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Aliases for PROKR1 Gene

Aliases for PROKR1 Gene

  • Prokineticin Receptor 1 2 3 5
  • G-Protein Coupled Receptor ZAQ 3 4
  • G Protein-Coupled Receptor 73 2 3
  • G-Protein Coupled Receptor 73 3 4
  • GPR73a 3 4
  • GPR73 3 4
  • PK-R1 3 4
  • PKR1 3 4
  • G Protein-Coupled Receptor ZAQ 3
  • ZAQ 3

External Ids for PROKR1 Gene

Previous HGNC Symbols for PROKR1 Gene

  • GPR73

Previous GeneCards Identifiers for PROKR1 Gene

  • GC02P068727
  • GC02P068614
  • GC02P068870

Summaries for PROKR1 Gene

GeneCards Summary for PROKR1 Gene

PROKR1 (Prokineticin Receptor 1) is a Protein Coding gene. Diseases associated with PROKR1 include ectopic pregnancy and orchitis. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include G-protein coupled receptor activity and neuropeptide Y receptor activity. An important paralog of this gene is PROKR2.

UniProtKB/Swiss-Prot for PROKR1 Gene

  • Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy.

Gene Wiki entry for PROKR1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PROKR1 Gene

Genomics for PROKR1 Gene

Regulatory Elements for PROKR1 Gene

Genomic Location for PROKR1 Gene

Chromosome:
2
Start:
68,643,589 bp from pter
End:
68,658,247 bp from pter
Size:
14,659 bases
Orientation:
Plus strand

Genomic View for PROKR1 Gene

Genes around PROKR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PROKR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PROKR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PROKR1 Gene

Proteins for PROKR1 Gene

  • Protein details for PROKR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCW9-PKR1_HUMAN
    Recommended name:
    Prokineticin receptor 1
    Protein Accession:
    Q8TCW9
    Secondary Accessions:
    • A5JUU2
    • Q53QT9
    • Q8NFJ7

    Protein attributes for PROKR1 Gene

    Size:
    393 amino acids
    Molecular mass:
    44770 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PROKR1 Gene

Proteomics data for PROKR1 Gene at MOPED

Post-translational modifications for PROKR1 Gene

  • Glycosylation at Asn 11, Asn 14, and Asn 36
  • Modification sites at PhosphoSitePlus

Other Protein References for PROKR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PROKR1 (Prokineticin R1/PROKR1)
  • Santa Cruz Biotechnology (SCBT) Antibodies for PROKR1

No data available for DME Specific Peptides for PROKR1 Gene

Domains & Families for PROKR1 Gene

Gene Families for PROKR1 Gene

Protein Domains for PROKR1 Gene

Suggested Antigen Peptide Sequences for PROKR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TCW9

UniProtKB/Swiss-Prot:

PKR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with PROKR1: view

Function for PROKR1 Gene

Molecular function for PROKR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy.
genes like me logo Genes that share phenotypes with PROKR1: view

Animal Models for PROKR1 Gene

MGI Knock Outs for PROKR1:

Animal Model Products

CRISPR Products

miRNA for PROKR1 Gene

miRTarBase miRNAs that target PROKR1

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PROKR1 Gene

Localization for PROKR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PROKR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PROKR1 Gene COMPARTMENTS Subcellular localization image for PROKR1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for PROKR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with PROKR1: view

Pathways & Interactions for PROKR1 Gene

genes like me logo Genes that share pathways with PROKR1: view

Interacting Proteins for PROKR1 Gene

SIGNOR curated interactions for PROKR1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PROKR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007218 neuropeptide signaling pathway IEA --
GO:0007623 circadian rhythm IBA --
genes like me logo Genes that share ontologies with PROKR1: view

Drugs & Compounds for PROKR1 Gene

(8) Drugs for PROKR1 Gene - From: IUPHAR, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MIT1 Pharma Full agonist, Agonist 0
prokineticin-1 Pharma Full agonist, Agonist 0
prokineticin-2 Pharma Full agonist, Agonist 0
PROKINETICIN-2Β Pharma 0
triazine compound 1 Pharma Antagonist 0

(2) Additional Compounds for PROKR1 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
prokineticin-2beta
Full agonist, Agonist
genes like me logo Genes that share compounds with PROKR1: view

Transcripts for PROKR1 Gene

mRNA/cDNA for PROKR1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(53) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PROKR1 Gene

Prokineticin receptor 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PROKR1 Gene

No ASD Table

Relevant External Links for PROKR1 Gene

GeneLoc Exon Structure for
PROKR1
ECgene alternative splicing isoforms for
PROKR1

Expression for PROKR1 Gene

mRNA expression in normal human tissues for PROKR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PROKR1 Gene

This gene is overexpressed in Testis (x11.5), Adipose - Visceral (Omentum) (x5.8), and Breast - Mammary Tissue (x4.1).

