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PROKR2 Gene

protein-coding   GIFtS: 60
GCID: GC20M005282

Prokineticin Receptor 2

(Previous names: G protein-coupled receptor 73-like 1, Kallmann syndrome...)
(Previous symbols: GPR73L1, KAL3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Prokineticin Receptor 21 2     GPRg22 3
GPR73L11 2 3 5     PK-R22 3
PKR22 3 5     HH32 5
KAL31 2     Kallmann Syndrome 3 (Autosomal Dominant)1
G Protein-Coupled Receptor 73-Like 11 2     dJ680N4.32
GPR73b2 3     G-Protein Coupled Receptor 73-Like 13

External Ids:    HGNC: 158361   Entrez Gene: 1286742   Ensembl: ENSG000001012927   OMIM: 6071235   UniProtKB: Q8NFJ63   

Export aliases for PROKR2 gene to outside databases

Previous GC identifers: GC20M005231 GC20M005238


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PROKR2 Gene:
Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle
contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for
prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for
prokineticins. (provided by RefSeq, Jul 2008)

GeneCards Summary for PROKR2 Gene:
PROKR2 (prokineticin receptor 2) is a protein-coding gene. Diseases associated with PROKR2 include hypogonadotropic hypogonadism 3 with or without anosmia, and kallmann syndrome 3. GO annotations related to this gene include neuropeptide Y receptor activity. An important paralog of this gene is PROKR1.

UniProtKB/Swiss-Prot: PKR2_HUMAN, Q8NFJ6
Function: Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins.
Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42
mitogen-activated protein kinase

Gene Wiki entry for PROKR2 (Prokineticin receptor 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NT_011387.9  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PROKR2 gene promoter:
         SRF   Elk-1   SRF (504 AA)   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   XBP-1   POU3F2   N-Myc   NRF-2   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPROKR2 promoter sequence
   Search Chromatin IP Primers for PROKR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PROKR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p12.3   Ensembl cytogenetic band:  20p12.3   HGNC cytogenetic band: 20p12.3

PROKR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PROKR2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M005282:  view genomic region     (about GC identifiers)

Start:
5,282,317 bp from pter      End:
5,297,378 bp from pter
Size:
15,062 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PKR2_HUMAN, Q8NFJ6 (See protein sequence)
Recommended Name: Prokineticin receptor 2  
Size: 384 amino acids; 43996 Da
Subunit: Homodimer
Secondary accessions: A5JUU1 Q2M3C0 Q5TDY1 Q9NTT0

Explore the universe of human proteins at neXtProt for PROKR2: NX_Q8NFJ6

Explore proteomics data for PROKR2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn7, Asn27

  • See PROKR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_658986.1  
    ENSEMBL proteins: 
     ENSP00000217270   ENSP00000440790  
    Reactome Protein details: Q8NFJ6

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PROKR: GPCR / Class A : Prokineticin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: PKR2
    Prokineticin receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn
     IPR000611 NPY_rcpt

    Graphical View of Domain Structure for InterPro Entry Q8NFJ6

    ProtoNet protein and cluster: Q8NFJ6

    UniProtKB/Swiss-Prot: PKR2_HUMAN, Q8NFJ6
    Similarity: Belongs to the G-protein coupled receptor 1 family


    PROKR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PKR2_HUMAN, Q8NFJ6
    Function: Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins.
    Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42
    mitogen-activated protein kinase

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004983neuropeptide Y receptor activity IEA--
         
    PROKR2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PROKR2:
     High actin ratio cells  Increased gamma-H2AX phosphory 

         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Prokr2):
     behavior/neurological  cellular  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism 
     integument  mortality/aging  nervous system  reproductive system 

    PROKR2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PROKR2: Prokr2tm1Brd Prokr2tm1Api

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PROKR2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PROKR2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PROKR2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PROKR2

    miRNA
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    miRTarBase miRNAs that target PROKR2:
    hsa-mir-148b-3p (MIRT019359)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PKR2_HUMAN, Q8NFJ6: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    PROKR2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PROKR2 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Neuropeptides signaling through G protein alpha i and G protein alpha q
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    5GPCRs, Other
    GPCRs, Other

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for PROKR2
        GPCRs, Other

    2 Reactome Pathways for PROKR2
        Peptide ligand-binding receptors
    G alpha (q) signalling events



    PROKR2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PROKR2: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Circadian Rhythms in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for PROKR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PROKR2 (ENSP000002172704) via UniProtKB, MINT, STRING, and/or I2D (see all 123)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AVPR1AENSP000002991784STRING: ENSP00000299178
    EDN3ENSP000003371284STRING: ENSP00000337128
    EDNRBENSP000003353114STRING: ENSP00000335311
    GNRH1ENSP000002764144STRING: ENSP00000276414
    GNRH2ENSP000002459834STRING: ENSP00000245983
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007623circadian rhythm IEA--

    PROKR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PROKR2 (PKR2)

    1 HMDB Compound for PROKR2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    6 IUPHAR Ligands for PROKR2 (PKR2)    About this table
    LigandTypeActionAffinityPubmed IDs
    MIT1
    AgonistFull agonist9.212054613
    prokineticin-2
    AgonistFull agonist8.1 - 8.212054613 15772293
    PKR-A
    AntagonistAntagonist7.28 - 7.3622431614
    prokineticin-1
    AgonistFull agonist7.1 - 7.312054613 15772293
    prokineticin-2beta
    AgonistFull agonist615772293
    triazine compound 1
    AntagonistAntagonist5.7919006379



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PROKR2 gene: 
    NM_144773.2  

    Unigene Cluster for PROKR2:

    Prokineticin receptor 2
    Hs.375029  [show with all ESTs]
    Unigene Representative Sequence: AK090863
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000217270 ENST00000546004(uc010zqw.2 uc010zqx.2 uc010zqy.2)

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      QuantiTect SYBR Green Assays in human, mouse, rat PROKR2
      QuantiFast Probe-based Assays in human, mouse, rat PROKR2

    Additional mRNA sequence: 

    AB084081.1 AF506288.1 AK090863.1 AK289995.1 BC104959.1 BC104961.1 EF577398.1 

    3 DOTS entries:

    DT.100009581  DT.99930271  DT.100675803 

    3 AceView cDNA sequences:

    AB084081 NM_144773 AF506288 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PROKR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTACTTCA
    PROKR2 Expression
    About this image


