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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PROZ Gene

protein-coding   GIFtS: 59
GCID: GC13P113812

Protein Z, Vitamin K-Dependent Plasma Glycoprotein

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Z, Vitamin K-Dependent Plasma Glycoprotein1 2
PZ2
Vitamin K-Dependent Protein Z2

External Ids:    HGNC: 94601   Entrez Gene: 88582   Ensembl: ENSG000001262317   OMIM: 1768955   UniProtKB: P228913   

Export aliases for PROZ gene to outside databases

Previous GC identifers: GC13P112422 GC13P108450 GC13P112899 GC13P111760 GC13P112860 GC13P094251


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PROZ Gene:
This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the
plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent
protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this
protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this
gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. (provided
by RefSeq, Jan 2012)

GeneCards Summary for PROZ Gene: 
PROZ (protein Z, vitamin K-dependent plasma glycoprotein) is a protein-coding gene. Diseases associated with PROZ include hiatus hernia, and warfarin sensitivity, and among its related super-pathways are Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus and Post-translational protein modification. GO annotations related to this gene include serine-type endopeptidase activity and calcium ion binding. An important paralog of this gene is PAMR1.

UniProtKB/Swiss-Prot: PROZ_HUMAN, P22891
Function: Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid
vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and
phospholipids




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.2  NT_027140.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PROZ gene promoter:
         Sp1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPROZ promoter sequence
   Search SABiosciences Chromatin IP Primers for PROZ

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PROZ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

PROZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PROZ gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P113812:  view genomic region     (about GC identifiers)

Start:
113,812,968 bp from pter      End:
113,826,694 bp from pter
Size:
13,727 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PROZ_HUMAN, P22891 (See protein sequence)
Recommended Name: Vitamin K-dependent protein Z precursor  
Size: 400 amino acids; 44744 Da
Subunit: Interacts with SERPINA10
Subcellular location: Secreted
Caution: Although related to peptidase S1 family vitamin K-dependent clotting factors, it has lost two of the
essential catalytic residues and therefore lacks protease activity
2 PDB 3D structures from and Proteopedia for PROZ:
3F1S (3D)        3H5C (3D)    
Secondary accessions: A6NMB4 Q15213 Q5JVF5 Q5JVF6
Alternative splicing: 2 isoforms:  P22891-1   P22891-2   

Explore the universe of human proteins at neXtProt for PROZ: NX_P22891

Explore proteomics data for PROZ at MOPED 

Post-translational modifications:

  • UniProtKB: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF
    domains (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P22891

  • PROZ Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PROZ Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001243063.1  NP_003882.1  

    ENSEMBL proteins: 
     ENSP00000364697   ENSP00000344458  
    Reactome Protein details: P22891
    Human Recombinant Protein Products for PROZ: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PROZ
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for PROZ
    GenScript Custom Purified and Recombinant Proteins Services for PROZ
    Novus Biologicals PROZ Protein
    Novus Biologicals PROZ Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PROZ 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0005796Golgi lumen TAS--

    PROZ for ontologies           About GeneDecksing



    PROZ Antibody Products: 
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    Novus Biologicals PROZ Antibodies
    Abcam antibodies for PROZ
    Cloud-Clone Corp. Antibodies for PROZ 
    ThermoFisher Antibodies for PROZ
    LSBio Antibodies in human, mouse, rat for PROZ 

    Assay Products for PROZ: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PROZ
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PROZ 
    Cloud-Clone Corp. CLIAs for PROZ


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/8 InterPro protein domains (see all 8):
     IPR017857 Coagulation_fac_subgr_Gla_dom
     IPR000742 EG-like_dom
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR012224 Pept_S1A_FX
     IPR001254 Peptidase_S1

    Graphical View of Domain Structure for InterPro Entry P22891

    ProtoNet protein and cluster: P22891

    5/6 Blocks protein domains (see all 6):
    IPB000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature
    IPB001438 Type II EGF-like signature
    IPB002383 Coagulation factor GLA domain signature


