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Aliases for PROSC Gene

Aliases for PROSC Gene

  • Proline Synthetase Cotranscribed Homolog (Bacterial) 2 3 5
  • Proline Synthetase Co-Transcribed (Bacterial Homolog) 2

External Ids for PROSC Gene

Previous GeneCards Identifiers for PROSC Gene

  • GC08U990081
  • GC08P037475
  • GC08P037677
  • GC08P037676
  • GC08P037738
  • GC08P036154
  • GC08P037620

Summaries for PROSC Gene

GeneCards Summary for PROSC Gene

PROSC (Proline Synthetase Cotranscribed Homolog (Bacterial)) is a Protein Coding gene. GO annotations related to this gene include pyridoxal phosphate binding.

Gene Wiki entry for PROSC Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PROSC Gene

Genomics for PROSC Gene

Regulatory Elements for PROSC Gene

Enhancers for PROSC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F037915 1.5 FANTOM5 Ensembl ENCODE 10.3 +153.5 153515 1.8 HDAC1 KLF17 ARID4B ZNF2 RAD21 ZNF366 ZNF143 CREM ZNF263 ZNF362 GOT1L1 PROSC RNU6-323P RN7SL709P PIR49654
GH08F037869 1.2 Ensembl ENCODE 11 +110.2 110168 6.1 HDGF PKNOX1 KLF17 SIN3A FEZF1 BMI1 ZNF335 ZNF366 SCRT2 ETV6 RAB11FIP1 ADGRA2 EIF4EBP1 GOT1L1 PROSC ENSG00000280064
GH08F037796 1.3 FANTOM5 ENCODE 8 +38.2 38196 9.3 PKNOX1 ATF1 ZNF133 SIN3A ZNF2 ZNF143 ZNF263 REST TSHZ1 SMARCA4 GOT1L1 RAB11FIP1 PROSC ADGRA2 GC08M037706 GC08P037815
GH08F037720 0.6 ENCODE 10.3 -41.6 -41639 0.7 ZNF664 TEAD4 NFE2 NR3C1 MAFK ZNF703 ENSG00000253344 PROSC LOC105379379 ENSG00000253414 LOC101929622 ERLIN2
GH08F037761 1.1 ENCODE 5.4 +0.3 340 2.1 PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ENSG00000255201 BRF2 LOC100507403 ADGRA2 LOC102723701 ERLIN2 ENSG00000254290 RAB11FIP1 PROSC
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PROSC on UCSC Golden Path with GeneCards custom track

Promoters for PROSC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001389949 217 2001 PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for PROSC Gene

Chromosome:
8
Start:
37,762,583 bp from pter
End:
37,779,768 bp from pter
Size:
17,186 bases
Orientation:
Plus strand

Genomic View for PROSC Gene

Genes around PROSC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PROSC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PROSC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PROSC Gene

Proteins for PROSC Gene

  • Protein details for PROSC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94903-PROSC_HUMAN
    Recommended name:
    Proline synthase co-transcribed bacterial homolog protein
    Protein Accession:
    O94903
    Secondary Accessions:
    • Q6FI94

    Protein attributes for PROSC Gene

    Size:
    275 amino acids
    Molecular mass:
    30344 Da
    Cofactor:
    Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    No Data Available

neXtProt entry for PROSC Gene

Post-translational modifications for PROSC Gene

  • Ubiquitination at Lys 47 and Lys 76
  • Modification sites at PhosphoSitePlus

Other Protein References for PROSC Gene

No data available for DME Specific Peptides for PROSC Gene

Domains & Families for PROSC Gene

Graphical View of Domain Structure for InterPro Entry

O94903

UniProtKB/Swiss-Prot:

PROSC_HUMAN :
  • Belongs to the UPF0001 family.
Family:
  • Belongs to the UPF0001 family.
genes like me logo Genes that share domains with PROSC: view

No data available for Gene Families for PROSC Gene

Function for PROSC Gene

Molecular function for PROSC Gene

GENATLAS Biochemistry:
proline synthetase co-transcribed,bacterial homolog,ubiquitously expressed

Gene Ontology (GO) - Molecular Function for PROSC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030170 pyridoxal phosphate binding IBA --
genes like me logo Genes that share ontologies with PROSC: view
genes like me logo Genes that share phenotypes with PROSC: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PROSC Gene

Localization for PROSC Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PROSC gene
Compartment Confidence
extracellular 5
cytosol 4
mitochondrion 3
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PROSC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005737 cytoplasm NAS 10496079
GO:0005739 mitochondrion IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PROSC: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PROSC Gene

Pathways & Interactions for PROSC Gene

SuperPathways for PROSC Gene

No Data Available

Gene Ontology (GO) - Biological Process for PROSC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with PROSC: view

