Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PRPF19 Gene

protein-coding   GIFtS: 60
GCID: GC11M060658

Pre-MRNA Processing Factor 19

(Previous names: PRP19/PSO4 homolog (S. cerevisiae), PRP19/PSO4 pre-mRNA...)
(Previous symbol: PRP19)
  See PRPF19-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Pre-MRNA Processing Factor 191 2     PSO42 5
PRP191 2 3 5     PRP19/PSO4 Homolog (S. Cerevisiae)1
NMP2002 3 5     PRP19/PSO4 Pre-MRNA Processing Factor 19 Homolog (S. Cerevisiae)1
Nuclear Matrix Protein NMP200 Related To Splicing Factor PRP191 2     UBOX42
Nuclear Matrix Protein 2002 3     hPSO42
Senescence Evasion Factor2 3     Pre-MRNA-Processing Factor 192
SNEV2 3     PRP19/PSO4 Pre-MRNA Processing Factor 19 Homolog2
PRP19/PSO4 Homolog2 3     hPso43

External Ids:    HGNC: 178961   Entrez Gene: 273392   Ensembl: ENSG000001101077   OMIM: 6083305   UniProtKB: Q9UMS43   

Export aliases for PRPF19 gene to outside databases

Previous GC identifers: GC11M060415 GC11M057004


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PRPF19 Gene:
PSO4 is the human homolog of yeast Pso4, a gene essential for cell survival and DNA repair (Beck et al., 2008
(PubMed 18263876)).(supplied by OMIM, Sep 2008)

GeneCards Summary for PRPF19 Gene:
PRPF19 (pre-mRNA processing factor 19) is a protein-coding gene. Diseases associated with PRPF19 include poikiloderma with neutropenia. GO annotations related to this gene include ubiquitin-ubiquitin ligase activity and identical protein binding. An important paralog of this gene is PRPF4.

UniProtKB/Swiss-Prot: PRP19_HUMAN, Q9UMS4
Function: Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a
sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support
for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner
and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is
required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L complex that
forms an integral part of the spliceosome and is required for activating pre-mRNA splicing

Gene Wiki entry for PRPF19 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRPF19 gene promoter:
         COUP-TF1   CREB   COUP-TF   deltaCREB   COUP   Lmo2   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PRPF19 promoter sequence
   Search Chromatin IP Primers for PRPF19

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRPF19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.2   Ensembl cytogenetic band:  11q12.2   HGNC cytogenetic band: 11q12.2

PRPF19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRPF19 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M060658:  view genomic region     (about GC identifiers)

Start:
60,658,019 bp from pter      End:
60,674,061 bp from pter
Size:
16,043 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PRP19_HUMAN, Q9UMS4 (See protein sequence)
Recommended Name: Pre-mRNA-processing factor 19  
Size: 504 amino acids; 55181 Da
Subunit: Homooligomer. Identified in the spliceosome C complex. Component of the PSO4 complex, composed of PRPF19,
CDC5L, PLRG1. Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer
of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8.
Interacts in the complex directly with CDC5L, PLRG1 and BCAS2. Interacts with APEX1, DNTT and PSMB4. Interacts
with CWC22 and EIF4A3 in an RNA-independent manner
1 PDB 3D structure from and Proteopedia for PRPF19:
4LG8 (3D)    

Explore the universe of human proteins at neXtProt for PRPF19: NX_Q9UMS4

Explore proteomics data for PRPF19 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys266, Lys428
  • Modification sites at PhosphoSitePlus

  • See PRPF19 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055317.1  
    ENSEMBL proteins: 
     ENSP00000227524   ENSP00000443031   ENSP00000445435   ENSP00000440266   ENSP00000446259  

    PRPF19 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PRPF19
    OriGene Protein Over-expression Lysate for PRPF19
    OriGene MassSpec for PRPF19
    OriGene Custom Protein Services for PRPF19
    GenScript Custom Purified and Recombinant Proteins Services for PRPF19
    Novus Biologicals PRPF19 Proteins
    Novus Biologicals PRPF19 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PRPF19

