Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PROZ Gene

protein-coding   GIFtS: 58
GCID: GC13P113812

Protein Z, Vitamin K-Dependent Plasma Glycoprotein

  See PROZ-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Protein Z, Vitamin K-Dependent Plasma Glycoprotein1 2
PZ2 5
Vitamin K-Dependent Protein Z2

External Ids:    HGNC: 94601   Entrez Gene: 88582   Ensembl: ENSG000001262317   OMIM: 1768955   UniProtKB: P228913   

Export aliases for PROZ gene to outside databases

Previous GC identifers: GC13P112422 GC13P108450 GC13P112899 GC13P111760 GC13P112860 GC13P094251


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PROZ Gene:
This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the
plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent
protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this
protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this
gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. (provided
by RefSeq, Jan 2012)

GeneCards Summary for PROZ Gene:
PROZ (protein Z, vitamin K-dependent plasma glycoprotein) is a protein-coding gene. Diseases associated with PROZ include cerebral sinovenous thrombosis. GO annotations related to this gene include serine-type endopeptidase activity and calcium ion binding. An important paralog of this gene is C1S.

UniProtKB/Swiss-Prot: PROZ_HUMAN, P22891
Function: Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid
vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and
phospholipids




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NC_018924.2  NT_027140.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the PROZ gene promoter:
         Sp1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPROZ promoter sequence
   Search Chromatin IP Primers for PROZ

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PROZ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

PROZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PROZ gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P113812:  view genomic region     (about GC identifiers)

Start:
113,812,968 bp from pter      End:
113,826,694 bp from pter
Size:
13,727 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PROZ_HUMAN, P22891 (See protein sequence)
Recommended Name: Vitamin K-dependent protein Z precursor  
Size: 400 amino acids; 44744 Da
Subunit: Interacts with SERPINA10
Caution: Although related to peptidase S1 family vitamin K-dependent clotting factors, it has lost two of the
essential catalytic residues and therefore lacks protease activity
2 PDB 3D structures from and Proteopedia for PROZ:
3F1S (3D)        3H5C (3D)    
Secondary accessions: A6NMB4 Q15213 Q5JVF5 Q5JVF6
Alternative splicing: 2 isoforms:  P22891-1   P22891-2   

Explore the universe of human proteins at neXtProt for PROZ: NX_P22891

Explore proteomics data for PROZ at MOPED

Post-translational modifications: 

  • The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF
    domains (By similarity)1
  • Glycosylation2 at Ser93, Asn99, Asn225, Asn233, Asn306, Asn332

  • See PROZ Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243063.1  NP_003882.1  

    ENSEMBL proteins: 
     ENSP00000364697   ENSP00000344458  
    Reactome Protein details: P22891

    PROZ Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PROZ
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PROZ
    GenScript Custom Purified and Recombinant Proteins Services for PROZ
    Novus Biologicals PROZ Protein
    Novus Biologicals PROZ Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PROZ

     
    Search eBioscience for Proteins for PROZ 

     
    antibodies-online proteins for PROZ (4 products) 

     
    Search antibodies-online for peptides for PROZ

    PROZ Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PROZ
    Novus Biologicals PROZ Antibodies
    Abcam antibodies for PROZ
    Cloud-Clone Corp. Antibodies for PROZ
    ThermoFisher Antibodies for PROZ
    antibodies-online antibodies for PROZ (14 products) 

    PROZ Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PROZ
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PROZ
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PROZ
    Cloud-Clone Corp. CLIAs for PROZ
    Search eBioscience for ELISAs for PROZ 
    antibodies-online kits for PROZ (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    Selected InterPro protein domains (see all 8):
     IPR017857 Coagulation_fac_subgr_Gla_dom
     IPR000742 EG-like_dom
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR012224 Pept_S1A_FX
     IPR001254 Peptidase_S1

    Graphical View of Domain Structure for InterPro Entry P22891

    ProtoNet protein and cluster: P22891

    Selected Blocks protein domains (see all 6):
    IPB000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature
    IPB001438 Type II EGF-like signature
    IPB002383 Coagulation factor GLA domain signature


    UniProtKB/Swiss-Prot: PROZ_HUMAN, P22891
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 2 EGF-like domains
    Similarity: Contains 1 Gla (gamma-carboxy-glutamate) domain
    Similarity: Contains 1 peptidase S1 domain


    Find genes that share domains with PROZ           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PROZ_HUMAN, P22891
    Function: Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid
    vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and
    phospholipids

         Genatlas biochemistry entry for PROZ:
    plasma glycoprotein Z,62kDa,vitamin K-dependent glycoprotein,with two alternatively spliced isoforms,binding to
    thrombin and promoting its association with phospholipid vesicles

