Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PROKR1 Gene

Aliases for PROKR1 Gene

  • Prokineticin Receptor 1 2 3 5
  • G Protein-Coupled Receptor 73 2 3
  • GPR73a 3 4
  • GPR73 3 4
  • PK-R1 3 4
  • PKR1 3 4
  • G Protein-Coupled Receptor ZAQ 3
  • G-Protein Coupled Receptor ZAQ 4
  • G-Protein Coupled Receptor 73 4
  • ZAQ 3

External Ids for PROKR1 Gene

Previous HGNC Symbols for PROKR1 Gene

  • GPR73

Previous GeneCards Identifiers for PROKR1 Gene

  • GC02P068727
  • GC02P068614
  • GC02P068870

Summaries for PROKR1 Gene

Entrez Gene Summary for PROKR1 Gene

  • This gene encodes a member of the G-protein-coupled receptor family. The encoded protein binds to prokineticins (1 and 2), leading to the activation of MAPK and STAT signaling pathways. Prokineticins are protein ligands involved in angiogenesis and inflammation. The encoded protein is expressed in peripheral tissues such as those comprising the circulatory system, lungs, reproductive system, endocrine system and the gastrointestinal system. The protein may be involved in signaling in human fetal ovary during initiation of primordial follicle formation. Sequence variants in this gene may be associated with recurrent miscarriage. [provided by RefSeq, Aug 2016]

GeneCards Summary for PROKR1 Gene

PROKR1 (Prokineticin Receptor 1) is a Protein Coding gene. Diseases associated with PROKR1 include Ectopic Pregnancy. Among its related pathways are Peptide ligand-binding receptors and RET signaling. GO annotations related to this gene include G-protein coupled receptor activity and neuropeptide Y receptor activity. An important paralog of this gene is PROKR2.

UniProtKB/Swiss-Prot for PROKR1 Gene

  • Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy.

Gene Wiki entry for PROKR1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PROKR1 Gene

Genomics for PROKR1 Gene

Regulatory Elements for PROKR1 Gene

Enhancers for PROKR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G068423 1.9 FANTOM5 Ensembl ENCODE dbSUPER 3.2 -217.5 -217543 5.1 HDGF PKNOX1 FOXA2 ARNT CREB3L1 WRNIP1 YY1 ZNF766 FOS JUNB APLF PROKR1 PLEK FBXO48 LOC391383 LOC101927723
GH02G068440 1.8 FANTOM5 Ensembl ENCODE dbSUPER 2.3 -202.3 -202342 2.4 FOXA2 PKNOX1 CREB3L1 ARNT WRNIP1 SIN3A YY1 SLC30A9 ZNF766 GATA2 LOC101927723 PLEK PROKR1 APLF C1D LOC391383
GH02G069136 1.7 FANTOM5 Ensembl ENCODE dbSUPER 1.9 +500.0 500017 14.1 TBP ZFP64 RAD21 CHAMP1 RFX5 ZNF766 GATA2 ZSCAN5C SCRT2 RCOR1 ANTXR1 RNA5SP96 RNU6-1216P GKN1 PROKR1 GC02M069149 MIR3126
GH02G068688 1.5 FANTOM5 Ensembl ENCODE 1.7 +46.6 46579 2.5 TBP PKNOX1 BMI1 YY1 CBX5 FOS RELB ETV6 IKZF2 CREM LINC01888 ARHGAP25 PPP3R1 PROKR1 APLF LOC105374790
GH02G068642 0.9 Ensembl 0.7 -0.1 -93 1.3 PKNOX1 RB1 NFRKB ZBTB40 GLIS2 ETV6 FOS ELF4 ZEB2 REST PROKR1 LOC100379290
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PROKR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PROKR1 Gene

Chromosome:
2
Start:
68,643,589 bp from pter
End:
68,658,247 bp from pter
Size:
14,659 bases
Orientation:
Plus strand