     
    Search eBioscience for Proteins for PRPF19 

     
    antibodies-online proteins for PRPF19 (8 products) 

     
    antibodies-online peptides for PRPF19

    PRPF19 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for PRPF19
    OriGene Custom Antibody Services for PRPF19
    Novus Biologicals PRPF19 Antibodies
    Abcam antibodies for PRPF19
    Cloud-Clone Corp. Antibodies for PRPF19
    ThermoFisher Antibody for PRPF19
    antibodies-online antibodies for PRPF19 (51 products) 

    PRPF19 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PRPF19
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PRPF19
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PRPF19
    Cloud-Clone Corp. CLIAs for PRPF19
    Search eBioscience for ELISAs for PRPF19 
    antibodies-online kits for PRPF19 (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    UBOX: U-box domain containing
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 9):
     IPR003613 Ubox_domain
     IPR019775 WD40_repeat_CS
     IPR000772 Ricin_B_lectin
     IPR013083 Znf_RING/FYVE/PHD
     IPR001680 WD40_repeat

    Graphical View of Domain Structure for InterPro Entry Q9UMS4

    ProtoNet protein and cluster: Q9UMS4

    3 Blocks protein domains:
    IPB000772 Ricin B lectin domain
    IPB003613 Zn-finger
    IPB013915 Pre-mRNA-splicing factor 19


    UniProtKB/Swiss-Prot: PRP19_HUMAN, Q9UMS4
    Similarity: Belongs to the WD repeat PRP19 family
    Similarity: Contains 1 U-box domain
    Similarity: Contains 7 WD repeats


    Find genes that share domains with PRPF19           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRP19_HUMAN, Q9UMS4
    Function: Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a
    sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support
    for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner
    and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is
    required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L complex that
    forms an integral part of the spliceosome and is required for activating pre-mRNA splicing
    Induction: By gamma irradiation and chemical mutagens but not by UV irradiation

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004842ubiquitin-protein ligase activity IDA11435423
    GO:0005515protein binding IPI19188445
    GO:0034450ubiquitin-ubiquitin ligase activity IDA11435423
    GO:0042802identical protein binding IPI16332694
         
    Find genes that share ontologies with PRPF19           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for PRPF19:
     Decreased viability  Increased Salmonella enterica   Increased Salmonella enterica   Increased Salmonella-containin 
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Prpf19):
     cellular  embryogenesis  mortality/aging  normal 

    Find genes that share phenotypes with PRPF19           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Prpf19tm1Glri for PRPF19

       genOway: Develop your customized and physiologically relevant rodent model for PRPF19

    miRNA
    Products:
        
    miRTarBase miRNAs that target PRPF19:
    hsa-let-7b-5p (MIRT051973), hsa-mir-30a-5p (MIRT049927), hsa-mir-193b-3p (MIRT041329)

    Block miRNA regulation of human, mouse, rat PRPF19 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRPF19 (see all 14):
    hsa-miR-28-3p hsa-miR-623 hsa-miR-203 hsa-miR-520d-5p hsa-miR-513a-5p hsa-miR-27a hsa-miR-128 hsa-miR-708*
    SwitchGear 3'UTR luciferase reporter plasmidPRPF19 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PRPF19
    Predesigned siRNA for gene silencing in human, mouse, rat PRPF19

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PRPF19

    Clone
    Products:
         
    OriGene clones in human, mouse for PRPF19 (see all 6)
    OriGene ORF clones in mouse, rat for PRPF19
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRPF19 (NM_014502)
    Sino Biological Human cDNA Clone for PRPF19
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRPF19
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRPF19

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PRPF19
    Browse ESI BIO Cell Lines and PureStem Progenitors for PRPF19 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRPF19


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    PRP19_HUMAN, Q9UMS4: Nucleus. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Note=Nucleoplasmic in
    interphase cells. Irregularly distributed in anaphase cells. In prophase cells, uniformly distributed, but not
    associated with condensing chromosomes. Found in extrachromosomal regions in metaphase cells. Mainly localized to
    the mitotic spindle apparatus when chromosomes segregate during anaphase. When nuclei reform during late
    telophase, uniformly distributed in daughter cells and displays no preferred association with decondensing
    chromatin
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    plasma membrane3
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IEA--
    GO:0000974Prp19 complex IDA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA11435423

    Find genes that share ontologies with PRPF19           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for PRPF19 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Ubiquitin mediated proteolysis0.35
    2Spliceosome
    Spliceosome


