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PRODH2 Gene

protein-coding   GIFtS: 53
GCID: GC19M037061

Proline Dehydrogenase (Oxidase) 2

  See PRODH2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Proline Dehydrogenase (Oxidase) 21 2     EC 1.5.5.23
Kidney And Liver Proline Oxidase 12 3     HsPOX13
Probable Proline Oxidase 22 3     PRODH5
HSPOX12     SCZD45
Probable Proline Dehydrogenase 22     EC 1.5.99.88

External Ids:    HGNC: 173251   Entrez Gene: 585102   Ensembl: ENSG000002507997   OMIM: 6068105   UniProtKB: Q9UF123   

Export aliases for PRODH2 gene to outside databases

Previous GC identifers: GC19M036930 GC19M036739 GC19M040967 GC19M040982 GC19M036291 GC19M036292 GC19M032795 GC19M036416 GC19M036543


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRODH2 Gene:
The protein encoded by this gene is similar to proline dehydrogenase (oxidase) 1, a mitochondrial enzyme which
catalyzes the first step in proline catabolism. The function of this protein has not been determined. (provided
by RefSeq, Jul 2008)

GeneCards Summary for PRODH2 Gene:
PRODH2 (proline dehydrogenase (oxidase) 2) is a protein-coding gene. Diseases associated with PRODH2 include hyperprolinemia, and schizophrenia 4. GO annotations related to this gene include proline dehydrogenase activity. An important paralog of this gene is PRODH.

UniProtKB/Swiss-Prot: PROD2_HUMAN, Q9UF12
Function: Converts proline to delta-1-pyrroline-5-carboxylate (Probable)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRODH2 gene promoter:
         USF1   AP-4   RelA   Tal-1beta   NF-kappaB   PPAR-gamma1   USF-1   PPAR-gamma2   NF-kappaB1   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PRODH2 promoter sequence
   Search Chromatin IP Primers for PRODH2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRODH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.1

PRODH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRODH2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M037061:  view genomic region     (about GC identifiers)

Start:
36,290,890 bp from pter      End:
36,304,201 bp from pter
Size:
13,312 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PROD2_HUMAN, Q9UF12 (See protein sequence)
Recommended Name: Probable proline dehydrogenase 2  
Size: 536 amino acids; 58871 Da
Cofactor: FAD (By similarity)

Explore the universe of human proteins at neXtProt for PRODH2: NX_Q9UF12

Explore proteomics data for PRODH2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PRODH2 (Q9UF12) (see all 6)
     MVASHNE  KLVRGAY  YGQFVAGET  FGQLLGMCD 


    See PRODH2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_067055.1  
    ENSEMBL proteins: 
     ENSP00000465214   ENSP00000301175   ENSP00000474199  

    PRODH2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for PRODH2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PRODH2
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    Novus Biologicals PRODH2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PRODH2

     
    Search eBioscience for Proteins for PRODH2 

    PRODH2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    LSBio Antibodies in human, mouse, rat for PRODH2

    PRODH2 Assay Products:

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    Cloud-Clone Corp. ELISAs for PRODH2
    Cloud-Clone Corp. CLIAs for PRODH2
    Search eBioscience for ELISAs for PRODH2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR015659 Proline_oxidase
     IPR002872 Proline_DH

    Graphical View of Domain Structure for InterPro Entry Q9UF12

    ProtoNet protein and cluster: Q9UF12

    1 Blocks protein domain: IPB002872 Proline dehydrogenase

    UniProtKB/Swiss-Prot: PROD2_HUMAN, Q9UF12
    Similarity: Belongs to the proline oxidase family


    Find genes that share domains with PRODH2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PROD2_HUMAN, Q9UF12
    Function: Converts proline to delta-1-pyrroline-5-carboxylate (Probable)
    Catalytic activity: L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol

         Enzyme Numbers (IUBMB): EC 1.5.99.82 EC 1.5.5.21

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004657proline dehydrogenase activity IEA--
         