SOURCE GeneReport for Unigene cluster for PROKR1 Gene Hs.683430

mRNA Expression by UniProt/SwissProt for PROKR1 Gene

Q8TCW9-PKR1_HUMAN
Tissue specificity: Localizes to glandular epithelium, stroma and vascular endothelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the stomach, throughout the small intestine, colon, rectum, thyroid gland, pituitary gland, salivary gland, adrenal gland, testis, ovary, brain, spleen, prostate and pancreas.
genes like me logo Genes that share expression patterns with PROKR1: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PROKR1 Gene

Orthologs for PROKR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PROKR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PROKR1 36
  • 100 (a)
OneToOne
PROKR1 35
  • 99.66 (n)
  • 99.75 (a)
cow
(Bos Taurus)
Mammalia PROKR1 35
  • 89.31 (n)
  • 92.37 (a)
PROKR1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PROKR1 36
  • 88 (a)
OneToOne
PROKR1 35
  • 87.7 (n)
  • 87.79 (a)
mouse
(Mus musculus)
Mammalia Prokr1 16
Prokr1 36
  • 84 (a)
OneToOne
Prokr1 35
  • 83.55 (n)
  • 84.48 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 87 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 85 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Prokr1 35
  • 83.46 (n)
  • 83.97 (a)
chicken
(Gallus gallus)
Aves PROKR2 36
  • 76 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 81 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii prokr1a 35
  • 63.93 (n)
  • 61.9 (a)
CU929052.1 36
  • 62 (a)
ManyToMany
prokr1a 36
  • 60 (a)
ManyToMany
Species with no ortholog for PROKR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PROKR1 Gene

ENSEMBL:
Gene Tree for PROKR1 (if available)
TreeFam:
Gene Tree for PROKR1 (if available)

Paralogs for PROKR1 Gene

Paralogs for PROKR1 Gene

(3) SIMAP similar genes for PROKR1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PROKR1: view

Variants for PROKR1 Gene

Sequence variations from dbSNP and Humsavar for PROKR1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs7570797 - 68,645,939(+) GCTAC(A/G)GCGAC reference, missense
rs4267541 -- 68,652,259(+) ATCTA(C/G)TGAAA intron-variant
rs4428042 -- 68,653,679(+) GCCAC(A/G)GGACG intron-variant
rs4467308 -- 68,652,324(+) ACACA(A/G)CATTA intron-variant
rs5831933 -- 68,653,436(+) AAAAA(-/A/AA)TAAGT intron-variant

Variation tolerance for PROKR1 Gene

Residual Variation Intolerance Score: 20.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.21; 52.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PROKR1 Gene

HapMap Linkage Disequilibrium report
PROKR1
Human Gene Mutation Database (HGMD)
PROKR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PROKR1 Gene

Disorders for PROKR1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PROKR1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ectopic pregnancy
  • eccyesis
orchitis
  • inflammation of testis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PROKR1

Genetic Association Database (GAD)
PROKR1
Human Genome Epidemiology (HuGE) Navigator
PROKR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PROKR1
genes like me logo Genes that share disorders with PROKR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PROKR1 Gene

Publications for PROKR1 Gene

  1. Prokineticin 1 signaling and gene regulation in early human pregnancy. (PMID: 18339712) Evans J. … Jabbour H.N. (Endocrinology 2008) 3 4 23 67
  2. Divergent roles of prokineticin receptors in the endothelial cells: angiogenesis and fenestration. (PMID: 20023120) Guilini C. … Nebigil C.G. (Am. J. Physiol. Heart Circ. Physiol. 2010) 3 23
  3. Prokineticin-1 (PROK1) modulates interleukin (IL)-11 expression via prokineticin receptor 1 (PROKR1) and the calcineurin/NFAT signalling pathway. (PMID: 19801577) Cook I.H. … Jabbour H.N. (Mol. Hum. Reprod. 2010) 3 23
  4. The endocrine-gland-derived vascular endothelial growth factor (EG-VEGF)/prokineticin 1 and 2 and receptor expression in human prostate: Up-regulation of EG-VEGF/prokineticin 1 with malignancy. (PMID: 16763065) Pasquali D. … Sinisi A.A. (Endocrinology 2006) 3 23
  5. Y-receptor-like genes GPR72 and GPR73: molecular cloning, genomic organisation and assignment to human chromosome 11q21.1 and 2p14 and mouse chromosome 9 and 6. (PMID: 10760605) Parker R. … Herzog H. (Biochim. Biophys. Acta 2000) 2 3

Products for PROKR1 Gene

Sources for PROKR1 Gene

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