    PROKR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Thalamus
             Septum   
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Testicular Interstitial Cells Testis Interstitium
             Testis Cord
    PROKR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PROKR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.375029

    UniProtKB/Swiss-Prot: PKR2_HUMAN, Q8NFJ6
    Tissue specificity: Expressed in the ileocecum, thyroid gland, pituitary gland, salivary gland, adrenal gland,
    testis, ovary and brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PROKR2: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Circadian Rhythms in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PROKR2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prokr21 , 5 prokineticin receptor 21, 5 86.18(n)1
    90.29(a)1
      2 (64.15 cM)5
    2463131  NM_144944.31  NP_659193.31 
     1323377335 
    chicken
    (Gallus gallus)
    Aves PROKR21 prokineticin receptor 2 76.5(n)
    87.13(a)
      421263  NM_001145229.1  NP_001138701.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    80(a)
    1 → many
    1(126816950-126830584)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia prokr21 prokineticin receptor 2 73.76(n)
    85.36(a)
      100490059  XM_002931756.1  XP_002931802.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7982311 Prokineticin receptor 1-like 69.24(n)
    69.73(a)
      798231  NM_001173407.1  NP_001166878.1 


    ENSEMBL Gene Tree for PROKR2 (if available)
    TreeFam Gene Tree for PROKR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PROKR2 gene
    PROKR12  
    3 SIMAP similar genes for PROKR2 using alignment to 1 protein entry:     PKR2_HUMAN:
    PROKR1    PRLHR    NPY2R