    UniProtKB/Swiss-Prot: PROZ_HUMAN, P22891
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 2 EGF-like domains
    Similarity: Contains 1 Gla (gamma-carboxy-glutamate) domain
    Similarity: Contains 1 peptidase S1 domain


    PROZ for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PROZ_HUMAN, P22891
    Function: Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid
    vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and
    phospholipids

         Genatlas biochemistry entry for PROZ:
    plasma glycoprotein Z,62kDa,vitamin K-dependent glycoprotein,with two alternatively spliced isoforms,binding to
    thrombin and promoting its association with phospholipid vesicles

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    PROZ for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Proz):
     cardiovascular system  homeostasis/metabolism  mortality/aging  normal 

    PROZ for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Proztm1Gjb for PROZ

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PROZ 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PROZ

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PROZ 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PROZ 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PROZ
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PROZ
    SwitchGear 3'UTR luciferase reporter plasmidPROZ 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PROZ
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PROZ

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PROZ
    Sirion Biotech Customized adenovirus for overexpression of PROZ

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PROZ (see all 8)
    OriGene ORF clones in mouse, rat for PROZ
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    GenScript: all cDNA clones in your preferred vector: PROZ (NM_003891)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PROZ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PROZ
    Sirion Biotech Customized lentivirus for stable overexpression of PROZ 
                         Customized lentivirus expression plasmids for stable overexpression of PROZ 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PROZ


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PROZ About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
    Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus0.89
    Gamma-carboxylation, transport, and amino-terminal cleavage of proteins0.82
    Removal of aminoterminal propeptides from gamma-carboxylated proteins0.89
    Warfarin Pathway, Pharmacodynamics0.67
    Gamma-carboxylation of protein precursors0.89
    2Asparagine N-linked glycosylation
    Post-translational protein modification0.44
    Metabolism of proteins0.35
    3PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
    PTM: gamma carboxylation, hypusine formation and arylsulfatase activation0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/7        Reactome Pathways for PROZ (see all 7)
        Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
    Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
    Metabolism of proteins
    Post-translational protein modification
    Removal of aminoterminal propeptides from gamma-carboxylated proteins

    1 PharmGKB Pathway for PROZ
        Warfarin Pathway, Pharmacodynamics


    PROZ for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PROZ

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for PROZ (P228913 ENSP000003646974) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    F2P007343, ENSP000003085414I2D: score=1 STRING: ENSP00000308541
    GGCXENSP000002338384STRING: ENSP00000233838
    SERPINA10ENSP000002619944STRING: ENSP00000261994
    FURINENSP000002681714STRING: ENSP00000268171
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis TAS--
    GO:0007596blood coagulation IEA--
    GO:0017187peptidyl-glutamic acid carboxylation TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    PROZ for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PROZ

    1 HMDB Compound for PROZ    About this table
    CompoundSynonyms CAS #PubMed Ids
    MenadioneVitamin K3: 1,4-Dihydro-1,4-dioxo-2-methylnaphthalene (see all 49)58-27-5--

    1 DrugBank Compound for PROZ    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Menadione2-Methyl-1,4-Naphthalenedione (see all 7)58-27-5targetactivator17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about PROZ

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PROZ gene (2 alternative transcripts): 
    NM_001256134.1  NM_003891.2  

    Unigene Cluster for PROZ:

    Protein Z, vitamin K-dependent plasma glycoprotein
    Hs.1011  [show with all ESTs]
    Unigene Representative Sequence: NM_001256134
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375547(uc001vta.1) ENST00000342783(uc010agr.1) ENST00000493630

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PROZ
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PROZ
    SwitchGear 3'UTR luciferase reporter plasmidPROZ 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PROZ
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PROZ
    Clone
    Products:
         
