PRODH Gene
protein-coding GIFtS: 67
GCID: GC22M018900
|
|
proline dehydrogenase (oxidase) 1(Previous name: proline dehydrogenase (proline oxidase ) )
| |
Aliases
for PRODH gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Proline Dehydrogenase (Oxidase) 11 2 | | Proline Dehydrogenase (Proline Oxidase )1 | | PIG61 2 3 | | POX2 | | PRODH21 2 5 | | Proline Dehydrogenase 1, Mitochondrial2 | | HSPOX21 2 | | Proline Oxidase, Mitochondrial2 | | PRODH11 2 | | Tumor Protein P53 Inducible Protein 62 | | TP53I61 2 | | POX23 | | Proline Oxidase 22 3 | | Proline Oxidase3 | | P53-Induced Gene 6 Protein2 3 | | SCZD45 | | EC 1.5.99.83 8 | | |
Export aliases for PRODH gene to outside databasesPrevious GC identifers: GC22M015840 GC22M017274 GC22M002522 |
Summaries
for PRODH gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PRODH:
This gene encodes a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this geneare associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4). This gene is located onchromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes, DiGeorge andCATCH22. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.(provided by RefSeq, Aug 2010)
UniProtKB/Swiss-Prot: PROD_HUMAN, O43272Function: Converts proline to delta-1-pyrroline-5-carboxylate
Gene Wiki entry for PRODH (Proline oxidase)
|
Genomic Views
for PRODH gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011519.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PRODH gene promoter:
COUP-TF1 RFX1 COUP HNF-4alpha2 HNF-4alpha1 CREB COUP-TF deltaCREB SEF-1 (1)
Other transcription factors
Search SABiosciences Chromatin IP Primers for PRODH
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRODH |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q11.21 Ensembl cytogenetic band: 22q11.21 HGNC cytogenetic band: 22q11.2PRODH Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M018900: view genomic region
(about GC identifiers)
Start:
|
18,900,294 bp from pter |
End:
|
18,924,066 bp from pter |
Size:
|
23,773 bases |
Orientation:
|
minus strand |
|
Proteins
for PRODH gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PROD_HUMAN, O43272 (See
protein sequence)Recommended Name: Proline dehydrogenase 1, mitochondrial precursor Size: 600 amino acids; 68002 Da
Cofactor: FAD
Subcellular location: Mitochondrion matrix
Sequence caution: Sequence=AAC39529.1; Type=Frameshift; Positions=540, 563, 568, 577, 580, 582; Sequence=AAH68260.1;Type=Frameshift; Positions=123; Sequence=AAH94736.1; Type=Frameshift; Positions=40; Sequence=AAH94736.1;Type=Miscellaneous discrepancy; Note=Artifact. Missing internal sequence that doesn't correspond to an exon-intronboundary; Sequence=BAD92709.1; Type=Miscellaneous discrepancy; Note=Intron retention. Includes intronic sequence atthe 5' end;
Secondary accessions: A6NF53 O14680 Q0P507 Q147W8 Q504W1 Q59FI8 Q6NV86 Q9UF13Alternative splicing: 3 isoforms: O43272-4 O43272-2 O43272-1 Explore the universe of human proteins at neXtProt for PRODH: NX_O43272
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O43272
4 DME Specific Peptides for PRODH (O43272)
PRODH Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001182155.1 NP_057419.4
ENSEMBL proteins: ENSP00000410805 ENSP00000334726 ENSP00000349577 ENSP00000409742 ENSP00000396806 ENSP00000413941 Reactome Protein details: O43272
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
PRODH for ontologies About GeneDecksing
PRODH Antibody Products:
Assay Products for PRODH: |
Protein
Domains /
Families
for PRODH gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PRODH for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O43272ProtoNet protein and cluster: O43272 1 Blocks protein family: IPB002872 Proline dehydrogenase
UniProtKB/Swiss-Prot: PROD_HUMAN, O43272Similarity: Belongs to the proline oxidase family |
Function
for PRODH gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PROD_HUMAN, O43272Function: Converts proline to delta-1-pyrroline-5-carboxylateCatalytic activity: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptorInduction: During p53/TP53-induced apoptosis Genatlas biochemistry entry for PRODH:proline dehydrogenase,Drosophila sluggish-A homolog,predominantly expressed in lung,skeletalmuscle,brain,heart,kidney,proline metabolic pathway,mitochondrial matrix,involved putatively in any psychiatricdisorders
Enzyme Number (IUBMB): EC 1.5.99.81 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRODH (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRODH
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): PRODH (NM_001195226) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRODH | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRODH |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRODH |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
PRODH for ontologies About GeneDecksing
Animal Models:
4 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Prodh):
PRODH for phenotypes About GeneDecksing
|
Pathways & Interactions
for PRODH gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Metabolism | | | 2 | Metabolism of amino acids and derivatives | | | 3 | Arginine and proline metabolism | | | 4 | proline degradation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Reactome Pathways for PRODH
2 
Kegg Pathways (Kegg details for PRODH):
UniProtKB/Swiss-Prot: PROD_HUMAN, O43272Pathway: Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2
PRODH for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRODH