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with PROZ           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Proz):
     cardiovascular system  homeostasis/metabolism  mortality/aging  normal 

    Find genes that share phenotypes with PROZ           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Proztm1Gjb for PROZ

       genOway: Develop your customized and physiologically relevant rodent model for PROZ

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat PROZ using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate PROZ
    SwitchGear 3'UTR luciferase reporter plasmidPROZ 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PROZ
    Predesigned siRNA for gene silencing in human, mouse, rat PROZ

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PROZ

    Clone
    Products:
         
    OriGene clones in human, mouse for PROZ (see all 8)
    OriGene ORF clones in mouse, rat for PROZ
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PROZ (NM_003891)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PROZ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PROZ

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PROZ
    Browse ESI BIO Cell Lines and PureStem Progenitors for PROZ 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PROZ


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    PROZ_HUMAN, P22891: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum4
    golgi apparatus4
    cytosol1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0005796Golgi lumen TAS--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with PROZ           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for PROZ About    
    See pathways by source

    SuperPathContained pathways About
    1PTM- gamma carboxylation, hypusine formation and arylsulfatase activation
    PTM- gamma carboxylation, hypusine formation and arylsulfatase activation0.31
    Removal of aminoterminal propeptides from gamma-carboxylated proteins0.00
    Warfarin Pathway, Pharmacodynamics0.31
    Gamma-carboxylation of protein precursors0.00
    Gamma-carboxylation, transport, and amino-terminal cleavage of proteins0.00
    Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus0.00
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30


    Find genes that share SuperPaths with PROZ           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Reactome Pathways for PROZ
        Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
    Removal of aminoterminal propeptides from gamma-carboxylated proteins
    Gamma-carboxylation of protein precursors

    1 PharmGKB Pathway for PROZ
        Warfarin Pathway, Pharmacodynamics

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PROZ
    Interactions:

        GeneGlobe Interaction Network for PROZ

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for PROZ (P228913 ENSP000003646974) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    F2P007343, ENSP000003085414I2D: score=1 STRING: ENSP00000308541
    GGCXENSP000002338384STRING: ENSP00000233838
    SERPINA10ENSP000002619944STRING: ENSP00000261994
    FURINENSP000002681714STRING: ENSP00000268171
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis TAS--
    GO:0007596blood coagulation IEA--
    GO:0017187peptidyl-glutamic acid carboxylation TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    Find genes that share ontologies with PROZ           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PROZ

    1 HMDB Compound for PROZ    About this table
    CompoundSynonyms CAS #PubMed Ids
    MenadioneVitamin K3: 1,4-Dihydro-1,4-dioxo-2-methylnaphthalene (see all 49)58-27-5--

    1 DrugBank Compound for PROZ    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Menadione2-Methyl-1,4-Naphthalenedione (see all 7)58-27-5targetactivator17139284 17016423



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PROZ gene (2 alternative transcripts): 
    NM_001256134.1  NM_003891.2  

    Unigene Cluster for PROZ:

    Protein Z, vitamin K-dependent plasma glycoprotein
    Hs.1011  [show with all ESTs]
    Unigene Representative Sequence: NM_001256134
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375547(uc001vta.1) ENST00000342783(uc010agr.1) ENST00000493630

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PROZ using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate PROZ
    SwitchGear 3'UTR luciferase reporter plasmidPROZ 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PROZ
    Predesigned siRNA for gene silencing in human, mouse, rat PROZ
    Clone
    Products:
         
    OriGene clones in human, mouse for PROZ (see all 8)
    OriGene ORF clones in mouse, rat for PROZ
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PROZ (NM_003891)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PROZ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PROZ
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PROZ
    OriGene qSTAR qPCR primer pairs in human, mouse for PROZ
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PROZ
      QuantiTect SYBR Green Assays in human, mouse, rat PROZ
      QuantiFast Probe-based Assays in human, mouse, rat PROZ

    Additional mRNA sequence: 

    AY927601.1 BC074906.2 BC074907.2 M55670.1 M55671.1 M59303.1 

    5 DOTS entries:

    DT.92025947  DT.100746624  DT.95156448  DT.100722879  DT.40130758 

    Selected AceView cDNA sequences (see all 28):

    AW016352 AI767499 M55671 M55670 AI492996 BC074906 CB162081 M59303 
    NM_003891 BC074907 AI478550 BX115777 AW016361 CB164334 AW235106 AA777559 
    R85275 AW469680 CB148254 AA680349 W87606 AI522084 W87897 H74064 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PROZ    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b
    SP1:                                -                       -     -                                       
    SP2:        -                       -                       -     -                                       
    SP3:                          -                                                                           
    SP4:                                                                          -     -                     


