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PROKR2 Gene

protein-coding   GIFtS: 60
GCID: GC20M005282

Prokineticin Receptor 2

(Previous names: G protein-coupled receptor 73-like 1, Kallmann syndrome...)
(Previous symbols: GPR73L1, KAL3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Prokineticin Receptor 21 2     GPRg22 3
GPR73L11 2 3 5     PK-R22 3
PKR22 3 5     HH32 5
KAL31 2     Kallmann Syndrome 3 (Autosomal Dominant)1
G Protein-Coupled Receptor 73-Like 11 2     dJ680N4.32
GPR73b2 3     G-Protein Coupled Receptor 73-Like 13

External Ids:    HGNC: 158361   Entrez Gene: 1286742   Ensembl: ENSG000001012927   OMIM: 6071235   UniProtKB: Q8NFJ63   

Export aliases for PROKR2 gene to outside databases

Previous GC identifers: GC20M005231 GC20M005238


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PROKR2 Gene:
Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle
contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for
prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for
prokineticins. (provided by RefSeq, Jul 2008)

GeneCards Summary for PROKR2 Gene:
PROKR2 (prokineticin receptor 2) is a protein-coding gene. Diseases associated with PROKR2 include hypogonadotropic hypogonadism 3 with or without anosmia, and kallmann syndrome 3. GO annotations related to this gene include neuropeptide Y receptor activity. An important paralog of this gene is PROKR1.

UniProtKB/Swiss-Prot: PKR2_HUMAN, Q8NFJ6
Function: Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins.
Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42
mitogen-activated protein kinase

Gene Wiki entry for PROKR2 (Prokineticin receptor 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NT_011387.9  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PROKR2 gene promoter:
         SRF   Elk-1   SRF (504 AA)   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   XBP-1   POU3F2   N-Myc   NRF-2   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPROKR2 promoter sequence
   Search Chromatin IP Primers for PROKR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PROKR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p12.3   Ensembl cytogenetic band:  20p12.3   HGNC cytogenetic band: 20p12.3

PROKR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PROKR2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M005282:  view genomic region     (about GC identifiers)

Start:
5,282,317 bp from pter      End:
5,297,378 bp from pter
Size:
15,062 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PKR2_HUMAN, Q8NFJ6 (See protein sequence)
Recommended Name: Prokineticin receptor 2  
Size: 384 amino acids; 43996 Da
Subunit: Homodimer
Secondary accessions: A5JUU1 Q2M3C0 Q5TDY1 Q9NTT0

Explore the universe of human proteins at neXtProt for PROKR2: NX_Q8NFJ6

Explore proteomics data for PROKR2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn7, Asn27

  • See PROKR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_658986.1  
    ENSEMBL proteins: 
     ENSP00000217270   ENSP00000440790  
    Reactome Protein details: Q8NFJ6

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PROKR: GPCR / Class A : Prokineticin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: PKR2
    Prokineticin receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn
     IPR000611 NPY_rcpt

    Graphical View of Domain Structure for InterPro Entry Q8NFJ6

    ProtoNet protein and cluster: Q8NFJ6

    UniProtKB/Swiss-Prot: PKR2_HUMAN, Q8NFJ6
    Similarity: Belongs to the G-protein coupled receptor 1 family


    PROKR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PKR2_HUMAN, Q8NFJ6
    Function: Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins.
    Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42
    mitogen-activated protein kinase

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004983neuropeptide Y receptor activity IEA--
         
    PROKR2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PROKR2:
     High actin ratio cells  Increased gamma-H2AX phosphory 

         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Prokr2):
     behavior/neurological  cellular  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism 
     integument  mortality/aging  nervous system  reproductive system 

    PROKR2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PROKR2: Prokr2tm1Brd Prokr2tm1Api

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PROKR2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PROKR2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PROKR2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PROKR2

    miRNA
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    miRTarBase miRNAs that target PROKR2:
    hsa-mir-148b-3p (MIRT019359)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PKR2_HUMAN, Q8NFJ6: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    PROKR2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PROKR2 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Neuropeptides signaling through G protein alpha i and G protein alpha q
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    5GPCRs, Other
    GPCRs, Other

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for PROKR2
        GPCRs, Other

    2 Reactome Pathways for PROKR2
        Peptide ligand-binding receptors
    G alpha (q) signalling events



    PROKR2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PROKR2: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Circadian Rhythms in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for PROKR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PROKR2 (ENSP000002172704) via UniProtKB, MINT, STRING, and/or I2D (see all 123)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AVPR1AENSP000002991784STRING: ENSP00000299178
    EDN3ENSP000003371284STRING: ENSP00000337128
    EDNRBENSP000003353114STRING: ENSP00000335311
    GNRH1ENSP000002764144STRING: ENSP00000276414
    GNRH2ENSP000002459834STRING: ENSP00000245983
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007623circadian rhythm IEA--