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/21 Interacting proteins for PRODH (O432723 ENSP000003495774) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
PRODH for ontologies About GeneDecksing
|
Drugs & Compounds
for PRODH gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PRODH for compounds About GeneDecksing
 Browse Tocris compounds for PRODH
9 HMDB Compounds for PRODH About this table
1 DrugBank Compound for PRODH About this table
6 Novoseek chemical compound relationships for PRODH gene About this table
Search CenterWatch for drugs/clinical trials and news about PRODH / PROD
|
Transcripts
for PRODH gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PRODH gene (2 alternative transcripts): NM_001195226.1 NM_016335.4 Unigene Cluster for PRODH: Proline dehydrogenase (oxidase) 1 Hs.517352 [show with all ESTs]Unigene Representative Sequence: AB20947213 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000491604 ENST00000420436(uc002zoj.4) ENST00000313755 ENST00000429300
ENST00000482858 ENST00000334029 ENST00000357068(uc002zok.4 uc002zol.4)
ENST00000446371 ENST00000438924 ENST00000399694 ENST00000450579 ENST00000457083
ENST00000496625
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRODH (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRODH
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): PRODH (NM_001195226) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRODH | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRODH |
Additional cDNA sequence: AB209472.1 AK001359.1 AK091063.1 BC036534.1 BC068260.1 BC094736.1 BC118597.1 BC121809.1 U79754.1 13 DOTS entries: DT.100786983 DT.40304057 DT.120674956 DT.100024640 DT.97808873 DT.95365020 DT.92423385 DT.97842554 DT.92423380 DT.97842556 DT.120674953 DT.91804652 DT.97842555 24/97 AceView cDNA sequences (see all 97): BU730461 AW449360 H55548 CB216963 NM_016335 AW196957 T16831 CB153617 BM855026 BM726222 AI650486 AI566145 BV197306 BV196185 BU732414 BM709266 U79754 BI602093 BM929704 AK001359 CD671570 BC036534 BM996569 BM926123
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for PRODH (see all 8) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | - | | - | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for PRODH
|
Expression
for PRODH gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PRODH expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCTTGGACC
About this image
See PRODH Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PRODH
SOURCE GeneReport for Unigene cluster: Hs.517352
UniProtKB/Swiss-Prot: PROD_HUMAN, O43272Tissue specificity: Expressed in lung, skeletal muscle and brain, to a lesser extent in heart and kidney, and weakly inliver, placenta and pancreas
SABiosciences Expression via Pathway-Focused PCR Arrays including PRODH:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRODH
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PRODH | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRODH | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRODH | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRODH |
Orthologs
for PRODH gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PRODH gene from 7/25 species (see all 25) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PRODH1 |
proline dehydrogenase (oxidase) 1 |
77.32(n)
74.94(a) |
|
770734 XM_001234061.2 XP_001234062.2 |
lizard
(Anolis carolinensis) |
Reptilia |
PRODH6 |
-- |
68(a) |
1 ↔ 1 |
GL343417.1(748891-757810) |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.124602 |
Transcribed sequence with moderate similarity to protein more |
77.83(n) |
|
BG303940.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
slgA1 , 3 |
glutamine biosynthesis proline dehydrogenase3
sluggish A1 |
47(a)3
56.11(n)1
49.23(a)1 |
|
331171 NM_206805.21 NP_996528.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
B0513.53
CELE_B0513.51 |
Protein B0513.51 |
45(a)3
51.43(n)1
47.39(a)1 |
|
IV(13868957-13874501)3
1783501 NM_070268.31 NP_502669.21 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ATPOX6AT5G387106 |
proline dehydrogenase 2 |
28(a)27(a) |
many ↔ manymany ↔ many |
3(12448636-12451248) 5(15501245-15504109) |
rice
(Oryza sativa) |
Liliopsida |
-- |
proline oxidase, mitochondrial precursor, putative... |
28(a) |
1 → many |
10(21546430-21549067) |
ENSEMBL Gene Tree for PRODH (if available)
TreeFam Gene Tree for PRODH (if available) |
Paralogs
for PRODH gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PRODH gene
- PRODH22
1 SIMAP similar gene for PRODH using alignment to 5 protein entries: PROD_HUMAN (see all proteins):PRODH2
PRODH for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for PRODH
PGOHUM00000246409 PGOHUM00000237890
|
Genomic Variants
for PRODH gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PRODH (18900294 - 18924066 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 25 variations for PRODH
15/25 CNVs (see all 25): 3237 50803 34524 30148 34485 50800 73703 4116 34650 37722 53199 31070 73702 50802 34618
Human Gene Mutation Database (HGMD): PRODH
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRODH |
|
Disorders
/ Diseases
for PRODH gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PRODH for disorders About GeneDecksing
OMIM gene information: 606810
OMIM disorders: 239500 600850
UniProtKB/Swiss-Prot: PROD_HUMAN, O43272
