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Aliases for PRODH2 Gene

Aliases for PRODH2 Gene

  • Proline Dehydrogenase (Oxidase) 2 2 3
  • Kidney And Liver Proline Oxidase 1 3 4
  • Probable Proline Oxidase 2 3 4
  • HSPOX1 3 4
  • Probable Proline Dehydrogenase 2 3
  • EC 1.5.99.8 63
  • EC 1.5.5.2 4
  • PRODH 6
  • SCZD4 6

External Ids for PRODH2 Gene

Summaries for PRODH2 Gene

Entrez Gene Summary for PRODH2 Gene

  • The protein encoded by this gene is similar to proline dehydrogenase (oxidase) 1, a mitochondrial enzyme which catalyzes the first step in proline catabolism. The function of this protein has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRODH2 Gene

PRODH2 (Proline Dehydrogenase (Oxidase) 2) is a Protein Coding gene. Diseases associated with PRODH2 include schizophrenia 4 and hyperprolinemia, type i. Among its related pathways are Cell junction organization and Metabolism. GO annotations related to this gene include proline dehydrogenase activity. An important paralog of this gene is PRODH.

UniProtKB/Swiss-Prot for PRODH2 Gene

  • Converts proline to delta-1-pyrroline-5-carboxylate.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRODH2 Gene

Genomics for PRODH2 Gene

Genomic Location for PRODH2 Gene

Start:
35,799,988 bp from pter
End:
35,813,299 bp from pter
Size:
13,312 bases
Orientation:
Minus strand

Genomic View for PRODH2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRODH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRODH2 Gene

Regulatory Elements for PRODH2 Gene

Proteins for PRODH2 Gene

  • Protein details for PRODH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UF12-PROD2_HUMAN
    Recommended name:
    Probable proline dehydrogenase 2
    Protein Accession:
    Q9UF12
    Secondary Accessions:

    Protein attributes for PRODH2 Gene

    Size:
    536 amino acids
    Molecular mass:
    58871 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

neXtProt entry for PRODH2 Gene

Proteomics data for PRODH2 Gene at MOPED

Selected DME Specific Peptides for PRODH2 Gene

Post-translational modifications for PRODH2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRODH2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for PRODH2 Gene

Protein Domains for PRODH2 Gene

Suggested Antigen Peptide Sequences for PRODH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UF12

UniProtKB/Swiss-Prot:

PROD2_HUMAN
Family:
  • Belongs to the proline oxidase family.:
    • Q9UF12
genes like me logo Genes that share domains with PRODH2: view

No data available for Gene Families for PRODH2 Gene

Function for PRODH2 Gene

Molecular function for PRODH2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol
UniProtKB/Swiss-Prot Function: Converts proline to delta-1-pyrroline-5-carboxylate.

Enzyme Numbers (IUBMB) for PRODH2 Gene

Gene Ontology (GO) - Molecular Function for PRODH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004657 proline dehydrogenase activity IEA --
genes like me logo Genes that share ontologies with PRODH2: view

Phenotypes for PRODH2 Gene

GenomeRNAi human phenotypes for PRODH2:
genes like me logo Genes that share phenotypes with PRODH2: view

miRNA for PRODH2 Gene

miRTarBase miRNAs that target PRODH2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PRODH2 Gene

Localization for PRODH2 Gene

Gene Ontology (GO) - Cellular Components for PRODH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane IEA --
genes like me logo Genes that share ontologies with PRODH2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for PRODH2 Gene

Pathways for PRODH2 Gene

genes like me logo Genes that share pathways with PRODH2: view

Pathways by source for PRODH2 Gene

UniProtKB/Swiss-Prot Q9UF12-PROD2_HUMAN

  • Pathway: Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2

Interacting Proteins for PRODH2 Gene

Gene Ontology (GO) - Biological Process for PRODH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006562 proline catabolic process --
GO:0010133 proline catabolic process to glutamate IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with PRODH2: view

Compounds for PRODH2 Gene

(1) HMDB Compounds for PRODH2 Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
genes like me logo Genes that share compounds with PRODH2: view

Transcripts for PRODH2 Gene

mRNA/cDNA for PRODH2 Gene

Unigene Clusters for PRODH2 Gene

Proline dehydrogenase (oxidase) 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRODH2 Gene

