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Aliases for PROX1 Gene

Aliases for PROX1 Gene

  • Prospero Homeobox 1 2 3 5
  • Homeobox Prospero-Like Protein PROX1 4
  • Prospero-Related Homeobox 1 2
  • PROX-1 4

External Ids for PROX1 Gene

Previous GeneCards Identifiers for PROX1 Gene

  • GC01P212818
  • GC01P209982
  • GC01P210777
  • GC01P211218
  • GC01P210550
  • GC01P212228
  • GC01P214156
  • GC01P184836

Summaries for PROX1 Gene

Entrez Gene Summary for PROX1 Gene

  • The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

GeneCards Summary for PROX1 Gene

PROX1 (Prospero Homeobox 1) is a Protein Coding gene. Diseases associated with PROX1 include Kaposiform Hemangioendothelioma and Lymphatic Malformations. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Angiogenesis (CST). GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription regulatory region DNA binding. An important paralog of this gene is PROX2.

UniProtKB/Swiss-Prot for PROX1 Gene

  • Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.

Gene Wiki entry for PROX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PROX1 Gene

Genomics for PROX1 Gene

Regulatory Elements for PROX1 Gene

Enhancers for PROX1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F214026 2.2 Ensembl ENCODE 10.7 +46.0 45980 5.6 MLX ARID4B ZNF48 YY1 MXD4 PPARG KAT8 SSRP1 MIER3 ATF4 PROX1 ENSG00000272167 PROX1-AS1
GH01F213986 1.4 FANTOM5 ENCODE 10.7 +5.7 5651 3.9 PKNOX1 ATF1 ARID4B FEZF1 GLI4 ZNF48 ZNF2 GLIS2 KLF7 ZNF263 PROX1 PROX1-AS1 ENSG00000272167
GH01F213953 1 FANTOM5 14.6 -29.5 -29540 0.4 ELF3 ATF1 MLX ARID4B DMAP1 ZNF48 THRB ZSCAN9 RAD21 YY1 PROX1 GC01P213925 LINC00538
GH01F214123 1.2 Ensembl ENCODE 10.8 +141.3 141324 2.9 ELF3 PKNOX1 ZNF133 ARID4B FEZF1 ZNF48 RAD21 YY1 ZNF335 SLC30A9 PROX1 LOC105372911 GC01M214040
GH01F213984 0.9 FANTOM5 10 +1.4 1376 0.1 PKNOX1 FEZF1 ZIC2 ZNF2 HIC1 ZNF366 PATZ1 PRDM10 TCF7L2 ZBTB20 PROX1 ENSG00000274895
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PROX1 on UCSC Golden Path with GeneCards custom track

Promoters for PROX1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001754485 -281 601 KLF17 ZNF48 RAD21 YY1 GLIS2 SCRT2 EGR2 ZNF263 SP3 YY2

Genomic Location for PROX1 Gene

Chromosome:
1
Start:
213,983,181 bp from pter
End:
214,041,510 bp from pter
Size:
58,330 bases
Orientation:
Plus strand

Genomic View for PROX1 Gene

Genes around PROX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PROX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PROX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PROX1 Gene

Proteins for PROX1 Gene

  • Protein details for PROX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92786-PROX1_HUMAN
    Recommended name:
    Prospero homeobox protein 1
    Protein Accession:
    Q92786
    Secondary Accessions:
    • A6NK29
    • A8K2B1
    • Q5SW76
    • Q8TB91

    Protein attributes for PROX1 Gene

    Size:
    737 amino acids
    Molecular mass:
    83203 Da
    Quaternary structure:
    • Interacts with RORA and RORG (via AF-2 motif).
    SequenceCaution:
    • Sequence=CAI15309.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PROX1 Gene

neXtProt entry for PROX1 Gene

Post-translational modifications for PROX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PROX1 (PROX1)
  • Santa Cruz Biotechnology (SCBT) Antibodies for PROX1