    PROKR2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PROKR2 (see all 523)    About this table    
    <
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2018354961,2,,4
    Hypogonadotropic hypogonadism 3 with or without anosmia (HH3)4 --5231244(+) CCATCC/GAGACC 2 S W mis10--------
    rs743154161,2,,4
    C,FHypogonadotropic hypogonadism 3 with or without anosmia (HH3)4 pathogenic15231259(-) CTTCCT/GGATCG 2 /R /L mis12Minor allele frequency- G:0.00NA EU 5541
    rs743154181,2,,4
    C,FHypogonadotropic hypogonadism 3 with or without anosmia (HH3)4 pathogenic15242698(-) GTTGCA/G/TCAACC 2 H R mis12NA EU 5873
    VAR_0309644
    Hypogonadotropic hypogonadism 3 with or without anosmia (HH3)4--see VAR_0309642 P S mis40--------
    VAR_0309654
    Hypogonadotropic hypogonadism 3 with or without anosmia (HH3)4--see VAR_0309652 M I mis40--------
    VAR_0309624
    Hypogonadotropic hypogonadism 3 with or without anosmia (HH3)4--see VAR_0309622 Q R mis40--------
    VAR_0699644
    Hypogonadotropic hypogonadism 3 with or without anosmia (HH3)4--see VAR_0699642 V M mis40--------
    VAR_0309594
    Hypogonadotropic hypogonadism 3 with or without anosmia (HH3)4--see VAR_0309592 R Q mis40--------
    VAR_0699654
    Hypogonadotropic hypogonadism 3 with or without anosmia (HH3)4--see VAR_0699652 S G mis40--------
    rs743154191,2
    Cpathogenic15230808(-) GCCATA/GAGCAA 2 I M mis10--------
    rs743154171,2
    Cpathogenic15231148(-) TGGCCA/GGATCT 2 Q R mis10--------
    rs577235241,2
    C,F--5230205(+) AAACTC/TCAATA 1 -- ds50014Minor allele frequency- T:0.12WA CSA EA 242
    rs735944671,2
    C,F--5230220(+) CTGCTG/ACTTTG 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1483179591,2
    C--5230236(+) TTTTT-/TATATGT 1 -- ds50010--------
    rs9271061,2
    C,F,O,A,H--5230272(+) TTTTTG/TATTAC 1 -- ds500112Minor allele frequency- T:0.32NA WA CSA EA 375
    rs1402600901,2
    --5230315(+) TCCCTC/GTCTAA 1 -- ds50010--------
    rs730719281,2
    --5230418(+) TAGGTA/GTCGAG 1 -- ds50010--------
    rs1864685461,2
    --5230425(+) CGAGCA/GGATAT 1 -- ds50010--------
    rs730719311,2
    C,F--5230494(+) GCATTC/TAGCTT 1 -- ds50013Minor allele frequency- T:0.11WA NA EA 358
    rs37466801,2
    C,F,A,H--5230495(+) CATTCG/AGCTTC 1 -- ds500121Minor allele frequency- A:0.32EA NS NA WA CSA 1506
    rs735944721,2
    C,F--5230536(+) TGTCAT/CTTCCC 1 -- ds50012Minor allele frequency- C:0.09WA 120
    rs1932614581,2
    --5230549(+) GCAGCC/TTATGA 1 -- ds50010--------
    rs37466811,2
    C,F,A,H--5230555(+) TATGAA/TCTTGG 1 -- ds500116Minor allele frequency- T:0.38EA NA CSA WA 2235
    rs1473112781,2
    C,F--5230623(+) TGGGTC/AACTTC 2 /* /L --1Minor allele frequency- A:0.00NA 4550
    rs764690931,2
    C,F--5230655(+) TCTGTG/TGTGGG 2 T syn11Minor allele frequency- T:0.04EA 120
    rs2010236391,2
    C--5230666(+) CACCCC/G/TGTTGG 3 R G mis10--------
    rs760492871,2
    C,F--5230667(+) ACCCCG/ATTGGT 2 /N syn11Minor allele frequency- A:0.04EA 120
    rs3750366281,2
    C--5230708(+) CCCCCA/GCTGGG 2 R W mis10--------
    rs1503813861,2
    C,F--5230772(+) TTGACC/TGTCAC 2 T syn12Minor allele frequency- T:0.00NA EU 5875
    rs1381017421,2
    C--5230778(+) GTCACG/AAAGCA 2 /F syn11Minor allele frequency- A:0.00NA 4552
    rs1171060811,2
    C,F--5230786(+) GCACAC/TGGTGT 2 M V mis11Minor allele frequency- T:0.04EA 120
    rs1422571491,2
    C,F--5230814(+) ATGGCG/AATGCA 2 /I syn11Minor allele frequency- A:0.00NA 4552
    rs2004491681,2
    --5230834(+) GTAGAA/GGGCAG 2 L F mis10--------
    rs1996964431,2
    --5230861(+) CTTCAC/TGAACA 2 M V mis10--------
    rs2016006831,2
    --5230865(+) ACGAAC/TACAGT 2 V syn10--------
    rs1999585851,2
    C--5230873(+) AGTGGA/GGAAGA 2 P S mis10--------
    rs1393990611,2
    C,F--5230888(+) ACGAAC/TGATGG 2 I V mis12Minor allele frequency- T:0.00NA EU 5875
    rs1887441901,2
    C--5230962(+) CCGTCG/TTCCTG 2 K T mis10--------
    rs1465445391,2
    C--5230968(+) TCCTGC/TGGCAG 2 H R mis11Minor allele frequency- T:0.00NA 4548
    rs788616281,2,,4
    C,F--5230975(+) GCAGCG/ACAGCC 2 /R /C mis14Minor allele frequency- A:0.02CSA WA NA EU 5993
    rs1488683551,2
    C,F--5230987(+) CTTGCG/AAATCT 2 /R /C mis11Minor allele frequency- A:0.00NA 4552
    rs3761420951,2
    C--5231034(+) GCTCCC/TGGGAG 2 Q R mis10--------
    rs1928552371,2
    C--5231066(+) ATGGTA/GACCAC 2 V syn10--------
    rs2007555541,2
    C--5231173(+) CTGGCT/CCTTGA 2 /S /G mis11Minor allele frequency- C:0.00EU 1323
    rs37466821,2
    C,F,A,H--5231192(+) AGGACG/CGTTTC 2 /T syn1 ese327Minor allele frequency- C:0.29EA NS NA WA CSA EU 8667