    Find genes that share SuperPaths with PRPF19           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    2 Kegg Pathways  (Kegg details for PRPF19):
        Spliceosome
    Ubiquitin mediated proteolysis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRPF19
    Interactions:

        GeneGlobe Interaction Network for PRPF19

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRPF19 (Q9UMS41, 2, 3 ENSP000002275244) via UniProtKB, MINT, STRING, and/or I2D (see all 1001)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBM5P527561, 2, ENSP000003430544EBI-395746,EBI-714003 MINT-8335209 MINT-8332229 MINT-8328221 MINT-8327994 MINT-8328209 MINT-8328060 MINT-8328016 MINT-8328605 STRING: ENSP00000343054
    PRPF8Q6P2Q91, 2, ENSP000003043504EBI-395746,EBI-538479 MINT-8331811 MINT-7945693 MINT-8335979 MINT-8328016 MINT-7947479 STRING: ENSP00000304350
    BCAS2O759341, 2, ENSP000003585544EBI-395746,EBI-1050106 MINT-8332471 MINT-7945693 MINT-8336705 MINT-7947479 STRING: ENSP00000358554
    RBM10P981751, 2, ENSP000003668294EBI-395746,EBI-721525 MINT-7945693 MINT-8332196 MINT-8334912 STRING: ENSP00000366829
    PLRG1O436602, 3, ENSP000003031914MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000303191
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IDA11435423
    GO:0000245spliceosomal complex assembly IMP16332694
    GO:0000398mRNA splicing, via spliceosome IDA--
    GO:0001833inner cell mass cell proliferation IEA--
    GO:0006281DNA repair IEA--

    Find genes that share ontologies with PRPF19           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRPF19 (PRP19)

    4 HMDB Compounds for PRPF19    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PRPF19 gene: 
    NM_014502.4  

    Unigene Cluster for PRPF19:

    PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)
    Hs.502705  [show with all ESTs]
    Unigene Representative Sequence: NM_014502
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000227524(uc001nqf.3) ENST00000540473 ENST00000535326 ENST00000539960
    ENST00000539180 ENST00000541371 ENST00000546152
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PRPF19 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRPF19 (see all 14):
    hsa-miR-28-3p hsa-miR-623 hsa-miR-203 hsa-miR-520d-5p hsa-miR-513a-5p hsa-miR-27a hsa-miR-128 hsa-miR-708*
    SwitchGear 3'UTR luciferase reporter plasmidPRPF19 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PRPF19
    Predesigned siRNA for gene silencing in human, mouse, rat PRPF19
    Clone
    Products:
         
    OriGene clones in human, mouse for PRPF19 (see all 6)
    OriGene ORF clones in mouse, rat for PRPF19
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRPF19 (NM_014502)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRPF19
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRPF19
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PRPF19
    OriGene qSTAR qPCR primer pairs in human, mouse for PRPF19
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRPF19
      QuantiTect SYBR Green Assays in human, mouse, rat PRPF19
      QuantiFast Probe-based Assays in human, mouse, rat PRPF19

    Additional mRNA sequence: 

    AF086469.1 AJ131186.1 BC008719.2 BC018665.2 BC018698.2 

    18 DOTS entries:

    DT.100838257  DT.100706929  DT.455032  DT.99944427  DT.95157494  DT.100766003  DT.86997467  DT.120716219 
    DT.86847368  DT.92009207  DT.100807750  DT.100808602  DT.120716036  DT.120716245  DT.91721954  DT.91849888 
    DT.100659496  DT.91755533 

    Selected AceView cDNA sequences (see all 315):

    BG056890 BQ926978 AA776253 BM462159 BQ185243 BF527285 AI276312 CK299914 
    AA938526 AA911203 AA372407 CK299654 BM824069 BM875511 AA555164 BC018665 
    AA983171 AA877543 AI589597 AA468492 BM450927 AI140224 AI339755 AI290155 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PRPF19    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17
    SP1:                    -                                                                                                     -         
    SP2:                    -                                                     -     -     -     -     -                                 
    SP3:                                                                                                                                    
    SP4:                                                                                                                                    


    ECgene alternative splicing isoforms for PRPF19

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PRPF19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAACGGATG
    PRPF19 Expression
    About this image


    PRPF19 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    PRPF19 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRPF19 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.502705