No data available for DME Specific Peptides for PROX1 Gene

Domains & Families for PROX1 Gene

Gene Families for PROX1 Gene

Protein Domains for PROX1 Gene

Suggested Antigen Peptide Sequences for PROX1 Gene

Graphical View of Domain Structure for InterPro Entry

Q92786

UniProtKB/Swiss-Prot:

PROX1_HUMAN :
  • The Prospero-type homeodomain and the adjacent Prospero domain act as a single structural unit, the Homeo-Prospero domain. The Prospero-type homeodomain is essential for repression of RORG transcriptional activator activity.
Domain:
  • The Prospero-type homeodomain and the adjacent Prospero domain act as a single structural unit, the Homeo-Prospero domain. The Prospero-type homeodomain is essential for repression of RORG transcriptional activator activity.
  • Belongs to the Prospero homeodomain family.
  • Contains 1 Prospero domain.
  • Contains 1 Prospero-type homeo domain.
genes like me logo Genes that share domains with PROX1: view

Function for PROX1 Gene

Molecular function for PROX1 Gene

GENATLAS Biochemistry:
prospero-related homeo box 1,chicken homeo domain protein PROX1 homolog,highly expressed in lens,retina,pancreas
UniProtKB/Swiss-Prot Function:
Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.

Gene Ontology (GO) - Molecular Function for PROX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA --
GO:0001046 core promoter sequence-specific DNA binding ISS --
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IBA --
GO:0003677 DNA binding IMP 18815287
GO:0003700 transcription factor activity, sequence-specific DNA binding IC 19210544
genes like me logo Genes that share ontologies with PROX1: view
genes like me logo Genes that share phenotypes with PROX1: view

Animal Models for PROX1 Gene

MGI Knock Outs for PROX1:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PROX1 Gene

Localization for PROX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PROX1 Gene

Nucleus. Note=RORG promotes its nuclear localization. {ECO:0000250 UniProtKB:P48437}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PROX1 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PROX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS,IDA --
GO:0005737 cytoplasm IDA 11850194
genes like me logo Genes that share ontologies with PROX1: view

Pathways & Interactions for PROX1 Gene

genes like me logo Genes that share pathways with PROX1: view

Pathways by source for PROX1 Gene

1 Cell Signaling Technology pathway for PROX1 Gene

Gene Ontology (GO) - Biological Process for PROX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 15205472
GO:0001709 cell fate determination IEA --
GO:0001822 kidney development IEP 8812486
GO:0001889 liver development IEP 11789987
GO:0001938 positive regulation of endothelial cell proliferation IDA 19210544
genes like me logo Genes that share ontologies with PROX1: view

No data available for SIGNOR curated interactions for PROX1 Gene

Drugs & Compounds for PROX1 Gene

(1) Drugs for PROX1 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atenolol Approved Pharma Antagonist 99

(1) Additional Compounds for PROX1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PROX1: view

Transcripts for PROX1 Gene

Unigene Clusters for PROX1 Gene

Prospero homeobox 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PROX1 Gene

No ASD Table

Relevant External Links for PROX1 Gene

GeneLoc Exon Structure for
PROX1
ECgene alternative splicing isoforms for
PROX1

Expression for PROX1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PROX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PROX1 Gene

This gene is overexpressed in Liver (x13.2).

Protein differential expression in normal tissues from HIPED for PROX1 Gene

This gene is overexpressed in Liver (25.0), Fetal testis (15.2), Fetal ovary (7.7), and Fetal Liver (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PROX1 Gene



NURSA nuclear receptor signaling pathways regulating expression of PROX1 Gene:

PROX1

SOURCE GeneReport for Unigene cluster for PROX1 Gene:

Hs.744931

mRNA Expression by UniProt/SwissProt for PROX1 Gene:

Q92786-PROX1_HUMAN
Tissue specificity: Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with PROX1: view

