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Aliases for PROKR2 Gene

Aliases for PROKR2 Gene

  • Prokineticin Receptor 2 2 3 5
  • G Protein-Coupled Receptor 73-Like 1 2 3
  • G-Protein Coupled Receptor I5E 3 4
  • GPR73L1 3 4
  • GPR73b 3 4
  • GPRg2 3 4
  • PK-R2 3 4
  • PKR2 3 4
  • Kallmann Syndrome 3 (Autosomal Dominant) 2
  • G-Protein Coupled Receptor 73-Like 1 4
  • DJ680N4.3 3
  • KAL3 3
  • HH3 3

External Ids for PROKR2 Gene

Previous HGNC Symbols for PROKR2 Gene

  • GPR73L1
  • KAL3

Previous GeneCards Identifiers for PROKR2 Gene

  • GC20M005231
  • GC20M005282
  • GC20M005238

Summaries for PROKR2 Gene

Entrez Gene Summary for PROKR2 Gene

  • Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins. [provided by RefSeq, Jul 2008]

GeneCards Summary for PROKR2 Gene

PROKR2 (Prokineticin Receptor 2) is a Protein Coding gene. Diseases associated with PROKR2 include hypogonadotropic hypogonadism 3 with or without anosmia and kallmann syndrome 3. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include G-protein coupled receptor activity and neuropeptide Y receptor activity. An important paralog of this gene is PROKR1.

UniProtKB/Swiss-Prot for PROKR2 Gene

  • Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase.

Gene Wiki entry for PROKR2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PROKR2 Gene

Genomics for PROKR2 Gene

Regulatory Elements for PROKR2 Gene

Genomic Location for PROKR2 Gene

Chromosome:
20
Start:
5,299,874 bp from pter
End:
5,317,547 bp from pter
Size:
17,674 bases
Orientation:
Minus strand

Genomic View for PROKR2 Gene

Genes around PROKR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PROKR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PROKR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PROKR2 Gene

Proteins for PROKR2 Gene

  • Protein details for PROKR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFJ6-PKR2_HUMAN
    Recommended name:
    Prokineticin receptor 2
    Protein Accession:
    Q8NFJ6
    Secondary Accessions:
    • A5JUU1
    • Q2M3C0
    • Q5TDY1
    • Q9NTT0

    Protein attributes for PROKR2 Gene

    Size:
    384 amino acids
    Molecular mass:
    43996 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for PROKR2 Gene

Proteomics data for PROKR2 Gene at MOPED

Post-translational modifications for PROKR2 Gene

  • Glycosylation at Asn 7 and Asn 27
  • Modification sites at PhosphoSitePlus

Other Protein References for PROKR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PROKR2 Gene

Domains & Families for PROKR2 Gene

Gene Families for PROKR2 Gene

Protein Domains for PROKR2 Gene

Suggested Antigen Peptide Sequences for PROKR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NFJ6

UniProtKB/Swiss-Prot:

PKR2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with PROKR2: view

Function for PROKR2 Gene

Molecular function for PROKR2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase.
genes like me logo Genes that share phenotypes with PROKR2: view

Human Phenotype Ontology for PROKR2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PROKR2 Gene

MGI Knock Outs for PROKR2:

Animal Model Products

  • Taconic Biosciences Mouse Models for PROKR2

CRISPR Products

miRNA for PROKR2 Gene

miRTarBase miRNAs that target PROKR2

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for PROKR2 Gene

Localization for PROKR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PROKR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PROKR2 Gene COMPARTMENTS Subcellular localization image for PROKR2 gene
Compartment Confidence
plasma membrane 5
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PROKR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with PROKR2: view

Pathways & Interactions for PROKR2 Gene

genes like me logo Genes that share pathways with PROKR2: view

Pathways by source for PROKR2 Gene

Interacting Proteins for PROKR2 Gene

SIGNOR curated interactions for PROKR2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PROKR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007623 circadian rhythm IEA,IBA --
genes like me logo Genes that share ontologies with PROKR2: view

Drugs & Compounds for PROKR2 Gene

(8) Drugs for PROKR2 Gene - From: IUPHAR, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MIT1 Pharma Full agonist, Agonist 0
PKR-A Pharma Antagonist 0
prokineticin-1 Pharma Full agonist, Agonist 0
prokineticin-2 Pharma Full agonist, Agonist 0
triazine compound 1 Pharma Antagonist 0

(1) Additional Compounds for PROKR2 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
prokineticin-2beta
Full agonist, Agonist
genes like me logo Genes that share compounds with PROKR2: view

Transcripts for PROKR2 Gene

mRNA/cDNA for PROKR2 Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PROKR2 Gene

Prokineticin receptor 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PROKR2 Gene

No ASD Table

Relevant External Links for PROKR2 Gene

GeneLoc Exon Structure for
PROKR2
ECgene alternative splicing isoforms for
PROKR2

Expression for PROKR2 Gene

mRNA expression in normal human tissues for PROKR2 Gene

mRNA differential expression in normal tissues according to GTEx for PROKR2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x10.1), Brain - Anterior cingulate cortex (BA24) (x9.8), Brain - Cortex (x6.6), and Brain - Hippocampus (x4.4).

