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Aliases for PROM2 Gene

Aliases for PROM2 Gene

  • Prominin 2 2 3 5
  • Prominin-Like Protein 2 3 4
  • PROML2 3 4
  • Prominin-Related Protein 3
  • Prominin-2 3
  • HPROML2 4
  • PROM-2 4

External Ids for PROM2 Gene

Previous GeneCards Identifiers for PROM2 Gene

  • GC02P094373
  • GC02P095408
  • GC02P095424
  • GC02P095362
  • GC02P095942
  • GC02P089982

Summaries for PROM2 Gene

Entrez Gene Summary for PROM2 Gene

  • This gene encodes a member of the prominin family of pentaspan membrane glycoproteins. The encoded protein localizes to basal epithelial cells and may be involved in the organization of plasma membrane microdomains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

GeneCards Summary for PROM2 Gene

PROM2 (Prominin 2) is a Protein Coding gene. GO annotations related to this gene include cholesterol binding. An important paralog of this gene is PROM1.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PROM2 Gene

Genomics for PROM2 Gene

Regulatory Elements for PROM2 Gene

Enhancers for PROM2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G095305 0.9 ENCODE dbSUPER 12.9 +31.4 31412 0.2 E2F1 HNF1A FOXA2 TEAD1 MLX HNF4A ZNF644 YY1 TEAD3 PROM2 KCNIP3 PIR58224
GH02G095300 0.7 ENCODE dbSUPER 12.9 +28.4 28357 3.7 POLR2A ZBTB33 KCNIP3 PROM2 ZNF514 PIR58224
GH02G095345 1 ENCODE 7.4 +71.8 71808 2.4 ATF1 ZNF48 GLIS2 ZNF207 ZNF143 FOS KLF7 ZNF263 SP3 REST KCNIP3 PROM2 GC02P095355 PIR58224
GH02G095306 0.5 FANTOM5 dbSUPER 12.9 +32.1 32117 0.3 PROM2 GPAT2 KCNIP3 PIR58224
GH02G095308 0.5 dbSUPER 12.9 +34.6 34552 1.7 KLF1 ZSCAN4 MNT ZIC2 KCNIP3 PROM2 PIR58224
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PROM2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PROM2 Gene

Chromosome:
2
Start:
95,274,416 bp from pter
End:
95,291,320 bp from pter
Size:
16,905 bases
Orientation:
Plus strand

Genomic View for PROM2 Gene

Genes around PROM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PROM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PROM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PROM2 Gene

Proteins for PROM2 Gene

  • Protein details for PROM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N271-PROM2_HUMAN
    Recommended name:
    Prominin-2
    Protein Accession:
    Q8N271
    Secondary Accessions:
    • A8K2V1
    • Q2HIX6
    • Q8NB84
    • Q8TAE2

    Protein attributes for PROM2 Gene

    Size:
    834 amino acids
    Molecular mass:
    91883 Da
    Quaternary structure:
    • Binds cholesterol.
    SequenceCaution:
    • Sequence=BAC03657.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PROM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PROM2 Gene

Post-translational modifications for PROM2 Gene

No data available for DME Specific Peptides for PROM2 Gene

Domains & Families for PROM2 Gene

Protein Domains for PROM2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PROM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N271

UniProtKB/Swiss-Prot:

PROM2_HUMAN :
  • Belongs to the prominin family.
Family:
  • Belongs to the prominin family.
genes like me logo Genes that share domains with PROM2: view

No data available for Gene Families for PROM2 Gene

Function for PROM2 Gene

Gene Ontology (GO) - Molecular Function for PROM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015485 cholesterol binding ISS 12514187
genes like me logo Genes that share ontologies with PROM2: view
genes like me logo Genes that share phenotypes with PROM2: view

Animal Models for PROM2 Gene

MGI Knock Outs for PROM2:

Animal Model Products

  • Taconic Biosciences Mouse Models for PROM2

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PROM2 Gene

Localization for PROM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PROM2 Gene

Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cell projection, microvillus membrane; Multi-pass membrane protein. Cell projection, cilium membrane; Multi-pass membrane protein. Note=Colocalizes with PROM1. Associates with membrane in a cholesterol-dependent manner. Localizes to the apical and basolateral membranes of epithelial cells (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PROM2 gene
Compartment Confidence
plasma membrane 5
extracellular 5

Gene Ontology (GO) - Cellular Components for PROM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane ISS 12514187
GO:0005902 microvillus ISS 12514187
GO:0005929 cilium ISS 12514187
GO:0009986 cell surface ISS 12514187
genes like me logo Genes that share ontologies with PROM2: view

Pathways & Interactions for PROM2 Gene

SuperPathways for PROM2 Gene

No Data Available

Interacting Proteins for PROM2 Gene

Selected Interacting proteins: Q8N271-PROM2_HUMAN for PROM2 Gene via IID

Symbol External ID(s) Details
NPHP4

Gene Ontology (GO) - Biological Process for PROM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IDA 23583380
GO:0031346 positive regulation of cell projection organization IDA 23583380
GO:0043087 regulation of GTPase activity IDA 23583380
GO:0048550 negative regulation of pinocytosis IDA 23583380
GO:2000369 NOT regulation of clathrin-dependent endocytosis IDA 23583380
genes like me logo Genes that share ontologies with PROM2: view

No data available for Pathways by source and SIGNOR curated interactions for PROM2 Gene

Drugs & Compounds for PROM2 Gene

No Compound Related Data Available

Transcripts for PROM2 Gene

Unigene Clusters for PROM2 Gene

Prominin 2:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PROM2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1: - -
SP2: - -
SP3: - -
SP4: -
SP5: - - - - -
SP6: - - -
SP7:
SP8:

ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27
SP1: - -
SP2: - - -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:

Relevant External Links for PROM2 Gene

GeneLoc Exon Structure for
PROM2
ECgene alternative splicing isoforms for
PROM2

Expression for PROM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PROM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PROM2 Gene

This gene is overexpressed in Esophagus - Mucosa (x9.6), Skin - Not Sun Exposed (Suprapubic) (x5.1), Skin - Sun Exposed (Lower leg) (x4.8), and Bladder (x4.6).