    ECgene alternative splicing isoforms for PROZ

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PROZ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGATACGTTA
    PROZ Expression
    About this image

    PROZ Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PROZ Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1011

    UniProtKB/Swiss-Prot: PROZ_HUMAN, P22891
    Tissue specificity: Plasma

        Custom PCR Arrays for PROZ
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PROZ
    OriGene qSTAR qPCR primer pairs in human, mouse for PROZ
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PROZ
    QuantiTect SYBR Green Assays in human, mouse, rat PROZ
    QuantiFast Probe-based Assays in human, mouse, rat PROZ
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PROZ

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for PROZ gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Proz1 , 5 protein Z, vitamin K-dependent plasma glycoprotein1, 5 74.2(n)1
    67.51(a)1
      8 (5.73 cM)5
    669011  NM_025834.31  NP_080110.11 
     130609085 
    chicken
    (Gallus gallus)
    Aves PROZ1 protein Z, vitamin K-dependent plasma glycoprotein 56.79(n)
    48.86(a)
      418746  XM_416945.4  XP_416945.3 
    lizard
    (Anolis carolinensis)
    Reptilia PROZ6
    protein Z, vitamin K-dependent plasma glycoprotein...
    45(a)
    1 ↔ 1
    3(105978360-105988812)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia proz1 protein Z, vitamin K-dependent plasma glycoprotein 50.63(n)
    43.54(a)
      496781  NM_001122717.1  NP_001116189.1 
    zebrafish
    (Danio rerio)
    Actinopterygii PROZ (2 of 2)6
    proza6
    protein Z, vitamin K-dependent plasma glycoprotein...
    protein Z, vitamin K-dependent plasma glycoprotein...
    33(a)
    32(a)
    1 ↔ many
    1 ↔ many
    1(40286-48000) ENSDARG00000076900
    3(63044926-63055718) ENSDARG00000037783


    ENSEMBL Gene Tree for PROZ (if available)
    TreeFam Gene Tree for PROZ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PROZ gene
    C1S2  C1R2  C1RL2  F92  F102  MASP12  F22  HPR2  
    HP2  PROC2  F72  MASP22  
    6 SIMAP similar genes for PROZ using alignment to 2 protein entries:     PROZ_HUMAN (see all proteins):
    PRRG3    PROS1    PROC1    F2    F9    PROC

    Find genes that share paralogs with PROZ           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PROZ (see all 479)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs785346671,2
    C,F--113811034(+) AGATAC/ACCATG 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1903843541,2
    --113811225(+) GGCCAC/TGTAGA 2 -- us2k10--------
    rs1835413201,2
    --113811277(+) ATCAAC/TTTCTG 2 -- us2k10--------
    rs1889900371,2
    --113811310(+) CTCACC/TAAAGA 2 -- us2k10--------
    rs30246991,2
    C,F--113811354(+) CAAACT/GTCACA 2 -- us2k112Minor allele frequency- G:0.05NS NA WA 922
    rs1920956681,2
    --113811376(+) TTTGCC/GGGCAT 2 -- us2k10--------
    rs1511193011,2
    C--113811404(+) TGTCAA/GCTTCT 2 -- us2k10--------
    rs1828419221,2
    --113811421(+) TCTTCC/TGTTCC 2 -- us2k10--------
    rs30247001,2
    C,F,H--113811478(+) CCTTTG/AAGTGT 2 -- us2k1 tfbs318Minor allele frequency- A:0.02NS EA NA WA 1782
    rs1410196721,2
    --113811570(+) TTCTCA/GGATGC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for PROZ (113812968 - 113826694 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PROZ (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1604471CNV Deletion17803354
    esv2748265CNV Deletion23290073
    nsv901049CNV Loss21882294
    nsv901039CNV Loss21882294
    nsv901066CNV Loss21882294
    nsv901067CNV Loss21882294
    dgv1797n71CNV Loss21882294
    nsv901065CNV Loss21882294
    nsv901064CNV Gain21882294
    nsv518044CNV Gain19592680

    Human Gene Mutation Database (HGMD): PROZ
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing PROZ
    DNA2.0 Custom Variant and Variant Library Synthesis for PROZ

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 176895   
    OMIM disorders: 614024  
    1 disease for PROZ:    
    About MalaCards
    cerebral sinovenous thrombosis


    Find genes that share disorders with PROZ           About GenesLikeMe

    1 Novoseek inferred disease relationship for PROZ gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    stroke 25.1 5 14671240 (2), 16155788 (1)

