PROKR2 Gene
protein-coding GIFtS : 59
GCID: GC20 M005282
prokineticin receptor 2 (Previous names: G protein-coupled receptor 73-like 1, Kallmann syndrome... ) (Previous symbols: GPR73L1, KAL3 )
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Aliasesfor PROKR2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Prokineticin Receptor 2 1 2 DJ680N4.31 GPR73L11 2 3 5 G Protein-Coupled Receptor 73-Like 11 2 PKR21 2 3 5 PK-R22 3 GPR73b1 2 3 Kallmann Syndrome 3 (Autosomal Dominant)1 GPRg21 2 3 HH32 KAL31 2 5 G-Protein Coupled Receptor 73-Like 13
Export aliases for PROKR2 gene to outside databases Previous GC identifers: GC20M005231 GC20M005238
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Summariesfor PROKR2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for PROKR2 : Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: PKR2_HUMAN, Q8NFJ6 Function : Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activationleads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase Gene Wiki entry for PROKR2 (Prokineticin receptor 2)
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Genomic Viewsfor PROKR2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000020.10 NC_018931.1 NT_011387.8 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the PROKR2 gene promoter: SRF Elk-1 SRF (504 AA) POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) XBP-1 POU3F2 N-Myc NRF-2 c-Myb Other transcription factors Search SABiosciences Chromatin IP Primers for PROKR2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat PROKR2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 20p12.3 Ensembl cytogenetic band: 20p12.3 HGNC cytogenetic band: 20p12.3 PROKR2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 20 GeneLoc Exon Structure
GeneLoc location for GC20M005282: view genomic region
(about GC identifiers )
Start:
5,282,317 bp from pter
End:
5,297,378 bp from pter
Size:
15,062 bases
Orientation:
minus strand
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Proteinsfor PROKR2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: PKR2_HUMAN, Q8NFJ6 (See
protein sequence )Recommended Name: Prokineticin receptor 2 Size : 384 amino acids; 43996 Da
Subunit : Homodimer
Subcellular location : Cell membrane; Multi-pass membrane protein
Secondary accessions : A5JUU1 Q2M3C0 Q5TDY1 Q9NTT0Explore the universe of human proteins at neXtProt for PROKR2: NX_Q8NFJ6 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8NFJ6 PROKR2 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_658986.1 ENSEMBL proteins: ENSP00000217270 ENSP00000440790 Reactome Protein details: Q8NFJ6 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005886 plasma membrane
TAS -- GO:0016021 integral to membrane
IEA --
PROKR2 for ontologies About GeneDecksing PROKR2 Antibody Products: Assay Products for PROKR2:
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Protein
Domains / Familiesfor PROKR2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
PROKR2 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8NFJ6 ProtoNet protein and cluster: Q8NFJ6
UniProtKB/Swiss-Prot: PKR2_HUMAN, Q8NFJ6 Similarity : Belongs to the G-protein coupled receptor 1 family
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Functionfor PROKR2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: PKR2_HUMAN, Q8NFJ6 Function : Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activationleads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase
Clone Products: EMD Millipore Clones for the Expression of PROKR2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for PROKR2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for PROKR2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: PROKR2 (NM_144773 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PROKR2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat PROKR2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PROKR2
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0004930 G-protein coupled receptor activity
-- -- GO:0004983 neuropeptide Y receptor activity
IEA --
PROKR2 for ontologies About GeneDecksing 2 GenomeRNAi human phenotypes for PROKR2 :Animal Models: Mouse knock-outs for PROKR2: Prokr2 tm1Brd Prokr2 tm1Api 9 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Prokr2) :
PROKR2 for phenotypes About GeneDecksing
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Pathways & Interactionsfor PROKR2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Class A/1 (Rhodopsin-like receptors) 2 Signaling by GPCR 3 G alpha (q) signalling events 4 Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q 5 GPCRs, Other
Pathway sources See GeneCards unified pathways Show all pathways 1 EMD Millipore Pathway for PROKR2 1 BioSystems Pathway for PROKR2 5/8
Reactome Pathways for PROKR2 (see all 8 )
PROKR2 for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PROKR2 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/123 Interacting proteins for PROKR2 (ENSP00000217270 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 123 )About this table Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0007186 G-protein coupled receptor signaling pathway
-- -- GO:0007623 circadian rhythm
IEA --
PROKR2 for ontologies About GeneDecksing
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Drugs & Compoundsfor PROKR2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for PROKR2 1 HMDB Compound for PROKR2 About this table Search CenterWatch for drugs/clinical trials and news about PROKR2 / PKR2
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Transcriptsfor PROKR2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for PROKR2 gene: NM_144773.2 Unigene Cluster for PROKR2:
Prokineticin receptor 2 Hs.375029 [show with all ESTs ] Unigene Representative Sequence: AK090863 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000217270 ENST00000546004 (uc010zqw.2 uc010zqx.2 uc010zqy.2 )Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for PROKR2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for PROKR2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: PROKR2 (NM_144773 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PROKR2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat PROKR2
Additional cDNA sequence: AB084081.1 AF506288.1 AK090863.1 AK289995.1 BC104959.1 BC104961.1 EF577398.1
3 DOTS entries : DT.100009581 DT.99930271
DT.100675803 3 AceView cDNA sequences :
AB084081 NM_144773 AF506288 GeneLoc Exon Structure
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Expression for PROKR2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section PROKR2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AAGTACTTCA
About this image PROKR2 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See PROKR2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for PROKR2 SOURCE GeneReport for Unigene cluster: Hs.375029 UniProtKB/Swiss-Prot: PKR2_HUMAN, Q8NFJ6 Tissue specificity : Expressed in the ileocecum, thyroid gland, pituitary gland, salivary gland, adrenal gland, testis,ovary and brain SABiosciences Expression via Pathway-Focused PCR Arrays including PROKR2 : Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for PROKR2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat PROKR2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat PROKR2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat PROKR2 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PROKR2
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Orthologsfor PROKR2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for PROKR2 gene from 3/14 species (see all 14 ) About this table
ENSEMBL Gene Tree for PROKR2 (if available)TreeFam Gene Tree for PROKR2 (if available)
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Paralogsfor PROKR2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for PROKR2 gene PROKR1 2 3 SIMAP similar genes for PROKR2 using alignment to 1 protein entry: PKR2_HUMAN :PROKR1 PRLHR NPY2R
PROKR2 for paralogs About GeneDecksing
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Genomic Variantsfor PROKR2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 20 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More