Protein differential expression in normal tissues from HIPED for PROM2 Gene

This gene is overexpressed in Urine (48.9) and Milk (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PROM2 Gene



NURSA nuclear receptor signaling pathways regulating expression of PROM2 Gene:

PROM2

SOURCE GeneReport for Unigene cluster for PROM2 Gene:

Hs.469313

mRNA Expression by UniProt/SwissProt for PROM2 Gene:

Q8N271-PROM2_HUMAN
Tissue specificity: Present in saliva within small membrane particles (at protein level). Expressed in kidney, prostate, trachea, esophagus, salivary gland, thyroid gland, mammary gland adrenal gland, placenta, stomach, spinal cord and liver. In submucosal tumor, expressed in spindle-shaped or stellate stromal cells. Expressed in prostate cancer cell lines.

Evidence on tissue expression from TISSUES for PROM2 Gene

  • Kidney(4.4)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with PROM2: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PROM2 Gene

Orthologs for PROM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PROM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PROM2 34 35
  • 99.08 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 86 (a)
OneToMany
-- 35
  • 44 (a)
OneToMany
-- 35
  • 28 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PROM2 34 35
  • 84.39 (n)
cow
(Bos Taurus)
Mammalia PROM2 34 35
  • 83.05 (n)
mouse
(Mus musculus)
Mammalia Prom2 34 16 35
  • 79.55 (n)
rat
(Rattus norvegicus)
Mammalia Prom2 34
  • 76.64 (n)
oppossum
(Monodelphis domestica)
Mammalia PROM2 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves PROM2 34 35
  • 59.4 (n)
lizard
(Anolis carolinensis)
Reptilia PROM2 35
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prom2 34
  • 47.88 (n)
zebrafish
(Danio rerio)
Actinopterygii prom2 35
  • 26 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta prom 35
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea prmn-1 35
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 20 (a)
OneToMany
Species where no ortholog for PROM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PROM2 Gene

ENSEMBL:
Gene Tree for PROM2 (if available)
TreeFam:
Gene Tree for PROM2 (if available)

Paralogs for PROM2 Gene

Paralogs for PROM2 Gene

(1) SIMAP similar genes for PROM2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PROM2: view

Variants for PROM2 Gene

Sequence variations from dbSNP and Humsavar for PROM2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000495096 -- 95,286,327(+) CCCCC(A/G)AACCA intron-variant
rs1000757296 -- 95,273,793(+) GTGGT(A/G)GCTTT upstream-variant-2KB
rs1001013733 -- 95,286,701(+) CTCCC(C/G)TCCTC intron-variant
rs1001245931 -- 95,289,082(+) GTCTG(A/G)GGTTT intron-variant
rs1001488315 -- 95,276,841(+) CGTGT(A/C)CCCGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PROM2 Gene

Variant ID Type Subtype PubMed ID
esv3591652 OTHER inversion 21293372
nsv1160825 CNV duplication 26073780
nsv528011 CNV loss 19592680
nsv953478 CNV deletion 24416366
nsv998014 CNV gain 25217958

Variation tolerance for PROM2 Gene

Residual Variation Intolerance Score: 75.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.32; 76.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PROM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PROM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PROM2 Gene

Disorders for PROM2 Gene

Relevant External Links for PROM2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PROM2

No disorders were found for PROM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PROM2 Gene

Publications for PROM2 Gene

  1. Characterization of prominin-2, a new member of the prominin family of pentaspan membrane glycoproteins. (PMID: 12514187) Fargeas C.A. … Corbeil D. (J. Biol. Chem. 2003) 2 3 4 22 64
  2. Prominin-2 is a novel marker of distal tubules and collecting ducts of the human and murine kidney. (PMID: 20333396) JA!szai J. … Corbeil D. (Histochem. Cell Biol. 2010) 3 22 64
  3. Effect of CD133/prominin-1 antisense oligodeoxynucleotide on in vitro growth characteristics of Huh-7 human hepatocarcinoma cells and U251 human glioma cells. (PMID: 19724856) Yao J. … Wu G. (Oncol. Rep. 2009) 3 22 64
  4. Robust expression of Prominin-2 all along the adult male reproductive system and urinary bladder. (PMID: 18536929) JA!szai J. … Corbeil D. (Histochem. Cell Biol. 2008) 3 22 64
  5. Differential expression of prominin-1 (CD133) and prominin-2 in major cephalic exocrine glands of adult mice. (PMID: 17874118) Jaszai J. … Corbeil D. (Histochem. Cell Biol. 2007) 4 22 64

Products for PROM2 Gene

Sources for PROM2 Gene

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