWY3Domain: Interacts with the snRNP via the Nop domainDomain: The coiled coil domain is formed by two non-contiguous helicesSimilarity: Belongs to the PRP31 familySimilarity: Contains 1 Nop domain |
Function
for PRPF31 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PRP31_HUMAN, Q8WWY3Function: Involved in pre-mRNA splicing. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of thebuilding blocks of the spliceosome
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRPF31 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRPF31
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PRPF31 (NM_015629) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRPF31 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRPF31 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRPF31 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
PRPF31 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for PRPF31:
Animal Models:
Mouse knock-out Prpf31tm1.1Bha for PRPF31
3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Prpf31):
PRPF31 for phenotypes About GeneDecksing
|
Pathways & Interactions
for PRPF31 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | mRNA Splicing - Major Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for PRPF31):
PRPF31 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRPF31
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/154 Interacting proteins for PRPF31 (Q8WWY32, 3 ENSP000003241224) via UniProtKB, MINT, STRING, and/or I2D (see all 154)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
PRPF31 for ontologies About GeneDecksing
|
Drugs & Compounds
for PRPF31 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PRPF31
Search CenterWatch for drugs/clinical trials and news about PRPF31 / PRP31
|
Transcripts
for PRPF31 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PRPF31 gene: NM_015629.3 Unigene Cluster for PRPF31: PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae) Hs.515598 [show with all ESTs]Unigene Representative Sequence: AB5930249 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000321030(uc002qdh.2 uc010yek.1 uc021vbi.1) ENST00000445811
ENST00000445124 ENST00000447810 ENST00000391755 ENST00000467851 ENST00000466404
ENST00000498612 ENST00000419967
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRPF31 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRPF31
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PRPF31 (NM_015629) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRPF31 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRPF31 |
Additional cDNA sequence: AB593024.1 AB593025.1 AF308303.1 AK091105.1 AK098547.1 AK301709.1 AL050369.1 AY040822.1 BC117389.1 10 DOTS entries: DT.447997 DT.97845460 DT.453078 DT.100801697 DT.121451857 DT.80100470 DT.100801691 DT.92030994 DT.95278253 DT.97855108 24/503 AceView cDNA sequences (see all 503): CK821381 BF434647 BG256298 BE390280 BQ068584 BE670791 BM740136 BF062595 AW615662 AI301199 BM450019 BQ053446 AI697590 BU159560 BE742680 AI521939 BM553114 BE206993 BM772272 AI857673 AI338174 BE504808 BF061105 AA477187
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for PRPF31 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for PRPF31
|
Expression
for PRPF31 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PRPF31 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTTGTCTTT
About this image
See PRPF31 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PRPF31
SOURCE GeneReport for Unigene cluster: Hs.515598
UniProtKB/Swiss-Prot: PRP31_HUMAN, Q8WWY3Tissue specificity: Ubiquitously expressed
SABiosciences Custom PCR Arrays for PRPF31
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRPF31
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PRPF31 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRPF31 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRPF31 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRPF31 |
Orthologs
for PRPF31 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PRPF31 gene from 8/34 species (see all 34) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Prpf311 , 5 |
PRP31 pre-mRNA processing factor 31 homolog (yeast)1, 5 |
89.58(n)1
99(a)1 |
|
7 (2.09 cM)5
689881 NM_027328.41 NP_081604.31
36299855 |
lizard
(Anolis carolinensis) |
Reptilia |
PRPF316 |
-- |
95(a) |
1 ↔ 1 |
GL343279.1(1544340-1552918) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.58942 |
Xenopus laevis transcribed sequence with moderate similarity more |
74.95(n) |
|
CA787914.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc661772 |
hypothetical protein MGC66177 |
79.05(n) |
|
393476 BC052224.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG68763
Prp311 |
mRNA splicing pre-mRNA splicing factor3
CG6876-PA1 |
63(a)3
64.21(n)1
62.09(a)1 |
|
71B63
396551 NM_140499.21 NP_648756.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
Y110A7A.83
prp-311 |
mRNA splicing protein3
Protein PRP-311 |
47(a)3
50.68(n)1
47.34(a)1 |
|
I(5127854-5129538)3
1721461 NM_059126.41 NP_491527.11 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