    PROKR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PROKR2 (PKR2)

    1 HMDB Compound for PROKR2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Calcium
    • Ca
    • Calcium element
    (see top 1)
    7440-70-2--

    6 IUPHAR Ligands for PROKR2 (PKR2)    About this table
    LigandTypeActionAffinityPubmed IDs
    MIT1
    AgonistFull agonist9.212054613
    prokineticin-2
    AgonistFull agonist8.1 - 8.212054613 15772293
    PKR-A
    AntagonistAntagonist7.28 - 7.3622431614
    prokineticin-1
    AgonistFull agonist7.1 - 7.312054613 15772293
    prokineticin-2beta
    AgonistFull agonist615772293
    triazine compound 1
    AntagonistAntagonist5.7919006379



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PROKR2 gene: 
    NM_144773.2  

    Unigene Cluster for PROKR2:

    Prokineticin receptor 2
    Hs.375029  [show with all ESTs]
    Unigene Representative Sequence: AK090863
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000217270 ENST00000546004(uc010zqw.2 uc010zqx.2 uc010zqy.2)

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      QuantiTect SYBR Green Assays in human, mouse, rat PROKR2
      QuantiFast Probe-based Assays in human, mouse, rat PROKR2

    Additional mRNA sequence: 

    AB084081.1 AF506288.1 AK090863.1 AK289995.1 BC104959.1 BC104961.1 EF577398.1 

    3 DOTS entries:

    DT.100009581  DT.99930271  DT.100675803 

    3 AceView cDNA sequences:

    AB084081 NM_144773 AF506288 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PROKR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTACTTCA
    PROKR2 Expression
    About this image


    PROKR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Thalamus
             Septum   
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Testicular Interstitial Cells Testis Interstitium
             Testis Cord
    PROKR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PROKR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.375029

    UniProtKB/Swiss-Prot: PKR2_HUMAN, Q8NFJ6
    Tissue specificity: Expressed in the ileocecum, thyroid gland, pituitary gland, salivary gland, adrenal gland,
    testis, ovary and brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PROKR2: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Circadian Rhythms in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PROKR2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prokr21 , 5 prokineticin receptor 21, 5 86.18(n)1
    90.29(a)1
      2 (64.15 cM)5
    2463131  NM_144944.31  NP_659193.31 
     1323377335 
    chicken
    (Gallus gallus)
    Aves PROKR21 prokineticin receptor 2 76.5(n)
    87.13(a)
      421263  NM_001145229.1  NP_001138701.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    80(a)
    1 → many
    1(126816950-126830584)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia prokr21 prokineticin receptor 2 73.76(n)
    85.36(a)
      100490059  XM_002931756.1  XP_002931802.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7982311 Prokineticin receptor 1-like 69.24(n)
    69.73(a)
      798231  NM_001173407.1  NP_001166878.1 


    ENSEMBL Gene Tree for PROKR2 (if available)
    TreeFam Gene Tree for PROKR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PROKR2 gene
    PROKR12  
    3 SIMAP similar genes for PROKR2 using alignment to 1 protein entry:     PKR2_HUMAN:
    PROKR1    PRLHR    NPY2R

    PROKR2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PROKR2 (see all 523)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2018354961,2,,4
    Hypogonadotropic hypogonadism 3 with or without anosmia (HH3)4 --5231244(+) CCATCC/GAGACC 2 S W mis10--------
    rs743154161,2,,4
    C,FHypogonadotropic hypogonadism 3 with or without anosmia (HH3)4 pathogenic15231259(-) CTTCCT/GGATCG 2 /R /L mis12Minor allele frequency- G:0.00NA EU 5541
    rs743154181,2,,4
    C,FHypogonadotropic hypogonadism 3 with or without anosmia (HH3)4 pathogenic15242698(-) GTTGCA/G/TCAACC 2 H R mis12NA EU 5873
    VAR_0309644
    Hypogonadotropic hypogonadism 3 with or without anosmia (HH3)4--see VAR_0309642 P S mis40--------
    VAR_0309654
    Hypogonadotropic hypogonadism 3 with or without anosmia (HH3)4--see VAR_0309652 M I mis40--------
    VAR_0309624
    Hypogonadotropic hypogonadism 3 with or without anosmia (HH3)4--see VAR_0309622 Q R mis40--------
    VAR_0699644
    Hypogonadotropic hypogonadism 3 with or without anosmia (HH3)4--see VAR_0699642 V M mis40--------
    VAR_0309594
    Hypogonadotropic hypogonadism 3 with or without anosmia (HH3)4--see VAR_0309592 R Q mis40--------
    VAR_0699654
    Hypogonadotropic hypogonadism 3 with or without anosmia (HH3)4--see VAR_0699652 S G mis40--------
    rs743154191,2
    Cpathogenic15230808(-) GCCATA/GAGCAA 2 I M mis10--------

