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Aliases for PROCR Gene

Aliases for PROCR Gene

  • Protein C Receptor 2 3 5
  • Protein C Receptor, Endothelial 2 3
  • Activated Protein C Receptor 3 4
  • CD201 Antigen 3 4
  • APC Receptor 3 4
  • EPCR 3 4
  • Cell Cycle, Centrosome-Associated Protein 3
  • Endothelial Cell Protein C Receptor 4
  • Endothelial Protein C Receptor 3
  • Centrocyclin 3
  • CCD41 3
  • CCCA 3

External Ids for PROCR Gene

Previous GeneCards Identifiers for PROCR Gene

  • GC20P033518
  • GC20P034428
  • GC20P034476
  • GC20P034477
  • GC20P033223
  • GC20P033758
  • GC20P030537

Summaries for PROCR Gene

Entrez Gene Summary for PROCR Gene

  • The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013]

GeneCards Summary for PROCR Gene

PROCR (Protein C Receptor) is a Protein Coding gene. Diseases associated with PROCR include Purpura Fulminans and Thrombophilia. Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+. GO annotations related to this gene include receptor activity.

UniProtKB/Swiss-Prot for PROCR Gene

  • Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.

Gene Wiki entry for PROCR Gene

Additional gene information for PROCR Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PROCR Gene

Genomics for PROCR Gene

Regulatory Elements for PROCR Gene

Enhancers for PROCR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H034954 1.4 ENCODE dbSUPER 18.6 -216.0 -215993 2.7 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 RBM12 RBM39 NCOA6 CPNE1 ERGIC3 ENSG00000272945 PROCR RPL36P4 MYH7B TRPC4AP
GH20H035170 0.9 ENCODE 19.5 +0.2 169 2.3 SIN3A YBX1 TCF12 ZNF121 GLIS2 GATA2 SP3 SMARCB1 ZNF184 GLIS1 PROCR RBM12 RBM39 CPNE1 ERGIC3 RPL36P4 TRPC4AP EDEM2 MMP24-AS1 ENSG00000278367
GH20H035615 1.4 ENCODE dbSUPER 11.7 +445.9 445891 5 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC CPNE1 RBM12 RBM39 C20orf173 RPF2P1 HMGB3P2 ENSG00000242507 AAR2 PROCR GDF5
GH20H035436 1.2 Ensembl ENCODE 13.5 +266.2 266160 3.4 ATF1 ZNF493 ARID4B GLIS2 ZNF302 ZNF416 ZNF143 ATF7 MCM3 YY2 UQCC1 RBM12 GGT7 NCOA6 RBM39 AAR2 CPNE1 PROCR ERGIC3 MMP24-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PROCR on UCSC Golden Path with GeneCards custom track

Promoters for PROCR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000136517 163 601 HDAC1 SREBF2 SIN3A YBX1 TCF12 ZNF121 GLIS2 GATA2 ZNF366 SCRT2

Genomic Locations for PROCR Gene

Genomic Locations for PROCR Gene
44,304 bases
Plus strand

Genomic View for PROCR Gene

Genes around PROCR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PROCR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PROCR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PROCR Gene

Proteins for PROCR Gene

  • Protein details for PROCR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Endothelial protein C receptor
    Protein Accession:
    Secondary Accessions:
    • B2RC04
    • Q14218
    • Q6IB56
    • Q96CB3
    • Q9ULX1

    Protein attributes for PROCR Gene

    238 amino acids
    Molecular mass:
    26671 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PROCR Gene

neXtProt entry for PROCR Gene

Post-translational modifications for PROCR Gene

  • A soluble form exists; probably released by a metalloprotease. Seems to have the same activity as the membrane-bound form.
  • N-glycosylated.
  • Glycosylation at Asn47, isoforms=64, isoforms=136, and Asn172
  • Modification sites at PhosphoSitePlus

Other Protein References for PROCR Gene

No data available for DME Specific Peptides for PROCR Gene

Domains & Families for PROCR Gene

Gene Families for PROCR Gene

Human Protein Atlas (HPA):
  • Candidate cardiovascular disease genes
  • CD markers
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PROCR Gene

Suggested Antigen Peptide Sequences for PROCR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PROCR: view

No data available for UniProtKB/Swiss-Prot for PROCR Gene

Function for PROCR Gene

Molecular function for PROCR Gene

UniProtKB/Swiss-Prot Function:
Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.

