Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRPF19 Gene

protein-coding   GIFtS: 59
GCID: GC11M060658

Pre-MRNA Processing Factor 19

(Previous names: PRP19/PSO4 homolog (S. cerevisiae), PRP19/PSO4 pre-mRNA...)
(Previous symbol: PRP19)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Pre-MRNA Processing Factor 191 2     PSO42 5
PRP191 2 3 5     PRP19/PSO4 Homolog (S. Cerevisiae)1
NMP2002 3 5     PRP19/PSO4 Pre-MRNA Processing Factor 19 Homolog (S. Cerevisiae)1
Nuclear Matrix Protein NMP200 Related To Splicing Factor PRP191 2     UBOX42
Nuclear Matrix Protein 2002 3     hPSO42
Senescence Evasion Factor2 3     Pre-MRNA-Processing Factor 192
SNEV2 3     PRP19/PSO4 Pre-MRNA Processing Factor 19 Homolog2
PRP19/PSO4 Homolog2 3     hPso43

External Ids:    HGNC: 178961   Entrez Gene: 273392   Ensembl: ENSG000001101077   OMIM: 6083305   UniProtKB: Q9UMS43   

Export aliases for PRPF19 gene to outside databases

Previous GC identifers: GC11M060415 GC11M057004


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PRPF19 Gene:
PSO4 is the human homolog of yeast Pso4, a gene essential for cell survival and DNA repair (Beck et al., 2008
(PubMed 18263876)).(supplied by OMIM, Sep 2008)

GeneCards Summary for PRPF19 Gene: 
PRPF19 (pre-mRNA processing factor 19) is a protein-coding gene. Diseases associated with PRPF19 include poikiloderma with neutropenia, and neutropenia, and among its related super-pathways are Antigen processing: Ubiquitination & Proteasome degradation and mRNA Splicing - Major Pathway. GO annotations related to this gene include ubiquitin-ubiquitin ligase activity and identical protein binding. An important paralog of this gene is CSTF1.

UniProtKB/Swiss-Prot: PRP19_HUMAN, Q9UMS4
Function: Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a
sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support
for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner
and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is
required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L complex that
forms an integral part of the spliceosome and is required for activating pre-mRNA splicing

Gene Wiki entry for PRPF19 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRPF19 gene promoter:
         COUP-TF1   CREB   COUP-TF   deltaCREB   COUP   Lmo2   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PRPF19 promoter sequence
   Search SABiosciences Chromatin IP Primers for PRPF19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRPF19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.2   Ensembl cytogenetic band:  11q12.2   HGNC cytogenetic band: 11q12.2

PRPF19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRPF19 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M060658:  view genomic region     (about GC identifiers)

Start:
60,658,019 bp from pter      End:
60,674,061 bp from pter
Size:
16,043 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PRP19_HUMAN, Q9UMS4 (See protein sequence)
Recommended Name: Pre-mRNA-processing factor 19  
Size: 504 amino acids; 55181 Da
Subunit: Homooligomer. Identified in the spliceosome C complex. Component of the PSO4 complex, composed of PRPF19,
CDC5L, PLRG1. Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer
of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8.
Interacts in the complex directly with CDC5L, PLRG1 and BCAS2. Interacts with APEX1, DNTT and PSMB4
Subcellular location: Nucleus. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Note=Nucleoplasmic in
interphase cells. Irregularly distributed in anaphase cells. In prophase cells, uniformly distributed, but not
associated with condensing chromosomes. Found in extrachromosomal regions in metaphase cells. Mainly localized to
the mitotic spindle apparatus when chromosomes segregate during anaphase. When nuclei reform during late
telophase, uniformly distributed in daughter cells and displays no preferred association with decondensing
chromatin

Explore the universe of human proteins at neXtProt for PRPF19: NX_Q9UMS4

Explore proteomics data for PRPF19 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UMS4

  • PRPF19 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PRPF19 Protein Expression
    REFSEQ proteins: NP_055317.1  
    ENSEMBL proteins: 
     ENSP00000227524   ENSP00000443031   ENSP00000445435   ENSP00000440266   ENSP00000446259  

