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Aliases for PROZ Gene

Aliases for PROZ Gene

  • Protein Z, Vitamin K Dependent Plasma Glycoprotein 2 3
  • Protein Z, Vitamin K-Dependent Plasma Glycoprotein 2 3 5
  • Vitamin K-Dependent Protein Z Precursor Variant 1 3
  • PZ 3

External Ids for PROZ Gene

Previous GeneCards Identifiers for PROZ Gene

  • GC13P112422
  • GC13P108450
  • GC13P112899
  • GC13P111760
  • GC13P112860
  • GC13P113812
  • GC13P094251

Summaries for PROZ Gene

Entrez Gene Summary for PROZ Gene

  • This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

GeneCards Summary for PROZ Gene

PROZ (Protein Z, Vitamin K Dependent Plasma Glycoprotein) is a Protein Coding gene. Diseases associated with PROZ include Cerebral Sinovenous Thrombosis. Among its related pathways are Gamma carboxylation, hypusine formation and arylsulfatase activation and Warfarin Pathway, Pharmacodynamics. GO annotations related to this gene include calcium ion binding and serine-type endopeptidase activity. An important paralog of this gene is HP.

UniProtKB/Swiss-Prot for PROZ Gene

  • Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PROZ Gene

Genomics for PROZ Gene

Regulatory Elements for PROZ Gene

Enhancers for PROZ Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PROZ on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the PROZ gene promoter:

Genomic Location for PROZ Gene

Chromosome:
13
Start:
113,155,061 bp from pter
End:
113,172,386 bp from pter
Size:
17,326 bases
Orientation:
Plus strand

Genomic View for PROZ Gene

Genes around PROZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PROZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PROZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PROZ Gene

Proteins for PROZ Gene

  • Protein details for PROZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22891-PROZ_HUMAN
    Recommended name:
    Vitamin K-dependent protein Z
    Protein Accession:
    P22891
    Secondary Accessions:
    • A6NMB4
    • Q15213
    • Q5JVF5
    • Q5JVF6

    Protein attributes for PROZ Gene

    Size:
    400 amino acids
    Molecular mass:
    44744 Da
    Quaternary structure:
    • Interacts with SERPINA10.

    Three dimensional structures from OCA and Proteopedia for PROZ Gene

    Alternative splice isoforms for PROZ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PROZ Gene

Proteomics data for PROZ Gene at MOPED

Post-translational modifications for PROZ Gene

  • The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PROZ Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PROZ Gene

Domains & Families for PROZ Gene

Gene Families for PROZ Gene

Suggested Antigen Peptide Sequences for PROZ Gene

Graphical View of Domain Structure for InterPro Entry

P22891

UniProtKB/Swiss-Prot:

PROZ_HUMAN :
  • Contains 2 EGF-like domains.
  • Belongs to the peptidase S1 family.
Domain:
  • Contains 2 EGF-like domains.
  • Contains 1 Gla (gamma-carboxy-glutamate) domain.
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with PROZ: view

Function for PROZ Gene

Molecular function for PROZ Gene

GENATLAS Biochemistry:
plasma glycoprotein Z,62kDa,vitamin K-dependent glycoprotein,with two alternatively spliced isoforms,binding to thrombin and promoting its association with phospholipid vesicles
UniProtKB/Swiss-Prot Function:
Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids.
genes like me logo Genes that share phenotypes with PROZ: view

Animal Models for PROZ Gene

MGI Knock Outs for PROZ:

Animal Model Products

  • Taconic Biosciences Mouse Models for PROZ

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PROZ Gene

Localization for PROZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for PROZ Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PROZ Gene COMPARTMENTS Subcellular localization image for PROZ gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
golgi apparatus 4
cytosol 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PROZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with PROZ: view

Pathways & Interactions for PROZ Gene

genes like me logo Genes that share pathways with PROZ: view

Interacting Proteins for PROZ Gene

Gene Ontology (GO) - Biological Process for PROZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with PROZ: view

No data available for SIGNOR curated interactions for PROZ Gene

Drugs & Compounds for PROZ Gene

(1) Drugs for PROZ Gene - From: DrugBank, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Menadione Approved Nutra inhibitor, Target, activator 207
genes like me logo Genes that share compounds with PROZ: view

Transcripts for PROZ Gene

Unigene Clusters for PROZ Gene

Protein Z, vitamin K-dependent plasma glycoprotein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PROZ Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b
SP1: - - -
SP2: - - - -
SP3: -
SP4: - -

Relevant External Links for PROZ Gene

GeneLoc Exon Structure for
PROZ
ECgene alternative splicing isoforms for
PROZ

Expression for PROZ Gene

mRNA expression in normal human tissues for PROZ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PROZ Gene

This gene is overexpressed in Liver (x39.8) and Kidney - Cortex (x6.3).

