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Aliases for PROZ Gene

Aliases for PROZ Gene

  • Protein Z, Vitamin K Dependent Plasma Glycoprotein 2 3 5
  • Protein Z, Vitamin K-Dependent Plasma Glycoprotein 2
  • Vitamin K-Dependent Protein Z Precursor Variant 1 3
  • Vitamin K-Dependent Protein Z 3
  • PZ 3

External Ids for PROZ Gene

Previous GeneCards Identifiers for PROZ Gene

  • GC13P112422
  • GC13P108450
  • GC13P112899
  • GC13P111760
  • GC13P112860
  • GC13P113812
  • GC13P094251

Summaries for PROZ Gene

Entrez Gene Summary for PROZ Gene

  • This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

GeneCards Summary for PROZ Gene

PROZ (Protein Z, Vitamin K Dependent Plasma Glycoprotein) is a Protein Coding gene. Diseases associated with PROZ include Cerebral Sinovenous Thrombosis and Stroke, Ischemic. Among its related pathways are Gamma carboxylation, hypusine formation and arylsulfatase activation and Warfarin Pathway, Pharmacodynamics. GO annotations related to this gene include calcium ion binding and serine-type endopeptidase activity. An important paralog of this gene is F9.

UniProtKB/Swiss-Prot for PROZ Gene

  • Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PROZ Gene

Genomics for PROZ Gene

Regulatory Elements for PROZ Gene

Enhancers for PROZ Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13G113182 1.6 Ensembl ENCODE dbSUPER 26.9 +31.2 31180 6.5 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 PROZ PCID2 CUL4A F10-AS1 KARSP2 F10 GRTP1 F7 LAMP1 ENSG00000269356
GH13G113214 1.7 FANTOM5 Ensembl ENCODE dbSUPER 23.2 +61.0 60951 2.8 HDAC1 HDGF PKNOX1 ATF1 NFRKB ARID4B THRB RFX5 ZNF366 SCRT2 PROZ GRTP1 ADPRHL1 PCID2 MCF2L DCUN1D2 F10 PIR53444
GH13G113206 1.4 ENCODE dbSUPER 26.4 +53.8 53781 5.0 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 TUBGCP3 PROZ GAS6-AS1 LAMP1 PCID2 CUL4A
GH13G113175 1.3 Ensembl ENCODE dbSUPER 27.5 +23.4 23412 5.7 PKNOX1 JUN SIN3A ZIC2 ZFHX2 POLR2A FOS MAFK NFE2L2 EGR2 PROZ PCID2 CUL4A F10-AS1 KARSP2 F10 F7 GRTP1 GRTP1-AS1 ENSG00000269356
GH13G113219 1.3 ENCODE dbSUPER 21.1 +65.1 65111 1.8 PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF48 YY1 TCF12 PROZ PCID2 PIR53444
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PROZ on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the PROZ gene promoter:

Genomic Location for PROZ Gene

Chromosome:
13
Start:
113,155,061 bp from pter
End:
113,172,386 bp from pter
Size:
17,326 bases
Orientation:
Plus strand

Genomic View for PROZ Gene

Genes around PROZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PROZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PROZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PROZ Gene

Proteins for PROZ Gene

  • Protein details for PROZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22891-PROZ_HUMAN
    Recommended name:
    Vitamin K-dependent protein Z
    Protein Accession:
    P22891
    Secondary Accessions:
    • A6NMB4
    • Q15213
    • Q5JVF5
    • Q5JVF6

    Protein attributes for PROZ Gene

    Size:
    400 amino acids
    Molecular mass:
    44744 Da
    Quaternary structure:
    • Interacts with SERPINA10.

