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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PRPF19 Gene

protein-coding GIFtS: 59
GCID: GC11M060658

PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)

(Previous name: PRP19/PSO4 homolog (S. cerevisiae) )
(Previous symbol: PRP19)

Explore 3 diseases affiliated with
PRPF19 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
PRP19/PSO4 Pre-MRNA Processing Factor 19 Homolog (S. Cerevisiae)¹ ²		Senescence Evasion Factor² ³
NMP200¹ ² ³ ⁵		SNEV² ³
PRP19¹ ² ³ ⁵		PRP19/PSO4 Homolog² ³
PSO4¹ ² ⁵		PRP19/PSO4 Homolog (S. Cerevisiae)¹
UBOX4¹ ²		Nuclear Matrix Protein NMP200 Related To Splicing Factor PRP19²
HPSO4¹		Pre-MRNA-Processing Factor 19²
Nuclear Matrix Protein 200² ³		HPso4¹

External Ids:	HGNC: 17896¹	Entrez Gene: 27339²	Ensembl: ENSG00000110107⁷	OMIM: 608330⁵	UniProtKB: Q9UMS4³

Export aliases for PRPF19 gene to outside databases

Previous GC identifers: GC11M060415 GC11M057004

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PRPF19:

PSO4 is the human homolog of yeast Pso4, a gene essential for cell survival and DNA repair (Beck et al., 2008 (PubMed

18263876)).(supplied by OMIM, Sep 2008)

UniProtKB/Swiss-Prot: PRP19_HUMAN, Q9UMS4

Function: Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific

manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding

and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for

spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand

cross-links (ICLs) repair process. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome

and is required for activating pre-mRNA splicing

Gene Wiki entry for PRPF19

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PRPF19 gene promoter:
COUP-TF1 CREB COUP-TF deltaCREB COUP Lmo2 HNF-4alpha2 HNF-4alpha1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PRPF19 promoter sequence

Search SABiosciences Chromatin IP Primers for PRPF19

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRPF19

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.2 Ensembl cytogenetic band: 11q12.2 HGNC cytogenetic band: 11q12.2

PRPF19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRPF19 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M060658: view genomic region (about GC identifiers)

Start:	60,658,019 bp from pter	End:	60,674,061 bp from pter
Size:	16,043 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PRP19_HUMAN, Q9UMS4 (See protein sequence)

Recommended Name: Pre-mRNA-processing factor 19

Size: 504 amino acids; 55181 Da

Subunit: Homooligomer. Identified in the spliceosome C complex. Component of the PSO4 complex, composed of PRPF19,

CDC5L, PLRG1. Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of

PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts

in the complex directly with CDC5L, PLRG1 and BCAS2. Interacts with APEX1, DNTT and PSMB4

Subcellular location: Nucleus. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Note=Nucleoplasmic in interphase

cells. Irregularly distributed in anaphase cells. In prophase cells, uniformly distributed, but not associated with

condensing chromosomes. Found in extrachromosomal regions in metaphase cells. Mainly localized to the mitotic spindle

apparatus when chromosomes segregate during anaphase. When nuclei reform during late telophase, uniformly distributed

in daughter cells and displays no preferred association with decondensing chromatin

Explore the universe of human proteins at neXtProt for PRPF19: NX_Q9UMS4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UMS4

PRPF19 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055317.1

ENSEMBL proteins:

ENSP00000227524 ENSP00000443031 ENSP00000445435 ENSP00000440266 ENSP00000446259

Human Recombinant Protein Products:

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	Novus Biologicals PRPF19 Proteins Novus Biologicals PRPF19 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PRPF19

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000151	ubiquitin ligase complex	IEA	--
GO:0000974	Prp19 complex	IDA	--
GO:0005634	nucleus	IDA	11435423
GO:0005737	cytoplasm	IDA	11435423
GO:0005811	lipid particle	IEA	--

PRPF19 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for PRPF19

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PRPF19 for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR003613 Ubox_domain

