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Aliases for PROSC Gene

Aliases for PROSC Gene

  • Proline Synthetase Co-Transcribed Homolog (Bacterial) 2 3 5
  • Proline Synthetase Co-Transcribed (Bacterial Homolog) 2

External Ids for PROSC Gene

Previous GeneCards Identifiers for PROSC Gene

  • GC08U990081
  • GC08P037475
  • GC08P037677
  • GC08P037676
  • GC08P037738
  • GC08P036154
  • GC08P037620

Summaries for PROSC Gene

GeneCards Summary for PROSC Gene

PROSC (Proline Synthetase Co-Transcribed Homolog (Bacterial)) is a Protein Coding gene. GO annotations related to this gene include pyridoxal phosphate binding.

Gene Wiki entry for PROSC Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PROSC Gene

Genomics for PROSC Gene

Regulatory Elements for PROSC Gene

Enhancers for PROSC Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PROSC on UCSC Golden Path with GeneCards custom track

Promoters for PROSC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PROSC on UCSC Golden Path with GeneCards custom track

Genomic Location for PROSC Gene

Chromosome:
8
Start:
37,762,583 bp from pter
End:
37,779,768 bp from pter
Size:
17,186 bases
Orientation:
Plus strand

Genomic View for PROSC Gene

Genes around PROSC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PROSC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PROSC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PROSC Gene

Proteins for PROSC Gene

  • Protein details for PROSC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94903-PROSC_HUMAN
    Recommended name:
    Proline synthase co-transcribed bacterial homolog protein
    Protein Accession:
    O94903
    Secondary Accessions:
    • Q6FI94

    Protein attributes for PROSC Gene

    Size:
    275 amino acids
    Molecular mass:
    30344 Da
    Cofactor:
    Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    No Data Available

neXtProt entry for PROSC Gene

Proteomics data for PROSC Gene at MOPED

Post-translational modifications for PROSC Gene

  • Ubiquitination at Lys 47 and Lys 76
  • Modification sites at PhosphoSitePlus

Other Protein References for PROSC Gene

No data available for DME Specific Peptides for PROSC Gene

Domains & Families for PROSC Gene

Graphical View of Domain Structure for InterPro Entry

O94903

UniProtKB/Swiss-Prot:

PROSC_HUMAN :
  • Belongs to the UPF0001 family.
Family:
  • Belongs to the UPF0001 family.
genes like me logo Genes that share domains with PROSC: view

No data available for Gene Families for PROSC Gene

Function for PROSC Gene

Molecular function for PROSC Gene

GENATLAS Biochemistry:
proline synthetase co-transcribed,bacterial homolog,ubiquitously expressed
genes like me logo Genes that share phenotypes with PROSC: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PROSC Gene

Localization for PROSC Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PROSC Gene COMPARTMENTS Subcellular localization image for PROSC gene
Compartment Confidence
extracellular 5
cytosol 4
mitochondrion 3
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PROSC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 10496079
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PROSC: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PROSC Gene

Pathways & Interactions for PROSC Gene

SuperPathways for PROSC Gene

No Data Available

Gene Ontology (GO) - Biological Process for PROSC Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PROSC Gene

Drugs & Compounds for PROSC Gene

(2) Drugs for PROSC Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Proline Approved Nutra Target 0
Pyridoxal Phosphate Nutra Target, cofactor 14
genes like me logo Genes that share compounds with PROSC: view

Transcripts for PROSC Gene

Unigene Clusters for PROSC Gene

Proline synthetase co-transcribed homolog (bacterial):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PROSC Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: -
SP2:
SP3:

Relevant External Links for PROSC Gene

GeneLoc Exon Structure for
PROSC
ECgene alternative splicing isoforms for
PROSC

Expression for PROSC Gene

mRNA expression in normal human tissues for PROSC Gene

Protein differential expression in normal tissues from HIPED for PROSC Gene

This gene is overexpressed in Lymph node (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PROSC Gene



