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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PROKR2 Gene

protein-coding GIFtS: 59
GCID: GC20M005282

prokineticin receptor 2

(Previous names: G protein-coupled receptor 73-like 1, Kallmann syndrome...)
(Previous symbols: GPR73L1, KAL3)

Explore 17 diseases affiliated with
PROKR2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Prokineticin Receptor 2¹ ²		DJ680N4.3¹
GPR73L1¹ ² ³ ⁵		G Protein-Coupled Receptor 73-Like 1¹ ²
PKR2¹ ² ³ ⁵		PK-R2² ³
GPR73b¹ ² ³		Kallmann Syndrome 3 (Autosomal Dominant)¹
GPRg2¹ ² ³		HH3²
KAL3¹ ² ⁵		G-Protein Coupled Receptor 73-Like 1³

External Ids:	HGNC: 15836¹	Entrez Gene: 128674²	Ensembl: ENSG00000101292⁷	OMIM: 607123⁵	UniProtKB: Q8NFJ6³

Export aliases for PROKR2 gene to outside databases

Previous GC identifers: GC20M005231 GC20M005238

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PROKR2:

Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle

contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for

prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for

prokineticins. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PKR2_HUMAN, Q8NFJ6

Function: Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation

leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated

protein kinase

Gene Wiki entry for PROKR2 (Prokineticin receptor 2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011387.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PROKR2 gene promoter:
SRF Elk-1 SRF (504 AA) POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) XBP-1 POU3F2 N-Myc NRF-2 c-Myb
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PROKR2 promoter sequence

Search SABiosciences Chromatin IP Primers for PROKR2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PROKR2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p12.3 Ensembl cytogenetic band: 20p12.3 HGNC cytogenetic band: 20p12.3

PROKR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PROKR2 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M005282: view genomic region (about GC identifiers)

Start:	5,282,317 bp from pter	End:	5,297,378 bp from pter
Size:	15,062 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PKR2_HUMAN, Q8NFJ6 (See protein sequence)

Recommended Name: Prokineticin receptor 2

Size: 384 amino acids; 43996 Da

Subunit: Homodimer

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: A5JUU1 Q2M3C0 Q5TDY1 Q9NTT0

Explore the universe of human proteins at neXtProt for PROKR2: NX_Q8NFJ6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8NFJ6

PROKR2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_658986.1

ENSEMBL proteins:

ENSP00000217270 ENSP00000440790

Reactome Protein details: Q8NFJ6
Human Recombinant Protein Products for PROKR2:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PROKR2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	IEA	--

PROKR2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for PROKR2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PROKR2 for domains About GeneDecksing

3 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_7TM

IPR000276 GPCR_Rhodpsn

IPR000611 NPY_rcpt

Graphical View of Domain Structure for InterPro Entry Q8NFJ6

ProtoNet protein and cluster: Q8NFJ6

UniProtKB/Swiss-Prot: PKR2_HUMAN, Q8NFJ6

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PKR2_HUMAN, Q8NFJ6

Function: Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation

leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated

protein kinase

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004930	G-protein coupled receptor activity	--	--
GO:0004983	neuropeptide Y receptor activity	IEA	--

PROKR2 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for PROKR2:

High actin ratio cells

Increased gamma-H2AX phosphory

9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Prokr2):

behavior/neurological	cellular	endocrine/exocrine gland	growth/size	homeostasis/metabolism
integument	mortality/aging	nervous system	reproductive system

PROKR2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for PROKR2: Prokr2^tm1Brd Prokr2^tm1Api

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PROKR2

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PROKR2
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		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PROKR2 (see all 7) OriGene shRNA RFP: PROKR2 OriGene siRNA: PROKR2
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PROKR2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			Peptide ligand-binding receptors	0.61
	GPCR ligand binding	0.75

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

1.00

GPCRs, Other

GPCRs, Other

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for PROKR2

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

1 BioSystems Pathway for PROKR2

GPCRs, Other

5/8 Reactome Pathways for PROKR2 (see all 8)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR
	GPCR ligand binding