IPR019775 WD40_repeat_CS

IPR000772 Ricin_B_lectin

IPR013083 Znf_RING/FYVE/PHD

IPR001680 WD40_repeat

Graphical View of Domain Structure for InterPro Entry Q9UMS4

ProtoNet protein and cluster: Q9UMS4

3 Blocks protein families:

IPB000772 Ricin B lectin domain

IPB003613 Zn-finger

IPB013915 Pre-mRNA-splicing factor 19

UniProtKB/Swiss-Prot: PRP19_HUMAN, Q9UMS4

Similarity: Belongs to the WD repeat PRP19 family

Similarity: Contains 1 U-box domain

Similarity: Contains 7 WD repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PRP19_HUMAN, Q9UMS4

Function: Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific

manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding

and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for

spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand

cross-links (ICLs) repair process. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome

and is required for activating pre-mRNA splicing

Induction: By gamma irradiation and chemical mutagens but not by UV irradiation

miRNA Products:		OriGene 3'-UTR Clone: PRPF19 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRPF19
		8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate PRPF19 (see all 14):
		hsa-miR-28-3p hsa-miR-623 hsa-miR-203 hsa-miR-520d-5p hsa-miR-513a-5p hsa-miR-27a hsa-miR-128 hsa-miR-708*

		SwitchGear 3'UTR luciferase reporter plasmid: PRPF19 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRPF19 (see all 7) OriGene shRNA RFP: PRPF19 OriGene siRNA: PRPF19
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Gene Editing
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		GenScript: all cDNA clones in your preferred vector: PRPF19 (NM_014502)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PRPF19
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRPF19

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0004842	ubiquitin-protein ligase activity	IDA	11435423
GO:0005515	protein binding	IPI	--
GO:0034450	ubiquitin-ubiquitin ligase activity	IDA	11435423
GO:0042802	identical protein binding	IPI	16332694

PRPF19 for ontologies About GeneDecksing

6 GenomeRNAi human phenotypes for PRPF19:

Decreased viability	Increased Salmonella enterica	Increased Salmonella enterica	Increased Salmonella-containin
Increased gamma-H2AX phosphory	Synthetic lethal with Ras

Animal Models:
Mouse knock-out Prpf19^tm1Glri for PRPF19
4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Prpf19):

cellular

embryogenesis

mortality/aging

normal

PRPF19 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Antigen processing: Ubiquitination & Proteasome degradation

Ubiquitin mediated proteolysis

0.36

mRNA Splicing - Major Pathway

Spliceosome

0.31

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Kegg Pathways (Kegg details for PRPF19):

	Spliceosome
	Ubiquitin mediated proteolysis

PRPF19 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PRPF19

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/830 Interacting proteins for PRPF19 (Q9UMS4^{2, 3} ENSP00000227524⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 830)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PLRG1	O43660²^,³, ENSP00000303191⁴	MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000303191
KPNA2	P52292²^,³, ENSP00000332455⁴	MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000332455
SF3A2	Q15428²^,³, ENSP00000221494⁴	MINT-5205926 MINT-7947479 I2D: score=1 STRING: ENSP00000221494
SRRM1	Q8IYB3²^,³, ENSP00000326261⁴	MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000326261
SRRM2	Q9UQ35²^,³, ENSP00000301740⁴	MINT-7945693 I2D: score=1 STRING: ENSP00000301740

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000209	protein polyubiquitination	IDA	11435423
GO:0000245	spliceosomal complex assembly	IMP	16332694
GO:0000398	mRNA splicing, via spliceosome	IDA	--
GO:0001833	inner cell mass cell proliferation	IEA	--
GO:0006281	DNA repair	IEA	--

PRPF19 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PRPF19

4 HMDB Compounds for PRPF19 About this table

Compound	Synonyms	CAS #	PubMed Ids
Adenosine monophosphate	5'-AMP (see all 28)	61-19-8	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Phosphoric acid	acide phosphorique (FRENCH) (see all 20)	7664-38-2	--
Pyrophosphate	(4-)Diphosphoric acid ion (see all 10)	14000-31-8	--