    rs3762395801,2
    C--5231214(+) AAGCCA/GATGGG 2 S L mis10--------
    rs37466831,2
    C,F--5231252(+) ACCAAG/CGCGAT 2 /A syn17Minor allele frequency- C:0.12CSA WA NA EA EU 5979
    rs1427530461,2
    F--5231270(+) GAGGCC/TGTTTG 2 T syn11Minor allele frequency- T:0.00NA 4552
    rs2008871881,2
    --5231311(+) GATGGC/TGAGAT 2 T A mis10--------
    rs37466841,2
    C,F,A,H--5231312(+) ATGGCG/AAGATA 2 /L syn129Minor allele frequency- A:0.42NS EA NA WA CSA EU 7638
    rs1842861651,2
    --5231517(+) TTTGGA/GTCAAA 1 -- int10--------
    rs1382914121,2
    --5231541(+) TCCTGA/GGTTTT 1 -- int10--------
    rs21450891,2
    C,F,A,H--5231570(+) GTCTGG/AGATGA 1 -- int113Minor allele frequency- A:0.47NS EA NA WA CSA 786
    rs1150095621,2
    C,F--5231582(+) TTATTC/TAATCT 1 -- int11Minor allele frequency- T:0.02WA 118
    rs72670631,2
    C,F,H--5231615(+) tgcaaC/Tctgga 1 -- int14Minor allele frequency- T:0.00NS EA 420
    rs557968121,2
    C,F--5231668(+) TATGGC/TAATTT 1 -- int13Minor allele frequency- T:0.09WA NA EA 358
    rs72666391,2
    C,F,H--5231701(+) TAGGCG/ATTCAA 1 -- int17Minor allele frequency- A:0.10NS EA CSA WA NA 626
    rs1442656091,2
    C--5231788(+) AGAACA/GTACAA 1 -- int10--------
    rs1483552771,2
    C--5231796(+) CAATAC/TTCTCA 1 -- int10--------
    rs21805731,2
    C,F,O,A--5231802(+) TCTCAA/GAGCTC 1 -- int113Minor allele frequency- G:0.45NA WA CSA EA 513
    rs21805741,2
    C,F,O,A--5231849(+) GGCTTG/ATGGCC 1 -- int114Minor allele frequency- A:0.45NA WA CSA EA 512
    rs23266201,2
    C,F,O--5231898(+) AAGAAC/TTTGCT 1 -- int113Minor allele frequency- T:0.45NA WA CSA EA 513
    rs355965261,2
    C,F--5231935(+) ATTTCA/GGAGGC 1 -- int110Minor allele frequency- G:0.43NA WA CSA EA 372
    rs1415067861,2
    --5232026(+) GGGACC/GAGAAT 1 -- int10--------
    rs787532981,2
    C,F--5232161(+) GAGCCC/TTTTGT 1 -- int11Minor allele frequency- T:0.04EA 120
    rs72634381,2
    C,F,H--5232187(+) TTGTGT/CGGATT 1 -- int127Minor allele frequency- C:0.12NS EA NA CSA WA 2582
    rs48157881,2
    C,F,A,H--5232217(+) AGACCT/CAATGA 1 -- int125Minor allele frequency- C:0.44NS EA NA WA CSA 2490
    rs72689461,2
    C--5232223(+) AATGAC/TACCTA 1 -- int10--------
    rs72618561,2
    C,F--5232224(+) ATGACA/GCCTAT 1 -- int19Minor allele frequency- G:0.10NS CSA WA NA EA 458
    rs566863051,2
    C,F--5232250(+) CCTGGC/TATCAT 1 -- int14Minor allele frequency- T:0.18WA CSA EA 242
    rs1508723001,2
    C--5232311(+) ATATGA/GTAGAT 1 -- int10--------
    rs104854851,2
    C,F,H--5232316(+) GTAGAT/CGAAGA 1 -- int125Minor allele frequency- C:0.10NS NA EA CSA WA 2412
    rs1394299441,2
    --5232330(+) GAGGCA/GTGAAG 1 -- int10--------
    rs1444994381,2
    --5232375(+) CGTGTA/GCTTCA 1 -- int10--------
    rs1915992671,2
    --5232421(+) GATGCC/TGCCTG 1 -- int10--------
    rs1167127931,2
    C,F--5232444(+) CCCCCC/TAAAAC 1 -- int11Minor allele frequency- T:0.09WA 118
    rs748139201,2
    C--5232487(+) GACAAG/TTGTGG 1 -- int10--------
    rs48157891,2
    C,F--5232503(+) GGTTCG/ATTCCA 1 -- int14Minor allele frequency- A:0.50NA 8
    rs1397896181,2
    --5232533(+) TGATGA/GTGAGG 1 -- int10--------
    rs1432831621,2
    --5232608(+) AAAGCA/GGCAAA 1 -- int10--------
    rs48157901,2
    C,F,A--5232617(+) aaaggA/Ggggag 1 -- int1 trp34Minor allele frequency- G:0.38NA CSA 8
    rs748453621,2
    C--5232672(+) GAAAAA/CGACCC 1 -- int10--------
    rs1488439601,2
    --5232683(+) TCCAGA/GTCTTT 1 -- int10--------
    rs72637491,2
    C,F,A,H--5232709(+) ctgggC/Tgaaaa 1 -- int15Minor allele frequency- T:0.33NA CSA 9
    rs72621641,2
    C,F,A,H--5232733(+) tgactA/Gttcga 1 -- int16Minor allele frequency- G:0.46NA CSA EA 247
    rs1838375911,2
    --5232736(+) CTATTC/TGAGCA 1 -- int10--------
    rs1890427251,2
    --5232779(+) GGCAGC/GAATTC 1 -- int10--------
    rs1423140251,2
    --5232841(+) TACACC/TGCCCC 1 -- int10--------
    rs792617461,2
    C--5232916(+) AAACAA/CGCTAT 1 -- int10--------
    rs757035961,2
    C--5232921(+) AGCTAC/TAAATC 1 -- int10--------
    rs1460625031,2
    --5232986(+) CCAGTC/TGGATG 1 -- int10--------
    rs1169972531,2
    F--5233023(+) TTACTC/TGAGCT 1 -- int11Minor allele frequency- T:0.02NA 120
    rs759765701,2
    C--5233029(+) GAGCTC/TGTCTA 1 -- int10--------
    rs72704081,2
    C,F,A,H--5233030(+) agctcG/Atctaa 1 -- int114Minor allele frequency- A:0.44NS EA NA WA CSA 788
    rs1824859271,2
    --5233031(+) GCTCGC/TCTAAC 1 -- int10--------
    rs761064331,2
    C--5233066(+) AACTTA/GGTGGG 1 -- int10--------
    rs72704721,2