    Human Recombinant Protein Products for PRPF19: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PRPF19
    OriGene Protein Over-expression Lysate for PRPF19
    OriGene MassSpec for PRPF19 
    OriGene Custom Protein Services for PRPF19
    GenScript Custom Purified and Recombinant Proteins Services for PRPF19
    Novus Biologicals PRPF19 Proteins
    Novus Biologicals PRPF19 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PRPF19 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IEA--
    GO:0000974Prp19 complex IDA--
    GO:0005634nucleus IDA11435423
    GO:0005737cytoplasm IDA11435423
    GO:0005811lipid particle IEA--

    PRPF19 for ontologies           About GeneDecksing



    PRPF19 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for PRPF19
    OriGene Custom Antibody Services for PRPF19
    GenScript Custom Superior Antibodies Services for PRPF19
    Novus Biologicals PRPF19 Antibodies
    Abcam antibodies for PRPF19
    Cloud-Clone Corp. Antibodies for PRPF19 
    ThermoFisher Antibody for PRPF19
    LSBio Antibodies in human, mouse, rat for PRPF19 

    Assay Products for PRPF19: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PRPF19
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PRPF19
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PRPF19 
    Cloud-Clone Corp. CLIAs for PRPF19


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UBOX: U-box domain containing
    WDR: WD repeat domain containing

    5/9 InterPro protein domains (see all 9):
     IPR003613 Ubox_domain
     IPR019775 WD40_repeat_CS
     IPR000772 Ricin_B_lectin
     IPR013083 Znf_RING/FYVE/PHD
     IPR001680 WD40_repeat

    Graphical View of Domain Structure for InterPro Entry Q9UMS4

    ProtoNet protein and cluster: Q9UMS4

    3 Blocks protein domains:
    IPB000772 Ricin B lectin domain
    IPB003613 Zn-finger
    IPB013915 Pre-mRNA-splicing factor 19


    UniProtKB/Swiss-Prot: PRP19_HUMAN, Q9UMS4
    Similarity: Belongs to the WD repeat PRP19 family
    Similarity: Contains 1 U-box domain
    Similarity: Contains 7 WD repeats


    PRPF19 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRP19_HUMAN, Q9UMS4
    Function: Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a
    sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support
    for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner
    and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is
    required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L complex that
    forms an integral part of the spliceosome and is required for activating pre-mRNA splicing
    Induction: By gamma irradiation and chemical mutagens but not by UV irradiation

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004842ubiquitin-protein ligase activity IDA11435423
    GO:0005515protein binding IPI19188445
    GO:0034450ubiquitin-ubiquitin ligase activity IDA11435423
    GO:0042802identical protein binding IPI16332694
         
    PRPF19 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for PRPF19:
     Decreased viability  Increased Salmonella enterica   Increased Salmonella enterica   Increased Salmonella-containin 
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Prpf19):
     cellular  embryogenesis  mortality/aging  normal 

    PRPF19 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Prpf19tm1Glri for PRPF19

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PRPF19 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PRPF19

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRPF19 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRPF19 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRPF19
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate PRPF19 (see all 14):
    hsa-miR-28-3p hsa-miR-623 hsa-miR-203 hsa-miR-520d-5p hsa-miR-513a-5p hsa-miR-27a hsa-miR-128 hsa-miR-708*
    SwitchGear 3'UTR luciferase reporter plasmidPRPF19 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PRPF19
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRPF19

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PRPF19
    Sirion Biotech Customized adenovirus for overexpression of PRPF19

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PRPF19 (see all 7)
    OriGene ORF clones in mouse, rat for PRPF19
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRPF19 (NM_014502)
    Sino Biological Human cDNA Clone for PRPF19
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRPF19
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRPF19
    Sirion Biotech Customized lentivirus for stable overexpression of PRPF19 
                         Customized lentivirus expression plasmids for stable overexpression of PRPF19 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PRPF19
    Search LifeMap BioReagents cell lines for PRPF19
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRPF19