No ASD Table

Relevant External Links for PRODH2 Gene

GeneLoc Exon Structure for
PRODH2
ECgene alternative splicing isoforms for
PRODH2

Expression for PRODH2 Gene

mRNA expression in normal human tissues for PRODH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRODH2 Gene

This gene is overexpressed in Liver (28.9) and Kidney - Cortex (22.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRODH2 Gene

SOURCE GeneReport for Unigene cluster for PRODH2 Gene Hs.515366

genes like me logo Genes that share expressions with PRODH2: view

No data available for mRNA Expression by UniProt/SwissProt for PRODH2 Gene

Orthologs for PRODH2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRODH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRODH2 35
  • 99.19 (n)
  • 99.07 (a)
PRODH2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRODH2 35
  • 85.28 (n)
  • 85.2 (a)
PRODH2 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRODH2 35
  • 86.55 (n)
  • 85.2 (a)
PRODH2 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prodh2 35
  • 80.83 (n)
  • 80.97 (a)
Prodh2 16
Prodh2 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRODH2 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prodh2 35
  • 80.83 (n)
  • 80.75 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68483 35
zebrafish
(Danio rerio)
Actinopterygii PRODH2 36
  • 41 (a)
OneToOne
zgc:92040 35
  • 55.58 (n)
  • 50 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUT1 36
  • 18 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ERD5 35
  • 41.18 (n)
  • 31.13 (a)
rice
(Oryza sativa)
Liliopsida Os10g0550900 35
  • 48.29 (n)
  • 37.32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8337 36
  • 36 (a)
OneToOne
Species with no ortholog for PRODH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRODH2 Gene

ENSEMBL:
Gene Tree for PRODH2 (if available)
TreeFam:
Gene Tree for PRODH2 (if available)

Paralogs for PRODH2 Gene

Paralogs for PRODH2 Gene

Selected SIMAP similar genes for PRODH2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PRODH2: view

Variants for PRODH2 Gene

Sequence variations from dbSNP and Humsavar for PRODH2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs401522 -- 35,803,677(+) ATCAC(A/G)TGCAC intron-variant
rs409792 -- 35,810,593(+) CTCGG(C/T)TTACT intron-variant
rs416341 -- 35,814,568(-) ttggg(A/G)ggaca upstream-variant-2KB
rs1133745 -- 35,799,998(-) CTTAG(C/G)TGCTG utr-variant-3-prime
rs2312051 -- 35,809,111(-) GGAAG(A/G)AAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRODH2 Gene

Variant ID Type Subtype PubMed ID
dgv3852n71 CNV Loss 21882294
dgv3853n71 CNV Loss 21882294
nsv911636 CNV Loss 21882294
nsv911637 CNV Loss 21882294
nsv911638 CNV Loss 21882294
esv2718500 CNV Deletion 23290073

Relevant External Links for PRODH2 Gene

HapMap Linkage Disequilibrium report
PRODH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRODH2 Gene

Disorders for PRODH2 Gene

(2) OMIM Diseases for PRODH2 Gene (606810)

Relevant External Links for PRODH2

Genetic Association Database (GAD)
PRODH2
Human Genome Epidemiology (HuGE) Navigator
PRODH2
genes like me logo Genes that share disorders with PRODH2: view

No data available for UniProtKB/Swiss-Prot for PRODH2 Gene

Publications for PRODH2 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  2. P53 family members modulate the expression of PRODH, but not PRODH2, via intronic p53 response elements. (PMID: 23861960) Raimondi I. … Campomenosi P. (PLoS ONE 2013) 3
  3. Genetic study of schizophrenia: new targets for therapy. (PMID: 19810846) Ujike H. … Nakata K. (Expert Rev Neurother 2003) 23
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. A novel function for hydroxyproline oxidase in apoptosis through generation of reactive oxygen species. (PMID: 18287100) Cooper S.K. … Phang J.M. (J. Biol. Chem. 2008) 3

Products for PRODH2 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate PRODH2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for PRODH2
    • Block miRNA regulation of PRODH2 using miScript Target Protectors

    Sources for PRODH2 Gene

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