    C,F,A,H--5233095(+) aggctG/Ccttgc 1 -- int14Minor allele frequency- C:0.50NA 8
    rs72653191,2
    C,F,A,H--5233115(+) gcccaT/Acctca 1 -- int17Minor allele frequency- A:0.48NA CSA 131
    rs72639151,2
    C,F,A,H--5233159(+) tggcgG/Actggg 1 -- int15Minor allele frequency- A:0.44NA CSA 9
    rs766662841,2
    C--5233255(+) TTCATA/GTGGAG 1 -- int10--------
    rs791481981,2
    C--5233274(+) CCTTCA/CTTTAG 1 -- int10--------
    rs802909281,2
    C--5233300(+) ACCAAA/GAGAAC 1 -- int10--------
    rs1147860801,2
    C,F--5233363(+) AGATTC/TGGCTG 1 -- int12Minor allele frequency- T:0.09WA EA 238
    rs1502253011,2
    C--5233385(+) GTGTTA/GCAGTT 1 -- int10--------
    rs1871202701,2
    --5233434(+) CTCTGC/TGACCT 1 -- int10--------
    rs1903786581,2
    --5233504(+) TCTGCA/GTAAGG 1 -- int10--------
    rs21450901,2
    C,F,A--5233530(+) aggcaA/Gtggca 1 -- int15Minor allele frequency- G:0.33NA CSA 9
    rs763175201,2
    C--5233576(+) TGGAGC/TTTGTT 1 -- int10--------
    rs777717431,2
    C--5233653(+) ATAGGA/G/TGAAAA 1 -- int10--------
    rs1856629491,2
    --5233654(+) TAGGGA/GAAAAA 1 -- int10--------
    rs348868241,2
    C--5233722(+) TCAGTG/-TCACT 1 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs1463917851,2
    C--5233723(+) CAGTT-/GCACTC 1 -- int10--------
    rs1170607701,2
    F--5233750(+) GGGAAC/ACTGAT 1 -- int11Minor allele frequency- A:0.01NA 120
    rs1901216481,2
    C--5233833(+) CTGACC/G/TCCTGT 1 -- int10--------
    rs1823895081,2
    --5233873(+) GTGCTA/GCAGTA 1 -- int10--------
    rs1851331401,2
    C--5233943(+) AACAGA/GAGTCT 1 -- int10--------
    rs72729501,2
    C,F,A--5233964(+) gccagT/Cgggga 1 -- int13Minor allele frequency- C:0.40NA CSA 5
    rs72729521,2
    C,F,A--5233970(+) ggggaT/Cgatag 1 -- int13Minor allele frequency- C:0.33NA 6
    rs1398235921,2
    --5233991(+) AGGAAA/GGTCTA 1 -- int10--------
    rs72724841,2
    C,F,A--5234013(+) aaaggA/Ggtaca 1 -- int14Minor allele frequency- G:0.38NA CSA 8
    rs60532721,2
    C--5234035(+) gagtcA/Gttgat 1 -- int12Minor allele frequency- G:0.25NA 4
    rs72725481,2
    C,F,A--5234067(+) caaatT/Ggttat 1 -- int17Minor allele frequency- G:0.49NA CSA WA EA 365
    rs72725591,2
    C,F,A,H--5234111(+) agagcG/Atctgg 1 -- int112Minor allele frequency- A:0.28NS EA NA WA 750
    rs1391151251,2
    --5234119(+) TGGCAC/TAGCTC 1 -- int10--------
    rs1906699721,2
    --5234128(+) TCCTGA/CTTGTG 1 -- int10--------
    rs1450016401,2
    --5234205(+) GGCAAA/CGCAGC 1 -- int10--------
    rs116996241,2
    C,F,H--5234240(+) taaacG/Atccta 1 -- int13Minor allele frequency- A:0.33NA 6
    rs1445338401,2
    --5234302(+) GGAGCA/GGATAT 1 -- int10--------
    rs1180386331,2
    C,F--5234314(+) TCAATC/AATTTC 1 -- int11Minor allele frequency- A:0.04EA 120
    rs1478432331,2
    --5234329(+) CAGCAC/TTGGCT 1 -- int10--------
    rs1841610131,2
    --5234332(+) CACTGC/GCTGTC 1 -- int10--------
    rs769614901,2
    C--5234375(+) TAGTTA/GGAGTT 1 -- int10--------
    rs1414158861,2
    --5234410(+) AGTAGG/TTATAT 1 -- int10--------
    rs1887035101,2
    --5234446(+) CAACCC/TGGGAC 1 -- int10--------
    rs1931919771,2
    --5234481(+) ACCTAC/TAAATT 1 -- int10--------
    rs1830253421,2
    --5234554(+) CAACAC/TATGAT 1 -- int10--------
    rs1432559031,2
    C--5234576(+) GGTATA/GTCCCT 1 -- int10--------
    rs1873508351,2
    --5234703(+) AACCTA/GTACCT 1 -- int10--------
    rs60850771,2
    C,F,A,H--5234729(+) gataaG/Accaat 1 -- int113Minor allele frequency- A:0.44NS EA NA CSA 525
    rs60532731,2
    C,F--5234827(+) tccaaC/Tatttt 1 -- int14Minor allele frequency- T:0.50NA CSA 8
    rs60532741,2
    C,F--5234855(+) gttttC/Tgtaat 1 -- int12Minor allele frequency- T:0.50NA CSA 4
    rs60532751,2
    C,F,A--5234954(+) attgcT/Cttctc 1 -- int17Minor allele frequency- C:0.41NA CSA WA EA 366
    rs1918419711,2
    --5235042(+) CAAGAC/TTGTGA 1 -- int10--------
    rs60532761,2
    C,F--5235049(+) gtgaaC/Tggttt 1 -- int12Minor allele frequency- T:0.50NA 4
    rs60850781,2
    C,F--5235152(+) tggctC/Tgaaaa 1 -- int12Minor allele frequency- T:0.50NA 4
    rs744425381,2
    C--5235197(+) AAAAGC/TGGAGC 1 -- int10--------
    rs1840594931,2
    --5235240(+) GATATC/GCCTAT 1 -- int10--------
    rs1444666701,2
    --5235332(+) ACAACC/TGATGA 1 -- int10--------
    rs790472421,2
    C--5235336(+) CTGATA/GACAAA 1 -- int10--------
    rs771633541,2
    C--5235338(+) GATGAC/TAAAAA 1 -- int10--------
    rs1483905081,2
    --5235346(+) AAACAA/GAAAAG 1 -- int10--------
    rs60768031,2
    C,F,H--5235368(+) gggatG/Tacagg 1 -- int112Minor allele frequency- T:0.43NS EA NA WA CSA 571
