Aliases for PROP1 Gene
External Ids for PROP1 Gene
This gene encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, and thyroid-stimulating hormone. [provided by RefSeq, Sep 2011]
GeneCards Summary for PROP1 Gene
PROP1 (PROP Paired-Like Homeobox 1) is a Protein Coding gene. Diseases associated with PROP1 include pituitary hormone deficiency, combined, 2 and prop1-related combined pituitary hormone deficiency. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein C-terminus binding. An important paralog of this gene is PITX3.
UniProtKB/Swiss-Prot for PROP1 Gene
Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes