Aliases for PROKR2 Gene
External Ids for PROKR2 Gene
Previous HGNC Symbols for PROKR2 Gene
Previous GeneCards Identifiers for PROKR2 Gene
Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins. [provided by RefSeq, Jul 2008]
GeneCards Summary for PROKR2 Gene
PROKR2 (Prokineticin Receptor 2) is a Protein Coding gene. Diseases associated with PROKR2 include hypogonadotropic hypogonadism 3 with or without anosmia and kallmann syndrome 3. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include G-protein coupled receptor activity and neuropeptide Y receptor activity. An important paralog of this gene is PROKR1.
UniProtKB/Swiss-Prot for PROKR2 Gene
Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase.