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Aliases for PROK1 Gene

Aliases for PROK1 Gene

  • Prokineticin 1 2 3 5
  • Mambakine 2 3 4
  • Endocrine-Gland-Derived Vascular Endothelial Growth Factor 3 4
  • Black Mamba Toxin-Related Protein 2 3
  • EG-VEGF 3 4
  • Prokineticin-1 3
  • EGVEGF 3
  • PRK1 3
  • PK1 3

External Ids for PROK1 Gene

Previous GeneCards Identifiers for PROK1 Gene

  • GC01P111410
  • GC01P109860
  • GC01P110095
  • GC01P110292
  • GC01P110705
  • GC01P110994
  • GC01P108865

Summaries for PROK1 Gene

Entrez Gene Summary for PROK1 Gene

  • The protein encoded by this gene induces proliferation, migration, and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. It has little or no effect on a variety of other endothelial and non-endothelial cell types. Its expression is restricted to the steroidogenic glands (ovary, testis, adrenal, and placenta), is induced by hypoxia, and often complementary to the expression of vascular endothelial growth factor (VEGF), suggesting that these molecules function in a coordinated manner. [provided by RefSeq, Sep 2011]

GeneCards Summary for PROK1 Gene

PROK1 (Prokineticin 1) is a Protein Coding gene. Diseases associated with PROK1 include Placental Insufficiency and Ectopic Pregnancy. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include growth factor activity. An important paralog of this gene is PROK2.

UniProtKB/Swiss-Prot for PROK1 Gene

  • Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PROK1 Gene

Genomics for PROK1 Gene

Regulatory Elements for PROK1 Gene

Enhancers for PROK1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F110412 1.2 Ensembl ENCODE 30.4 -38.2 -38157 1.2 HDGF HDAC1 CBX3 ARNT TBL1XR1 RAD21 RFX5 CHAMP1 GATA2 ZNF143 PROK1 RBM15 LOC440600 LAMTOR5 GC01M110420
GH01F110382 1.5 FANTOM5 Ensembl ENCODE 22.6 -66.6 -66635 3.5 PKNOX1 FOS CREM SMARCA5 ZNF362 HCFC1 CBFB USF2 CEBPB ZEB2 PROK1 RBM15 SLC16A4 LAMTOR5 LOC440600 LAMTOR5-AS1 STRIP1 CD53 GC01P110380
GH01F110421 1.8 FANTOM5 Ensembl ENCODE 12.3 -29.7 -29743 0.4 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 CBX5 PROK1 ENSG00000258634 CD53 LOC440600 RBM15 KCNC4 KCNC4-AS1 KCNA10 GC01M110420
GH01F110406 1.2 ENCODE 18.4 -43.3 -43332 3.3 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 CEPT1 GSTM2 ENSG00000258634 PROK1 SLC16A4 GNAI3 GSTM5 GSTM3 LAMTOR5-AS1 LAMTOR5
GH01F110312 1.1 Ensembl ENCODE 17.9 -138.4 -138355 0.8 WRNIP1 ZNF2 RAD21 ZNF366 ZNF143 ZNF654 REST KLF16 GLIS1 ZNF524 LOC440600 PROK1 RBM15 KCNC4 KCNC4-AS1 ENSG00000200536 ENSG00000235526 LOC105378897 ENSG00000258634 UBL4B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PROK1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PROK1 Gene

Chromosome:
1
Start:
110,451,166 bp from pter
End:
110,457,354 bp from pter
Size:
6,189 bases
Orientation:
Plus strand

Genomic View for PROK1 Gene

Genes around PROK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PROK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PROK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PROK1 Gene

Proteins for PROK1 Gene

  • Protein details for PROK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P58294-PROK1_HUMAN
    Recommended name:
    Prokineticin-1
    Protein Accession:
    P58294
    Secondary Accessions:
    • Q5VWD4
    • Q8TC69

    Protein attributes for PROK1 Gene

    Size:
    105 amino acids
    Molecular mass:
    11715 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PROK1 Gene

Post-translational modifications for PROK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PROK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for PROK1

No data available for DME Specific Peptides for PROK1 Gene

Domains & Families for PROK1 Gene

Gene Families for PROK1 Gene

Protein Domains for PROK1 Gene

Suggested Antigen Peptide Sequences for PROK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P58294

UniProtKB/Swiss-Prot:

PROK1_HUMAN :
  • Belongs to the AVIT (prokineticin) family.
Family:
  • Belongs to the AVIT (prokineticin) family.
genes like me logo Genes that share domains with PROK1: view

Function for PROK1 Gene

Molecular function for PROK1 Gene

UniProtKB/Swiss-Prot Function:
Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis.