Genomic View for PROKR1 Gene

Genes around PROKR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PROKR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PROKR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PROKR1 Gene

Proteins for PROKR1 Gene

  • Protein details for PROKR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCW9-PKR1_HUMAN
    Recommended name:
    Prokineticin receptor 1
    Protein Accession:
    Q8TCW9
    Secondary Accessions:
    • A5JUU2
    • Q53QT9
    • Q8NFJ7

    Protein attributes for PROKR1 Gene

    Size:
    393 amino acids
    Molecular mass:
    44770 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PROKR1 Gene

Post-translational modifications for PROKR1 Gene

  • Glycosylation at isoforms=11, Asn14, and Asn36
  • Modification sites at PhosphoSitePlus

Other Protein References for PROKR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PROKR1 Gene

Domains & Families for PROKR1 Gene

Gene Families for PROKR1 Gene

Protein Domains for PROKR1 Gene

Suggested Antigen Peptide Sequences for PROKR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TCW9

UniProtKB/Swiss-Prot:

PKR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with PROKR1: view

Function for PROKR1 Gene

Molecular function for PROKR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy.

Gene Ontology (GO) - Molecular Function for PROKR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001602 pancreatic polypeptide receptor activity IBA --
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004983 neuropeptide Y receptor activity IEA --
genes like me logo Genes that share ontologies with PROKR1: view
genes like me logo Genes that share phenotypes with PROKR1: view

Animal Models for PROKR1 Gene

MGI Knock Outs for PROKR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for PROKR1

CRISPR Products

miRNA for PROKR1 Gene

miRTarBase miRNAs that target PROKR1

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for PROKR1 (Prokineticin R1/PROKR1)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PROKR1 Gene

Localization for PROKR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PROKR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PROKR1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for PROKR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PROKR1: view

Pathways & Interactions for PROKR1 Gene

genes like me logo Genes that share pathways with PROKR1: view

SIGNOR curated interactions for PROKR1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PROKR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007218 neuropeptide signaling pathway IBA --
GO:0007268 chemical synaptic transmission IBA --
GO:0007623 circadian rhythm IBA --
genes like me logo Genes that share ontologies with PROKR1: view

Drugs & Compounds for PROKR1 Gene

(8) Drugs for PROKR1 Gene - From: DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MIT1 Pharma Full agonist, Agonist 0
prokineticin-1 Pharma Full agonist, Agonist 0
prokineticin-2 Pharma Full agonist, Agonist 0
PROKINETICIN-2Β Pharma 0
triazine compound 1 Pharma Antagonist 0

(2) Additional Compounds for PROKR1 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
prokineticin-2beta
Full agonist, Agonist
genes like me logo Genes that share compounds with PROKR1: view

Transcripts for PROKR1 Gene

mRNA/cDNA for PROKR1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(53) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PROKR1 Gene

Prokineticin receptor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for PROKR1 (Prokineticin R1/PROKR1)

Alternative Splicing Database (ASD) splice patterns (SP) for PROKR1 Gene

No ASD Table

Relevant External Links for PROKR1 Gene

GeneLoc Exon Structure for
PROKR1
ECgene alternative splicing isoforms for
PROKR1

Expression for PROKR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PROKR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PROKR1 Gene

This gene is overexpressed in Testis (x11.5), Adipose - Visceral (Omentum) (x5.8), and Breast - Mammary Tissue (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of PROKR1 Gene:

PROKR1

SOURCE GeneReport for Unigene cluster for PROKR1 Gene:

Hs.683430

mRNA Expression by UniProt/SwissProt for PROKR1 Gene:

Q8TCW9-PKR1_HUMAN
Tissue specificity: Localizes to glandular epithelium, stroma and vascular endothelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the stomach, throughout the small intestine, colon, rectum, thyroid gland, pituitary gland, salivary gland, adrenal gland, testis, ovary, brain, spleen, prostate and pancreas.