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PRPF19 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Ubiquitin mediated proteolysis0.36
    2mRNA Splicing - Major Pathway
    Spliceosome0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    2         Kegg Pathways  (Kegg details for PRPF19):
        Spliceosome
    Ubiquitin mediated proteolysis


    PRPF19 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRPF19

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/867 Interacting proteins for PRPF19 (Q9UMS42, 3 ENSP000002275244) via UniProtKB, MINT, STRING, and/or I2D (see all 867)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLRG1O436602, 3, ENSP000003031914MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000303191
    KPNA2P522922, 3, ENSP000003324554MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000332455
    SF3A2Q154282, 3, ENSP000002214944MINT-5205926 MINT-7947479 I2D: score=1 STRING: ENSP00000221494
    SRRM1Q8IYB32, 3, ENSP000003262614MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000326261
    SRRM2Q9UQ352, 3, ENSP000003017404MINT-7945693 I2D: score=1 STRING: ENSP00000301740
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IDA11435423
    GO:0000245spliceosomal complex assembly IMP16332694
    GO:0000398mRNA splicing, via spliceosome IDA--
    GO:0001833inner cell mass cell proliferation IEA--
    GO:0006281DNA repair IEA--

    PRPF19 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PRPF19 (PRP19)

    4 HMDB Compounds for PRPF19    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    Search CenterWatch for drugs/clinical trials and news about PRPF19 / PRP19

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PRPF19 gene: 
    NM_014502.4  

    Unigene Cluster for PRPF19:

    PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)
    Hs.502705  [show with all ESTs]
    Unigene Representative Sequence: NM_014502
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000227524(uc001nqf.3) ENST00000540473 ENST00000535326 ENST00000539960
    ENST00000539180 ENST00000541371 ENST00000546152
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRPF19
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate PRPF19 (see all 14):
    hsa-miR-28-3p hsa-miR-623 hsa-miR-203 hsa-miR-520d-5p hsa-miR-513a-5p hsa-miR-27a hsa-miR-128 hsa-miR-708*
    SwitchGear 3'UTR luciferase reporter plasmidPRPF19 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PRPF19
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRPF19
    Clone
    Products:
         
    OriGene clones in human, mouse for PRPF19 (see all 7)
    OriGene ORF clones in mouse, rat for PRPF19
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRPF19 (NM_014502)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRPF19
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRPF19
    Sirion Biotech Customized lentivirus for stable overexpression of PRPF19 
                         Customized lentivirus expression plasmids for stable overexpression of PRPF19 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PRPF19
    OriGene qSTAR qPCR primer pairs in human, mouse for PRPF19
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PRPF19
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRPF19
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRPF19

    Additional mRNA sequence: 

    AF086469.1 AJ131186.1 BC008719.2 BC018665.2 BC018698.2 

    18 DOTS entries:

    DT.100838257  DT.100706929  DT.455032  DT.99944427  DT.95157494  DT.100766003  DT.86997467  DT.120716219 
    DT.86847368  DT.92009207  DT.100807750  DT.100808602  DT.120716036  DT.120716245  DT.91721954  DT.91849888 
    DT.100659496  DT.91755533 

    24/315 AceView cDNA sequences (see all 315):

    AI589597 BM450927 BU146328 BC018698 BC008719 BI224356 BU783821 AA308559 
    AA374334 BM875511 BQ223915 AI609690 BM458292 NM_014502 AI290155 AW300772 
    AA768046 AI799436 AI339755 AA776253 BG388089 BM825097 BM929787 BG056752 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PRPF19    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17
    SP1:                    -                                                                                                     -         
    SP2:                    -                                                     -     -     -     -     -                                 
    SP3:                                                                                                                                    
    SP4:                                                                                                                                    


    ECgene alternative splicing isoforms for PRPF19

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRPF19 expression in normal human tissues (normalized intensities)      PRPF19 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAACGGATG
    PRPF19 Expression
    About this image


    PRPF19 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See PRPF19 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRPF19