Gene Ontology (GO) - Molecular Function for PROK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IBA --
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with PROK1: view
genes like me logo Genes that share phenotypes with PROK1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PROK1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PROK1 Gene

Localization for PROK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PROK1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PROK1 gene
Compartment Confidence
extracellular 5
cytosol 2

Gene Ontology (GO) - Cellular Components for PROK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with PROK1: view

Pathways & Interactions for PROK1 Gene

genes like me logo Genes that share pathways with PROK1: view

SIGNOR curated interactions for PROK1 Gene

Activates:

Gene Ontology (GO) - Biological Process for PROK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IBA --
GO:0001525 angiogenesis IEA --
GO:0007623 circadian rhythm IBA --
GO:0008284 positive regulation of cell proliferation IBA --
GO:0045765 regulation of angiogenesis IBA --
genes like me logo Genes that share ontologies with PROK1: view

Drugs & Compounds for PROK1 Gene

(2) Drugs for PROK1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for PROK1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PROK1: view

Transcripts for PROK1 Gene

mRNA/cDNA for PROK1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(35) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PROK1 Gene

Prokineticin 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PROK1 Gene

No ASD Table

Relevant External Links for PROK1 Gene

GeneLoc Exon Structure for
PROK1
ECgene alternative splicing isoforms for
PROK1

Expression for PROK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PROK1 Gene

mRNA differential expression in normal tissues according to GTEx for PROK1 Gene

This gene is overexpressed in Ovary (x27.4) and Testis (x8.2).

NURSA nuclear receptor signaling pathways regulating expression of PROK1 Gene:

PROK1

SOURCE GeneReport for Unigene cluster for PROK1 Gene:

Hs.514793

mRNA Expression by UniProt/SwissProt for PROK1 Gene:

P58294-PROK1_HUMAN
Tissue specificity: Localizes to glandular epithelium, stroma and vascular epithelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the steroidogenic glands, ovary, testis, adrenal and placenta.
genes like me logo Genes that share expression patterns with PROK1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PROK1 Gene

Orthologs for PROK1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PROK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PROK1 34 35
  • 99.37 (n)
dog
(Canis familiaris)
Mammalia PROK1 34 35
  • 89.52 (n)
cow
(Bos Taurus)
Mammalia PROK1 34 35
  • 87.3 (n)
rat
(Rattus norvegicus)
Mammalia Prok1 34
  • 86.67 (n)
mouse
(Mus musculus)
Mammalia Prok1 34 16 35
  • 84.44 (n)
oppossum
(Monodelphis domestica)
Mammalia PROK1 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PROK1 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves PROK1 34 35
  • 72.06 (n)
lizard
(Anolis carolinensis)
Reptilia PROK1 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prok1 34
  • 68.25 (n)
zebrafish
(Danio rerio)
Actinopterygii prok1 34 35
  • 68.98 (n)
Species where no ortholog for PROK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PROK1 Gene

ENSEMBL:
Gene Tree for PROK1 (if available)
TreeFam:
Gene Tree for PROK1 (if available)

Paralogs for PROK1 Gene

Paralogs for PROK1 Gene

(1) SIMAP similar genes for PROK1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PROK1: view

Variants for PROK1 Gene

Sequence variations from dbSNP and Humsavar for PROK1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1044837 -- 110,457,083(+) ATTCC(C/T)ACAGC utr-variant-3-prime
rs111441481 -- 110,454,089(+) AAGGT(A/C/T)CTCTG intron-variant
rs111595836 -- 110,455,585(+) TGCCA(C/T)CCTTC intron-variant
rs111680736 -- 110,456,170(+) CAGAG(A/G)CTGCT intron-variant
rs111946027 -- 110,451,460(+) GTTAG(A/G)CCTCA intron-variant

Variation tolerance for PROK1 Gene

Residual Variation Intolerance Score: 64.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.60; 82.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PROK1 Gene

Human Gene Mutation Database (HGMD)
PROK1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PROK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PROK1 Gene

Disorders for PROK1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for PROK1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
placental insufficiency
  • uteroplacental vascular insufficiency
ectopic pregnancy
  • eccyesis
preeclampsia/eclampsia 1
  • preeclampsia
neuroblastoma
  • neuroblastoma 1
- elite association - COSMIC cancer census association via MalaCards
Search PROK1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PROK1

Genetic Association Database (GAD)
PROK1
Human Genome Epidemiology (HuGE) Navigator
PROK1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PROK1
genes like me logo Genes that share disorders with PROK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PROK1 Gene

Publications for PROK1 Gene

  1. Prokineticin 1 signaling and gene regulation in early human pregnancy. (PMID: 18339712) Evans J. … Jabbour H.N. (Endocrinology 2008) 3 4 22 64
  2. Implications of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 signaling in human neuroblastoma progression. (PMID: 17289879) Ngan E.S.W. … Tam P.K.H. (Clin. Cancer Res. 2007) 3 4 22 64
  3. Human endocrine gland-derived vascular endothelial growth factor: expression early in development and in Leydig cell tumors suggests roles in normal and pathological testis angiogenesis. (PMID: 15292351) Samson M. … Ferrara N. (J. Clin. Endocrinol. Metab. 2004) 3 4 22 64
  4. Identification of two prokineticin cDNAs: recombinant proteins potently contract gastrointestinal smooth muscle. (PMID: 11259612) Li M. … Zhou Q.-Y. (Mol. Pharmacol. 2001) 2 3 4 64
  5. Identification of an angiogenic mitogen selective for endocrine gland endothelium. (PMID: 11528470) LeCouter J. … Ferrara N. (Nature 2001) 3 4 22 64

Products for PROK1 Gene

Sources for PROK1 Gene

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