    Find genes that share ontologies with PRODH2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PRODH2:
     Cells with protrusions  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRODH2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRODH2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRODH2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRODH2

    miRNA
    Products:
        
    miRTarBase miRNAs that target PRODH2:
    hsa-mir-23b-5p (MIRT004581)

    Block miRNA regulation of human, mouse, rat PRODH2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate PRODH2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat PRODH2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for PRODH2

    Clone
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    OriGene clones in human, mouse for PRODH2 (see all 5)
    OriGene ORF clones in mouse, rat for PRODH2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRODH2 (NM_021232)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRODH2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRODH2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRODH2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane IEA--

    Find genes that share ontologies with PRODH2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRODH2 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell-Cell communication0.64
    2Metabolism
    Metabolic pathways0.38
    3Nephrin interactions
    Nephrin interactions
    4Arginine and proline metabolism
    Arginine and proline metabolism


    Find genes that share SuperPaths with PRODH2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Kegg Pathways  (Kegg details for PRODH2):
        Arginine and proline metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: PROD2_HUMAN, Q9UF12
    Pathway: Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2

        Pathway & Disease-focused RT2 Profiler PCR Array including PRODH2: 

              Amino Acid Metabolism I in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for PRODH2

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006537glutamate biosynthetic process IEA--
    GO:0006562proline catabolic process ----
    GO:0010133proline catabolic process to glutamate IEA--
    GO:0055114oxidation-reduction process ----

    Find genes that share ontologies with PRODH2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRODH2 (PROD2)

    1 HMDB Compound for PRODH2    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRODH2 gene: 
    NM_021232.1  

    Unigene Cluster for PRODH2:

    Proline dehydrogenase (oxidase) 2
    Hs.515366  [show with all ESTs]
    Unigene Representative Sequence: AK130040
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000587808 ENST00000588266 ENST00000587695 ENST00000301175(uc002obx.1)
    ENST00000589835 ENST00000591694
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PRODH2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate PRODH2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PRODH2
    Predesigned siRNA for gene silencing in human, mouse, rat PRODH2
    Clone
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    OriGene clones in human, mouse for PRODH2 (see all 5)
    OriGene ORF clones in mouse, rat for PRODH2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRODH2 (NM_021232)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRODH2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRODH2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PRODH2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRODH2
      QuantiTect SYBR Green Assays in human, mouse, rat PRODH2
      QuantiFast Probe-based Assays in human, mouse, rat PRODH2

    Additional mRNA sequence: 

    AK130040.1 BC038853.1 BC039710.1 U80018.1 

    5 DOTS entries:

    DT.207893  DT.95160918  DT.101958357  DT.95160915  DT.95160916 

    Selected AceView cDNA sequences (see all 33):

    BC038853 BG054558 BC039710 AW771490 NM_021232 U80018 BX955574 AI927829 
    BI761466 AI796255 AI640611 BX110212 AW612108 AI823488 BI772725 BF197299 
    BI766014 AI263072 AW772333 AI915857 AI700948 AA203731 R02681 BI763429 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRODH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PRODH2 Expression
    About this image


    PRODH2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             Proximal Tubule Cells Proximal Tubule
             Metanephros
     
     Epithelial Cells
             Proximal Tubule Cells Proximal Tubule
    PRODH2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRODH2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515366
        Pathway & Disease-focused RT2 Profiler PCR Array including PRODH2: 
              Amino Acid Metabolism I in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PRODH2
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    QuantiFast Probe-based Assays in human, mouse, rat PRODH2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRODH2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PRODH2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prodh21 , 5 proline dehydrogenase (oxidase) 21, 5 80.83(n)1
    80.97(a)1
      7 (18.36 cM)5
    561891  NM_019546.51  NP_062419.21 
     304936225 
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC684832 hypothetical protein MGC68483 74.03(n)    BC059998.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570577272   -- 75.69(n)    57057727 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PUT16
    Proline oxidase, nuclear-encoded mitochondrial pro...
    18(a)
    1 → many
    XII(425186-426616) YLR142W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ERD51 ERD5 41.18(n)
    31.13(a)
      822833  NM_113981.5  NP_189701.3 
    rice
    (Oryza sativa)
    Liliopsida Os10g05509001 Os10g0550900 48.29(n)
    37.32(a)
      4349318  NM_001071853.1  NP_001065321.1 