PROKR2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PROKR2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/123 Interacting proteins for PROKR2 (ENSP00000217270⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 123)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EDN3	ENSP00000337128⁴	STRING: ENSP00000337128
EDNRB	ENSP00000335311⁴	STRING: ENSP00000335311
GNRH1	ENSP00000276414⁴	STRING: ENSP00000276414
GNRH2	ENSP00000245983⁴	STRING: ENSP00000245983
GNRHR	ENSP00000226413⁴	STRING: ENSP00000226413

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007186	G-protein coupled receptor signaling pathway	--	--
GO:0007623	circadian rhythm	IEA	--

PROKR2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PROKR2

1 HMDB Compound for PROKR2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

Search CenterWatch for drugs/clinical trials and news about PROKR2 / PKR2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PROKR2 gene:

NM_144773.2

Unigene Cluster for PROKR2:

Prokineticin receptor 2

Hs.375029 [show with all ESTs]

Unigene Representative Sequence: AK090863

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000217270 ENST00000546004(uc010zqw.2 uc010zqx.2 uc010zqy.2)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PROKR2
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		GenScript: all cDNA clones in your preferred vector: PROKR2 (NM_144773)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PROKR2
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PROKR2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PROKR2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PROKR2

Additional cDNA sequence:

AB084081.1 AF506288.1 AK090863.1 AK289995.1 BC104959.1 BC104961.1 EF577398.1

3 DOTS entries:

DT.100009581 DT.99930271 DT.100675803

3 AceView cDNA sequences:

AB084081 NM_144773 AF506288

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PROKR2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGTACTTCA

About this image

PROKR2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Head Mesenchyme

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

Nkx2-1 GFP+ cells (Efficient derivation...)

See PROKR2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PROKR2

SOURCE GeneReport for Unigene cluster: Hs.375029

UniProtKB/Swiss-Prot: PKR2_HUMAN, Q8NFJ6

Tissue specificity: Expressed in the ileocecum, thyroid gland, pituitary gland, salivary gland, adrenal gland, testis,

ovary and brain

SABiosciences Expression via Pathway-Focused PCR Arrays including PROKR2:

Neurotransmitter Receptors in human mouse rat

G Protein Coupled Receptors 384HT in human mouse rat

Circadian Rhythms in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PROKR2 Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PROKR2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for PROKR2 gene from 3/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PROKR2¹	prokineticin receptor 2	77.62(n) 88.95(a)		421263 NM_001145229.1 NP_001138701.1
lizard (Anolis carolinensis)	Reptilia	-- --	--	80(a) 13(a)	1 ↔ many possible ortholog	1(126820405-126827840) GL344580.1(6867-15398)
zebrafish (Danio rerio)	Actinopterygii	LOC798231¹	similar to G protein-coupled receptor 73	69.44(n) 69.94(a)		798231 NM_001173407.1 NP_001166878.1

ENSEMBL Gene Tree for PROKR2 (if available)
TreeFam Gene Tree for PROKR2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PROKR2 gene

PROKR1²

3 SIMAP similar genes for PROKR2 using alignment to 1 protein entry: PKR2_HUMAN:

PROKR1 PRLHR NPY2R

PROKR2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74315419^1,2	C	pathogenic	5282872(-)	`GCCATA/GAGCAA`	2	I M	mis¹		0	--	--	--	--
rs74315417^1,2	C	pathogenic	5283212(-)	`TGGCCA/GGATCT`	2	Q R	mis¹		0	--	--	--	--
rs74315416^1,2	C,F	pathogenic	5283323(-)	`CTTCCT/GGATCG`	2	/R /L	mis¹		2		NA EU	5541
rs74315418^1,2	C,F	pathogenic	5294762(-)	`GTTGCA/G/TCAACC`	3	H R L	mis¹		2		NA EU	5873
rs57723524^1,2	C,F	--	5282269(+)	`AAACTC/TCAATA`	1	--	ds500¹		4		WA CSA EA	242
rs73594467^1,2	C	--	5282284(+)	`CTGCTG/ACTTTG`	1	--	ds500¹		1		WA	2
rs148317959^1,2	C	--	5282300(+)	`TTTTT-/TATATGT`	1	--	ds500¹		0	--	--	--	--
rs927106^1,2	C,F,O,A,H	--	5282336(+)	`TTTTTG/TATTAC`	1	--	ds500¹		12		NA WA CSA EA	375
rs140260090^1,2		--	5282379(+)	`TCCCTC/GTCTAA`	1	--	ds500¹		0	--	--	--	--
rs73071928^1,2		--	5282482(+)	`TAGGTA/GTCGAG`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PROKR2 (5282317 - 5297378 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for PROKR2
3 CNVs: 50692 50693 73462
Human Gene Mutation Database (HGMD): PROKR2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PROKR2