No data available for Pathways by source and SIGNOR curated interactions for PROSC Gene

Drugs & Compounds for PROSC Gene

(2) Drugs for PROSC Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Proline Approved Nutra Target 0
Pyridoxal Phosphate Nutra Target, cofactor 14
genes like me logo Genes that share compounds with PROSC: view

Transcripts for PROSC Gene

Unigene Clusters for PROSC Gene

Proline synthetase co-transcribed homolog (bacterial):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PROSC Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: -
SP2:
SP3:

Relevant External Links for PROSC Gene

GeneLoc Exon Structure for
PROSC
ECgene alternative splicing isoforms for
PROSC

Expression for PROSC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PROSC Gene

Protein differential expression in normal tissues from HIPED for PROSC Gene

This gene is overexpressed in Lymph node (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PROSC Gene



Protein tissue co-expression partners for PROSC Gene

NURSA nuclear receptor signaling pathways regulating expression of PROSC Gene:

PROSC

SOURCE GeneReport for Unigene cluster for PROSC Gene:

Hs.304792

mRNA Expression by UniProt/SwissProt for PROSC Gene:

O94903-PROSC_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with PROSC: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PROSC Gene

Orthologs for PROSC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PROSC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PROSC 34 35
  • 99.39 (n)
dog
(Canis familiaris)
Mammalia PROSC 34
  • 89.94 (n)
-- 35
  • 86 (a)
OneToMany
-- 35
  • 81 (a)
OneToMany
cow
(Bos Taurus)
Mammalia PROSC 34 35
  • 86.57 (n)
mouse
(Mus musculus)
Mammalia Prosc 34 16 35
  • 84.55 (n)
rat
(Rattus norvegicus)
Mammalia Prosc 34
  • 83.88 (n)
oppossum
(Monodelphis domestica)
Mammalia PROSC 35
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PROSC 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves PROSC 34 35
  • 74.66 (n)
lizard
(Anolis carolinensis)
Reptilia PROSC 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prosc 34
  • 67.81 (n)
Str.18617 34
zebrafish
(Danio rerio)
Actinopterygii prosc 34 35
  • 67.71 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3436 34
fruit fly
(Drosophila melanogaster)
Insecta CG1983 36 34 35
  • 56.34 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001621 34
  • 55.33 (n)
worm
(Caenorhabditis elegans)
Secernentea F09E5.8 36 34 35
  • 53.08 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YBL036C 34
  • 50.51 (n)
-- 35
  • 38 (a)
OneToOne
-- 37
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B12265g 34
  • 47.92 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL301C 34
  • 47.17 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G11930 34
  • 56.93 (n)
rice
(Oryza sativa)
Liliopsida Os05g0150000 34
  • 57.65 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC644.09 34
  • 51.56 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03579 34
  • 49.92 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
OneToOne
Species where no ortholog for PROSC was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PROSC Gene

ENSEMBL:
Gene Tree for PROSC (if available)
TreeFam:
Gene Tree for PROSC (if available)

Paralogs for PROSC Gene

No data available for Paralogs for PROSC Gene

Variants for PROSC Gene

Sequence variations from dbSNP and Humsavar for PROSC Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10089505 -- 37,766,213(+) GTGCA(C/T)GAGGC intron-variant
rs1056017 -- 37,767,417(+) TTTTT(C/T)AGAGT intron-variant, utr-variant-3-prime
rs111267034 -- 37,772,133(+) TTAAC(-/AA)GAGGA intron-variant
rs111392951 -- 37,775,120(+) AGAAT(C/G)CAACT intron-variant
rs111428457 -- 37,764,939(+) GCCGA(A/G)GTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PROSC Gene

Variant ID Type Subtype PubMed ID
nsv509261 CNV insertion 20534489

Variation tolerance for PROSC Gene

Residual Variation Intolerance Score: 40.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.75; 33.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PROSC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PROSC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PROSC Gene

Disorders for PROSC Gene

Relevant External Links for PROSC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PROSC

No disorders were found for PROSC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PROSC Gene

Publications for PROSC Gene

  1. Cloning and characterization of human and mouse PROSC (proline synthetase co-transcribed) genes. (PMID: 10496079) Ikegawa S. … Nakamura Y. (J. Hum. Genet. 1999) 3 4 22 64
  2. Mutations in PROSC Disrupt Cellular Pyridoxal Phosphate Homeostasis and Cause Vitamin-B6-Dependent Epilepsy. (PMID: 27912044) Darin N. … Clayton P.T. (Am. J. Hum. Genet. 2016) 2 3 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64
  5. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd B.J. … Pagliarini D.J. (Mol. Cell 2016) 3 64

Products for PROSC Gene

Sources for PROSC Gene

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