Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PROP1 Gene

Aliases for PROP1 Gene

  • PROP Paired-Like Homeobox 1 2 3
  • Prophet Of Pit1, Paired-Like Homeodomain Transcription Factor 2 3
  • Pituitary-Specific Homeodomain Factor 3 4
  • PROP-1 3 4
  • CPHD2 3 6
  • Homeobox Protein Prophet Of Pit-1 3

External Ids for PROP1 Gene

Previous GeneCards Identifiers for PROP1 Gene

  • GC05M177574
  • GC05M178307
  • GC05M177487
  • GC05M177532
  • GC05M177351
  • GC05M172154
  • GC05M177419

Summaries for PROP1 Gene

Entrez Gene Summary for PROP1 Gene

  • This gene encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, and thyroid-stimulating hormone. [provided by RefSeq, Sep 2011]

GeneCards Summary for PROP1 Gene

PROP1 (PROP Paired-Like Homeobox 1) is a Protein Coding gene. Diseases associated with PROP1 include pituitary hormone deficiency, combined, 2 and prop1-related combined pituitary hormone deficiency. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein C-terminus binding. An important paralog of this gene is PITX3.

UniProtKB/Swiss-Prot for PROP1 Gene

  • Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes

Gene Wiki entry for PROP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PROP1 Gene

Genomics for PROP1 Gene

Regulatory Elements for PROP1 Gene

Genomic Location for PROP1 Gene

177,992,235 bp from pter
177,996,242 bp from pter
4,008 bases
Minus strand

Genomic View for PROP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PROP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PROP1 Gene

Proteins for PROP1 Gene

  • Protein details for PROP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeobox protein prophet of Pit-1
    Protein Accession:
    Secondary Accessions:

    Protein attributes for PROP1 Gene

    226 amino acids
    Molecular mass:
    24984 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PROP1 Gene

Proteomics data for PROP1 Gene at MOPED

Post-translational modifications for PROP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PROP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PROP1 Gene

Domains for PROP1 Gene

Gene Families for PROP1 Gene

  • PRD :Homeoboxes / PRD class

Suggested Antigen Peptide Sequences for PROP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O75360
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the paired homeobox family.
genes like me logo Genes that share domains with PROP1: view

Function for PROP1 Gene

Molecular function for PROP1 Gene

GENATLAS Biochemistry:
prophet of PIT1,pituitary-specific,paired-like homeo domain,transcription factor,specifically expressed in embryonic pituitary and in pituitary tumors,necessary for PIT1 (POU1F1) expression,homolog to murine Ames dwarf (df),involved in the proper development of somatotrophs,lactotrophs,thyreotrophs and gonadotrophs
UniProtKB/Swiss-Prot Function:
Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes

Gene Ontology (GO) - Molecular Function for PROP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 23732115
GO:0008013 beta-catenin binding IEA --
GO:0008022 protein C-terminus binding IEA --
genes like me logo Genes that share ontologies with PROP1: view
genes like me logo Genes that share phenotypes with PROP1: view

Animal Models for PROP1 Gene

MGI Knock Outs for PROP1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PROP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for PROP1 Gene

Localization for PROP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PROP1 Gene

Subcellular locations from

Jensen Localization Image for PROP1 Gene COMPARTMENTS Subcellular localization image for PROP1 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for PROP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with PROP1: view

Pathways for PROP1 Gene

SuperPathways for PROP1 Gene

No Data Available

PCR Array Products

Gene Ontology (GO) - Biological Process for PROP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001568 blood vessel development IEA --
GO:0007417 central nervous system development TAS 9462743
GO:0009887 organ morphogenesis --
GO:0009953 dorsal/ventral pattern formation IEA --
genes like me logo Genes that share ontologies with PROP1: view

No data available for Pathways by source for PROP1 Gene

Compounds for PROP1 Gene

(5) Novoseek inferred chemical compound relationships for PROP1 Gene

Compound -log(P) Hits PubMed IDs
acth 62.5 5
gnrh 30.4 2
steroid 0 1
testosterone 0 1
serine 0 2
genes like me logo Genes that share compounds with PROP1: view

Transcripts for PROP1 Gene

mRNA/cDNA for PROP1 Gene

(3) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PROP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PROP1 Gene

No ASD Table

Relevant External Links for PROP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PROP1 Gene

mRNA expression in normal human tissues for PROP1 Gene

mRNA differential expression in normal tissues according to GTEx for PROP1 Gene

This gene is overexpressed in Pituitary (33.1) and Brain - Cerebellum (5.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PROP1 Gene

SOURCE GeneReport for Unigene cluster for PROP1 Gene Hs.158301

mRNA Expression by UniProt/SwissProt for PROP1 Gene

Tissue specificity: Expressed specifically in embryonic pituitary
genes like me logo Genes that share expressions with PROP1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Expression partners for PROP1 Gene

