PROKR1 Gene

Aliases
for PROKR1 gene

Previous GC identifers: GC02P068727 GC02P068614

Summaries
for PROKR1 gene

Genomic Views
for PROKR1 gene

RefSeq DNA sequence:

NC_000002.11  NC_018913.1  NT_022184.15  

SwitchGear Promoter luciferase reporter plasmid: PROKR1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PROKR1

PROKR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P068870:  view genomic region     (about GC identifiers)

Proteins
for PROKR1 gene

Explore the universe of human proteins at neXtProt for PROKR1: NX_Q8TCW9

Post-translational modifications:

	EMD Millipore Purified and/or Recombinant PROKR1 Protein
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: PROKR1 OriGene Protein Over-expression Lysate: PROKR1 OriGene Custom Protein Services for PROKR1
	GenScript Custom Purified and Recombinant Proteins Services for PROKR1
	Novus Biologicals PROKR1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PROKR1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for PROKR1 (Prokineticin R1/PROKR1)
	Browse OriGene Antibodies OriGene Custom Antibody Services for PROKR1
	GenScript Custom Superior Antibodies Services for PROKR1
	Novus Biologicals PROKR1 Antibodies
	Search for Antibodies for PROKR1 at Abcam
	Uscn Antibodies for PROKR1
	ThermoFisher Antibodies for PROKR1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PROKR1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PROKR1

Protein Domains /
Families
for PROKR1 gene

ProtoNet protein and cluster: Q8TCW9

Function
for PROKR1 gene

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PROKR1
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PROKR1
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PROKR1 (see all 7) OriGene shRNA RFP: PROKR1 OriGene siRNA: PROKR1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PROKR1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for PROKR1

Clone Products:		EMD Millipore Clones for the Expression of PROKR1
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PROKR1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PROKR1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PROKR1 (NM_138964)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PROKR1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PROKR1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PROKR1
		Search LifeMap BioReagents cell lines for PROKR1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PROKR1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 4 alleles) (MGI details for Prokr1)

Pathways & Interactions
for PROKR1 gene

	Super-pathway	contained gene-specific pathways
1	Class A/1 (Rhodopsin-like receptors)	Class A/1 (Rhodopsin-like receptors) 1.00 Peptide ligand-binding receptors 0.61 GPCR ligand binding 0.75
2	Signaling by GPCR	Signaling by GPCR 1.00 Signal Transduction 0.56 GPCR downstream signaling 0.89
3	G alpha (q) signalling events	G alpha (q) signalling events 1.00 Gastrin-CREB signalling pathway via PKC and MAPK 0.90
4	Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q	Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q 1.00

1 EMD Millipore Pathway for PROKR1

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

5/8        Reactome Pathways for PROKR1

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR
	GPCR ligand binding

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for PROKR1 gene

Transcripts
for PROKR1 gene

Expression
for PROKR1 gene

PROKR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCAACACTC

5 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BrainMedulla Oblongata			Brain
	Neural TubeDiencephalic Ventricular Zone			Neural Tube
	Neural TubeMesencephalic Ventricular Zone			Neural Tube
	Neural TubeTelencephalon			Neural Tube
	Spinal CordPresumptive Spinal Cord			Spinal Cord
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Definitive endoderm-like cells (A scalable, suspensi...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PROKR1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PROKR1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PROKR1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PROKR1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PROKR1

Orthologs
for PROKR1 gene

Paralogs
for PROKR1 gene

Paralogs for PROKR1 gene

PROKR2²  

3 SIMAP similar genes for PROKR1 using alignment to 1 protein entry:     PKR1_HUMAN:

PROKR2    NPY2R    PRLHR

PROKR1 for paralogs           About GeneDecksing

Genomic Variants
for PROKR1 gene

10/270 NCBI SNPs in PROKR1 are shown (see all 270)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs750538761,2	C,F,	--	68871100(+)	CTGTGA/CGTTTC	1	--	us2k1		1		WA	118
rs1402815971,2		--	68871126(+)	CTTCCA/CCTCCT	1	--	us2k1		0	--	--	--	--
rs795359551,2	F,	--	68871133(+)	TCCTCT/CGTCCT	1	--	us2k1		1		WA	118
rs1890694851,2		--	68871404(+)	GTAGGG/TGTACC	1	--	us2k1		0	--	--	--	--
rs729078411,2	C,F,	--	68871530(+)	CCTGAG/CTGGGC	1	--	us2k1		8		WA NA CSA EA	368
rs48544791,2	C,F,A,H,	--	68871573(+)	AGCTCG/CGAGGA	1	--	us2k1 trp3		10		NS EA NA CSA WA	663
rs1926685931,2		--	68871694(+)	TTTGCC/TTCGGA	1	--	us2k1		0	--	--	--	--
rs75908071,2	C,F,	--	68871710(+)	ATGGAG/CAGCAG	1	--	us2k1		5		NA CSA WA	244
rs1140784641,2	F,	--	68871748(+)	CCTGGG/ACATCT	1	--	us2k1		1		WA	118
rs787374691,2		--	68871798(+)	CTTCCC/TTCTGT	1	--	us2k1		2		CSA WA	120

HapMap Linkage Disequilibrium report for PROKR1 (68870721 - 68882708 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for PROKR1: --
Human Gene Mutation Database (HGMD): PROKR1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PROKR1

DNA2.0 Custom Variant and Variant Library Synthesis for PROKR1

Disorders / Diseases
for PROKR1 gene

Publications
for PROKR1 gene

PubMed articles for PROKR1 gene, integrated from 9 sources (see all 36): (articles sorted by number of sources associating them with PROKR1)

Utopia: connect your pdf to the dynamic world of online information

1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
3. Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors. (PubMed id 12054613)^{1, 2} Masuda Y.... Fujino M. (2002)
4. Molecular cloning and characterization of prokineticin receptors. (PubMed id 12427552)^{1, 2} Soga T.... Furuichi K. (2002)
5. Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor. (PubMed id 11886876)^{1, 2} Lin D.C.-H....Zhou Q.-Y. (2002)
6. Y-receptor-like genes GPR72 and GPR73: molecular cloning, genomic organisation and assignment to human chromosome 11q21.1 and 2p14 and mouse chromosome 9 and 6. (PubMed id 10760605)^{1, 3} Parker R.... Herzog H. (2000)
7. Prokineticin-1 (PROK1) modulates interleukin (IL)-11 expression via prokineticin receptor 1 (PROKR1) and the calcineurin/NFAT signal ling pathway. (PubMed id 19801577)^{1, 9} Cook I.H....Jabbour H.N. (2010)
8. Prokineticin 1 signaling and gene regulation in early human pregnancy. (PubMed id 18339712)^{1, 9} Evans J....Jabbour H.N. (2008)
9. Divergent roles of prokineticin receptors in the endo thelial cells: angiogenesis and fenestration. (PubMed id 20023120)^{1, 9} Guilini C....Nebigil C.G. (2010)
10. The endocrine-gland-derived vascular endothelial growth factor (EG-VEGF)/prokineticin 1 and 2 and receptor expression in human prostate: Up-regulation of EG-VEGF/prokineticin 1 with malignancy. (PubMed id 16763065)^{1, 9} Pasquali D....Sinisi A.A. (2006)

External Searches for PROKR1 gene

Genome Databases showing PROKR1 gene

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Products
for PROKR1 gene