    Three dimensional structures from OCA and Proteopedia for PROZ Gene

    Alternative splice isoforms for PROZ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PROZ Gene

Post-translational modifications for PROZ Gene

  • The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PROZ Gene

No data available for DME Specific Peptides for PROZ Gene

Domains & Families for PROZ Gene

Gene Families for PROZ Gene

Suggested Antigen Peptide Sequences for PROZ Gene

Graphical View of Domain Structure for InterPro Entry

P22891

UniProtKB/Swiss-Prot:

PROZ_HUMAN :
  • Belongs to the peptidase S1 family.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PROZ: view

Function for PROZ Gene

Molecular function for PROZ Gene

GENATLAS Biochemistry:
plasma glycoprotein Z,62kDa,vitamin K-dependent glycoprotein,with two alternatively spliced isoforms,binding to thrombin and promoting its association with phospholipid vesicles
UniProtKB/Swiss-Prot Function:
Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids.

Gene Ontology (GO) - Molecular Function for PROZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IBA --
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PROZ: view
genes like me logo Genes that share phenotypes with PROZ: view

Animal Models for PROZ Gene

MGI Knock Outs for PROZ:

Animal Model Products

  • Taconic Biosciences Mouse Models for PROZ

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PROZ

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PROZ Gene

Localization for PROZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for PROZ Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PROZ gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
golgi apparatus 4
plasma membrane 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for PROZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005796 Golgi lumen TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PROZ: view

Pathways & Interactions for PROZ Gene

genes like me logo Genes that share pathways with PROZ: view

Gene Ontology (GO) - Biological Process for PROZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006465 signal peptide processing TAS --
GO:0006508 proteolysis IEA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0007596 blood coagulation IEA --
GO:0007599 hemostasis IEA --
genes like me logo Genes that share ontologies with PROZ: view

No data available for SIGNOR curated interactions for PROZ Gene

Drugs & Compounds for PROZ Gene

(1) Drugs for PROZ Gene - From: DrugBank, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Menadione Approved Nutra inhibitor, Target, activator 239
genes like me logo Genes that share compounds with PROZ: view

Transcripts for PROZ Gene

Unigene Clusters for PROZ Gene

Protein Z, vitamin K-dependent plasma glycoprotein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PROZ

Alternative Splicing Database (ASD) splice patterns (SP) for PROZ Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b
SP1: - - -
SP2: - - - -
SP3: -
SP4: - -

Relevant External Links for PROZ Gene

GeneLoc Exon Structure for
PROZ
ECgene alternative splicing isoforms for
PROZ

Expression for PROZ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PROZ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PROZ Gene

This gene is overexpressed in Liver (x39.8) and Kidney - Cortex (x6.3).

Protein differential expression in normal tissues from HIPED for PROZ Gene

This gene is overexpressed in Urine (47.5), Plasma (12.7), and Serum (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PROZ Gene



Protein tissue co-expression partners for PROZ Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PROZ Gene:

PROZ

SOURCE GeneReport for Unigene cluster for PROZ Gene:

Hs.1011

mRNA Expression by UniProt/SwissProt for PROZ Gene:

P22891-PROZ_HUMAN
Tissue specificity: Plasma.

Evidence on tissue expression from TISSUES for PROZ Gene

  • Liver(4.4)
genes like me logo Genes that share expression patterns with PROZ: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PROZ Gene

Orthologs for PROZ Gene

This gene was present in the common ancestor of chordates.

Orthologs for PROZ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PROZ 34 35
  • 98.67 (n)
mouse
(Mus musculus)
Mammalia Proz 34 16 35
  • 74.2 (n)
rat
(Rattus norvegicus)
Mammalia Proz 34
  • 72 (n)
cow
(Bos Taurus)
Mammalia PROZ 34 35
  • 68.97 (n)
oppossum
(Monodelphis domestica)
Mammalia PROZ 35
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PROZ 35
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves PROZ 34 35
  • 56.79 (n)
lizard
(Anolis carolinensis)
Reptilia PROZ 35
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia proz 34
  • 50.63 (n)
zebrafish
(Danio rerio)
Actinopterygii PROZ (2 of 2) 35
  • 33 (a)
OneToMany
proza 35
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 12 (a)
OneToMany
Species where no ortholog for PROZ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PROZ Gene