SOURCE GeneReport for Unigene cluster for PROKR2 Gene Hs.375029

mRNA Expression by UniProt/SwissProt for PROKR2 Gene

Q8NFJ6-PKR2_HUMAN
Tissue specificity: Expressed in the ileocecum, thyroid gland, pituitary gland, salivary gland, adrenal gland, testis, ovary and brain.
genes like me logo Genes that share expression patterns with PROKR2: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PROKR2 Gene

Orthologs for PROKR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PROKR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PROKR2 35
  • 99.13 (n)
  • 98.96 (a)
PROKR2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PROKR2 36
  • 91 (a)
OneToOne
PROKR2 35
  • 87.85 (n)
  • 90.62 (a)
dog
(Canis familiaris)
Mammalia PROKR2 35
  • 90.45 (n)
  • 94.01 (a)
PROKR2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prokr2 16
Prokr2 35
  • 86.18 (n)
  • 90.29 (a)
Prokr2 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 88 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 85 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Prokr2 35
  • 86.34 (n)
  • 90.08 (a)
chicken
(Gallus gallus)
Aves PROKR2 35
  • 76.5 (n)
  • 87.13 (a)
PROKR2 36
  • 76 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 80 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia prokr2 35
  • 73.76 (n)
  • 85.36 (a)
zebrafish
(Danio rerio)
Actinopterygii CU929052.1 36
  • 61 (a)
ManyToMany
prokr1a 36
  • 59 (a)
ManyToMany
LOC798231 35
  • 69.24 (n)
  • 69.73 (a)
Species with no ortholog for PROKR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PROKR2 Gene

ENSEMBL:
Gene Tree for PROKR2 (if available)
TreeFam:
Gene Tree for PROKR2 (if available)

Paralogs for PROKR2 Gene

Paralogs for PROKR2 Gene

(3) SIMAP similar genes for PROKR2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PROKR2: view

Variants for PROKR2 Gene

Sequence variations from dbSNP and Humsavar for PROKR2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_030957 Hypogonadotropic hypogonadism 3 with or without anosmia (HH3)
VAR_030958 Hypogonadotropic hypogonadism 3 with or without anosmia (HH3)
VAR_030959 Hypogonadotropic hypogonadism 3 with or without anosmia (HH3)
rs74315416 Hypogonadotropic hypogonadism 3 with or without anosmia (HH3) 5,302,677(-) CTTCC(G/T)GATCG reference, missense
rs201835496 Hypogonadotropic hypogonadism 3 with or without anosmia (HH3) 5,302,662(+) CCATC(C/G)AGACC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PROKR2 Gene

Variant ID Type Subtype PubMed ID
nsv833904 CNV Gain 17160897
nsv515639 CNV Loss 19592680
nsv522879 CNV Loss 19592680
esv29566 CNV Loss 19812545

Variation tolerance for PROKR2 Gene

Residual Variation Intolerance Score: 50.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.92; 59.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PROKR2 Gene

HapMap Linkage Disequilibrium report
PROKR2
Human Gene Mutation Database (HGMD)
PROKR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PROKR2 Gene

Disorders for PROKR2 Gene

MalaCards: The human disease database

(15) MalaCards diseases for PROKR2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

PKR2_HUMAN
  • Hypogonadotropic hypogonadism 3 with or without anosmia (HH3) [MIM:244200]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). {ECO:0000269 PubMed:17054399, ECO:0000269 PubMed:18559922, ECO:0000269 PubMed:18826963, ECO:0000269 PubMed:22927827, ECO:0000269 PubMed:23643382, ECO:0000269 PubMed:25077900}. Note=The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. The genetics of hypogonadotropic hypogonadism involves various modes of transmission. Oligogenic inheritance has been reported in some patients carrying mutations in PROKR2 as well as in other HH-associated genes including KAL1, SEMA3A, PROK2, GNRH1 and FGFR1 (PubMed:17054399, PubMed:22927827, PubMed:23643382). {ECO:0000269 PubMed:17054399, ECO:0000269 PubMed:22927827, ECO:0000269 PubMed:23643382}.

Relevant External Links for PROKR2

Genetic Association Database (GAD)
PROKR2
Human Genome Epidemiology (HuGE) Navigator
PROKR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PROKR2
genes like me logo Genes that share disorders with PROKR2: view

No data available for Genatlas for PROKR2 Gene

Publications for PROKR2 Gene

  1. Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2. (PMID: 17054399) Dode C. … Hardelin J.-P. (PLoS Genet. 2006) 2 3 4 23 67
  2. Divergent roles of prokineticin receptors in the endothelial cells: angiogenesis and fenestration. (PMID: 20023120) Guilini C. … Nebigil C.G. (Am. J. Physiol. Heart Circ. Physiol. 2010) 3 23
  3. PROKR2 missense mutations associated with Kallmann syndrome impair receptor signalling activity. (PMID: 18826963) Monnier C. … Rondard P. (Hum. Mol. Genet. 2009) 3 23
  4. Genetic analysis in patients with Kallmann syndrome: coexistence of mutations in prokineticin receptor 2 and KAL1. (PMID: 18723471) Canto P. … MAcndez J.P. (J. Androl. 2009) 3 23
  5. Possible association of prokineticin 2 receptor gene (PROKR2) with mood disorders in the Japanese population. (PMID: 19544013) Kishi T. … Iwata N. (Neuromolecular Med. 2009) 3 23

Products for PROKR2 Gene

Sources for PROKR2 Gene

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