    SOURCE GeneReport for Unigene cluster: Hs.502705

    UniProtKB/Swiss-Prot: PRP19_HUMAN, Q9UMS4
    Tissue specificity: Ubiquitous. Weakly expressed in senescent cells of different tissue origins. Highly expressed
    in tumor cell lines

        SABiosciences Custom PCR Arrays for PRPF19
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PRPF19
    OriGene qSTAR qPCR primer pairs in human, mouse for PRPF19
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PRPF19
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRPF19
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRPF19
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRPF19

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PRPF19 gene from 10/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prpf191 , 5 PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. more1, 5 90.48(n)1
    99.4(a)1
      19 (7.33 cM)5
    280001  NM_134129.41  NP_598890.11 
     108952315 
    chicken
    (Gallus gallus)
    Aves PRPF191 PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. more 83(n)
    94.25(a)
      430767  NM_001039331.1  NP_001034420.1 
    lizard
    (Anolis carolinensis)
    Reptilia PRPF196
    PRP19/PSO4 pre-mRNA processing factor 19 homolog (...
    97(a)
    1 ↔ 1
    GL343235.1(356428-372294)
    African clawed frog
    (Xenopus laevis)
    Amphibia nmp200-prov2 nuclear matrix protein NMP200 related to splicing factor more 75.82(n)    BC044093.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.35642 Danio rerio mRNA similar to nuclear matrix protein more 78.38(n)    BC045954.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Prp191 CG5519-PA 65.28(n)
    66(a)
      37123  NM_079059.2  NP_523783.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T10F2.41 hypothetical protein 55.69(n)
    53.37(a)
      175705  NM_065695.2  NP_498096.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRP19(YLL036C)4 Splicing factor associated with the spliceosome; contains more   --   12(68256-66745) 850623  NP_013064.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MAC3B1 Pre-mRNA-processing factor 19-2 51.16(n)
    46.53(a)
      817897  NM_179875.6  NP_850206.4 
    rice
    (Oryza sativa)
    Liliopsida NM_196923.12   -- 73.67(n)    NM_196923.1 


    ENSEMBL Gene Tree for PRPF19 (if available)
    TreeFam Gene Tree for PRPF19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRPF19 gene
    CSTF12  SPAG162  PLRG12  KATNB12  

    PRPF19 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PRPF19
    PGOHUM00000234951


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/414 SNPs in PRPF19 are shown (see all 414)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1846357161,2
    --60657975(+) GACTTG/TAGGCC 1 -- int10--------
    rs1414936081,2
    C--60658057(+) CAATT-/ATAAAA 1 -- ut310--------
    rs1899835861,2
    --60658146(+) CCCTTA/GACCTT 1 -- ut310--------
    rs1815348591,2
    --60658194(+) GAGGTA/GGTTAT 1 -- ut310--------
    rs1860527851,2
    --60658271(+) CCCATC/TCCCTT 1 -- ut310--------
    rs18049721,2
    C,F,H--60658301(+) CCTCTC/TCTGTC 1 -- ut31 ese36Minor allele frequency- T:0.02NS NA 1070
    rs734910901,2
    C--60658463(+) GATGAG/AGGTGG 1 -- ut312Minor allele frequency- A:0.17WA 120
    rs1400047401,2
    F--60658694(+) CTTGGC/TGTGAT 2 T A mis11Minor allele frequency- T:0.00NA 4552
    rs1498030921,2
    C,F--60658704(+) TGCCCG/AAAGGC 2 /F syn12Minor allele frequency- A:0.00NA EU 5713
    rs1489495261,2
    C,F--60658731(+) CCGCTA/GTGCTC 2 H syn11Minor allele frequency- G:0.00NA 4550

    HapMap Linkage Disequilibrium report for PRPF19 (60658019 - 60674061 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PRPF19: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PRPF19
    DNA2.0 Custom Variant and Variant Library Synthesis for PRPF19

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608330    OMIM disorders: --

    5 diseases for PRPF19:    About MalaCards
    poikiloderma with neutropenia    neutropenia    hypoxia    endotheliitis
    neuronitis


