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Aliases for PROSER2 Gene

Aliases for PROSER2 Gene

  • Proline And Serine Rich 2 2 3
  • C10orf47 3 4
  • Chromosome 10 Open Reading Frame 47 2
  • Proline And Serine-Rich Protein 2 2

External Ids for PROSER2 Gene

Previous HGNC Symbols for PROSER2 Gene

  • C10orf47

Summaries for PROSER2 Gene

GeneCards Summary for PROSER2 Gene

PROSER2 (Proline And Serine Rich 2) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PROSER2 Gene

Genomics for PROSER2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PROSER2 Gene

Chromosome:
10
Start:
11,823,339 bp from pter
End:
11,872,277 bp from pter
Size:
48,939 bases
Orientation:
Plus strand

Genomic View for PROSER2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PROSER2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PROSER2 Gene

No data available for Regulatory Elements for PROSER2 Gene

Proteins for PROSER2 Gene

  • Protein details for PROSER2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WR7-PRSR2_HUMAN
    Recommended name:
    Proline and serine-rich protein 2
    Protein Accession:
    Q86WR7
    Secondary Accessions:
    • D3DRR8
    • Q5W0J9
    • Q5W0K0
    • Q5W0K1
    • Q5W0K2
    • Q6PJC8
    • Q8N317

    Protein attributes for PROSER2 Gene

    Size:
    435 amino acids
    Molecular mass:
    45802 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PROSER2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PROSER2 Gene

Proteomics data for PROSER2 Gene at MOPED

Post-translational modifications for PROSER2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PROSER2 Gene

No data available for DME Specific Peptides for PROSER2 Gene

Domains & Families for PROSER2 Gene

Protein Domains for PROSER2 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for PROSER2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PROSER2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PROSER2 Gene

Function for PROSER2 Gene

Phenotypes for PROSER2 Gene

genes like me logo Genes that share phenotypes with PROSER2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PROSER2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for PROSER2 Gene

Localization for PROSER2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for PROSER2 Gene

Pathways & Interactions for PROSER2 Gene

SuperPathways for PROSER2 Gene

No Data Available

Interacting Proteins for PROSER2 Gene

Gene Ontology (GO) - Biological Process for PROSER2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PROSER2 Gene

Drugs & Compounds for PROSER2 Gene

No Compound Related Data Available

Transcripts for PROSER2 Gene

Unigene Clusters for PROSER2 Gene

Proline and serine-rich protein 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PROSER2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PROSER2 Gene

No ASD Table

Relevant External Links for PROSER2 Gene

GeneLoc Exon Structure for
PROSER2
ECgene alternative splicing isoforms for
PROSER2

Expression for PROSER2 Gene

mRNA expression in normal human tissues for PROSER2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PROSER2 Gene

This gene is overexpressed in Liver (x7.9).

Protein differential expression in normal tissues from HIPED for PROSER2 Gene

This gene is overexpressed in Urine (35.9) and Peripheral blood mononuclear cells (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PROSER2 Gene



SOURCE GeneReport for Unigene cluster for PROSER2 Gene Hs.435775

genes like me logo Genes that share expression patterns with PROSER2: view

Protein tissue co-expression partners for PROSER2 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PROSER2 Gene

Orthologs for PROSER2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PROSER2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PROSER2 35
  • 70.83 (n)
  • 62.26 (a)
PROSER2 36
  • 57 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PROSER2 35
  • 72.11 (n)
  • 61.54 (a)
PROSER2 36
  • 54 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Proser2 35
  • 69.39 (n)
  • 62 (a)
Proser2 16
Proser2 36
  • 55 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PROSER2 35
  • 97.78 (n)
  • 96.78 (a)
PROSER2 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Proser2 35
  • 67.19 (n)
  • 60 (a)
oppossum
(Monodelphis domestica)
Mammalia PROSER2 36
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PROSER2 36
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1H10ORF47 35
  • 53.62 (n)
  • 46.72 (a)
PROSER2 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PROSER2 36
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100036636 35
  • 49.36 (n)
  • 45.51 (a)
Species with no ortholog for PROSER2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PROSER2 Gene

ENSEMBL:
Gene Tree for PROSER2 (if available)
TreeFam:
Gene Tree for PROSER2 (if available)

Paralogs for PROSER2 Gene

(1) SIMAP similar genes for PROSER2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PROSER2: view

No data available for Paralogs for PROSER2 Gene

Variants for PROSER2 Gene

Sequence variations from dbSNP and Humsavar for PROSER2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs942539 -- 11,837,927(+) GTCTT(C/T)GGACT intron-variant
rs1138983 -- 11,836,963(+) gcgtc(A/G/T)ttctg intron-variant
rs1324645 -- 11,835,438(+) AATTA(C/T)TTTTA intron-variant
rs1324646 -- 11,835,707(+) AAAAA(A/G)CAGGA intron-variant
rs1830845 -- 11,833,087(+) GATCC(A/G)CCCAC intron-variant

Variation tolerance for PROSER2 Gene

Gene Damage Index Score: 5.58; 72.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PROSER2 Gene

HapMap Linkage Disequilibrium report
PROSER2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PROSER2 Gene

Disorders for PROSER2 Gene

Relevant External Links for PROSER2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PROSER2
genes like me logo Genes that share disorders with PROSER2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PROSER2 Gene

Publications for PROSER2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  3. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PMID: 23455922) Varjosalo M. … Superti-Furga G. (Nat. Methods 2013) 67
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 67
  5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 67

Products for PROSER2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate PROSER2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for PROSER2
    • Block miRNA regulation of PROSER2 using miScript Target Protectors

    Sources for PROSER2 Gene

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