    Genatlas disease: PROZ
    bleeding tendency,PROZ deficiency

    Genetic Association Database (GAD): PROZ
    Human Genome Epidemiology (HuGE) Navigator: PROZ (20 documents)

    Export disorders for PROZ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PROZ gene, integrated from 10 sources (see all 82):
    (articles sorted by number of sources associating them with PROZ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure of vitamin K-dependent human protein Z. (PubMed id 2403355)1, 2, 3, 9 Sejima H.... Suzuki K. (Biochem. Biophys. Res. Commun. 1990)
    2. Amino acid sequence of human protein Z, a vitamin K-dependent plasma glycoprotein. (PubMed id 2244898)1, 2, 3 Ichinose A.... Davie E.W. (Biochem. Biophys. Res. Commun. 1990)
    3. A common polymorphism of the protein Z gene is associated with protein Z plasma levels and with risk of cerebral ischemia in the young. (PubMed id 14671240)1, 4, 9 Lichy C....Grau A. ( a journal of cerebral circulation 2004)
    4. Low protein Z levels, but not the intron F G79A polymorphism, are associated with unexplained pregnancy loss. (PubMed id 19026439)1, 4, 9 Topalidou M....Garipidou V. (Thromb. Res. 2009)
    5. Risk of cerebral venous thrombosis and novel gene polymorphisms of the coagulation and fibrinolytic systems. (PubMed id 16155788)1, 4, 9 Lichy C....Grau A. (J. Neurol. 2006)
    6. Protein Z G79A polymorphism in patients with severe sepsis. (PubMed id 19124455)1, 4 Sipahi T....Akar N. (Clin. Appl. Thromb. Hemost. 2010)
    7. Basis for the specificity and activation of the serpin protein Z- dependent proteinase inhibitor (ZPI) as an inhibitor of membrane- associated factor Xa. (PubMed id 20427285)1, 2 Huang X.... Gettins P.G. (J. Biol. Chem. 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Intron F G79A polymorphism of the protein Z gene in cancer patients with and without thrombosis. (PubMed id 18246466)1, 4 Eroglu A....Akar N. (J. Thromb. Thrombolysis 2009)
    10. Rare genotypes of protein Z gene are a risk factor for premature myocardial infarction but not protein Z plasma level. (PubMed id 19572077)1, 4 Le Cam-Duchez V....Collet J.P. (Thromb. Haemost. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8858 HGNC: 9460 AceView: PROZ Ensembl:ENSG00000126231 euGenes: HUgn8858
    ECgene: PROZ H-InvDB: PROZ

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PROZ Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/proz/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PROZ gene:
    Search GeneIP for patents involving PROZ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PROZ  
     OriGene qPCR primer pairs and template standards for PROZ   OriGene Protein Over-expression Lysate for PROZ  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PROZ  
     OriGene qSTAR qPCR primer pairs in human, mouse for PROZ   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PROZ   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PROZ   OriGene Custom Protein Services for PROZ  

     
     
     Block miRNA regulation of human, mouse, rat PROZ using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PROZ
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PROZ Predesigned siRNA for gene silencing in human, mouse, rat PROZ
     QuantiFast Probe-based Assays in human, mouse, rat PROZ QuantiTect SYBR Green Assays in human, mouse, rat PROZ
     Custom PCR Arrays for PROZ Search Chromatin IP Primers for PROZ
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PROZ  GeneGlobe Interaction Network for PROZ
     Regulatory tfbs in PROZ promoter
     GenScript Custom Purified and Recombinant Proteins Services for PROZ GenScript cDNA clones with any tag delivered in your preferred vector for PROZ
     GenScript Custom Assay Services for PROZ GenScript Custom overexpressing Cell Line Services for PROZ
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PROZ
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PROZ antibodies
     PROZ proteins
     PROZ lysates
     Antibodies for PROZ
     See all of Abcam's Antibodies, Kits and Proteins for PROZ
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for PROZ
     Antibodies for PROZ
     ELISAs for PROZ
     CLIAs for PROZ



     Browse ESI BIO Cell Lines and PureStem Progenitors for PROZ
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PROZ
     SwitchGear 3'UTR luciferase reporter plasmids for PROZ
     SwitchGear Promoter luciferase reporter plasmids for PROZ
     ThermoFisher Antibodies for PROZ
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PROZ
     Browse compounds at ApexBio
     Search Addgene for plasmids for PROZ
      Search eBioscience for proteins for PROZ
      Search eBioscience for elisas for PROZ
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for PROZ
     antibodies-online antibodies for PROZ (14 products)
     antibodies-online kits for PROZ (8 products)
      Search antibodies-online for peptides for PROZ
     antibodies-online proteins for PROZ (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PROZ gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4