Evidence on tissue expression from TISSUES for PROKR1 Gene

  • Eye(4.7)
  • Pancreas(3.4)
  • Nervous system(2.4)
  • Heart(2)
genes like me logo Genes that share expression patterns with PROKR1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PROKR1 Gene

Orthologs for PROKR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PROKR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PROKR1 34 35
  • 99.66 (n)
cow
(Bos Taurus)
Mammalia PROKR1 34 35
  • 89.31 (n)
dog
(Canis familiaris)
Mammalia PROKR1 34 35
  • 87.7 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 87 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 85 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Prokr1 34 16 35
  • 83.55 (n)
rat
(Rattus norvegicus)
Mammalia Prokr1 34
  • 83.46 (n)
chicken
(Gallus gallus)
Aves PROKR2 35
  • 76 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 81 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii prokr1a 34 35
  • 63.93 (n)
CU929052.1 35
  • 62 (a)
ManyToMany
Species where no ortholog for PROKR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PROKR1 Gene

ENSEMBL:
Gene Tree for PROKR1 (if available)
TreeFam:
Gene Tree for PROKR1 (if available)

Paralogs for PROKR1 Gene

Paralogs for PROKR1 Gene

(3) SIMAP similar genes for PROKR1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PROKR1: view

Variants for PROKR1 Gene

Sequence variations from dbSNP and Humsavar for PROKR1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs796052145 Likely benign 68,655,083(+) CTACA(A/C)GTCCT reference, missense
rs1000008730 -- 68,651,346(+) TCGGT(C/G)ACAGA intron-variant
rs1000112925 -- 68,642,777(+) ATACT(A/G)TATGT upstream-variant-2KB
rs1000433694 -- 68,643,069(+) CCCCT(C/T)GTTTG upstream-variant-2KB
rs1000697091 -- 68,648,289(+) TCTAT(A/G)TCAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PROKR1 Gene

Variant ID Type Subtype PubMed ID
nsv1003458 CNV loss 25217958
nsv582174 CNV loss 21841781

Variation tolerance for PROKR1 Gene

Residual Variation Intolerance Score: 20.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.21; 52.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PROKR1 Gene

Human Gene Mutation Database (HGMD)
PROKR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PROKR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PROKR1 Gene

Disorders for PROKR1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PROKR1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ectopic pregnancy
  • eccyesis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PROKR1

Genetic Association Database (GAD)
PROKR1
Human Genome Epidemiology (HuGE) Navigator
PROKR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PROKR1
genes like me logo Genes that share disorders with PROKR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PROKR1 Gene

Publications for PROKR1 Gene

  1. Prokineticin 1 signaling and gene regulation in early human pregnancy. (PMID: 18339712) Evans J. … Jabbour H.N. (Endocrinology 2008) 3 4 22 64
  2. Prokineticin-1 (PROK1) modulates interleukin (IL)-11 expression via prokineticin receptor 1 (PROKR1) and the calcineurin/NFAT signalling pathway. (PMID: 19801577) Cook I.H. … Jabbour H.N. (Mol. Hum. Reprod. 2010) 3 22 64
  3. Divergent roles of prokineticin receptors in the endothelial cells: angiogenesis and fenestration. (PMID: 20023120) Guilini C. … Nebigil C.G. (Am. J. Physiol. Heart Circ. Physiol. 2010) 3 22 64
  4. Polymorphisms of endocrine gland-derived vascular endothelial growth factor gene and its receptor genes are associated with recurrent pregnancy loss. (PMID: 20847187) Su M.T. … Kuo P.L. (Hum. Reprod. 2010) 3 46 64
  5. The endocrine-gland-derived vascular endothelial growth factor (EG-VEGF)/prokineticin 1 and 2 and receptor expression in human prostate: Up-regulation of EG-VEGF/prokineticin 1 with malignancy. (PMID: 16763065) Pasquali D. … Sinisi A.A. (Endocrinology 2006) 3 22 64

Products for PROKR1 Gene

Sources for PROKR1 Gene

Content
Loading form....