PROX1 Gene

Aliases
for PROX1 gene

Previous GC identifers: GC01P212818 GC01P209982 GC01P210777 GC01P211218 GC01P210550 GC01P212228 GC01P184836

Summaries
for PROX1 gene

Genomic Views
for PROX1 gene

RefSeq DNA sequence:

NC_000001.10  NC_018912.1  NT_167186.1  

SwitchGear Promoter luciferase reporter plasmid: PROX1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PROX1

PROX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P214156:  view genomic region     (about GC identifiers)

Proteins
for PROX1 gene

1 PDB 3D structure from and Proteopedia for PROX1:

2LMD (3D)    

Explore the universe of human proteins at neXtProt for PROX1: NX_Q92786

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: PROX1 OriGene Custom Protein Services for PROX1
	GenScript Custom Purified and Recombinant Proteins Services for PROX1
	Novus Biologicals PROX1 Protein Novus Biologicals PROX1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PROX1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of PROX1
	R&D Systems Antibodies for PROX1
	OriGene Antibodies (see all 3): PROX1 OriGene Custom Antibody Services for PROX1
	GenScript Custom Superior Antibodies Services for PROX1
	Novus Biologicals PROX1 Antibodies
	Abcam antibodies for PROX1
	Uscn Antibodies for PROX1
	ThermoFisher Antibody for PROX1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PROX1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PROX1

Protein Domains /
Families
for PROX1 gene

ProtoNet protein and cluster: Q92786

Function
for PROX1 gene

miRNA Products:		miRTarBase miRNAs that target PROX1: hsa-mir-181a (MIRT003630)
		OriGene 3'-UTR Clone: PROX1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PROX1
		8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate PROX1 (see all 19):
		hsa-miR-125a-5p hsa-miR-1288 hsa-miR-181c hsa-miR-3616-5p hsa-miR-4305 hsa-miR-485-3p hsa-miR-125b hsa-miR-635
		SwitchGear 3'UTR luciferase reporter plasmid: PROX1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PROX1 (see all 7) OriGene shRNA RFP: PROX1 OriGene siRNA: PROX1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PROX1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for PROX1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PROX1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PROX1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PROX1 (NM_002763)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PROX1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PROX1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PROX1
		Search LifeMap BioReagents cell lines for PROX1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PROX1

Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

15/16 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Prox1)

Pathways & Interactions
for PROX1 gene

Gene Ontology (GO): 5/59 biological process terms (GO ID links to tree view) (see all 59):    About this table

Drugs & Compounds
for PROX1 gene

Transcripts
for PROX1 gene

Expression
for PROX1 gene

PROX1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTAAAAATA

10/21 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 21)
	Tissue Anatomical Compartment Cell			Category (developmental path)
	EyeInner Nuclear LayerImmature Horizontal Cells			Horizontal, Retina
	LymphLymphatic VesselsLymphatic Endothelial Cells			Endothelium
	PancreasDorsal Pancreatic BudBipotent Endocrine/Duct Progenitor Cells			Pancreas
	PancreasVentral Pancreatic BudBipotent Endocrine/Duct Progenitor Cells			Pancreas
	EyeInner Nuclear LayerMature Horizontal Cells			Horizontal, Retina
	HeartCardinal VeinsVenous Endothelial Cells			Endothelium
	LimbLimb BudLimb Bud Mesenchyme Cells			Mesoderm
	LiverHepatic DiverticulumHepatic Diverticulum Cells			Liver
	LiverLiver BudHepatoblasts			Liver
	PancreasDorsal Pancreatic BudEndocrine Progenitor Cells			Pancreas
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 6 LifeMap Cells
	Name			Category
	Posterior foregut-like cells (A scalable, suspensi...)
	Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
	Indolactam V-induced cells (Derivation of pancre...)
	Primitive Streak Mesendoderm cells (Direct differentiati...)
	Chondrocyte-like cells (Direct differentiati...)			Bone, Cartilage
	Mesoderm-like cells (Direct differentiati...)			Mesoderm

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PROX1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PROX1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PROX1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PROX1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PROX1