No data available for Protein tissue co-expression partners for PROX1 Gene

Orthologs for PROX1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PROX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PROX1 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia PROX1 34 35
  • 96.79 (n)
cow
(Bos Taurus)
Mammalia PROX1 34 35
  • 94.93 (n)
rat
(Rattus norvegicus)
Mammalia Prox1 34
  • 92.26 (n)
mouse
(Mus musculus)
Mammalia Prox1 34 16 35
  • 92.04 (n)
oppossum
(Monodelphis domestica)
Mammalia PROX1 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PROX1 35
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves PROX1 34 35
  • 88.86 (n)
lizard
(Anolis carolinensis)
Reptilia PROX1 35
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prox1 34
  • 83.61 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1033 34
zebrafish
(Danio rerio)
Actinopterygii prox1a 34 35
  • 75.94 (n)
prox1 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3509 34
fruit fly
(Drosophila melanogaster)
Insecta pros 36 35
  • 62 (a)
worm
(Caenorhabditis elegans)
Secernentea ceh-26 36
  • 58 (a)
pros-1 35
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToMany
Species where no ortholog for PROX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PROX1 Gene

ENSEMBL:
Gene Tree for PROX1 (if available)
TreeFam:
Gene Tree for PROX1 (if available)

Paralogs for PROX1 Gene

Paralogs for PROX1 Gene

(1) SIMAP similar genes for PROX1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PROX1: view

Variants for PROX1 Gene

Sequence variations from dbSNP and Humsavar for PROX1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10157262 -- 214,031,066(+) GTGTG(C/T)GCGCG intron-variant
rs1019898 -- 214,031,115(-) CCAGT(A/C)CACAG intron-variant
rs10494972 -- 214,034,008(-) ACATA(A/T)TTCCC intron-variant
rs1053283 -- 214,040,519(+) ACTAA(A/G)AAAAA utr-variant-3-prime
rs1053284 -- 214,040,759(+) TTTTT(A/G/T)TTTGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PROX1 Gene

Variant ID Type Subtype PubMed ID
nsv4498 CNV insertion 18451855
nsv952088 CNV deletion 24416366

Variation tolerance for PROX1 Gene

Residual Variation Intolerance Score: 4.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PROX1 Gene

Human Gene Mutation Database (HGMD)
PROX1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PROX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PROX1 Gene

Disorders for PROX1 Gene

MalaCards: The human disease database

(18) MalaCards diseases for PROX1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
kaposiform hemangioendothelioma
  • congenital cutaneous multifocal kaposiform hemangioendothelioma
lymphatic malformations
  • lymphangioma
angiokeratoma of fordyce
  • fordyce angiokeratoma
acquired hemangioma
capillary lymphangioma
  • cutaneous lymphangioma
- elite association - COSMIC cancer census association via MalaCards
Search PROX1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PROX1

Genetic Association Database (GAD)
PROX1
Human Genome Epidemiology (HuGE) Navigator
PROX1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PROX1
genes like me logo Genes that share disorders with PROX1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PROX1 Gene

Publications for PROX1 Gene

  1. Structure and chromosomal localization of the human homeobox gene Prox 1. (PMID: 8812486) Zinovieva R.D. … Tomarev S.I. (Genomics 1996) 2 3 4 64
  2. Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors alpha- and gamma-mediated transactivation. (PMID: 23723244) Takeda Y. … Jetten A.M. (Nucleic Acids Res. 2013) 3 4 64
  3. Transcription factor PROX1: its role in development and cancer. (PMID: 22733308) Elsir T. … NistAcr M. (Cancer Metastasis Rev. 2012) 3 4 64
  4. Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-kappaB and Prox1. (PMID: 19901262) Flister M.J. … Ran S. (Blood 2010) 3 22 64
  5. Multistage genomewide association study identifies a locus at 1q41 associated with rate of HIV-1 disease progression to clinical AIDS. (PMID: 20064070) Herbeck J.T. … Mullins J.I. (J. Infect. Dis. 2010) 3 46 64

Products for PROX1 Gene

Sources for PROX1 Gene

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