SOURCE GeneReport for Unigene cluster for PROSC Gene Hs.304792

mRNA Expression by UniProt/SwissProt for PROSC Gene

O94903-PROSC_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with PROSC: view

Protein tissue co-expression partners for PROSC Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PROSC Gene

Orthologs for PROSC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PROSC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PROSC 35
  • 86.57 (n)
  • 89.01 (a)
PROSC 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PROSC 35
  • 89.94 (n)
  • 89.82 (a)
-- 36
  • 86 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Prosc 35
  • 84.55 (n)
  • 86.86 (a)
Prosc 16
Prosc 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PROSC 35
  • 99.39 (n)
  • 99.27 (a)
PROSC 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prosc 35
  • 83.88 (n)
  • 84.62 (a)
oppossum
(Monodelphis domestica)
Mammalia PROSC 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PROSC 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves PROSC 35
  • 74.66 (n)
  • 76.75 (a)
PROSC 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PROSC 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prosc 35
  • 67.81 (n)
  • 71.48 (a)
Str.18617 35
zebrafish
(Danio rerio)
Actinopterygii prosc 35
  • 67.71 (n)
  • 70.31 (a)
prosc 36
  • 64 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3436 35
fruit fly
(Drosophila melanogaster)
Insecta CG1983 37
  • 50 (a)
CG1983 35
  • 56.34 (n)
  • 51.24 (a)
CG1983 36
  • 49 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001621 35
  • 55.33 (n)
  • 47.77 (a)
worm
(Caenorhabditis elegans)
Secernentea F09E5.8 37
  • 46 (a)
F09E5.8 35
  • 53.08 (n)
  • 48.34 (a)
F09E5.8 36
  • 41 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL301C 35
  • 47.17 (n)
  • 42.86 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B12265g 35
  • 47.92 (n)
  • 43.75 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YBL036C 35
  • 50.51 (n)
  • 47.98 (a)
-- 36
  • 38 (a)
OneToOne
-- 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G11930 35
  • 56.93 (n)
  • 55.75 (a)
rice
(Oryza sativa)
Liliopsida Os05g0150000 35
  • 57.65 (n)
  • 54.59 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03579 35
  • 49.92 (n)
  • 45.7 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC644.09 35
  • 51.56 (n)
  • 48.28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToOne
Species with no ortholog for PROSC:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PROSC Gene

ENSEMBL:
Gene Tree for PROSC (if available)
TreeFam:
Gene Tree for PROSC (if available)

Paralogs for PROSC Gene

No data available for Paralogs for PROSC Gene

Variants for PROSC Gene

Sequence variations from dbSNP and Humsavar for PROSC Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs35423325 - 37,762,729(-) CTGCA(C/T)GCGCT reference, missense
rs10089505 -- 37,766,213(+) GTGCA(C/T)GAGGC intron-variant
rs3819034 -- 37,762,457(-) GGAGC(C/T)TAGGG upstream-variant-2KB
rs3935246 -- 37,774,262(+) AATAT(C/T)TTTAT intron-variant
rs11546424 -- 37,762,723(+) TGAAC(A/G)AGCGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PROSC Gene

Variant ID Type Subtype PubMed ID
nsv509261 CNV Insertion 20534489

Variation tolerance for PROSC Gene

Residual Variation Intolerance Score: 40.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.75; 33.15% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PROSC Gene

Disorders for PROSC Gene

Relevant External Links for PROSC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PROSC

No disorders were found for PROSC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PROSC Gene

Publications for PROSC Gene

  1. Cloning and characterization of human and mouse PROSC (proline synthetase co-transcribed) genes. (PMID: 10496079) Ikegawa S. … Nakamura Y. (J. Hum. Genet. 1999) 3 4 23 67
  2. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  3. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for PROSC Gene

Sources for PROSC Gene

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