Orthologs for PROP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PROP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PROP1 35
  • 81.86 (n)
  • 74.78 (a)
PROP1 36
  • 75 (a)
(Canis familiaris)
Mammalia PROP1 35
  • 84.07 (n)
  • 79.2 (a)
PROP1 36
  • 79 (a)
(Mus musculus)
Mammalia Prop1 35
  • 79.07 (n)
  • 73.54 (a)
Prop1 16
Prop1 36
  • 74 (a)
(Pan troglodytes)
Mammalia PROP1 35
  • 98.53 (n)
  • 98.67 (a)
PROP1 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Prop1 35
  • 78.18 (n)
  • 71.3 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 25 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
(Anolis carolinensis)
Reptilia PROP1 36
  • 40 (a)
(Danio rerio)
Actinopterygii mxtx2 36
  • 17 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32532 36
  • 9 (a)
(Caenorhabditis elegans)
Secernentea unc-42 36
  • 22 (a)
Species with no ortholog for PROP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PROP1 Gene

Gene Tree for PROP1 (if available)
Gene Tree for PROP1 (if available)

Paralogs for PROP1 Gene

Paralogs for PROP1 Gene

Selected SIMAP similar genes for PROP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PROP1: view

Variants for PROP1 Gene

Sequence variations from dbSNP and Humsavar for PROP1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1135320 -- 177,995,907(-) CAGGC(C/T)GAGAA synonymous-codon, reference
rs1135321 -- 177,992,774(-) GCCAT(A/C/T)TGCCC missense, reference, synonymous-codon
rs1800197 - 177,992,966(-) CTGCC(A/G)CCTTT missense, reference
rs2233780 -- 177,994,445(-) AAGAC(C/T)GGAGC intron-variant
rs2233781 -- 177,994,420(-) TGAGC(A/G)CAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PROP1 Gene

Variant ID Type Subtype PubMed ID
nsv883184 CNV Gain 21882294
nsv509105 CNV Insertion 20534489
nsv883186 CNV Gain 21882294
nsv883187 CNV Gain 21882294
nsv883188 CNV Gain 21882294
nsv883189 CNV Gain 21882294

Relevant External Links for PROP1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PROP1 Gene

Disorders for PROP1 Gene

(1) OMIM Diseases for PROP1 Gene (601538)


  • Pituitary hormone deficiency, combined, 2 (CPHD2) [MIM:262600]: Combined pituitary hormone deficiency is defined as the impaired production of growth hormone and one or more of the other five anterior pituitary hormones. CPHD2 is characterized by pleiotropic deficiencies of growth hormone, thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone, prolactin and adrenocorticotropic hormone. {ECO:0000269 PubMed:10946881, ECO:0000269 PubMed:11549703, ECO:0000269 PubMed:12519826, ECO:0000269 PubMed:15531542, ECO:0000269 PubMed:19128366, ECO:0000269 PubMed:9462743, ECO:0000269 PubMed:9768691}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(23) Novoseek inferred disease relationships for PROP1 Gene

Disease -log(P) Hits PubMed IDs
panhypopituitarism 97.1 66
septo-optic dysplasia 92.2 4
tsh deficiency 92 4
hormone deficiency 90.7 17
hypopituitarism 89.3 15

Relevant External Links for PROP1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with PROP1: view

No data available for Genatlas for PROP1 Gene

Publications for PROP1 Gene

  1. Mutations in PROP1 cause familial combined pituitary hormone deficiency. (PMID: 9462743) Wu W. … Rosenfeld M.G. (Nat. Genet. 1998) 2 3 4 23
  2. PROP1 gene screening in patients with multiple pituitary hormone deficiency reveals two sites of hypermutability and a high incidence of corticotroph deficiency. (PMID: 11549703) Vallette-Kasic S. … Brue T. (J. Clin. Endocrinol. Metab. 2001) 3 4 23
  3. Combined pituitary hormone deficiency caused by a novel mutation of a highly conserved residue (F88S) in the homeodomain of PROP-1. (PMID: 10946881) Osorio M.G. … Arnhold I.J. (J. Clin. Endocrinol. Metab. 2000) 3 4 23
  4. Phenotypic variability in familial combined pituitary hormone deficiency caused by a PROP1 gene mutation resulting in the substitution of Arg-->Cys at codon 120 (R120C). (PMID: 9768691) Fluck C. … Mullis P.E. (J. Clin. Endocrinol. Metab. 1998) 3 4 23
  5. Familial combined pituitary hormone deficiency due to a novel mutation R99Q in the hot spot region of Prophet of Pit-1 presenting as constitutional growth delay. (PMID: 12519826) Vieira T.C. … Abucham J. (J. Clin. Endocrinol. Metab. 2003) 3 4 23

Products for PROP1 Gene

Sources for PROP1 Gene

Back to Top