Defects in PRODH are the cause of hyperprolinemia type 1 (HP-1) [MIM:239500]. HP-1 is a disorder characterizedby elevated serum proline levels. May be involved in the psychiatric and behavioral phenotypes associated with the22q11 velocardiofacial and DiGeorge syndrome Defects in PRODH are associated with susceptibility to schizophrenia type 4 (SCZD4) [MIM:600850]. A complex,multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content ofthought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship tothe external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposelessbehavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances areprimary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias inwhich disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolardisorder symptoms and are often given the diagnosis of schizoaffective disorder
20/22  diseases for PRODH (see all 22): About MalaCardshyperprolinemia contagious pustular dermatitis schizophrenia childhood-onset schizophrenia
schizoaffective disorder bipolar affective disorder velocardiofacial syndrome digeorge syndrome
primary hyperoxaluria schizophrenia 4 monkeypox bipolar disorder
psychotic disorder smallpox dermatitis vaccinia
renal carcinoma dementia colorectal cancer lung cancer
7 diseases from the University of Copenhagen DISEASES database for PRODH:Velocardiofacial syndrome Schizophrenia Primary hyperoxaluria DiGeorge syndrome
Smallpox Schizoaffective disorder Monkeypox 8 Novoseek disease relationships for PRODH gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hyperprolinemia, type i |
97.2 |
5 |
12217952 (1), 17135275 (1), 18197084 (1) |
| hyperprolinemia |
96.1 |
13 |
12217952 (3), 15494707 (3), 17135275 (1), 16389584 (1) |
| velocardiofacial syndrome |
74.8 |
1 |
17412540 (1) |
| digeorge syndrome |
74.7 |
3 |
19420922 (1), 15494707 (1) |
| schizophrenia |
66.1 |
44 |
15274030 (5), 14618678 (5), 17504246 (5), 16094254 (4) (see all 14) |
| schizoaffective disorder |
62.9 |
4 |
17504246 (1), 16389584 (1), 15494707 (1) |
| bipolar disorder |
47.6 |
11 |
16094254 (4), 14618678 (2), 16389584 (1), 15494707 (1) |
| psychotic |
12.9 |
2 |
14618678 (1), 15494707 (1) |
Genetic Association Database (GAD): PRODH
Human Genome Epidemiology (HuGE) Navigator: PRODH (20 documents)
Export disorders for PRODH gene to outside databases
|
Publications
for PRODH gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PRODH gene, integrated from 9 sources (see all 100):
(articles sorted by number of sources associating them with PRODH) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- PRODH mutations and hyperprolinemia in a subset of schizophrenic patients. (PubMed id 12217952)1, 2, 4, 9 Jacquet H.... Frebourg T. (2002)
- The gene encoding proline dehydrogenase modulates sensorimotor gating in mice. (PubMed id 10192398)1, 2, 3, 9 Gogos J.A.... Karayiorgou M. (1999)
- Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia. (PubMed id 11891283)1, 2, 4, 9 Liu H....Karayiorgou M. (2002)
- A human homologue of the Drosophila melanogaster sluggish-A (proline oxidase) gene maps to 22q11.2, and is a candidate gene for type-I hyperprolinaemia. (PubMed id 9385373)1, 2, 3 Campbell H.D.... Young I.G. (1997)
- No evidence for an association between variants at the proline dehydrogenase locus and schizophrenia or bipolar affective disorder. (PubMed id 16094254)1, 4, 9 Abou Jamra R....Cichon S. (2005)
- Detailed analysis of PRODH and PsPRODH reveals no association with schizophrenia. (PubMed id 12815738)1, 4, 9 Williams H.J....O'Donovan M.C. (2003)
- Involvement of hyperprolinemia in cognitive and psychiatric features of the 22q11 deletion syndrome. (PubMed id 17135275)1, 2, 9 Raux G....Campion D. (2007)
- Functional consequences of PRODH missense mutations. (PubMed id 15662599)1, 2 Bender H.-U.... Valle D. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A model for p53-induced apoptosis. (PubMed id 9305847)1, 2 Polyak K....Vogelstein B. (1997)
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External Searches for PRODH gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing PRODH gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing PRODH gene
(According to HUGE)
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Specialized Databases showing PRODH gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for PRODH gene:
Search GeneIP for patents involving PRODH
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for PRODH gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for PRODH | | OriGene shRNA RFP for PRODH | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRODH | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRODH | | | OriGene Protein Over-expression Lysate for PRODH | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PRODH | | OriGene 3'-UTR Clone for PRODH | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRODH | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRODH | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PRODH | | OriGene Custom Protein Services for PRODH | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PRODH | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRODH | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRODH | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRODH | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRODH | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRODH |
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| | | | Search Tocris compounds for PRODH |
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 | | | PRODH Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRODH |
|  |  |  | | | | Search ThermoFisher Antibodies for PRODH |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRODH |
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