    rs60532771,2
    C,A,H--5235488(+) agacaG/Aaagca 1 -- int16Minor allele frequency- A:0.00NA WA CSA 13
    rs60850791,2
    C,F,H--5235576(+) tgcttC/Gtgttt 1 -- int15Minor allele frequency- G:0.45NA CSA 11
    rs43494101,2
    C,F,H--5235738(+) tcacaG/Agcaac 1 -- int16Minor allele frequency- A:0.38NA CSA 13
    rs748169811,2
    C--5235792(+) TGTCAC/TAGATG 1 -- int10--------
    rs21450911,2
    C,F,A--5235833(+) ccagtC/Tacaat 1 -- int14Minor allele frequency- T:0.29NA CSA 7
    rs61167431,2
    C--5235841(+) aatgaG/Ataatt 1 -- int12Minor allele frequency- A:0.00NA 4
    rs1879912381,2
    C--5235852(+) TAATGG/TTAGCT 1 -- int10--------
    rs1457126671,2
    --5235865(+) GATAGC/TGGTGA 1 -- int10--------
    rs1922658651,2
    --5235880(+) CATTGC/TCATGA 1 -- int10--------
    rs21450921,2
    C,F,A,H--5236022(+) ttaccA/Gtaata 1 -- int14Minor allele frequency- G:0.36NA CSA 11
    rs1903733091,2
    --5236039(+) CTCCTA/GTAATT 1 -- int10--------
    rs1437194611,2
    --5236053(+) GCATAC/GCACCC 1 -- int10--------
    rs21805751,2
    C,F,A,H--5236108(+) tgaacG/Atactt 1 -- int14Minor allele frequency- A:0.22NA CSA 9
    rs1412882911,2
    --5236138(+) CAGAAC/TGGGCA 1 -- int10--------
    rs19697021,2
    C,F,A,H--5236229(+) gtctgT/Cgtgcc 1 -- int16Minor allele frequency- C:0.41MN NA CSA 195
    rs1389615321,2
    --5236375(+) TAGAAA/GCTAAA 1 -- int10--------
    rs19697031,2
    C,F,A,H--5236436(+) GGaaaG/Taataa 1 -- int15Minor allele frequency- T:0.38NA CSA 13
    rs1817350061,2
    --5236607(+) AAACAC/TTTGGA 1 -- int10--------
    rs713328941,2
    C--5236627(+) TTTCAATG/-ATGAT 1 -- cds11Minor allele frequency- -:0.50NA 2
    rs1438080641,2
    C--5236628(+) TTCAA-/ATGTGATT 1 -- cds10--------
    rs1843655711,2
    C--5236727(+) CCTTTC/GCTTTT 1 -- int10--------
    rs60850821,2
    C,F,A,H--5236734(+) ttttaT/Ccgatt 1 -- int13Minor allele frequency- C:0.38NA 8
    rs60850831,2
    C,F,A,H--5236751(+) tcaaaG/Taaggg 1 -- int13Minor allele frequency- T:0.50NA 8
    rs1494503931,2
    --5236766(+) ATGTTA/GGGAAC 1 -- int10--------
    rs561721011,2
    C,F--5236778(+) GGCCCC/TCCCCC 1 -- int13Minor allele frequency- T:0.50NA 8
    rs2015214511,2
    C--5236783(+) CCCCC-/CCTCAAAA 1 -- int10--------
    rs794907541,2
    C--5236785(+) CCCCCC/TCAAAA 1 -- int10--------
    rs60768041,2
    C,F,H--5236897(+) ttaccG/Agaatg 1 -- int13Minor allele frequency- A:0.40NA CSA 5
    rs1888001221,2
    C--5236952(+) AGGCGC/TTCTTA 1 -- int10--------
    rs1419437311,2
    C--5237037(+) CCTTT-/ATTTCGGC
    CCATCCCTTC
    ATTTC
    1 -- int10--------
    rs60850841,2
    C,F,A--5237165(+) ctgttT/Cggggc 1 -- int13Minor allele frequency- C:0.40NA CSA 5
    rs72721571,2
    C,F--5237175(+) CTCTCG/AGCTCT 1 -- int13Minor allele frequency- A:0.40NA CSA 5
    rs72646691,2
    C,F,A--5237274(+) tctccT/Ccgacc 1 -- int18Minor allele frequency- C:0.47NA WA CSA EA 367
    rs1812667501,2
    --5237290(+) GGTCTC/TAGCAG 1 -- int10--------
    rs72722221,2
    C,F,A--5237302(+) TGCCTG/ATAGAA 1 -- int111Minor allele frequency- A:0.48NA WA CSA EA 373
    rs756466131,2
    F--5237360(+) TCTTTC/TCAAGT 1 -- int11Minor allele frequency- T:0.05WA 118
    rs1484438741,2
    --5237372(+) TCTGAA/CTGGAC 1 -- int10--------
    rs72738371,2
    C,F,A,H--5237417(+) CCCTGC/TCAATA 1 -- int129Minor allele frequency- T:0.44NS EA NA WA CSA 2987
    rs1427025971,2
    --5237418(+) CCTGTA/CAATAT 1 -- int10--------
    rs72643711,2
    C,F,A--5237458(+) TGCCTT/GCCCCC 1 -- int18Minor allele frequency- G:0.46NA WA CSA EA 367
    rs177211951,2
    C,F--5237556(+) CTAGGG/ATGAAG 1 -- int13Minor allele frequency- A:0.39NA 140
    rs743793721,2
    C,F--5237556(+) CTAGGA/-TGAAG 1 -- int12Minor allele frequency- -:0.50NA CSA 4
    rs60532811,2
    C,F,A,H--5237580(+) CAACCA/GCTGGC 1 -- int125Minor allele frequency- G:0.44NS EA NA WA CSA 2491
    rs803107081,2
    C,F--5237642(+) GCCATG/ACATGT 1 -- int11Minor allele frequency- A:0.03WA 118
    rs50120841,2
    C,F--5237654(+) ACCTGG/ACCTTG 1 -- int112Minor allele frequency- A:0.44NA WA CSA EA 511
    rs1862623801,2
    --5237679(+) ATGACC/TTGCCT 1 -- int10--------
    rs60532821,2
    C,H--5237730(+) GGGCAG/CGCTCA 1 -- int16Minor allele frequency- C:0.00NS EA NA 412
    rs50120831,2
    C,F,H--5237738(+) TCATTG/CTTGTT 1 -- int114Minor allele frequency- C:0.46NS EA NA WA CSA 779
    rs50120821,2
    C,F--5237752(+) GGCAGA/GGACAT 1 -- int110Minor allele frequency- G:0.46NA WA CSA EA 371
    rs50120811,2
    C,F--5237764(+) TCACAA/GTCACT 1 -- int110Minor allele frequency- G:0.46NA WA CSA EA 371
    rs746343941,2
