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PROS1 Gene

protein-coding   GIFtS: 62

GC03M095074
protein S (alpha)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PROS)
Services    

Aliases &
Descriptions
for PROS1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
PROS 2, 3
PS21 2
PS22 2
PS23 2
PS24 2
PS25 2
PSA 2
Descriptions
protein S (alpha) 2
protein S, alpha 2
protein Sa 2
vitamin K-dependent plasma protein S 2
External Ids
HGNC: 94561
Entrez Gene: 56272
UniProtKB: P072253
Ensembl: ENSG000001845007
Search outside databases for aliases for PROS1 gene

Previous GC identifers: GC03P090396 GC03M092806 GC03M090130 GC03M094912

Summaries
for PROS1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for PROS1:
This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the
anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in
plasma in both a free, functionally active form and also in an inactive form complexed with
C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia.
An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. [provided
by RefSeq]

UniProtKB/Swiss-Prot: PROS_HUMAN, P07225
Function: Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation
of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis

Gene Wiki entry for PROS1 (Protein_S)

Genomic Location
for PROS1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the PROS1 gene  

Entrez Gene cytogenetic band: 3q11.2   Ensembl cytogenetic band:  3q11.2   HGNC cytogenetic band: 3p11-q11.2

PROS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M095074:     (about GC identifiers)

Start:
 95,074,643 bp from pter
End:
 95,175,416 bp from pter
Size:
 100,774 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000003.10  NT_005612.15  

Proteins
for PROS1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: PROS_HUMAN, P07225 (See protein sequence)
Recommended Name: Vitamin K-dependent protein S precursor  
Size: 676 amino acids; 75123 Da
Subcellular location: Secreted
Sequence caution: Sequence=AAP45054.1; Type=Erroneous gene model prediction;
PDB structures from and Proteopedia :
1Z6C (3D)    
Secondary accessions: A8KAC9 Q15518 Q7Z715 Q9UCZ8

Post-translational modifications:

  • The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R)
    stereospecific within EGF domains (By similarity)1


    • REFSEQ proteins: NP_000304.2  

    ENSEMBL proteins: 
    ENSP00000330021 ENSP00000377783 ENSP00000385794 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Protein S)
    Human Recombinant Proteins from Abnova (PROS1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region NAS14718574
    GO:0005634 nucleus IDA18029348
    GO:0005737 cytoplasm IDA18029348
    About this table

    Antibodies for PROS1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibody Arrays and Antibodies for PROS1
    R&D Systems Antibodies for PROS1 (Protein S/PROS1)
    Antibodies from Abcam (Protein S), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (PROS1)
    Novus Biologicals Antibodies for PROS1

    Assays for PROS1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for PROS1

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/15 InterPro domains/families (see all 15 ):
     IPR000294 GLA_domain
     IPR017857 Coagulation_fac_subset_Gla
     IPR001881 EGF_Ca_bd
     IPR000742 EGF_3
     IPR013320 ConA-like_subgrp


       GeneDecks  PROS1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P07225

    ProtoNet protein and cluster: P07225

    5/7 Blocks protein families (see all 7 ):
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
    IPB001791 Laminin G
    IPB001881 EGF-like calcium-binding
    IPB002383 Coagulation factor GLA domain signature


    UniProtKB/Swiss-Prot: PROS_HUMAN, P07225
    Similarity: Contains 4 EGF-like domains
    Similarity: Contains 1 Gla (gamma-carboxy-glutamate) domain
    Similarity: Contains 2 laminin G-like domains

    Gene Function
    for PROS1

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (PROS1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (PROS1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000313

                  Applied Biosystems Silencer® siRNAs for PROS1

                  Sigma-Aldrich siRNA and siRNA Panels for PROS1  
                         Sigma-Aldrich shRNA for PROS1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for PROS1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_000313
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_000313
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_000313 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_000313

    UniProtKB/Swiss-Prot: PROS_HUMAN, P07225
    Function: Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation
    of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis

    Genatlas biochemistry entry for PROS1:
    protein S,alpha coagulation factor (cofactor of proC),vitamin K-dependent,ligand for TYRO3,AXL
    family of receptor tyrosine kinase

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004866 endopeptidase inhibitor activity TAS8146182
    GO:0005509 calcium ion binding IEA--
    About this table

    Pathways & Interactions
    for PROS1

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  PROS1  (Your Favorite Gene powered by Ingenuity) 
     Coagulation System

       GeneDecks  PROS1 for the pathways selected above  
    About GeneDecksing

    1 Kegg Pathway  (Kegg details for PROS1):
     hsa04610 Complement and coagulation cascades

       GeneDecks  PROS1 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  PROS1 


    5/52 Interacting proteins for PROS1 (ENSP000003300213) via UniProtKB, MINT, and/or STRING (see all 52 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SERPINC1ENSP000003566713STRING (score=.993)
    AXLENSP000003011783STRING (score=.992)
    MERTKENSP000002954083STRING (score=.992)
    C4BPBENSP000003560453STRING (score=.987)
    F8ENSP000003278953STRING (score=.986)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007596 blood coagulation TAS9657428
    About this table

