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Aliases for PROSER3 Gene

Aliases for PROSER3 Gene

  • Proline And Serine Rich 3 2 3 5
  • C19orf55 3 4
  • Chromosome 19 Open Reading Frame 55 2
  • Proline And Serine-Rich Protein 3 3

External Ids for PROSER3 Gene

Previous HGNC Symbols for PROSER3 Gene

  • C19orf55

Previous GeneCards Identifiers for PROSER3 Gene

  • GC19P035807
  • GC19P035833
  • GC19P035991
  • GC19P036013
  • GC19P036176
  • GC19P036254
  • GC19P036420

Summaries for PROSER3 Gene

GeneCards Summary for PROSER3 Gene

PROSER3 (Proline And Serine Rich 3) is a Protein Coding gene.

Additional gene information for PROSER3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PROSER3 Gene

Genomics for PROSER3 Gene

GeneHancer (GH) Regulatory Elements for PROSER3 Gene

Promoters and enhancers for PROSER3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I035753 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 572.6 -1.9 -1885 6.4 HDGF PKNOX1 SMAD1 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 SLC30A9 PROSER3 HSPB6 GC19M038818 ENSG00000267328 U2AF1L4 COX6B1 ZBTB32 ENSG00000267049 KMT2B ENSG00000261754
GH19I035946 Enhancer 1.5 FANTOM5 Ensembl ENCODE 140.4 +189.3 189250 0.8 HDGF ARNT ARID4B SIN3A FEZF1 ZNF2 IRF4 ZNF213 ZNF302 E2F8 LOC105372383 ZNF567 ZNF345 TMEM147-AS1 ZNF850 HAUS5 PROSER3 ZNF790 KMT2B ZNF529
GH19I035701 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 85.3 -55.5 -55542 1.6 HDGF PKNOX1 SMAD1 ARID4B SIN3A FEZF1 ZNF2 ZNF416 ZNF143 ZNF548 ZBTB32 ZNF567 PROSER3 TMEM147-AS1 ZNF599 HAUS5 U2AF1L4 KMT2B ENSG00000267049 ZNF792
GH19I036665 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 62.6 +908.7 908712 2.3 PKNOX1 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF461 ENSG00000276071 ZNF567 ZNF383 ZNF345 ZNF527 ZNF850 KMT2B HKR1 ZNF585B
GH19I036013 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 68.3 +256.1 256094 2.3 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 POLR2B LOC101927572 ALKBH6 ENSG00000248101 ZNF345 ZNF850 KMT2B ZNF567 PROSER3 TMEM147-AS1 RBM42
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PROSER3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PROSER3 Gene

Genomic Locations for PROSER3 Gene
chr19:35,758,143-35,771,028
(GRCh38/hg38)
Size:
12,886 bases
Orientation:
Plus strand
chr19:36,249,044-36,261,930
(GRCh37/hg19)

Genomic View for PROSER3 Gene

Genes around PROSER3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PROSER3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PROSER3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PROSER3 Gene

Proteins for PROSER3 Gene

  • Protein details for PROSER3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2NL68-PRSR3_HUMAN
    Recommended name:
    Proline and serine-rich protein 3
    Protein Accession:
    Q2NL68
    Secondary Accessions:
    • Q8NDI3
    • Q8WWC8
    • Q96NL4

    Protein attributes for PROSER3 Gene

    Size:
    480 amino acids
    Molecular mass:
    51075 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH17947.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PROSER3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PROSER3 Gene

Post-translational modifications for PROSER3 Gene

No Post-translational modifications

No data available for DME Specific Peptides for PROSER3 Gene

Domains & Families for PROSER3 Gene

Gene Families for PROSER3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PROSER3 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PROSER3: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for PROSER3 Gene

Function for PROSER3 Gene

Phenotypes for PROSER3 Gene

GenomeRNAi human phenotypes for PROSER3:
genes like me logo Genes that share phenotypes with PROSER3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PROSER3 Gene

Localization for PROSER3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PROSER3 gene
Compartment Confidence
golgi apparatus 3
nucleus 2
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PROSER3 Gene

Pathways & Interactions for PROSER3 Gene

SuperPathways for PROSER3 Gene

No Data Available

Interacting Proteins for PROSER3 Gene

Selected Interacting proteins: Q2NL68-PRSR3_HUMAN for PROSER3 Gene via IID

Gene Ontology (GO) - Biological Process for PROSER3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PROSER3 Gene

Drugs & Compounds for PROSER3 Gene

No Compound Related Data Available

Transcripts for PROSER3 Gene

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PROSER3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12
SP1: - - -
SP2: - -
SP3: - -
SP4: -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for PROSER3 Gene

GeneLoc Exon Structure for
PROSER3
ECgene alternative splicing isoforms for
PROSER3

Expression for PROSER3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PROSER3 Gene

Protein differential expression in normal tissues from HIPED for PROSER3 Gene

This gene is overexpressed in Liver (63.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PROSER3 Gene



Protein tissue co-expression partners for PROSER3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PROSER3 Gene:

PROSER3
genes like me logo Genes that share expression patterns with PROSER3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PROSER3 Gene

Orthologs for PROSER3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PROSER3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia C1H19orf55 33
  • 83.46 (n)
C19orf55 34
  • 46 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C19orf55 34
  • 83 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C18H19orf55 33
  • 78.73 (n)
C19orf55 34
  • 38 (a)
OneToOne
mouse
(Mus musculus)
Mammalia BC053749 34
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C19orf55 34
  • 31 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C15H19orf55 34
  • 17 (a)
OneToOne
Species where no ortholog for PROSER3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PROSER3 Gene

ENSEMBL:
Gene Tree for PROSER3 (if available)
TreeFam:
Gene Tree for PROSER3 (if available)

Paralogs for PROSER3 Gene

No data available for Paralogs for PROSER3 Gene

Variants for PROSER3 Gene

Sequence variations from dbSNP and Humsavar for PROSER3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000309698 -- 35,757,631(+) T/C upstream_transcript_variant
rs1000338983 -- 35,757,364(+) T/ upstream_transcript_variant
rs1000499931 -- 35,759,044(+) C/A intron_variant
rs1000686022 -- 35,766,257(+) A/G intron_variant
rs1000726103 -- 35,758,288(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PROSER3 Gene

Variant ID Type Subtype PubMed ID
esv2718499 CNV deletion 23290073
nsv1123251 CNV deletion 24896259
nsv579422 CNV loss 21841781
nsv579423 CNV loss 21841781
nsv953286 CNV deletion 24416366

Variation tolerance for PROSER3 Gene

Gene Damage Index Score: 7.06; 80.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PROSER3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PROSER3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PROSER3 Gene

Disorders for PROSER3 Gene

Additional Disease Information for PROSER3

No disorders were found for PROSER3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PROSER3 Gene

Publications for PROSER3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 58
  2. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 58
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 58
  4. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for PROSER3 Gene

Sources for PROSER3 Gene

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