    C,F--5237772(+) ACTGAC/GTCTTC 1 -- int13Minor allele frequency- G:0.10WA NA EA 358
    rs50120801,2
    C,F,H--5237776(+) ACTCTC/TCATGA 1 -- int112Minor allele frequency- T:0.48EA NS NA WA CSA 551
    rs50120791,2
    C,F--5237827(+) TTACCA/GCAAAC 1 -- int110Minor allele frequency- G:0.46NA WA CSA EA 371
    rs1505804471,2
    --5237869(+) GTTACA/GGTTTT 1 -- int10--------
    rs730737281,2
    C,F--5237919(+) TCAAGA/TTGTTG 1 -- int14Minor allele frequency- T:0.11CSA WA NA EA 360
    rs60532831,2
    C,F,H--5237924(+) ATGTTG/AGCAAG 1 -- int121Minor allele frequency- A:0.14NS EA NA CSA WA 2331
    rs670340281,2
    C,F--5237968(+) AATCTG/ATTTTT 1 -- int19Minor allele frequency- A:0.47NA WA CSA EA 369
    rs730737331,2
    C,F--5238011(+) GCTGAC/TGACTT 1 -- int16Minor allele frequency- T:0.36NA WA CSA 11
    rs60532841,2
    C,F--5238017(+) GACTTC/TTTCCC 1 -- int1 trp311Minor allele frequency- T:0.33NA WA CSA EA 373
    rs787171601,2
    C,F--5238021(+) TTTTCT/CCTTTC 1 -- int14Minor allele frequency- C:0.38NA WA 8
    rs769170571,2
    C,F--5238026(+) CCTTTT/CCAAAG 1 -- int14Minor allele frequency- C:0.38NA WA 8
    rs730737351,2
    C,F--5238047(+) TCAATT/CGAGTT 1 -- int15Minor allele frequency- C:0.48NA WA EA 362
    rs730737361,2
    C,F--5238048(+) CAATCA/GAGTTT 1 -- int15Minor allele frequency- G:0.48NA WA EA 362
    rs1911538391,2
    --5238080(+) AAACTA/CTTTGG 1 -- int10--------
    rs664749651,2
    C,F--5238096(+) CTCTTC/TCACAG 1 -- int19Minor allele frequency- T:0.46NA WA CSA EA 369
    rs1396102781,2
    C--5238123(+) TTTCAC/TTGGGT 1 -- int10--------
    rs738939261,2
    C,F--5238155(+) ATTTCG/TATATT 1 -- int11Minor allele frequency- T:0.50WA 2
    rs736142821,2
    C,F--5238156(+) TTTCTA/GTATTT 1 -- int11Minor allele frequency- G:0.06EA 120
    rs622038321,2
    C,F--5238203(+) TACCTT/CAATTC 1 -- int110Minor allele frequency- C:0.46NA WA CSA EA 373
    rs782776821,2
    C--5238246(+) TCCTGC/GGGATT 1 -- int10--------
    rs751334801,2
    C,F--5238301(+) TACTGA/CATCCA 1 -- int11Minor allele frequency- C:0.07EA 120
    rs177777161,2
    C,F,H--5238311(+) AAAGGC/GCTTAG 1 -- int130Minor allele frequency- G:0.45NA NS EA WA CSA 2921
    rs1876599731,2
    --5238322(+) ATAATA/GCAGAA 1 -- int10--------
    rs1465434491,2
    --5238347(+) TATAGC/TTCTCT 1 -- int10--------
    rs730737391,2
    C,F--5238349(+) TAGCTC/GTCTCT 1 -- int11Minor allele frequency- G:0.03NA 120
    rs622038331,2
    C,F--5238357(+) TCTCAG/ATCTGG 1 -- int18Minor allele frequency- A:0.47NA WA EA 368
    rs622038341,2
    C,F--5238363(+) TCTGGC/TTCCAC 1 -- int16Minor allele frequency- T:0.43NA WA 14
    rs1126311041,2
    C--5238371(+) ACCATAA/-AAAAA 1 -- int11Minor allele frequency- -:0.00CSA 2
    rs680257391,2
    C,F--5238387(+) TCAATC/AACCCA 1 -- int19Minor allele frequency- A:0.47NA WA EA 372
    rs60532851,2
    C,F--5238421(+) CTCCTC/TATTCT 1 -- int19Minor allele frequency- T:0.47NA WA CSA EA 369
    rs60532861,2
    C,F,A,H--5238438(+) AATTCC/TTAAAT 1 -- int128Minor allele frequency- T:0.29NS EA NA WA CSA 2495
    rs60532871,2
    C,F,A,H--5238563(+) CCTGGG/ATTCCA 1 -- int114Minor allele frequency- A:0.46NS EA NA WA CSA 787
    rs60850851,2
    C,F,A,H--5238594(+) CTGTGC/TACTTG 1 -- int114Minor allele frequency- T:0.46NS EA NA WA CSA 789
    rs1172718171,2
    C,F--5238696(+) CATGTT/CCTGAG 1 -- int11Minor allele frequency- C:0.01NA 120
    rs60532881,2
    C,F,A,H--5238762(+) ATTTCT/CTATGA 1 -- int114Minor allele frequency- C:0.45NA WA CSA EA 517
    rs1919688641,2
    --5238768(+) TATGAA/CTCATT 1 -- int10--------
    rs1832697471,2
    --5238815(+) CATCTC/GTCTGC 1 -- int10--------
    rs1172725261,2
    C,F--5238890(+) CTCTGG/TGCTTC 1 -- int11Minor allele frequency- T:0.04EA 120
    rs130387731,2
    C,F--5238977(+) GGAGGC/ACTGTG 1 -- int110Minor allele frequency- A:0.46NA WA CSA EA 371
    rs130382141,2
    C,F--5238994(+) CCACCT/CTACAT 1 -- int19Minor allele frequency- C:0.49NA WA EA 370
    rs130387811,2
    C,F--5238998(+) CCTACG/ATGTGT 1 -- int19Minor allele frequency- A:0.47NA WA EA 370
    rs130387891,2
    C,F--5239009(+) TAGGGT/AACACA 1 -- int19Minor allele frequency- A:0.47NA WA CSA EA 369
    rs130389651,2
    C,F--5239079(+) AGCATC/AATTGG 1 -- int16Minor allele frequency- A:0.48NA WA EA 364
    rs130430501,2
    C,F--5239081(+) CATAAC/TTGGGG 1 -- int15Minor allele frequency- T:0.48NA WA EA 362
    rs562374231,2
    C--5239157(+) AACCT-/GATCAGA 1 -- int10--------
    rs752832371,2
    C--5239157(+) AACCTG/TATCAG 1 -- int10--------
    rs1440981701,2
    C--5239157(+) AACCT-/GATCA 
            