    Drugs & Compounds
    for PROS1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for PROS1
    10/11 Novoseek chemical compound relationships for PROS1 gene (see all 11 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    gamma-carboxyglutamic acid 64.47 1 10200912 (1)
    streptavidin 23.23 3 11114110 (2)
    phospholipid 9.53 2 12193728 (1), 12871288 (1)
    vitamin-e 6.43 5 15774238 (3), 16614418 (1)
    cholesterol 4.06 7 14628495 (1), 2115854 (1)
    glucose 3.10 3 14628495 (1), 2106424 (1)
    estradiol 0.00 3 15963793 (1), 9655259 (1), 14628495 (1)
    hydrogen 0.00 3 17398049 (1), 16735174 (1)
    steroid 0.00 1 10200912 (1)
    calcium 0.00 3 2144524 (1), 10543957 (1), 11123899 (1)
    About this table


    Transcripts
    for PROS1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (PROS1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (PROS1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000313

                  Sigma-Aldrich siRNA and siRNA Panels for PROS1  
                         Sigma-Aldrich shRNA for PROS1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_000313  

    REFSEQ mRNAs for PROS1 gene: 

    NM_000313.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_000313  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_000313
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_000313
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_000313 

    Additional cDNA sequence: 

    AK292994.1 AK303895.1 BC015801.1 M14338.1 M15036.1 X12892.1 Y00692.1 

    7 DOTS entries:

    DT.92431429  DT.40293243  DT.97843414  DT.92431430  DT.120867618  DT.120867637  DT.95072512 

    24/174 AceView cDNA sequences (see all 174 ):

    AI140233 AW614607 AI056481 AA424875 BU633685 AW772518 H84032 CA390534 
    BQ004370 AA369126 BU620982 AI088493 N36607 H84031 H79684 BM473027 
    BU740972 AW772072 CB130160 CA502740 AA009723 CA392161 BM678370 AW950240 

    highest scoring ESTs for PROS1:

    M15036 BC015801 BE885958 BG703700 BG704855 BI762925 BM354095 BQ945724 AA009419 AA009723 

    Unigene Cluster for PROS1:

    Protein S (alpha)
    Hs.64016  [show with all ESTs]
    Unigene Representative Sequence: NM_000313


    GeneLoc Exon Structure

    3 Ensembl transcripts including schematic representations:
    ENST00000348974  ENST00000394236  ENST00000407433  

    Expression
    for PROS1

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    PROS1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for PROS1

    1 / 2 / 3

    3 probe-sets matching PROS1 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    35752_s_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 M15036 1.00 1.00 1.00 1

    		207808_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_000313 0.60 1.00 0.82 1

    		207808_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  PROS1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: AACTAGTGTC

    SOURCE GeneReport for Unigene cluster: Hs.64016

    Expression variation in blood from EXPOLDB for PROS1

    UniProtKB/Swiss-Prot: PROS_HUMAN, P07225
    Tissue specificity: Plasma

    Orthologs
    for PROS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for PROS1 gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 PROS11   -- protein S (alpha) 82.25(n)
    79.29(a)    		 478529  XM_535708.2  XP_535708.2 
    chimpanzee
    (Pan troglodytes)    		 PROS11   -- protein S (alpha) 99.51(n)
    99.11(a)    		 460533  XM_516603.2  XP_516603.2 
    cow
    (Bos taurus)    		 PROS11   -- protein S (alpha) 87.46(n)
    81.78(a)    		 282006  NM_174438.1  NP_776863.1 
    rat
    (Rattus norvegicus)    		 Pros11   -- protein S (alpha) 83.18(n)
    79.97(a)    		 81750  NM_031086.1  NP_112348.1 
    mouse
    (Mus musculus)    		 Pros11, 5 165
    		 protein S (alpha)1, 5 82.05(n)1
    79.53(a)1    		 191281  NM_011173.21  NP_035303.11 
     AK1330445  AK1455015  (see all 14)
    About this table        Species with no ortholog for PROS1

    ENSEMBL Gene Tree for PROS1

    Paralogs
    for PROS1

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for PROS1 gene
    SHBG2  GAS62  ENSG000001890022  

