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Aliases for PROSER2 Gene

Aliases for PROSER2 Gene

  • Proline And Serine Rich 2 2 3 5
  • Proline And Serine-Rich Protein 2 2 3
  • C10orf47 3 4
  • Chromosome 10 Open Reading Frame 47 2

External Ids for PROSER2 Gene

Previous HGNC Symbols for PROSER2 Gene

  • C10orf47

Summaries for PROSER2 Gene

GeneCards Summary for PROSER2 Gene

PROSER2 (Proline And Serine Rich 2) is a Protein Coding gene.

Additional gene information for PROSER2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PROSER2 Gene

Genomics for PROSER2 Gene

GeneHancer (GH) Regulatory Elements for PROSER2 Gene

Promoters and enhancers for PROSER2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I011822 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 555.8 +0.4 358 1.9 FOXA2 ARNT SIN3A ZNF48 YY1 ZNF121 POLR2B ZNF766 GLIS2 ATF7 PROSER2 GC10P011876
GH10I011824 Enhancer 1 FANTOM5 ENCODE 558.5 +1.6 1637 0.2 HDAC1 ATF1 TCF12 GATA2 ATF7 CREM ZBTB2 NCOA1 REST NFIC PROSER2 GC10P011876
GH10I011897 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 26.8 +75.3 75325 2 HDGF FOXA2 PKNOX1 SMAD1 ARNT YY1 POLR2B ZNF766 E2F8 REST PIR36850 PROSER2 UPF2 RNU6-1095P ENSG00000228302 PROSER2-AS1 GC10P011915
GH10I011879 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 16.2 +59.2 59187 5.5 ELF3 ARID4B DMAP1 ZNF48 RAD21 RARA POLR2B FOS THAP11 MIXL1 PROSER2 PROSER2-AS1 RNU6-1095P GC10P011876 GC10M011887 PIR51291
GH10I011873 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.7 +52.6 52553 4.3 PKNOX1 CLOCK FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 DEK GC10P011876 PROSER2-AS1 RNU6-1095P PROSER2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PROSER2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PROSER2 Gene

Genomic Locations for PROSER2 Gene
chr10:11,823,339-11,872,277
(GRCh38/hg38)
Size:
48,939 bases
Orientation:
Plus strand
chr10:11,865,338-11,914,276
(GRCh37/hg19)

Genomic View for PROSER2 Gene

Genes around PROSER2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PROSER2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PROSER2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PROSER2 Gene

Proteins for PROSER2 Gene

  • Protein details for PROSER2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WR7-PRSR2_HUMAN
    Recommended name:
    Proline and serine-rich protein 2
    Protein Accession:
    Q86WR7
    Secondary Accessions:
    • D3DRR8
    • Q5W0J9
    • Q5W0K0
    • Q5W0K1
    • Q5W0K2
    • Q6PJC8
    • Q8N317

    Protein attributes for PROSER2 Gene

    Size:
    435 amino acids
    Molecular mass:
    45802 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PROSER2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PROSER2 Gene

Post-translational modifications for PROSER2 Gene

No Post-translational modifications

Other Protein References for PROSER2 Gene

No data available for DME Specific Peptides for PROSER2 Gene

Domains & Families for PROSER2 Gene

Gene Families for PROSER2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PROSER2 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for PROSER2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PROSER2: view

No data available for UniProtKB/Swiss-Prot for PROSER2 Gene

Function for PROSER2 Gene

Phenotypes From GWAS Catalog for PROSER2 Gene

Gene Ontology (GO) - Molecular Function for PROSER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with PROSER2: view

Phenotypes for PROSER2 Gene

genes like me logo Genes that share phenotypes with PROSER2: view

Animal Model Products

miRNA for PROSER2 Gene

miRTarBase miRNAs that target PROSER2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PROSER2 Gene

Localization for PROSER2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PROSER2 gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Plasma membrane (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PROSER2 Gene

Pathways & Interactions for PROSER2 Gene

SuperPathways for PROSER2 Gene

No Data Available

Interacting Proteins for PROSER2 Gene

Gene Ontology (GO) - Biological Process for PROSER2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PROSER2 Gene

Drugs & Compounds for PROSER2 Gene

No Compound Related Data Available

Transcripts for PROSER2 Gene

Unigene Clusters for PROSER2 Gene

Proline and serine-rich protein 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PROSER2 Gene

No ASD Table

Relevant External Links for PROSER2 Gene

GeneLoc Exon Structure for
PROSER2
ECgene alternative splicing isoforms for
PROSER2

Expression for PROSER2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PROSER2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PROSER2 Gene

This gene is overexpressed in Liver (x7.9).

Protein differential expression in normal tissues from HIPED for PROSER2 Gene

This gene is overexpressed in Urine (35.9) and Peripheral blood mononuclear cells (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PROSER2 Gene



Protein tissue co-expression partners for PROSER2 Gene

NURSA nuclear receptor signaling pathways regulating expression of PROSER2 Gene:

PROSER2

SOURCE GeneReport for Unigene cluster for PROSER2 Gene:

Hs.435775
genes like me logo Genes that share expression patterns with PROSER2: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PROSER2 Gene

Orthologs for PROSER2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PROSER2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PROSER2 33 34
  • 97.78 (n)
dog
(Canis familiaris)
Mammalia PROSER2 33 34
  • 72.11 (n)
cow
(Bos Taurus)
Mammalia PROSER2 33 34
  • 70.83 (n)
mouse
(Mus musculus)
Mammalia Proser2 33 16 34
  • 69.39 (n)
rat
(Rattus norvegicus)
Mammalia Proser2 33
  • 67.19 (n)
oppossum
(Monodelphis domestica)
Mammalia PROSER2 34
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PROSER2 34
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1H10ORF47 33
  • 53.62 (n)
PROSER2 34
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PROSER2 34
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100036636 33
  • 49.36 (n)
Species where no ortholog for PROSER2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PROSER2 Gene

ENSEMBL:
Gene Tree for PROSER2 (if available)
TreeFam:
Gene Tree for PROSER2 (if available)

Paralogs for PROSER2 Gene

(1) SIMAP similar genes for PROSER2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PROSER2: view

No data available for Paralogs for PROSER2 Gene

Variants for PROSER2 Gene

Sequence variations from dbSNP and Humsavar for PROSER2 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000041200 -- 11,850,182(+) T/C 5_prime_UTR_variant, intron_variant
rs1000092307 -- 11,855,790(+) T/C intron_variant
rs1000148817 -- 11,833,509(+) G/A/T genic_upstream_transcript_variant, intron_variant
rs1000183008 -- 11,832,671(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000186619 -- 11,855,533(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PROSER2 Gene

Variant ID Type Subtype PubMed ID
esv2761572 CNV loss 21179565
esv3448631 CNV insertion 20981092
esv3622345 CNV gain 21293372
esv3622346 CNV gain 21293372
esv3622349 CNV loss 21293372
nsv523851 CNV gain 19592680
nsv825248 CNV loss 20364138

Variation tolerance for PROSER2 Gene

Gene Damage Index Score: 5.58; 72.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PROSER2 Gene

Human Gene Mutation Database (HGMD)
PROSER2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PROSER2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PROSER2 Gene

Disorders for PROSER2 Gene

Additional Disease Information for PROSER2

No disorders were found for PROSER2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PROSER2 Gene

Publications for PROSER2 Gene

  1. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) Kırlı K … Görlich D (eLife 2015) 3 58

Products for PROSER2 Gene

Sources for PROSER2 Gene

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