    GAGAA
    1 -- int10--------
    rs764262121,2
    C--5239159(+) CCTGA-/TCAGA 
            
    GAAGA
    1 -- int10--------
    rs719237151,2
    C--5239160(+) CTGAT-/CAGAGAAG 1 -- int10--------
    rs1875969111,2
    --5239184(+) TCTTTA/CTCCCT 1 -- int10--------
    rs560298281,2
    C,F--5239193(+) CTATCC/GTACCA 1 -- int18Minor allele frequency- G:0.43NA WA EA 368
    rs130386761,2
    C,F--5239236(+) CTCATC/TAATGA 1 -- int13Minor allele frequency- T:0.33NA 6
    rs1118204661,2
    C,F--5239263(+) GAACTC/TTCTGT 1 -- int12Minor allele frequency- T:0.11WA 120
    rs20572601,2
    C,F,A--5239270(+) CTGTAG/AAGCTG 1 -- int18Minor allele frequency- A:0.14NA CSA WA EA 368
    rs121062081,2
    C,F--5239272(+) GTAGAT/GCTGTG 1 -- int18Minor allele frequency- G:0.48NA WA EA 368
    rs765900191,2
    C--5239277(+) GCTGTG/TATCTA 1 -- int10--------
    rs121061201,2
    C,F--5239283(+) ATCTAC/TGCTGG 1 -- int17Minor allele frequency- T:0.49NA WA EA 366
    rs60381271,2
    C,F,A--5239294(+) CTCCAC/TTAGTC 1 -- int16Minor allele frequency- T:0.50NA CSA WA EA 363
    rs730755171,2
    C--5239295(+) TCCACG/TAGTCC 1 -- int12Minor allele frequency- T:0.33NA CSA 3
    rs1164327531,2
    C,F--5239312(+) AGGAAT/CATGCT 1 -- int11Minor allele frequency- C:0.02WA 118
    rs60532891,2
    H--5239440(+) TGCTAG/AGCACT 1 -- int14Minor allele frequency- A:0.00NS EA 416
    rs1905626531,2
    --5239467(+) AACATA/CGTTAT 1 -- int10--------
    rs1436456021,2
    --5239468(+) ACATCA/GTTATT 1 -- int10--------
    rs1468502751,2
    C--5239490(+) ACATTA/GTCTTC 1 -- int10--------
    rs60532901,2
    H--5239590(+) TGCTAG/AGCTCA 1 -- int14Minor allele frequency- A:0.00NS EA 420
    rs1489721161,2
    C--5239616(+) TCCGTA/GAGCAC 1 -- int10--------
    rs60532911,2
    C,F,A,H--5239696(+) CTTAAC/TATGGA 1 -- int121Minor allele frequency- N:0.00NS EA NA WA CSA 967
    rs563978451,2
    C,F--5239705(+) GATGAG/ATATGG 1 -- int14Minor allele frequency- A:0.10CSA WA NA EA 360
    rs60532921,2
    H--5239728(+) AGTCAG/AGAGCC 1 -- int14Minor allele frequency- A:0.00NS EA 418
    rs1180050171,2
    --5239788(+) TGACTT/CGCTAA 1 -- int11Minor allele frequency- C:0.01EA 120
    rs1828065961,2
    --5240009(+) TGTGGC/TGTTGT 1 -- int10--------
    rs65160151,2
    C,F,A,H--5240022(+) CAAGGC/TGATTG 1 -- int1106Minor allele frequency- T:0.47NS EA PA EU CA WA NA CSA 6507
    rs60768051,2
    C,F,A--5240104(+) GTGGGG/ACAAGG 1 -- int110Minor allele frequency- A:0.47NA WA CSA EA 371
    rs60768061,2
    C,F,A--5240112(+) AGGGGG/AATGGG 1 -- int19Minor allele frequency- A:0.47NA WA CSA EA 369
    rs60768071,2
    C,F,A,H--5240124(+) ACAGTA/GCTTAC 1 -- int113Minor allele frequency- G:0.47NS EA NA WA 772
    rs1879440251,2
    --5240139(+) TGTGAC/TGGTTA 1 -- int10--------
    rs1168313011,2
    F--5240157(+) TTGTCA/TACTTG 1 -- int11Minor allele frequency- T:0.06WA 118
    rs1438299861,2
    --5240296(+) TCAGCC/TGCCAG 1 -- int10--------
    rs1481746171,2
    --5240343(+) AGAGAA/GACTGA 1 -- int10--------
    rs60532931,2
    --5240415(+) cttcaA/Tgttct 1 -- int10--------
    rs1458112811,2
    C--5240445(+) TGGCTC/TTCCTT 1 -- int10--------
    rs60532941,2
    C,F,A,H--5240451(+) tccttT/Gcttct 1 -- int1 trp36Minor allele frequency- G:0.46NA WA CSA EA 129
    rs60532951,2
    C,F,A,H--5240474(+) ggcctA/Gttgtg 1 -- int15Minor allele frequency- G:0.17NA CSA EA 246
    rs614040471,2
    C--5240498(+) ATGTGA/GGTTAA 1 -- int14Minor allele frequency- G:0.17WA CSA EA 242
    rs1386571831,2
    C--5240504(+) GTTAAC/TACTTA 1 -- int10--------
    rs1427548981,2
    C--5240625(+) AAAAAC/TGCAGA 1 -- int10--------
    rs730755221,2
    C,F--5240626(+) AAAATG/ACAGAT 1 -- int14Minor allele frequency- A:0.12CSA WA NA EA 360
    rs73546491,2
    C,F,H--5240641(+) gggacC/Tttgcc 1 -- int14Minor allele frequency- T:0.00NS EA 404
    rs1380442921,2
    --5240748(+) CAATGA/GTGCAG 1 -- int10--------
    rs1113576351,2
    C,F--5240765(+) CTCACG/AGCAAC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs116987331,2
    C,F,H--5240817(+) CCAAGT/CAGCTG 1 -- int16Minor allele frequency- C:0.36NA 14
    rs1487006311,2
    C--5240837(+) GCACCC/TGCCAC 1 -- int10--------
    rs1928089961,2
    --5240900(+) GCCAGA/GCTGGT 1 -- int10--------
    rs1843684171,2
    --5240923(+) ACCTCA/GGGTGA 1 -- int10--------
    rs72708941,2
    C,F,A,H--5240937(+) gcccgC/Tctcag 1 -- int17Minor allele frequency- T:0.43NA WA CSA 14
    rs1400028831,2
    --5241043(+) GAATTA/GTGTGC 1 -- int10--------
    rs60850861,2
    C,F,A,H--5241062(+) GATAGG/ATACAC 1 -- int116Minor allele frequency- A:0.28NS EA NA WA 932
    rs758612561,2
    C,F--5241172(+) ACACCC/TGTCTG 1 -- int11Minor allele frequency- T:0.04EA 120
    rs1877214681,2
    C--5241181(+) TGTGTA/CTTTTA 1 -- int10--------
    rs1925607291,2
    --5241189(+) TTATTA/CCTAAA 1 -- int10--------
    rs169908741,2
    C,F,H--5241251(+) AGAACA/GGGGGA 1 -- int1 trp310Minor allele frequency- G:0.08NA NS EA WA 892
    rs61167441,2
    H--5241310(+) TCATCC/TTAATG 1 -- int14Minor allele frequency- T:0.00NS EA 418
    rs60381281,2
    C,F,A,H--5241336(+) GGTGGG/ACAGCA 1 -- int113Minor allele frequency- A:0.44NA WA CSA EA 515
    rs1845944641,2
    --5241355(+) AAGGTA/GACCAC 1 -- int10--------
    rs1437126741,2
    --5241425(+) AAAATC/GTGTGT 1 -- int10--------
    rs1512668591,2
    C--5241490(+) CAAGGG/TCTGGT 1 -- int10--------
    rs60532961,2
    C,F,A,H--5241547(+) AATTAT/CCACAA 1 -- int110Minor allele frequency- C:0.47NA WA CSA EA 375
    rs1890463331,2
    C--5241552(+) CCACAA/GTTTAT 1 -- int10--------
    rs1404870691,2
    --5241595(+) TTTGAA/TTGTTT 1 -- int10--------
    rs1500448341,2
    --5241602(+) GTTTCC/TAACAC 1 -- int10--------
    rs72622911,2
    C,F--5241649(+) aattaC/Tcttgg 1 -- int11Minor allele frequency- T:0.05WA 118
    rs105662971,2
    C--5241729(+) TATTATG/-TGTCA 1 -- int11Minor allele frequency- -:0.50NA 2
    rs72698531,2
    C,F,A--5241755(+) AAGCAA/CAAAAT 1 -- int17Minor allele frequency- C:0.14NA WA EA 366
    rs60850881,2
    C,F,A,H--5241855(+) CCAACG/ATATGC 1 -- int132Minor allele frequency- A:0.44NS EA NA WA CSA 2919
    rs65160201,2
    C,F,A,H--5241970(+) ATACGG/TTATGT 1 -- int128Minor allele frequency- T:0.45NS EA NA WA CSA 2777
    rs1453413311,2
    C--5242018(+) TAATGA/GTAGAA 1 -- int10--------
    rs60850891,2
    C,F--5242047(+) tggtgG/Agggag 1 -- int13Minor allele frequency- A:0.05NA 124
    rs1814846831,2
    C--5242146(+) TACATA/GTTTTC 1 -- int10--------
    rs81164421,2
    C,F,A,H--5242233(+) TGTTGA/GTGCCA 1 -- int1