    UniProtKB/Swiss-Prot: PRP19_HUMAN, Q9UMS4
    Tissue specificity: Ubiquitous. Weakly expressed in senescent cells of different tissue origins. Highly expressed
    in tumor cell lines

        Custom PCR Arrays for PRPF19
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PRPF19
    OriGene qSTAR qPCR primer pairs in human, mouse for PRPF19
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRPF19
    QuantiTect SYBR Green Assays in human, mouse, rat PRPF19
    QuantiFast Probe-based Assays in human, mouse, rat PRPF19
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRPF19

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PRPF19 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prpf191 , 5 PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. more1, 5 90.48(n)1
    99.4(a)1
      19 (7.33 cM)5
    280001  NM_134129.41  NP_598890.11 
     108952315 
    chicken
    (Gallus gallus)
    Aves PRPF191 PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. more 83.57(n)
    95.41(a)
      430767  NM_001039331.1  NP_001034420.1 
    lizard
    (Anolis carolinensis)
    Reptilia PRPF196
    pre-mRNA processing factor 19
    97(a)
    1 ↔ 1
    GL343235.1(356428-372294)
    African clawed frog
    (Xenopus laevis)
    Amphibia nmp200-prov2 nuclear matrix protein NMP200 related to splicing factor more 75.82(n)    BC044093.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.35642 Danio rerio mRNA similar to nuclear matrix protein more 78.38(n)    BC045954.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Prp191 Prp19 66.2(n)
    67.47(a)
      37123  NM_079059.2  NP_523783.1 
    worm
    (Caenorhabditis elegans)
    Secernentea prp-196
    Pre-mRNA-processing factor 19 homolog
    52(a)
    1 ↔ 1
    III(5169915-5172045) WBGene00020423
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRP19(YLL036C)4 Splicing factor associated with the spliceosome; contains more   --   12(68256-66745) 850623  NP_013064.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MAC3B1 MAC3B 51.54(n)
    47.23(a)
      817897  NM_179876.5  NP_850207.4 
    rice
    (Oryza sativa)
    Liliopsida NM_196923.12   -- 73.67(n)    NM_196923.1 


    ENSEMBL Gene Tree for PRPF19 (if available)
    TreeFam Gene Tree for PRPF19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PRPF19 gene
    PRPF42  CSTF12  SPAG162  

    Find genes that share paralogs with PRPF19           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for PRPF19
    PGOHUM00000234951


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PRPF19 (see all 414)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1846357161,2
    --60657975(+) GACTTG/TAGGCC 1 -- int10--------
    rs1414936081,2
    C--60658057(+) CAATT-/ATAAAA 1 -- ut310--------
    rs1899835861,2
    --60658146(+) CCCTTA/GACCTT 1 -- ut310--------
    rs1815348591,2
    --60658194(+) GAGGTA/GGTTAT 1 -- ut310--------
    rs1860527851,2
    --60658271(+) CCCATC/TCCCTT 1 -- ut310--------
    rs18049721,2
    C,F,H--60658301(+) CCTCTC/TCTGTC 1 -- ut31 ese36Minor allele frequency- T:0.02NS NA 1070
    rs734910901,2
    C--60658463(+) GATGAG/AGGTGG 1 -- ut312Minor allele frequency- A:0.17WA 120
    rs1400047401,2
    F--60658694(+) CTTGGC/TGTGAT 2 T A mis11Minor allele frequency- T:0.00NA 4552
    rs1498030921,2
    C,F--60658704(+) TGCCCG/AAAGGC 2 /F syn12Minor allele frequency- A:0.00NA EU 5713
    rs1489495261,2
    C,F--60658731(+) CCGCTA/GTGCTC 2 H syn11Minor allele frequency- G:0.00NA 4550

    HapMap Linkage Disequilibrium report for PRPF19 (60658019 - 60674061 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PRPF19: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRPF19
    DNA2.0 Custom Variant and Variant Library Synthesis for PRPF19

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608330    OMIM disorders: --

