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Aliases for PROZ Gene

Aliases for PROZ Gene

  • Protein Z, Vitamin K-Dependent Plasma Glycoprotein 2 3
  • PZ 3 6
  • Vitamin K-Dependent Protein Z 3

External Ids for PROZ Gene

Previous GeneCards Identifiers for PROZ Gene

  • GC13P112422
  • GC13P108450
  • GC13P112899
  • GC13P111760
  • GC13P112860
  • GC13P113812
  • GC13P094251

Summaries for PROZ Gene

Entrez Gene Summary for PROZ Gene

  • This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

GeneCards Summary for PROZ Gene

PROZ (Protein Z, Vitamin K-Dependent Plasma Glycoprotein) is a Protein Coding gene. Diseases associated with PROZ include cerebral sinovenous thrombosis. Among its related pathways are PTM- gamma carboxylation, hypusine formation and arylsulfatase activation and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include calcium ion binding and serine-type endopeptidase activity. An important paralog of this gene is HP.

UniProtKB/Swiss-Prot for PROZ Gene

  • Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PROZ Gene

Genomics for PROZ Gene

Regulatory Elements for PROZ Gene

Transcription factor binding sites by QIAGEN in the PROZ gene promoter:

Genomic Location for PROZ Gene

113,158,654 bp from pter
113,172,384 bp from pter
13,731 bases
Plus strand

Genomic View for PROZ Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PROZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PROZ Gene

Proteins for PROZ Gene

  • Protein details for PROZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Vitamin K-dependent protein Z
    Protein Accession:
    Secondary Accessions:
    • A6NMB4
    • Q15213
    • Q5JVF5
    • Q5JVF6

    Protein attributes for PROZ Gene

    400 amino acids
    Molecular mass:
    44744 Da
    Quaternary structure:
    • Interacts with SERPINA10.

    Three dimensional structures from OCA and Proteopedia for PROZ Gene

    Alternative splice isoforms for PROZ Gene


neXtProt entry for PROZ Gene

Proteomics data for PROZ Gene at MOPED

Post-translational modifications for PROZ Gene

  • The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  • Glycosylation at Ser93, Asn99, Asn225, Asn233, Asn306, and Asn332
  • Modification sites at PhosphoSitePlus

Other Protein References for PROZ Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PROZ Gene

Domains for PROZ Gene

Suggested Antigen Peptide Sequences for PROZ Gene

Graphical View of Domain Structure for InterPro Entry



  • P22891
  • Contains 2 EGF-like domains.
  • Contains 1 Gla (gamma-carboxy-glutamate) domain.
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PROZ: view

No data available for Gene Families for PROZ Gene

Function for PROZ Gene

Molecular function for PROZ Gene

GENATLAS Biochemistry: plasma glycoprotein Z,62kDa,vitamin K-dependent glycoprotein,with two alternatively spliced isoforms,binding to thrombin and promoting its association with phospholipid vesicles
UniProtKB/Swiss-Prot Function: Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids

Gene Ontology (GO) - Molecular Function for PROZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with PROZ: view
genes like me logo Genes that share phenotypes with PROZ: view

Animal Models for PROZ Gene

MGI Knock Outs for PROZ:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for PROZ Gene

Localization for PROZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for PROZ Gene


Subcellular locations from

Jensen Localization Image for PROZ Gene COMPARTMENTS Subcellular localization image for PROZ gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
golgi apparatus 4
cytosol 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PROZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005796 Golgi lumen TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PROZ: view

Pathways for PROZ Gene

genes like me logo Genes that share pathways with PROZ: view

Interacting Proteins for PROZ Gene

Gene Ontology (GO) - Biological Process for PROZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis TAS --
GO:0007596 blood coagulation IEA --
GO:0017187 peptidyl-glutamic acid carboxylation TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with PROZ: view

Compounds for PROZ Gene

(1) HMDB Compounds for PROZ Gene

Compound Synonyms Cas Number PubMed IDs
  • Vitamin K3: 1,4-Dihydro-1,4-dioxo-2-methylnaphthalene

(1) Drugbank Compounds for PROZ Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • 2-Methyl-1,4-Naphthalenedione
58-27-5 target activator
genes like me logo Genes that share compounds with PROZ: view

Transcripts for PROZ Gene

mRNA/cDNA for PROZ Gene

Unigene Clusters for PROZ Gene

Protein Z, vitamin K-dependent plasma glycoprotein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PROZ Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b
SP1: - - -
SP2: - - - -
SP3: -
SP4: - -

Relevant External Links for PROZ Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PROZ Gene

mRNA expression in normal human tissues for PROZ Gene

mRNA differential expression in normal tissues according to GTEx for PROZ Gene

This gene is overexpressed in Liver (39.8) and Kidney - Cortex (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PROZ Gene

SOURCE GeneReport for Unigene cluster for PROZ Gene Hs.1011

mRNA Expression by UniProt/SwissProt for PROZ Gene

Tissue specificity: Plasma
genes like me logo Genes that share expressions with PROZ: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PROZ Gene

Orthologs for PROZ Gene

This gene was present in the common ancestor of chordates.