    SNPs/Variants
    for PROS1

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/424 NCBI SNPs in PROS1 are shown (see all 424 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 45)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 3 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs76502301,2
    		A,C,F,H95177049(+) CAGTAG/AAATGT 1 -- ng3112Minor allele frequency- A:0.22NS EU EA WA 1168
    rs76447691,2
    		A,C,F,H95176907(+) ACAATT/CAAAAC 1 -- ng3116Minor allele frequency- C:0.39NS EU EA WA 1586
    --
    rs81785831,2
    		A,C,F95176144(-) tggtgG/Tcaggc 1 -- ng312Minor allele frequency- T:0.22NS 92
    --
    rs96812041,2
    		A,C95075259(+) AGCTGG/TTCCCC 1 -- ut310--------
    --
    rs76148351,2
    		F,H95128899(+) CACGAC/AGCTTC 1 L/R mis1 ese34Minor allele frequency- A:0.01EU EA WA 406
    rs81785821,2
    		F,H95176711(-) TTTGAC/TGTTAC 1 -- ng31 tfbs36Minor allele frequency- T:0.01NS EU EA WA 504
    rs43909711,2
    		H95175287(-) CGCTTC/TGAAAT 1 -- ut51 ese33Minor allele frequency- T:0.00EU EA 296
    --
    rs50177191,2
    		H95086421(-) ACCCTC/TGTCTA 1 R/C mis1 ese34Minor allele frequency- T:0.00EU EA WA 406
    --
    rs50177141,2
    		H95086291(-) TGGTTC/TTGGAA 1 S/F mis14Minor allele frequency- T:0.00EU EA WA 406
    --
    rs50177171,2
    		H95086403(-) GTATAC/TGAAGC 1 R/X non14Minor allele frequency- T:0.00EU EA WA 406
    About this table

    HapMap Linkage Disequilibrium images for PROS1 (up to first 250kb)

    Disorders & Mutations
    for PROS1

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 176880   disorders: 612336  

    UniProtKB/Swiss-Prot: PROS_HUMAN, P07225

  • Defects in PROS1 are the cause of protein S deficiency (PROS1D) [MIM:612336]; also known
    as thrombophilia due to protein S deficiency. PROS1D is a cause of hereditary thrombophilia, a
    hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to
    recurrent venous thrombosis. However, many adults with heterozygous disease may be asymptomatic.
    Based on the plasma levels of total and free PROS1 antigen as well as the serine
    protease-activated protein C cofactor activity, three types of PROS1D have been described: type I,
    characterized by reduced total and free PROS1 antigen levels together with reduced anticoagulant
    activity; type III, in which only free PROS1 antigen and PROS1 activity levels are reduced; and
    the rare type II which is characterized by normal concentrations of both total and free PROS1
    antigen, but low cofactor activity

    • 10/24 Novoseek disease relationships for PROS1 gene (see all 24 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    protein s deficiency 88.43 36 17938802 (3), 16363235 (3), 18322254 (3), 9657428 (2) (see all 23)
    prostate cancer 77.45 125 12746846 (6), 8694557 (5), 11744475 (4), 15389786 (4) (see all 54)
    prostate carcinoma 41.53 9 11555588 (3), 9105163 (1), 7504042 (1)
    chronic prostatitis 38.06 6 17009527 (3), 15978235 (1)
    venous thrombosis 32.72 2 12529748 (1), 17157360 (1)
    prostatic adenocarcinoma 32.00 3 16829479 (1), 16988533 (1)
    prostatitis 31.55 1 15389786 (1)
    cancer 30.52 29 10628358 (2), 18243505 (2), 18272471 (1), 18678846 (1) (see all 22)
    thrombosis 29.98 7 10706858 (2), 10607700 (1), 11297755 (1), 10790208 (1) (see all 6)
    deep vein thrombosis 27.81 4 17938802 (2), 18954896 (1), 16868938 (1)
    About this table

    Genatlas disease: PROS1
    thrombosis,recurrent (pro-S deficiency),types I with reduced level of antigen and activity,type II
    with normal antigen level,reduced activity but excluding most cases of type III

    Human Gene Mutation Database: PROS1
    Genetic Association Database: PROS1
    Human Genome Epidemiology Navigator: PROS1 (8 documents)

    Medical News
    for PROS1

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for PROS1

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/332 PubMed articles for PROS1 gene (see all 332 ):

    Search for PROS1

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PROS1

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 5627 HGNC: 9456 AceView: PROS1 Ensembl:ENSG00000184500 euGenes: HUgn5627
    ECgene: PROS1 H-InvDB: PROS1

    Other Databases showing PROS1

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing PROS1

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    GeneReviewshttp://www.genetests.org/query?gene=PROS1
    SeattleSNPshttp://pga.gs.washington.edu/data/pros1/

    Licensable Technologies
    for PROS1

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for PROS1

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for PROS1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for PROS1-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for PROS1 Antibodies for PROS1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for PROS1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (PROS1)
     Antibodies (PROS1)
     Chimera RNAi (PROS1)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (Protein S)
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     Antibodies for PROS1

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