Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PROSER1 Gene

Aliases for PROSER1 Gene

  • Proline And Serine Rich 1 2 3 5
  • C13orf23 3 4
  • Chromosome 13 Open Reading Frame 23 2
  • Proline And Serine-Rich Protein 1 3
  • KIAA2032 4

External Ids for PROSER1 Gene

Previous HGNC Symbols for PROSER1 Gene

  • C13orf23

Previous GeneCards Identifiers for PROSER1 Gene

  • GC13M039585

Summaries for PROSER1 Gene

Entrez Gene Summary for PROSER1 Gene

  • This gene encodes a conserved protein containing proline and serine rich regions. These regions may be important in protein-protein interactions. [provided by RefSeq, Aug 2012]

GeneCards Summary for PROSER1 Gene

PROSER1 (Proline And Serine Rich 1) is a Protein Coding gene.

Additional gene information for PROSER1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PROSER1 Gene

Genomics for PROSER1 Gene

Regulatory Elements for PROSER1 Gene

Enhancers for PROSER1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13H039035 1.1 ENCODE 22.7 -0.3 -279 5 HDGF PKNOX1 FOXA2 ARNT SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 PROSER1 NHLRC3 LHFPL6 STOML3 LOC105370169
GH13H038979 0.6 ENCODE 10.5 +57.5 57487 2 MXI1 HLF REST CEBPG ZNF589 POLR2A ZNF547 RCOR1 ZNF584 EZH2 NHLRC3 PROSER1 STOML3 LHFPL6 GC13P038946
GH13H039556 0.4 ENCODE 10.4 -518.9 -518925 1 ZNF707 PROSER1 GC13M039419 LHFPL6
GH13H039034 0.5 Ensembl 0.7 +3.8 3795 0 PKNOX1 PRDM6 ZNF600 PROSER1 GC13M038977
GH13H039022 0.7 ENCODE 0.4 +13.4 13441 4 SIN3A CEBPG CTBP1 GATA3 POLR2A RCOR1 SMARCE1 CEBPB MNT DPF2 STOML3 LHFPL6 PROSER1 GC13M038977
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PROSER1 on UCSC Golden Path with GeneCards custom track

Promoters for PROSER1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000061476 395 4201 HDGF PKNOX1 FOXA2 ARNT SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207

Genomic Location for PROSER1 Gene

Chromosome:
13
Start:
39,009,865 bp from pter
End:
39,038,095 bp from pter
Size:
28,231 bases
Orientation:
Minus strand

Genomic View for PROSER1 Gene

Genes around PROSER1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PROSER1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PROSER1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PROSER1 Gene

Proteins for PROSER1 Gene

  • Protein details for PROSER1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XN7-PRSR1_HUMAN
    Recommended name:
    Proline and serine-rich protein 1
    Protein Accession:
    Q86XN7
    Secondary Accessions:
    • A6NJ97
    • Q6P2S2
    • Q7Z3X5
    • Q8N3D2
    • Q8N3P1
    • Q9H9M1

    Protein attributes for PROSER1 Gene

    Size:
    944 amino acids
    Molecular mass:
    95698 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14204.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC67659.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PROSER1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PROSER1 Gene

Post-translational modifications for PROSER1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PROSER1 Gene

No data available for DME Specific Peptides for PROSER1 Gene

Domains & Families for PROSER1 Gene

Gene Families for PROSER1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PROSER1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PROSER1: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for PROSER1 Gene

Function for PROSER1 Gene

genes like me logo Genes that share phenotypes with PROSER1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PROSER1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PROSER1 Gene

Localization for PROSER1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PROSER1 gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 1
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PROSER1 Gene

Pathways & Interactions for PROSER1 Gene

SuperPathways for PROSER1 Gene

No Data Available

Interacting Proteins for PROSER1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000332034%0d%0a9606.ENSP00000367203%0d%0a
Selected Interacting proteins: Q86XN7-PRSR1_HUMAN ENSP00000332034 for PROSER1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for PROSER1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PROSER1 Gene

Drugs & Compounds for PROSER1 Gene

No Compound Related Data Available

Transcripts for PROSER1 Gene

Unigene Clusters for PROSER1 Gene

Proline and serine rich 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PROSER1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PROSER1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b · 14c
SP1: - - -
SP2: -
SP3: - - - - - - - -
SP4: -
SP5: -
SP6:
SP7:

Relevant External Links for PROSER1 Gene

GeneLoc Exon Structure for
PROSER1
ECgene alternative splicing isoforms for
PROSER1

Expression for PROSER1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PROSER1 Gene

Protein differential expression in normal tissues from HIPED for PROSER1 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PROSER1 Gene



Protein tissue co-expression partners for PROSER1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PROSER1 Gene:

PROSER1

SOURCE GeneReport for Unigene cluster for PROSER1 Gene:

Hs.318526

Evidence on tissue expression from TISSUES for PROSER1 Gene

  • Nervous system(2)
genes like me logo Genes that share expression patterns with PROSER1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PROSER1 Gene

Orthologs for PROSER1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PROSER1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PROSER1 33 34
  • 99.15 (n)
dog
(Canis familiaris)
Mammalia PROSER1 33 34
  • 84.75 (n)
mouse
(Mus musculus)
Mammalia Proser1 33 16 34
  • 79.22 (n)
oppossum
(Monodelphis domestica)
Mammalia PROSER1 34
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Proser1 33
  • 78.03 (n)
cow
(Bos Taurus)
Mammalia PROSER1 33 34
  • 76.25 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PROSER1 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves PROSER1 33 34
  • 74.69 (n)
lizard
(Anolis carolinensis)
Reptilia PROSER1 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia proser1 33
  • 62.34 (n)
zebrafish
(Danio rerio)
Actinopterygii PROSER1 34
  • 48 (a)
OneToOne
Species where no ortholog for PROSER1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PROSER1 Gene

ENSEMBL:
Gene Tree for PROSER1 (if available)
TreeFam:
Gene Tree for PROSER1 (if available)

Paralogs for PROSER1 Gene

(1) SIMAP similar genes for PROSER1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PROSER1: view

No data available for Paralogs for PROSER1 Gene

Variants for PROSER1 Gene

Sequence variations from dbSNP and Humsavar for PROSER1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000196293 -- 39,019,378(+) CCAGG(C/T)ATGGT intron-variant
rs1000290460 -- 39,028,182(+) TATTC(A/G)GAAAA intron-variant
rs1000306303 -- 39,034,393(+) AGGGA(C/G)ACACT intron-variant
rs1000369874 -- 39,033,671(+) TTACA(A/G)AAACT intron-variant
rs1000530719 -- 39,018,048(+) GAATT(C/T)GCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PROSER1 Gene

Variant ID Type Subtype PubMed ID
nsv977227 CNV duplication 23825009

Variation tolerance for PROSER1 Gene

Residual Variation Intolerance Score: 14.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.90; 59.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PROSER1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PROSER1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PROSER1 Gene

Disorders for PROSER1 Gene

Relevant External Links for PROSER1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PROSER1

No disorders were found for PROSER1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PROSER1 Gene

Publications for PROSER1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover. (PMID: 24999758) Elzi DJ … Shiio Y (Journal of proteome research 2014) 3 60

Products for PROSER1 Gene

Sources for PROSER1 Gene

Content
Loading form....