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Aliases for PROSER1 Gene

Aliases for PROSER1 Gene

  • Proline And Serine Rich 1 2 3 5
  • C13orf23 3 4
  • Chromosome 13 Open Reading Frame 23 2
  • KIAA2032 4

External Ids for PROSER1 Gene

Previous HGNC Symbols for PROSER1 Gene

  • C13orf23

Previous GeneCards Identifiers for PROSER1 Gene

  • GC13M039585

Summaries for PROSER1 Gene

Entrez Gene Summary for PROSER1 Gene

  • This gene encodes a conserved protein containing proline and serine rich regions. These regions may be important in protein-protein interactions. [provided by RefSeq, Aug 2012]

GeneCards Summary for PROSER1 Gene

PROSER1 (Proline And Serine Rich 1) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PROSER1 Gene

Genomics for PROSER1 Gene

Regulatory Elements for PROSER1 Gene

Enhancers for PROSER1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PROSER1 on UCSC Golden Path with GeneCards custom track

Promoters for PROSER1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PROSER1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PROSER1 Gene

Chromosome:
13
Start:
39,009,865 bp from pter
End:
39,038,095 bp from pter
Size:
28,231 bases
Orientation:
Minus strand

Genomic View for PROSER1 Gene

Genes around PROSER1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PROSER1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PROSER1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PROSER1 Gene

Proteins for PROSER1 Gene

  • Protein details for PROSER1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XN7-PRSR1_HUMAN
    Recommended name:
    Proline and serine-rich protein 1
    Protein Accession:
    Q86XN7
    Secondary Accessions:
    • A6NJ97
    • Q6P2S2
    • Q7Z3X5
    • Q8N3D2
    • Q8N3P1
    • Q9H9M1

    Protein attributes for PROSER1 Gene

    Size:
    944 amino acids
    Molecular mass:
    95698 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14204.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC67659.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PROSER1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PROSER1 Gene

Proteomics data for PROSER1 Gene at MOPED

Post-translational modifications for PROSER1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PROSER1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PROSER1 Gene

Domains & Families for PROSER1 Gene

Protein Domains for PROSER1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PROSER1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for PROSER1 Gene

Function for PROSER1 Gene

genes like me logo Genes that share phenotypes with PROSER1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PROSER1 Gene

Localization for PROSER1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PROSER1 Gene COMPARTMENTS Subcellular localization image for PROSER1 gene
Compartment Confidence
cytosol 3
nucleus 3
extracellular 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PROSER1 Gene

Pathways & Interactions for PROSER1 Gene

SuperPathways for PROSER1 Gene

No Data Available

Interacting Proteins for PROSER1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000332034%0d%0a9606.ENSP00000367203%0d%0a9606.ENSP00000405965%0d%0a
Selected Interacting proteins: ENSP00000332034 Q86XN7-PRSR1_HUMAN for PROSER1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for PROSER1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PROSER1 Gene

Drugs & Compounds for PROSER1 Gene

No Compound Related Data Available

Transcripts for PROSER1 Gene

Unigene Clusters for PROSER1 Gene

Proline and serine rich 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PROSER1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b · 14c
SP1: - - -
SP2: -
SP3: - - - - - - - -
SP4: -
SP5: -
SP6:
SP7:

Relevant External Links for PROSER1 Gene

GeneLoc Exon Structure for
PROSER1
ECgene alternative splicing isoforms for
PROSER1

Expression for PROSER1 Gene

mRNA expression in normal human tissues for PROSER1 Gene

Protein differential expression in normal tissues from HIPED for PROSER1 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PROSER1 Gene



SOURCE GeneReport for Unigene cluster for PROSER1 Gene Hs.318526

genes like me logo Genes that share expression patterns with PROSER1: view

Protein tissue co-expression partners for PROSER1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PROSER1 Gene

Orthologs for PROSER1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PROSER1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PROSER1 35
  • 76.25 (n)
  • 78.25 (a)
PROSER1 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PROSER1 35
  • 84.75 (n)
  • 87.21 (a)
PROSER1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Proser1 35
  • 79.22 (n)
  • 81.61 (a)
Proser1 16
Proser1 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PROSER1 35
  • 99.15 (n)
  • 99.05 (a)
PROSER1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Proser1 35
  • 78.03 (n)
  • 80.2 (a)
oppossum
(Monodelphis domestica)
Mammalia PROSER1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PROSER1 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves PROSER1 35
  • 74.69 (n)
  • 74.65 (a)
PROSER1 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PROSER1 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia proser1 35
  • 62.34 (n)
  • 59.84 (a)
zebrafish
(Danio rerio)
Actinopterygii PROSER1 36
  • 48 (a)
OneToOne
Species with no ortholog for PROSER1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PROSER1 Gene

ENSEMBL:
Gene Tree for PROSER1 (if available)
TreeFam:
Gene Tree for PROSER1 (if available)

Paralogs for PROSER1 Gene

(1) SIMAP similar genes for PROSER1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PROSER1: view

No data available for Paralogs for PROSER1 Gene

Variants for PROSER1 Gene

Sequence variations from dbSNP and Humsavar for PROSER1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs3751379 - 39,013,540(-) GTCAG(C/T)GCCAG reference, missense
rs17058955 - 39,012,713(+) AGCGG(A/T)GTTGA reference, missense
rs747752 -- 39,017,069(+) TCTTT(C/T)CTACA intron-variant
rs1043348 -- 39,010,236(-) TTCAA(C/G)ATAGG utr-variant-3-prime
rs1043351 -- 39,010,154(-) ATATG(A/C)CAAAT utr-variant-3-prime

Variation tolerance for PROSER1 Gene

Residual Variation Intolerance Score: 14.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.90; 59.29% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for PROSER1 Gene

Disorders for PROSER1 Gene

Relevant External Links for PROSER1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PROSER1

No disorders were found for PROSER1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PROSER1 Gene

Publications for PROSER1 Gene

  1. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4 67
  2. Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover. (PMID: 24999758) Elzi D.J. … Shiio Y. (J. Proteome Res. 2014) 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. An SNP linkage scan identifies significant Crohn's disease loci on chromosomes 13q13.3 and, in Jewish families, on 1p35.2 and 3q29. (PMID: 18246054) Shugart Y.Y. … Brant S.R. (Genes Immun. 2008) 3
  5. Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination. (PMID: 17761849) Lee M.G. … Shiekhattar R. (Science 2007) 3

Products for PROSER1 Gene

Sources for PROSER1 Gene

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