Orthologs for PROZ Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PROZ 35
  • 98.67 (n)
  • 98.25 (a)
  • 98 (a)
(Bos Taurus)
Mammalia PROZ 35
  • 68.97 (n)
  • 62.31 (a)
  • 54 (a)
(Mus musculus)
Mammalia Proz 35
  • 74.2 (n)
  • 67.51 (a)
Proz 16
Proz 36
  • 66 (a)
(Monodelphis domestica)
Mammalia PROZ 36
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia PROZ 36
  • 47 (a)
(Rattus norvegicus)
Mammalia Proz 35
  • 72 (n)
  • 65.99 (a)
(Gallus gallus)
Aves PROZ 35
  • 56.79 (n)
  • 48.86 (a)
  • 46 (a)
(Anolis carolinensis)
Reptilia PROZ 36
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia proz 35
  • 50.63 (n)
  • 43.54 (a)
(Danio rerio)
Actinopterygii PROZ (2 of 2) 36
  • 33 (a)
proza 36
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 12 (a)
Species with no ortholog for PROZ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PROZ Gene

Gene Tree for PROZ (if available)
Gene Tree for PROZ (if available)

Paralogs for PROZ Gene

Paralogs for PROZ Gene

Selected SIMAP similar genes for PROZ Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PROZ: view

Variants for PROZ Gene

Sequence variations from dbSNP and Humsavar for PROZ Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs494860 -- 113,164,695(+) CCCCG(A/T)CCACA intron-variant
rs510160 -- 113,168,167(+) cctgt(A/G)aagaa intron-variant
rs511022 -- 113,168,275(+) gtgta(A/G)atcca intron-variant
rs513479 -- 113,160,886(-) TTCCT(A/G)TAGAT intron-variant
rs525644 -- 113,160,524(+) CTAAG(C/T)GTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PROZ Gene

Variant ID Type Subtype PubMed ID
nsv901039 CNV Loss 21882294
dgv1797n71 CNV Loss 21882294
nsv901049 CNV Loss 21882294
nsv518044 CNV Gain 19592680
nsv901064 CNV Gain 21882294
nsv901065 CNV Loss 21882294
esv22603 CNV Gain 19812545
esv2748265 CNV Deletion 23290073
esv1604471 CNV Deletion 17803354
nsv901066 CNV Loss 21882294
nsv901067 CNV Loss 21882294
nsv901068 CNV Gain 21882294

Relevant External Links for PROZ Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PROZ Gene

Disorders for PROZ Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for PROZ Gene including...

Search for PROZ Gene in MalaCards »

(1) OMIM Diseases for PROZ Gene (176895)

(1) Novoseek inferred disease relationships for PROZ Gene

Disease -log(P) Hits PubMed IDs
stroke 25.1 3

Genatlas disease for PROZ Gene

bleeding tendency,PROZ deficiency

Relevant External Links for PROZ

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with PROZ: view

No data available for UniProtKB/Swiss-Prot for PROZ Gene

Publications for PROZ Gene

  1. Primary structure of vitamin K-dependent human protein Z. (PMID: 2403355) Sejima H. … Suzuki K. (Biochem. Biophys. Res. Commun. 1990) 2 3 4 23
  2. A common polymorphism of the protein Z gene is associated with protein Z plasma levels and with risk of cerebral ischemia in the young. (PMID: 14671240) Lichy C. … Grau A. (Stroke 2004) 3 23 48
  3. Risk of cerebral venous thrombosis and novel gene polymorphisms of the coagulation and fibrinolytic systems. (PMID: 16155788) Lichy C. … Grau A. (J. Neurol. 2006) 3 23 48
  4. Low protein Z levels, but not the intron F G79A polymorphism, are associated with unexplained pregnancy loss. (PMID: 19026439) Topalidou M. … Garipidou V. (Thromb. Res. 2009) 3 23 48
  5. Amino acid sequence of human protein Z, a vitamin K-dependent plasma glycoprotein. (PMID: 2244898) Ichinose A. … Davie E.W. (Biochem. Biophys. Res. Commun. 1990) 2 3 4

Products for PROZ Gene

Sources for PROZ Gene

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