Search CenterWatch for drugs/clinical trials and news about PRPF19 / PRP19

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PRPF19 gene:

NM_014502.4

Unigene Cluster for PRPF19:

PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)

Hs.502705 [show with all ESTs]

Unigene Representative Sequence: NM_014502

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000227524(uc001nqf.3) ENST00000540473 ENST00000535326 ENST00000539960

ENST00000539180 ENST00000541371 ENST00000546152

miRNA Products:		OriGene 3'-UTR Clone: PRPF19 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRPF19
		8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate PRPF19 (see all 14):
		hsa-miR-28-3p hsa-miR-623 hsa-miR-203 hsa-miR-520d-5p hsa-miR-513a-5p hsa-miR-27a hsa-miR-128 hsa-miR-708*

		SwitchGear 3'UTR luciferase reporter plasmid: PRPF19 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: PRPF19 (NM_014502)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRPF19
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRPF19

Additional cDNA sequence:

AF086469.1 AJ131186.1 BC008719.2 BC018665.2 BC018698.2

18 DOTS entries:

DT.100838257 DT.100706929 DT.455032 DT.99944427 DT.95157494 DT.100766003 DT.86997467 DT.120716219

DT.86847368 DT.92009207 DT.100807750 DT.100808602 DT.120716036 DT.120716245 DT.91721954 DT.91849888

DT.100659496 DT.91755533

24/315 AceView cDNA sequences (see all 315):

AW261999 BM450927 BM458292 AA555164 AI690348 BF527285 AI140224 BG388089

AA768046 BQ130000 AI420036 BC008719 BQ185243 AA877543 BM824069 BQ648589

BX387171 BM825097 CA432408 CK299654 AA776253 AI589597 AA911203 AI290155

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for PRPF19 About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14a	·	14b	^	15	^	16a	·	16b	^	17
SP1:							-																																		-
SP2:							-																		-		-		-		-		-
SP3:
SP4:

ECgene alternative splicing isoforms for PRPF19

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PRPF19 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAACGGATG

About this image

PRPF19 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Reproductive System

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PRPF19 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PRPF19

SOURCE GeneReport for Unigene cluster: Hs.502705

UniProtKB/Swiss-Prot: PRP19_HUMAN, Q9UMS4

Tissue specificity: Ubiquitous. Weakly expressed in senescent cells of different tissue origins. Highly expressed in

tumor cell lines

SABiosciences Custom PCR Arrays for PRPF19

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRPF19

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRPF19

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRPF19 gene from 8/36 species (see all 36) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PRPF19¹	PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. more	83(n) 94.25(a)		430767 NM_001039331.1 NP_001034420.1
lizard (Anolis carolinensis)	Reptilia	PRPF19⁶	--	96(a)	1 ↔ 1	GL343235.1(357162-366574)
African clawed frog (Xenopus laevis)	Amphibia	nmp200-prov²	nuclear matrix protein NMP200 related to splicing factor more	75.82(n)		BC044093.1
zebrafish (Danio rerio)	Actinopterygii	Dr.3564²	Danio rerio mRNA similar to nuclear matrix protein more	78.38(n)		BC045954.1
fruit fly (Drosophila melanogaster)	Insecta	Prp19¹	CG5519-PA	65.28(n) 66(a)		37123 NM_079059.2 NP_523783.1
worm (Caenorhabditis elegans)	Secernentea	T10F2.4¹	hypothetical protein	55.69(n) 53.37(a)		175705 NM_065695.2 NP_498096.2
thale cress (Arabidopsis thaliana)	eudicotyledons	MAC3B¹	Pre-mRNA-processing factor 19-2	51.16(n) 46.53(a)		817897 NM_179875.6 NP_850206.4
rice (Oryza sativa)	Liliopsida	NM_196923.1²	--	73.67(n)		NM_196923.1