    HapMap Linkage Disequilibrium report for PROKR2 (5282317 - 5297378 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PROKR2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv522879CNV Loss19592680
    esv29566CNV Loss19812545
    nsv515639CNV Loss19592680
    nsv833904CNV Gain17160897

    Human Gene Mutation Database (HGMD): PROKR2
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607123   
    OMIM disorders: 244200  
    UniProtKB/Swiss-Prot: PKR2_HUMAN, Q8NFJ6
  • Hypogonadotropic hypogonadism 3 with or without anosmia (HH3) [MIM:244200]: A disorder characterized by
    absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating
    gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it
    is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss.
    Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is
    due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of
    gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic
    hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been
    termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). Note=The disease is caused by mutations
    affecting distinct genetic loci, including the gene represented in this entry. The genetics of hypogonadotropic
    hypogonadism involves various modes of transmission. Oligogenic inheritance has been reported in some patients
    carrying mutations in PROKR2 as well as in other HH-associated genes including KAL1, SEMA3A, PROK2, GNRH1 and
    FGFR1 (PubMed:17054399, PubMed:22927827, PubMed:23643382)

  • Selected diseases for PROKR2 (see all 32):    
    About MalaCards
    hypogonadotropic hypogonadism 3 with or without anosmia    kallmann syndrome 3    prokr2-related isolated gonadotropin-releasing hormone deficiency    congenital anosmia
    kallmann syndrome    septo-optic dysplasia    ectopic pregnancy    hypogonadotropic hypogonadism 8 with or without anosmia
    hypogonadotropic hypogonadism 17 with or without anosmia    tooth agenesis    hypogonadotropism    combined pituitary hormone deficiency
    renal agenesis    hypopituitarism    hypogonadism    klinefelter's syndrome
    pregnancy loss    cryptorchidism    sensorineural hearing loss    amenorrhea

    2 diseases from the University of Copenhagen DISEASES database for PROKR2:
    Klinefelter's syndrome     Hypogonadism

    PROKR2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for PROKR2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kallmann syndrome 95.4 8 18826963 (1), 17624596 (1), 18596028 (1), 17054399 (1) (see all 8)
    congenital malformation 35.1 2 17054399 (1), 18559922 (1)

    GeneTests: PROKR2
    GeneReviews: PROKR2
    Genetic Association Database (GAD): PROKR2
    Human Genome Epidemiology (HuGE) Navigator: PROKR2 (11 documents)

    Export disorders for PROKR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PROKR2 gene, integrated from 10 sources (see all 61):
    (articles sorted by number of sources associating them with PROKR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2. (PubMed id 17054399)1, 2, 3, 9 Dode C.... Hardelin J.-P. (PLoS Genet. 2006)
    2. Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor. (PubMed id 11886876)1, 2, 3 Lin D.C.-H....Zhou Q.-Y. (J. Biol. Chem. 2002)
    3. Genetic analysis in patients with Kallmann syndrome: coexistence of mutations in prokineticin receptor 2 and KAL1. (PubMed id 18723471)1, 4, 9 Canto P....MAcndez J.P. (J. Androl. 2009)
    4. Loss-of-function mutations in the genes encoding prokineticin-2 or prokineticin receptor-2 cause autosomal recessive Kallmann syndrome. (PubMed id 18682503)1, 4, 9 Abreu A.P....Latronico A.C. (J. Clin. Endocrinol. Metab. 2008)
    5. Evidence that prokineticin receptor 2 exists as a dimer in vivo. (PubMed id 21161321)1, 2 Marsango S.... Miele R. (Cell. Mol. Life Sci. 2011)
    6. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Polymorphisms of endocrine gland-derived vascular endothelial growth factor gene and its receptor genes are associated with recurrent pregnancy loss. (PubMed id 20847187)1, 4 Su M.T....Kuo P.L. (Hum. Reprod. 2010)
    9. A comparative phenotypic study of kallmann syndrome patients carrying monoallelic and biallelic mutations in the prokineticin 2 or prokineticin receptor 2 genes. (PubMed id 20022991)1, 4 Sarfati J....Young J. (J. Clin. Endocrinol. Metab. 2010)
    10. PROKR2 is associated with methamphetamine dependence in the Japanese population. (PubMed id 20576534)1, 4 Kishi T....Iwata N. (amp 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 128674 HGNC: 15836 AceView: GPR73L1 Ensembl:ENSG00000101292 euGenes: HUgn128674
    ECgene: PROKR2 H-InvDB: PROKR2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PROKR2 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=PROKR2[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PROKR2 gene:
    Search GeneIP for patents involving PROKR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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