PROSER1 Gene
protein-coding GIFtS: 40
GCID: GC13M039585
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|
proline and serine rich 1(Previous name: chromosome 13 open reading frame 23 )
(Previous symbol: C13orf23)
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Aliases
for PROSER1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Proline And Serine Rich 11 2 | | Chromosome 13 Open Reading Frame 231 | | C13orf231 2 3 | | Proline And Serine-Rich Protein 12 | | FLJ126611 | | KIAA20323 | | BA50D16.21 | | |
Export aliases for PROSER1 gene to outside databases |
Summaries
for PROSER1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PROSER1:
This gene encodes a conserved protein containing proline and serine rich regions. These regions may be important inprotein-protein interactions. (provided by RefSeq, Aug 2012)
|
Genomic Views
for PROSER1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for PROSER1
Other transcription factors
Search SABiosciences Chromatin IP Primers for PROSER1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PROSER1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q13.3 Ensembl cytogenetic band: 13q13.3 HGNC cytogenetic band: 13q13.2PROSER1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13M039585: view genomic region
(about GC identifiers)
Start:
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39,584,002 bp from pter |
End:
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39,612,252 bp from pter |
Size:
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28,251 bases |
Orientation:
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minus strand |
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Proteins
for PROSER1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PRSR1_HUMAN, Q86XN7 (See
protein sequence)Recommended Name: Proline and serine-rich protein 1 Size: 944 amino acids; 95698 Da
Sequence caution: Sequence=BAB14204.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAC67659.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q6P2S2 Q7Z3X5 Q8N3D2 Q8N3P1 Q9H9M1Explore the universe of human proteins at neXtProt for PROSER1: NX_Q86XN7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86XN7
PROSER1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079414.3
ENSEMBL proteins: ENSP00000332034 ENSP00000405486 ENSP00000413879 ENSP00000339123
Human Recombinant Protein Products:
PROSER1 Antibody Products:
Assay Products for PROSER1: |
Protein
Domains /
Families
for PROSER1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q86XN7 |
Function
for PROSER1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PROSER1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PROSER1 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for PROSER1 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PROSER1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PROSER1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PROSER1 |
2 GenomeRNAi human phenotypes for PROSER1:
|
Pathways & Interactions
for PROSER1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PROSER1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for PROSER1 (Q86XN73 ENSP000003320344) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for PROSER1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PROSER1
Search CenterWatch for drugs/clinical trials and news about PROSER1 / PRSR1
|
Transcripts
for PROSER1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PROSER1 gene (2 alternative transcripts): NM_025138.4 NM_170719.2 Unigene Cluster for PROSER1: Proline and serine rich 1 Hs.318526 [show with all ESTs]Unigene Representative Sequence: NM_0251388 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000484434 ENST00000352251(uc001uwy.3) ENST00000468017 ENST00000492646
ENST00000496138 ENST00000436678 ENST00000418503 ENST00000350125(uc001uwz.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PROSER1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PROSER1 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for PROSER1 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PROSER1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PROSER1 |
Additional cDNA sequence: AB107354.1 AK022723.1 AK024308.1 AK074360.1 AK299663.1 AL833854.1 AL834435.1 BC042652.1 BC053566.1 BC064348.1 BX647471.1 12 DOTS entries: DT.211400 DT.99965250 DT.100787308 DT.95276943 DT.120786380 DT.86844661 DT.91689611 DT.120786350 DT.40119334 DT.91658711 DT.95108274 DT.95281725 24/165 AceView cDNA sequences (see all 165): AW675540 BE328626 BM976888 AI984566 BE302169 BQ021553 AW576266 NM_170719 AU125781 BI086923 BU621745 BC064348 CR592489 BM455996 AI823496 AA421343 BU193208 BG284881 CB132846 BE939604 BX333115 N29486 BX647471 BU633113
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for PROSER1 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | - | | - | | - | | - | | | | | | | | | | |
| SP4: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for PROSER1
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Expression
for PROSER1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PROSER1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGGAAGTAG
About this image
See PROSER1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PROSER1
SOURCE GeneReport for Unigene cluster: Hs.318526
SABiosciences Custom PCR Arrays for PROSER1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PROSER1
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat PROSER1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PROSER1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PROSER1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PROSER1 |
Orthologs
for PROSER1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PROSER1 gene from 5/12 species (see all 12) About this table
ENSEMBL Gene Tree for PROSER1 (if available)
TreeFam Gene Tree for PROSER1 (if available) |
Paralogs
for PROSER1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for PROSER1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PROSER1 (39584002 - 39612252 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PROSER1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PROSER1 |
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Disorders
/ Diseases
for PROSER1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PROSER1 for disorders About GeneDecksing
1  disease for PROSER1: About MalaCardscrohn's disease
Export disorders for PROSER1 gene to outside databases
|
Publications
for PROSER1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PROSER1 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with PROSER1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (2009)
- An SNP linkage scan identifies significant Crohn's disease loci on chromosomes 13q13.3 and, in Jewish families, on 1p35.2 and 3q29. (PubMed id 18246054)1 Shugart Y.Y....Brant S.R. (2008)
- Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination. (PubMed id 17761849)1 Lee M.G.... Shiekhattar R. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for PROSER1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing PROSER1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PROSER1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing PROSER1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PROSER1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for PROSER1 gene:
Search GeneIP for patents involving PROSER1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PROSER1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PROSER1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PROSER1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PROSER1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PROSER1 | | OriGene 3'-UTR Clone for PROSER1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PROSER1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PROSER1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PROSER1 | | OriGene Custom Protein Services for PROSER1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PROSER1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PROSER1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PROSER1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PROSER1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PROSER1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PROSER1 |
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 |  |  |  | |
| | | | Search Tocris compounds for PROSER1 |
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 | | | PROSER1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PROSER1 |
|  |  |  | | | | Search ThermoFisher Antibodies for PROSER1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PROSER1 |
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