    ENSEMBL Gene Tree for PRODH2 (if available)
    TreeFam Gene Tree for PRODH2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRODH2 gene
    PRODH2  
    1 SIMAP similar gene for PRODH2 using alignment to 4 protein entries:     PROD2_HUMAN (see all proteins):
    PRODH

    Find genes that share paralogs with PRODH2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRODH2 (see all 501)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1436857661,2
    C--36290408(+) GGTCTC/TGATCT 1 -- ds50010--------
    rs4484341,2
    F--36290452(+) aaactG/Cctggg 1 -- ds50011Minor allele frequency- C:0.00NA 2
    rs1445463761,2
    C--36290483(+) TGCCCG/TGCCTC 1 -- ds50010--------
    rs2005767981,2
    --36290500(+) TTTTC-/TTTTCT 1 -- ds50010--------
    rs2019466061,2
    --36290503(+) TCTTT-/TCTTTTT 1 -- ds50010--------
    rs1397412511,2
    C--36290504(+) CTTTT-/CTTTTT 1 -- ds50010--------
    rs735944101,2
    C--36290583(+) AGCCTA/CAAACC 1 -- ds50010--------
    rs772337541,2
    C,F--36290705(+) CCAGGC/GTGGTC 1 -- ds50011Minor allele frequency- G:0.10EA 120
    rs48051391,2
    C,F,A--36290779(+) AGAGCT/CACCAC 1 -- ds50015Minor allele frequency- C:0.08NA WA EA 362
    rs11337451,2
    C,F--36290900(-) CTTAGG/CTGCTG 1 -- ut316Minor allele frequency- C:0.16NA WA EA 364

    HapMap Linkage Disequilibrium report for PRODH2 (36290890 - 36304201 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for PRODH2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718500CNV Deletion23290073
    dgv3853n71CNV Loss21882294
    dgv3852n71CNV Loss21882294
    nsv911636CNV Loss21882294
    nsv911638CNV Loss21882294
    nsv911637CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing PRODH2
    DNA2.0 Custom Variant and Variant Library Synthesis for PRODH2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606810   
    OMIM disorders: 239500  600850  
    3 diseases for PRODH2:    
    About MalaCards
    hyperprolinemia    schizophrenia 4    schizophrenia


    Find genes that share disorders with PRODH2           About GenesLikeMe

    Genetic Association Database (GAD): PRODH2
    Human Genome Epidemiology (HuGE) Navigator: PRODH2 (20 documents)

    Export disorders for PRODH2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRODH2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with PRODH2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    2. P53 family members modulate the expression of PRODH, but not PRODH2, via intronic p53 response elements. (PubMed id 23861960)1 Raimondi I....Campomenosi P. (PLoS ONE 2013)
    3. A novel function for hydroxyproline oxidase in apoptosis through generation of reactive oxygen species. (PubMed id 18287100)1 Cooper S.K....Phang J.M. (J. Biol. Chem. 2008)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Genetic study of schizophrenia: new targets for therapy. (PubMed id 19810846)9 Ujike H. and Nakata K. (Expert Rev Neurother 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 58510 HGNC: 17325 AceView: PRODH2 Ensembl:ENSG00000250799 euGenes: HUgn58510
    ECgene: PRODH2 Kegg: 58510 H-InvDB: PRODH2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRODH2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRODH2 gene:
    Search GeneIP for patents involving PRODH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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