ENSEMBL Gene Tree for PRPF19 (if available)
TreeFam Gene Tree for PRPF19 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PRPF19 gene

CSTF1² PLRG1²

PRPF19 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for PRPF19
PGOHUM00000234951

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs184635716^1,2		--	60657975(+)	`GACTTG/TAGGCC`	1	--	int¹		0	--	--	--	--
rs11426757^1,2	C	--	60658058(+)	`AAAAAA/-GGGTA`	1	--	ut3¹		1		NA	2
rs189983586^1,2		--	60658146(+)	`CCCTTA/GACCTT`	1	--	ut3¹		0	--	--	--	--
rs181534859^1,2		--	60658194(+)	`GAGGTA/GGTTAT`	1	--	ut3¹		0	--	--	--	--
rs186052785^1,2		--	60658271(+)	`CCCATC/TCCCTT`	1	--	ut3¹		0	--	--	--	--
rs1804972^1,2	C,F,H,	--	60658301(+)	`NNNNTC/TCTGTC`	1	--	ut3¹ ese³		6		NS NA	1070
rs73491090^1,2	C,	--	60658463(+)	`GATGAG/AGGTGG`	1	--	ut3¹		2		WA	120
rs140004740^1,2	F	--	60658694(+)	`CTTGGC/TGTGAT`	2	T A	mis¹		1		NA	4552
rs149803092^1,2	C,F	--	60658704(+)	`TGCCCG/AAAGGC`	2	/F	syn¹		2		NA EU	5713
rs148949526^1,2	C,F,	--	60658731(+)	`CCGCTA/GTGCTC`	2	H	syn¹		1		NA	4550

HapMap Linkage Disequilibrium report for PRPF19 (60658019 - 60674061 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PRPF19: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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PRPF19 for disorders           About GeneDecksing

OMIM gene information: 608330    OMIM disorders: --

3 diseases for PRPF19:    About MalaCards

hypoxia malaria neuronitis

Export disorders for PRPF19 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PRPF19 gene, integrated from 9 sources (see all 57):
(articles sorted by number of sources associating them with PRPF19)

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world of online information

Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase. (PubMed id 12960389)^{1, 2, 3, 9} Mahajan K.N. and Mitchell B.S. (2003)
The Pso4 mRNA splicing and DNA repair complex interacts with WRN for processing of DNA interstrand cross-links. (PubMed id 16223718)^{1, 2, 9} Zhang N.... Legerski R.J. (2005)
hNMP 200: a novel human common nuclear matrix protein combining structural and regulatory functions. (PubMed id 11082287)^{1, 2, 9} Gotzmann J.... Sauermann G. (2000)
Molecular architecture of the human Prp19/CDC5L compl ex. (PubMed id 20176811)^{1, 2} Grote M....LA1hrmann R. (2010)
APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process. (PubMed id 19188445)^{1, 2} Vascotto C....Tell G. (2009)
SNEV overexpression extends the life span of human endothelial cells. (PubMed id 16388800)^{1, 2} Voglauer R.... Grillari J. (2006)
Interaction of U-box E3 ligase SNEV with PSMB4, the beta7 subunit of the 20 S proteasome. (PubMed id 15660529)^{1, 2} Loescher M.... Grillari J. (2005)
SNEV is an evolutionarily conserved splicing factor whose oligomerization is necessary for spliceosome assembly. (PubMed id 16332694)^{1, 2} Grillari J.... Katinger H. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)^{1, 2} Jurica M.S.... Moore M.J. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 27339	HGNC: 17896	AceView: PRP19	Ensembl:ENSG00000110107	euGenes: HUgn27339
ECgene: PRPF19	Kegg: 27339	H-InvDB: PRPF19

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PRPF19	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PRPF19	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for PRPF19 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PRPF19 gene:
Search GeneIP for patents involving PRPF19

GeneCards and IP:
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PRPF19 Gene

PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)

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PRPF19 Gene

PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)

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