emb12201 |
U4/U6 small nuclear ribonucleoprotein PRP31 |
51.33(n)
47.27(a) |
|
842312 NM_104707.3 NP_564754.1 |
rice
(Oryza sativa) |
Liliopsida |
Os04g05554001 |
hypothetical protein |
51.55(n)
48.95(a) |
|
4336619 NM_001060051.1 NP_001053516.1 |
ENSEMBL Gene Tree for PRPF31 (if available)
TreeFam Gene Tree for PRPF31 (if available) |
Paralogs
for PRPF31 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for PRPF31 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PRPF31 (54618790 - 54635150 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PRPF31
1 CNV: 50206
Human Gene Mutation Database (HGMD): PRPF31
Locus Specific Mutation Databases (LSDB): PRPF31
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRPF31 |
|
Disorders
/ Diseases
for PRPF31 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PRPF31 for disorders About GeneDecksing
OMIM gene information: 606419
OMIM disorders: 600138
UniProtKB/Swiss-Prot: PRP31_HUMAN, Q8WWY3
Defects in PRPF31 are the cause of retinitis pigmentosa type 11 (RP11) [MIM:600138]. RP leads to degenerationof retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field.As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP11inheritance is autosomal dominant
14  diseases for PRPF31: About MalaCardsretinitis pigmentosa retinitis pigmentosa 11 retinitis breast cancer
night blindness cone dystrophy intellectual disability fanconi's anemia
blindness gout anemia retinal disease
ovarian cancer malaria
1 disease from the University of Copenhagen DISEASES database for PRPF31:Retinitis pigmentosa 1 Novoseek disease relationship for PRPF31 gene About this table
Human Genome Epidemiology (HuGE) Navigator: PRPF31 (4 documents)
Export disorders for PRPF31 gene to outside databases
|
Publications
for PRPF31 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PRPF31 gene, integrated from 9 sources (see all 83):
(articles sorted by number of sources associating them with PRPF31) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A human homolog of yeast pre-mRNA splicing gene, PRP31, underlies autosomal dominant retinitis pigmentosa on chromosome 19q13.4 (RP11). (PubMed id 11545739)1, 2, 3, 9 Vithana E.N.... Bhattacharya S.S. (2001)
- Protein 61K, encoded by a gene (PRPF31) linked to autosomal dominant retinitis pigmentosa, is required for U4/U6.U5 tri-snRNP formation and pre-mRNA splicing. (PubMed id 11867543)1, 2, 9 Makarova O.V.... Luehrmann R. (2002)
- CTNNBL1 is a novel nuclear localization sequence-bind ing protein that recognizes RNA-splicing factors CDC5L and Prp31. (PubMed id 21385873)1, 2 Ganesh K....Neuberger M. (2011)
- Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP. (PubMed id 17412961)1, 2 Liu S....Wahl M.C. (2007)
- The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP. (PubMed id 16723661)1, 2 Liu S.... Luehrmann R. (2006)
- Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PubMed id 15960975)1, 2 Dou Y.... Roeder R.G. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Novel deletion in the pre-mRNA splicing gene PRPF31 causes autosomal dominant retinitis pigmentosa in a large Chinese family. (PubMed id 12923864)1, 2 Wang L....Wang Q. (2003)
|
External Searches for PRPF31 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PRPF31 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PRPF31 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PRPF31 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PRPF31 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PRPF31 gene:
Search GeneIP for patents involving PRPF31
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PRPF31 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for PRPF31 | | OriGene shRNA RFP for PRPF31 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRPF31 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRPF31 | | | OriGene Protein Over-expression Lysate for PRPF31 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PRPF31 | | OriGene 3'-UTR Clone for PRPF31 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRPF31 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRPF31 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PRPF31 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PRPF31 | | OriGene Custom Protein Services for PRPF31 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PRPF31 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRPF31 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRPF31 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRPF31 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRPF31 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRPF31 |
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| | | | Search Tocris compounds for PRPF31 |
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 | | | PRPF31 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRPF31 |
|  |  |  | | | | ThermoFisher Antibodies for PRPF31 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRPF31 |
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