    PRPF19 for disorders           About GeneDecksing


    Export disorders for PRPF19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRPF19 gene, integrated from 9 sources (see all 70):
    (articles sorted by number of sources associating them with PRPF19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase. (PubMed id 12960389)1, 2, 3, 9 Mahajan K.N. and Mitchell B.S. (2003)
    2. The Pso4 mRNA splicing and DNA repair complex interacts with WRN for processing of DNA interstrand cross-links. (PubMed id 16223718)1, 2, 9 Zhang N.... Legerski R.J. (2005)
    3. hNMP 200: a novel human common nuclear matrix protein combining structural and regulatory functions. (PubMed id 11082287)1, 2, 9 Gotzmann J.... Sauermann G. (2000)
    4. Molecular architecture of the human Prp19/CDC5L compl ex. (PubMed id 20176811)1, 2 Grote M....LA1hrmann R. (2010)
    5. APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process. (PubMed id 19188445)1, 2 Vascotto C....Tell G. (2009)
    6. SNEV overexpression extends the life span of human endothelial cells. (PubMed id 16388800)1, 2 Voglauer R.... Grillari J. (2006)
    7. Interaction of U-box E3 ligase SNEV with PSMB4, the beta7 subunit of the 20 S proteasome. (PubMed id 15660529)1, 2 Loescher M.... Grillari J. (2005)
    8. SNEV is an evolutionarily conserved splicing factor whose oligomerization is necessary for spliceosome assembly. (PubMed id 16332694)1, 2 Grillari J.... Katinger H. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27339 HGNC: 17896 AceView: PRP19 Ensembl:ENSG00000110107 euGenes: HUgn27339
    ECgene: PRPF19 Kegg: 27339 H-InvDB: PRPF19

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRPF19 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRPF19 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PRPF19 gene:
    Search GeneIP for patents involving PRPF19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PRPF19   OriGene RNAi products in human, mouse, rat for PRPF19  
     OriGene qPCR primer pairs and template standards for PRPF19   OriGene Protein Over-expression Lysate for PRPF19  
     OriGene MassSpec something-or-other for PRPF19   OriGene clones in human, mouse for PRPF19  
     OriGene qSTAR qPCR primer pairs in human, mouse for PRPF19   OriGene Purified Protein for PRPF19  
     OriGene ORF clones in mouse, rat for PRPF19   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PRPF19   OriGene Custom Protein Services for PRPF19  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PRPF19
     QIAGEN SeqTarget long-range PCR primers for resequencing PRPF19
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRPF19
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRPF19
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRPF19
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRPF19
     GenScript Custom Purified and Recombinant Proteins Services for PRPF19 GenScript cDNA clones with any tag delivered in your preferred vector for PRPF19
     GenScript Custom Assay Services for PRPF19 GenScript Custom Superior Antibodies Services for PRPF19
     GenScript Custom overexpressing Cell Line Services for PRPF19 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PRPF19 promoter
     Search Chromatin IP Primers for PRPF19
     RT2 qPCR Primer Assay in human, mouse, rat PRPF19
     GNC Network for PRPF19
     SABiosciences Custom PCR Arrays for PRPF19
     Search Tocris compounds for PRPF19 (PRP19)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for PRPF19
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PRPF19 antibodies
     PRPF19 proteins
     PRPF19 lysates
     Antibodies for PRPF19
     See all of Abcam's Antibodies, Kits and Proteins for PRPF19
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for PRPF19
     Antibodies for PRPF19
     ELISAs for PRPF19
     CLIAs for PRPF19
     Search LifeMap BioReagents cell lines for PRPF19
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRPF19
     SwitchGear 3'UTR luciferase reporter plasmids for PRPF19
     SwitchGear Promoter luciferase reporter plasmids for PRPF19
     ThermoFisher Antibody for PRPF19
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRPF19
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PRPF19
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PRPF19
    Customized:
     lentivirus for stable overexpression of PRPF19
     lentivirus expression plasmids for stable overexpression of PRPF19
     adenovirus for overexpression of PRPF19
     LSBio Antibodies in human, mouse, rat for PRPF19
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PRPF19 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4