    OriGene clones in human, mouse for PROZ (see all 8)
    OriGene ORF clones in mouse, rat for PROZ
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PROZ (NM_003891)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PROZ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PROZ
    Sirion Biotech Customized lentivirus for stable overexpression of PROZ 
                         Customized lentivirus expression plasmids for stable overexpression of PROZ 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PROZ
    OriGene qSTAR qPCR primer pairs in human, mouse for PROZ
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PROZ
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PROZ
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PROZ

    Additional mRNA sequence: 

    AY927601.1 BC074906.2 BC074907.2 M55670.1 M55671.1 M59303.1 

    5 DOTS entries:

    DT.92025947  DT.100746624  DT.95156448  DT.100722879  DT.40130758 

    24/28 AceView cDNA sequences (see all 28):

    AI478550 NM_003891 BC074907 M55671 AW016352 M55670 CB162081 BC074906 
    AI492996 AI767499 M59303 AW469680 AW235106 R85275 CB164334 AW016361 
    CB148254 AA777559 BX115777 AA680349 W87897 AI522084 W87606 AA033941 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PROZ    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b
    SP1:                                -                       -     -                                       
    SP2:        -                       -                       -     -                                       
    SP3:                          -                                                                           
    SP4:                                                                          -     -                     


    ECgene alternative splicing isoforms for PROZ

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PROZ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGATACGTTA
    PROZ Expression
    About this image


    See PROZ Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PROZ

    SOURCE GeneReport for Unigene cluster: Hs.1011

    UniProtKB/Swiss-Prot: PROZ_HUMAN, P22891
    Tissue specificity: Plasma

        SABiosciences Custom PCR Arrays for PROZ
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PROZ
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PROZ

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PROZ gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Proz1 , 5 protein Z, vitamin K-dependent plasma glycoprotein1, 5 74.22(n)1
    67.68(a)1
      8 (5.73 cM)5
    669011  NM_025834.31  NP_080110.11 
     130609085 
    chicken
    (Gallus gallus)
    Aves PROZ1 protein Z, vitamin K-dependent plasma glycoprotein 56.79(n)
    48.86(a)
      418746  XM_416945.3  XP_416945.3 
    lizard
    (Anolis carolinensis)
    Reptilia PROZ6
    protein Z, vitamin K-dependent plasma glycoprotein...
    45(a)
    1 ↔ 1
    3(105978360-105988812)
    zebrafish
    (Danio rerio)
    Actinopterygii PROZ (1 of 2)6
    proza6
    (see all 5)
    protein Z, vitamin K-dependent plasma glycoprotein...
    protein Z, vitamin K-dependent plasma glycoprotein...
    (see all 5)
    32(a)
    31(a)
    (see all 5)
    1 ↔ many
    1 ↔ many
    (see all 5)
    1(40286-48000)
    3(63044926-63055718)


    ENSEMBL Gene Tree for PROZ (if available)
    TreeFam Gene Tree for PROZ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PROZ gene
    PAMR12  C1S2  C1R2  C1RL2  F92  F102  MASP12  F22  
    HPR2  F72  PROC2  HP2  MASP22  
    6 SIMAP similar genes for PROZ using alignment to 2 protein entries:     PROZ_HUMAN (see all proteins):
    PRRG3    PROS1    PROC1    F2    F9    PROC

    PROZ for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/479 SNPs in PROZ are shown (see all 479)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs785346671,2
    C,F--113811034(+) AGATAC/ACCATG 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1903843541,2
    --113811225(+) GGCCAC/TGTAGA 2 -- us2k10--------
    rs1835413201,2
    --113811277(+) ATCAAC/TTTCTG 2 -- us2k10--------
    rs1889900371,2
    --113811310(+) CTCACC/TAAAGA 2 -- us2k10--------
    rs30246991,2
    C,F--113811354(+) CAAACT/GTCACA 2 -- us2k112Minor allele frequency- G:0.05NS NA WA 922
    rs1920956681,2
    --113811376(+) TTTGCC/GGGCAT 2 -- us2k10--------
    rs1511193011,2
    C--113811404(+) TGTCAA/GCTTCT 2 -- us2k10--------
    rs1828419221,2
    --113811421(+) TCTTCC/TGTTCC 2 -- us2k10--------
    rs30247001,2
    C,F,H--113811478(+) CCTTTG/AAGTGT 2 -- us2k1 tfbs318Minor allele frequency- A:0.02NS EA NA WA 1782
    rs1410196721,2
    --113811570(+) TTCTCA/GGATGC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for PROZ (113812968 - 113826694 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for PROZ (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1604471CNV Deletion17803354
    esv2748265CNV Deletion23290073
    nsv901049CNV Loss21882294
    nsv901039CNV Loss21882294
    nsv901066CNV Loss21882294
    nsv901067CNV Loss21882294
    dgv1797n71CNV Loss21882294
    nsv901065CNV Loss21882294
    nsv901064CNV Gain21882294
    nsv518044CNV Gain19592680