DNA2.0 Custom Variant and Variant Library Synthesis for PROKR2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PROKR2 for disorders           About GeneDecksing

OMIM gene information: 607123
OMIM disorders: 244200
UniProtKB/Swiss-Prot: PKR2_HUMAN, Q8NFJ6

Defects in PROKR2 are the cause of hypogonadotropic hypogonadism 3 with or without anosmia (HH3) [MIM:244200].

A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low

levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In

some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural

hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts.

Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic

migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic

hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell,

it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH)

17 diseases for PROKR2: About MalaCards

kallmann syndrome kallmann syndrome 3 ectopic pregnancy tooth agenesis

gonadotropin deficiency anosmia renal agenesis klinefelter's syndrome

mood disorder hypogonadotropism cryptorchidism hypogonadism

pancreatic cancer pancreatitis thyroiditis prostatitis

neuronitis

2 diseases from the University of Copenhagen DISEASES database for PROKR2:

Klinefelter's syndrome Hypogonadism

2 Novoseek disease relationships for PROKR2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
kallmann syndrome	95.4	8	18826963 (1), 17624596 (1), 18596028 (1), 17054399 (1) (see all 8)
congenital malformation	35.1	2	17054399 (1), 18559922 (1)

GeneTests: PROKR2

Kallmann Syndrome

Human Genome Epidemiology (HuGE) Navigator: PROKR2 (11 documents)

Export disorders for PROKR2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PROKR2 gene, integrated from 9 sources (see all 52):
(articles sorted by number of sources associating them with PROKR2)

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Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2. (PubMed id 17054399)^{1, 2, 3, 9} Dode C.... Hardelin J.-P. (2006)
Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor. (PubMed id 11886876)^{1, 2, 3} Lin D.C.-H....Zhou Q.-Y. (2002)
Evidence that prokineticin receptor 2 exists as a dim er in vivo. (PubMed id 21161321)^{1, 2} Marsango S....Miele R. (2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Molecular cloning and characterization of prokineticin receptors. (PubMed id 12427552)^{1, 2} Soga T.... Furuichi K. (2002)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
Divergent roles of prokineticin receptors in the endo thelial cells: angiogenesis and fenestration. (PubMed id 20023120)^{1, 9} Guilini C....Nebigil C.G. (2010)
Possible association of prokineticin 2 receptor gene (PROKR2) with mood disorders in the Japanese population. (PubMed id 19544013)^{1, 9} Kishi T....Iwata N. (2009)
Genetic analysis in patients with Kallmann syndrome: coexistence of mutations in prokineticin receptor 2 and KAL1. (PubMed id 18723471)^{1, 9} Canto P....Mendez J.P. (2009)
Mutations in prokineticin 2 and prokineticin receptor 2 genes in human gonadotrophin-releasing hormone deficiency: molecular genetics and clinical spectrum. (PubMed id 18559922)^{1, 9} Cole L.W....Pitteloud N. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 128674	HGNC: 15836	AceView: GPR73L1	Ensembl:ENSG00000101292	euGenes: HUgn128674
ECgene: PROKR2	H-InvDB: PROKR2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PROKR2	Pharmacogenomics, SNPs, Pathways
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/PROKR2

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