Orthologs
for PROX1 gene

Paralogs
for PROX1 gene

Paralogs for PROX1 gene

PROX2²  

PROX1 for paralogs           About GeneDecksing

Genomic Variants
for PROX1 gene

10/856 NCBI SNPs in PROX1 are shown (see all 856)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1479231361,2		--	214159280(+)	TTTATC/TTGTGG	1	--	us2k1		0	--	--	--	--
rs1485645191,2		--	214159434(+)	AATAGA/GAGCAT	1	--	us2k1		0	--	--	--	--
rs749564661,2	C,F,	--	214159446(+)	ATTCCG/TTCCTG	1	--	us2k1		1		WA	118
rs1165992081,2		--	214159538(+)	AGTTGG/AAGGTG	1	--	us2k1		1		WA	118
rs75362561,2	C,F,	--	214159644(+)	ATGCTC/ACCGCA	1	--	us2k1		2		NA EA	240
rs1856119251,2		--	214159672(+)	CGACAC/TCTAAC	1	--	us2k1		0	--	--	--	--
rs1900730381,2		--	214159751(+)	AGACTC/TGGACA	1	--	us2k1		0	--	--	--	--
rs1817157391,2		--	214159838(+)	GTAAAC/TTCCCT	1	--	us2k1		0	--	--	--	--
rs351465561,2	C,	--	214159851(+)	AAGGA-/GTGTGTG	2	--	us2k1		0	--	--	--	--
rs711659421,2	C	--	214159869(-)	CTGCGAC/-ACACA	2	--	us2k1		1		NA	2

HapMap Linkage Disequilibrium report for PROX1 (214156524 - 214214853 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for PROX1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PROX1

DNA2.0 Custom Variant and Variant Library Synthesis for PROX1

Disorders / Diseases
for PROX1 gene

20/38 diseases for PROX1

9 Novoseek disease relationships for PROX1 gene    About this table

Publications
for PROX1 gene

PubMed articles for PROX1 gene, integrated from 9 sources (see all 136): (articles sorted by number of sources associating them with PROX1)

Utopia: connect your pdf to the dynamic world of online information

1. Structure and chromosomal localization of the human homeobox gene Prox 1. (PubMed id 8812486)^{1, 2, 3} Zinovieva R.D.... Tomarev S.I. (1996)
2. Sumoylation of Prox1 controls its ability to induce V EGFR3 expression and lymphatic phenotypes in endothelial cells. (PubMed id 19706680)^{1, 9} Pan M.R....Hung W.C. (2009)
3. The homeobox transcription factor Prox1 is highly conserved in embryonic hepatoblasts and in adult and transformed hepatocytes, but is absent from bile duct epithelium. (PubMed id 15232737)^{1, 9} Dudas J....Wilting J. (2004)
4. COUP-TFII regulates the functions of Prox1 in lymphatic endothelial cells through direct interaction. (PubMed id 19210544)^{1, 9} Yamazaki T....Watabe T. (2009)
5. Prospero-related homeobox 1 (PROX1) is frequently inactivated by genomic deletions and epigenetic silencing in carcinomas of the bilary system. (PubMed id 17069925)^{1, 9} Laerm A....Ballhausen W.G. (2007)
6. A homeobox protein, prox1, is involved in the differentiation, proliferation, and prognosis in hepatocellular carcinoma. (PubMed id 17062673)^{1, 9} Shimoda M....Kubo H. (2006)
7. Repression of interferon-gamma expression in T cells by Prospero-related homeobox protein. (PubMed id 19160541)^{1, 9} Wang L....Xie Y. (2008)
8. Inflammation induces lymphangiogenesis through up-reg ulation of VEGFR-3 mediated by NF-kappaB and Prox1. (PubMed id 19901262)^{1, 9} Flister M.J....Ran S. (2010)
9. Identification of targets of Prox1 during in vitro va scular differentiation from embryonic stem cells: functional roles of HoxD8 in lymphangiogenesis. (PubMed id 19825936)^{1, 9} Harada K....Miyazono K. (2009)
10. Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate. (PubMed id 12412020)^{1, 9} Hong Y.K....Oliver G. (2002)

External Searches for PROX1 gene

Genome Databases showing PROX1 gene

Other Databases showing PROX1 gene

Specialized Databases showing PROX1 gene

Products
for PROX1 gene