    Human Gene Mutation Database (HGMD): PROZ
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing PROZ
    DNA2.0 Custom Variant and Variant Library Synthesis for PROZ

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 176895    OMIM disorders: --

    20 diseases for PROZ:    About MalaCards
    hiatus hernia    warfarin sensitivity    achalasia    venous thromboembolism
    hernia    gastroesophageal reflux disease    thromboembolism    thrombophilia
    pyelonephritis    behcet's disease    thrombosis    sickle cell disease
    kidney disease    myocardial infarction    ischemia    cerebritis
    retinitis    colon cancer    breast cancer    lung cancer


    PROZ for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for PROZ gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    stroke 25.1 5 14671240 (2), 16155788 (1)

    Genatlas disease: PROZ
    bleeding tendency,PROZ deficiency

    Genetic Association Database (GAD): PROZ
    Human Genome Epidemiology (HuGE) Navigator: PROZ (20 documents)

    Export disorders for PROZ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PROZ gene, integrated from 9 sources (see all 78):
    (articles sorted by number of sources associating them with PROZ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure of vitamin K-dependent human protein Z. (PubMed id 2403355)1, 2, 3, 9 Sejima H....Suzuki K. (1990)
    2. Amino acid sequence of human protein Z, a vitamin K-dependent plasma glycoprotein. (PubMed id 2244898)1, 2, 3 Ichinose A.... Davie E.W. (1990)
    3. A common polymorphism of the protein Z gene is associated with protein Z plasma levels and with risk of cerebral ischemia in the young. (PubMed id 14671240)1, 4, 9 Lichy C....Grau A. (2004)
    4. Low protein Z levels, but not the intron F G79A polymorphism, are associated with unexplained pregnancy loss. (PubMed id 19026439)1, 4, 9 Topalidou M....Garipidou V. (2008)
    5. Risk of cerebral venous thrombosis and novel gene polymorphisms of the coagulation and fibrinolytic systems. (PubMed id 16155788)1, 4, 9 Lichy C....Grau A. (2006)
    6. Basis for the specificity and activation of the serpi n protein Z-dependent proteinase inhibitor (ZPI) as an inhibitor of membrane-as sociated factor Xa. (PubMed id 20427285)1, 2 Huang X....Gettins P.G. (2010)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    8. Protein Z G79A Polymorphism in Patients With Severe Sepsis. (PubMed id 19124455)1, 4 Sipahi T....Akar N. (2009)
    9. Rare genotypes of protein Z gene are a risk factor fo r premature myocardial infarction but not protein Z plasma level. (PubMed id 19572077)1, 4 Le Cam-Duchez V....Collet J.P. (2009)
    10. Association of genetic variants with chronic kidney d isease in individuals with different lipid profiles. (PubMed id 19578796)1, 4 Yoshida T....Yamada Y. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8858 HGNC: 9460 AceView: PROZ Ensembl:ENSG00000126231 euGenes: HUgn8858
    ECgene: PROZ H-InvDB: PROZ

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PROZ Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/proz/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PROZ gene:
    Search GeneIP for patents involving PROZ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     Regulatory tfbs in PROZ promoter
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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