ENSEMBL:
Gene Tree for PROZ (if available)
TreeFam:
Gene Tree for PROZ (if available)

Paralogs for PROZ Gene

Paralogs for PROZ Gene

(6) SIMAP similar genes for PROZ Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PROZ: view

Variants for PROZ Gene

Sequence variations from dbSNP and Humsavar for PROZ Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000010267 -- 113,168,752(+) GAGAC(C/T)GGGTC intron-variant, nc-transcript-variant
rs1000108535 -- 113,172,870(+) CAGCA(A/C)CTCAC intron-variant, downstream-variant-500B
rs1000235355 -- 113,163,361(+) TTTCA(C/T)AGCAG intron-variant
rs1000316628 -- 113,156,328(+) CTGTG(G/T)GGATT intron-variant
rs1000373319 -- 113,161,578(+) AGGCC(A/G)GAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PROZ Gene

Variant ID Type Subtype PubMed ID
dgv1130e59 CNV duplication 20981092
dgv3426n54 CNV gain 21841781
dgv3430n54 CNV loss 21841781
dgv3431n54 CNV loss 21841781
dgv3432n54 CNV loss 21841781
dgv3433n54 CNV loss 21841781
esv1604471 CNV deletion 17803354
esv22603 CNV gain 19812545
esv2748265 CNV deletion 23290073
nsv1046663 CNV gain 25217958
nsv1048814 CNV gain 25217958
nsv1051556 CNV gain 25217958
nsv518044 CNV gain 19592680
nsv563300 CNV loss 21841781
nsv563301 CNV loss 21841781

Variation tolerance for PROZ Gene

Residual Variation Intolerance Score: 66.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.89; 48.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PROZ Gene

Human Gene Mutation Database (HGMD)
PROZ
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PROZ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PROZ Gene

Disorders for PROZ Gene

MalaCards: The human disease database

(2) MalaCards diseases for PROZ Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cerebral sinovenous thrombosis
  • csvt
stroke, ischemic
  • ischemic stroke
- elite association - COSMIC cancer census association via MalaCards
Search PROZ in MalaCards View complete list of genes associated with diseases

Genatlas disease for PROZ Gene

bleeding tendency,PROZ deficiency

Relevant External Links for PROZ

Genetic Association Database (GAD)
PROZ
Human Genome Epidemiology (HuGE) Navigator
PROZ
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PROZ
genes like me logo Genes that share disorders with PROZ: view

No data available for UniProtKB/Swiss-Prot for PROZ Gene

Publications for PROZ Gene

  1. Primary structure of vitamin K-dependent human protein Z. (PMID: 2403355) Sejima H. … Suzuki K. (Biochem. Biophys. Res. Commun. 1990) 2 3 4 22 64
  2. Low protein Z levels, but not the intron F G79A polymorphism, are associated with unexplained pregnancy loss. (PMID: 19026439) Topalidou M. … Garipidou V. (Thromb. Res. 2009) 3 22 46 64
  3. Risk of cerebral venous thrombosis and novel gene polymorphisms of the coagulation and fibrinolytic systems. (PMID: 16155788) Lichy C. … Grau A. (J. Neurol. 2006) 3 22 46 64
  4. A common polymorphism of the protein Z gene is associated with protein Z plasma levels and with risk of cerebral ischemia in the young. (PMID: 14671240) Lichy C. … Grau A. (Stroke 2004) 3 22 46 64
  5. Amino acid sequence of human protein Z, a vitamin K-dependent plasma glycoprotein. (PMID: 2244898) Ichinose A. … Davie E.W. (Biochem. Biophys. Res. Commun. 1990) 2 3 4 64

Products for PROZ Gene

Sources for PROZ Gene

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