    1 disease for PRPF19:    
    About MalaCards
    poikiloderma with neutropenia


    Find genes that share disorders with PRPF19           About GenesLikeMe


    Export disorders for PRPF19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PRPF19 gene, integrated from 10 sources (see all 74):
    (articles sorted by number of sources associating them with PRPF19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase. (PubMed id 12960389)1, 2, 3, 9 Mahajan K.N. and Mitchell B.S. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    2. The Pso4 mRNA splicing and DNA repair complex interacts with WRN for processing of DNA interstrand cross-links. (PubMed id 16223718)1, 2, 9 Zhang N.... Legerski R.J. (J. Biol. Chem. 2005)
    3. hNMP 200: a novel human common nuclear matrix protein combining structural and regulatory functions. (PubMed id 11082287)1, 2, 9 Gotzmann J.... Sauermann G. (Exp. Cell Res. 2000)
    4. Molecular architecture of the human Prp19/CDC5L complex. (PubMed id 20176811)1, 2 Grote M.... Luhrmann R. (Mol. Cell. Biol. 2010)
    5. APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process. (PubMed id 19188445)1, 2 Vascotto C.... Tell G. (Mol. Cell. Biol. 2009)
    6. SNEV overexpression extends the life span of human endothelial cells. (PubMed id 16388800)1, 2 Voglauer R.... Grillari J. (Exp. Cell Res. 2006)
    7. Interaction of U-box E3 ligase SNEV with PSMB4, the beta7 subunit of the 20 S proteasome. (PubMed id 15660529)1, 2 Loescher M.... Grillari J. (Biochem. J. 2005)
    8. SNEV is an evolutionarily conserved splicing factor whose oligomerization is necessary for spliceosome assembly. (PubMed id 16332694)1, 2 Grillari J.... Katinger H. (Nucleic Acids Res. 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (RNA 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 27339 HGNC: 17896 AceView: PRP19 Ensembl:ENSG00000110107 euGenes: HUgn27339
    ECgene: PRPF19 Kegg: 27339 H-InvDB: PRPF19

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PRPF19 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRPF19 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PRPF19 gene:
    Search GeneIP for patents involving PRPF19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PRPF19   OriGene RNAi products in human, mouse, rat for PRPF19  
     OriGene qPCR primer pairs and template standards for PRPF19   OriGene Protein Over-expression Lysate for PRPF19  
     OriGene MassSpec for PRPF19   OriGene clones in human, mouse for PRPF19  
     OriGene qSTAR qPCR primer pairs in human, mouse for PRPF19   OriGene Purified Protein for PRPF19  
     OriGene ORF clones in mouse, rat for PRPF19   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PRPF19   OriGene Custom Protein Services for PRPF19  

     
     
     Block miRNA regulation of human, mouse, rat PRPF19 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PRPF19
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRPF19 Predesigned siRNA for gene silencing in human, mouse, rat PRPF19
     QuantiFast Probe-based Assays in human, mouse, rat PRPF19 QuantiTect SYBR Green Assays in human, mouse, rat PRPF19
     Custom PCR Arrays for PRPF19 Search Chromatin IP Primers for PRPF19
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRPF19  GeneGlobe Interaction Network for PRPF19
     Regulatory tfbs in PRPF19 promoter
     GenScript Custom Purified and Recombinant Proteins Services for PRPF19 GenScript cDNA clones with any tag delivered in your preferred vector for PRPF19
     GenScript Custom Assay Services for PRPF19 GenScript Custom overexpressing Cell Line Services for PRPF19
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PRPF19 (PRP19)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for PRPF19
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PRPF19 antibodies
     PRPF19 proteins
     PRPF19 lysates
     Antibodies for PRPF19
     See all of Abcam's Antibodies, Kits and Proteins for PRPF19
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for PRPF19
     Antibodies for PRPF19
     ELISAs for PRPF19
     CLIAs for PRPF19



     Browse ESI BIO Cell Lines and PureStem Progenitors for PRPF19
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRPF19
     SwitchGear 3'UTR luciferase reporter plasmids for PRPF19
     SwitchGear Promoter luciferase reporter plasmids for PRPF19
     ThermoFisher Antibody for PRPF19
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRPF19
     Browse compounds at ApexBio
     Search Addgene for plasmids for PRPF19
      Search eBioscience for proteins for PRPF19
      Search eBioscience for elisas for PRPF19
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for PRPF19
     antibodies-online antibodies for PRPF19 (51 products)
     antibodies-online kits for PRPF19 (10 products)
     antibodies-online peptides for PRPF19
     antibodies-online proteins for PRPF19 (8 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PRPF19 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4