Protein differential expression in normal tissues from HIPED for PROZ Gene

This gene is overexpressed in Urine (47.5), Plasma (12.7), and Serum (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PROZ Gene



SOURCE GeneReport for Unigene cluster for PROZ Gene Hs.1011

mRNA Expression by UniProt/SwissProt for PROZ Gene

P22891-PROZ_HUMAN
Tissue specificity: Plasma.
genes like me logo Genes that share expression patterns with PROZ: view

Protein tissue co-expression partners for PROZ Gene

- Elite partner

Primer Products

Orthologs for PROZ Gene

This gene was present in the common ancestor of chordates.

Orthologs for PROZ Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PROZ 35
  • 68.97 (n)
  • 62.31 (a)
PROZ 36
  • 54 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Proz 35
  • 74.2 (n)
  • 67.51 (a)
Proz 16
Proz 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PROZ 35
  • 98.67 (n)
  • 98.25 (a)
PROZ 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Proz 35
  • 72 (n)
  • 65.99 (a)
oppossum
(Monodelphis domestica)
Mammalia PROZ 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PROZ 36
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves PROZ 35
  • 56.79 (n)
  • 48.86 (a)
PROZ 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PROZ 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia proz 35
  • 50.63 (n)
  • 43.54 (a)
zebrafish
(Danio rerio)
Actinopterygii PROZ (2 of 2) 36
  • 33 (a)
OneToMany
proza 36
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 12 (a)
OneToMany
Species with no ortholog for PROZ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PROZ Gene

ENSEMBL:
Gene Tree for PROZ (if available)
TreeFam:
Gene Tree for PROZ (if available)

Paralogs for PROZ Gene

Paralogs for PROZ Gene

(6) SIMAP similar genes for PROZ Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PROZ: view

Variants for PROZ Gene

Sequence variations from dbSNP and Humsavar for PROZ Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs3024778 - 113,160,151(+) CAAGA(A/G/T)AAGTG reference, missense
VAR_013125 -
rs513479 -- 113,160,886(-) TTCCT(A/G)TAGAT intron-variant
rs525644 -- 113,160,524(+) CTAAG(C/T)GTCCC intron-variant
rs564081 -- 113,164,586(+) TACAC(A/G/T)TGCAG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for PROZ Gene

Variant ID Type Subtype PubMed ID
nsv901039 CNV Loss 21882294
dgv1797n71 CNV Loss 21882294
nsv901049 CNV Loss 21882294
nsv518044 CNV Gain 19592680
nsv901064 CNV Gain 21882294
nsv901065 CNV Loss 21882294
esv22603 CNV Gain 19812545
esv2748265 CNV Deletion 23290073
esv1604471 CNV Deletion 17803354
nsv901066 CNV Loss 21882294
nsv901067 CNV Loss 21882294
nsv901068 CNV Gain 21882294

Variation tolerance for PROZ Gene

Residual Variation Intolerance Score: 66.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.89; 48.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PROZ Gene

Human Gene Mutation Database (HGMD)
PROZ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PROZ Gene

Disorders for PROZ Gene

MalaCards: The human disease database

(1) MalaCards diseases for PROZ Gene - From: Orphanet

Disorder Aliases PubMed IDs
cerebral sinovenous thrombosis
  • csvt
- elite association - COSMIC cancer census association via MalaCards
Search PROZ in MalaCards View complete list of genes associated with diseases

Genatlas disease for PROZ Gene

bleeding tendency,PROZ deficiency

Relevant External Links for PROZ

Genetic Association Database (GAD)
PROZ
Human Genome Epidemiology (HuGE) Navigator
PROZ
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PROZ
genes like me logo Genes that share disorders with PROZ: view

No data available for UniProtKB/Swiss-Prot for PROZ Gene

Publications for PROZ Gene

  1. Primary structure of vitamin K-dependent human protein Z. (PMID: 2403355) Sejima H. … Suzuki K. (Biochem. Biophys. Res. Commun. 1990) 2 3 4 23 67
  2. Low protein Z levels, but not the intron F G79A polymorphism, are associated with unexplained pregnancy loss. (PMID: 19026439) Topalidou M. … Garipidou V. (Thromb. Res. 2009) 3 23
  3. Protein Z, a protein seeking a pathology. (PMID: 18841275) Vasse M. (Thromb. Haemost. 2008) 3 23
  4. Risk of cerebral venous thrombosis and novel gene polymorphisms of the coagulation and fibrinolytic systems. (PMID: 16155788) Lichy C. … Grau A. (J. Neurol. 2006) 3 23
  5. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26

Products for PROZ Gene

Sources for PROZ Gene

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