Phenotypes From GWAS Catalog for PROCR Gene

Gene Ontology (GO) - Molecular Function for PROCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IEA --
GO:0005515 protein binding IPI 20826780
genes like me logo Genes that share ontologies with PROCR: view
genes like me logo Genes that share phenotypes with PROCR: view

Animal Models for PROCR Gene

MGI Knock Outs for PROCR:

Animal Model Products

miRNA for PROCR Gene

miRTarBase miRNAs that target PROCR

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PROCR Gene

Localization for PROCR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PROCR Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PROCR gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 3
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for PROCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005813 centrosome IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7929370
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with PROCR: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PROCR Gene

Pathways & Interactions for PROCR Gene

genes like me logo Genes that share pathways with PROCR: view

Interacting Proteins for PROCR Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)
Selected Interacting proteins: Q9UNN8-EPCR_HUMAN ENSP00000216968 for PROCR Gene via IID UniProtKB STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for PROCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007596 blood coagulation TAS --
GO:0007599 hemostasis IEA --
GO:0050819 negative regulation of coagulation IMP 19696402
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with PROCR: view

No data available for SIGNOR curated interactions for PROCR Gene

Drugs & Compounds for PROCR Gene

(8) Drugs for PROCR Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Drotrecogin alfa Approved, Investigational, Withdrawn Pharma Target 0
Phosphatidylethanolamine Experimental Pharma Target 0
GED-APC Pharma 0

(8) Additional Compounds for PROCR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PROCR: view

Transcripts for PROCR Gene

Unigene Clusters for PROCR Gene

Protein C receptor, endothelial:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PROCR Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7
SP1: - - -
SP2: -
SP3: -

Relevant External Links for PROCR Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PROCR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PROCR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PROCR Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x5.3).

Protein differential expression in normal tissues from HIPED for PROCR Gene

This gene is overexpressed in Urine (25.1) and Serum (23.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PROCR Gene

NURSA nuclear receptor signaling pathways regulating expression of PROCR Gene:


SOURCE GeneReport for Unigene cluster for PROCR Gene:


mRNA Expression by UniProt/SwissProt for PROCR Gene:

Tissue specificity: Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.

Evidence on tissue expression from TISSUES for PROCR Gene

  • Heart(4.6)
  • Pancreas(4.1)
  • Lung(3)
  • Blood(2.5)
  • Skin(2.4)
  • Nervous system(2.2)
  • Intestine(2.1)
  • Kidney(2.1)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with PROCR: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PROCR Gene

Orthologs for PROCR Gene

This gene was present in the common ancestor of chordates.

Orthologs for PROCR Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PROCR 33 34
  • 99.16 (n)
(Canis familiaris)
Mammalia PROCR 33 34
  • 85.04 (n)
(Bos Taurus)
Mammalia PROCR 33 34
  • 79.85 (n)
(Rattus norvegicus)
Mammalia Procr 33
  • 79.67 (n)
(Mus musculus)
Mammalia Procr 33 16 34
  • 78.77 (n)
(Monodelphis domestica)
Mammalia PROCR 34
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia PROCR 34
  • 42 (a)
(Gallus gallus)
Aves PROCR 33 34
  • 56.81 (n)
(Anolis carolinensis)
Reptilia PROCR 34
  • 34 (a)
Species where no ortholog for PROCR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PROCR Gene

Gene Tree for PROCR (if available)
Gene Tree for PROCR (if available)

Paralogs for PROCR Gene

No data available for Paralogs for PROCR Gene

Variants for PROCR Gene

Sequence variations from dbSNP and Humsavar for PROCR Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000032424 -- 35,188,934(+) TATGC(C/T)TGTCT intron-variant
rs1000108047 -- 35,212,590(+) CACAG(C/G)CACAC intron-variant
rs1000207485 -- 35,182,896(+) TTGCA(C/G)CCAGG intron-variant
rs1000311052 -- 35,172,641(+) GAAGT(A/G/T)GGGGA intron-variant
rs1000418473 -- 35,170,866(+) TATGA(A/G)GATGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PROCR Gene

Variant ID Type Subtype PubMed ID
esv3645712 CNV gain 21293372

Variation tolerance for PROCR Gene

Residual Variation Intolerance Score: 66.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.18; 69.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PROCR Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PROCR Gene

Disorders for PROCR Gene

MalaCards: The human disease database

(7) MalaCards diseases for PROCR Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
purpura fulminans
  • purpura gangrenosa
  • hypercoagulability state
thrombophilia due to thrombin defect
  • thromboembolism
  • purpuric disorder
- elite association - COSMIC cancer census association via MalaCards
Search PROCR in MalaCards View complete list of genes associated with diseases

Relevant External Links for PROCR

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PROCR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PROCR Gene

Publications for PROCR Gene

  1. The A6936G polymorphism of the endothelial protein C receptor gene is associated with the risk of unexplained foetal loss in Mediterranean European couples. (PMID: 19806250) Cochery-Nouvellon E … Gris JC (Thrombosis and haemostasis 2009) 3 22 45 60
  2. Haplotypes of the EPCR gene, prothrombin levels, and the risk of venous thrombosis in carriers of the prothrombin G20210A mutation. (PMID: 18403391) Navarro S … España F (Haematologica 2008) 3 22 45 60
  3. Association of endothelial protein C receptor haplotypes, factor V Leiden and recurrent first trimester pregnancy loss. (PMID: 18539144) Hopmeier P … Dossenbach-Glaninger A (Clinical biochemistry 2008) 3 22 45 60
  4. PROC, PROCR and PROS1 polymorphisms, plasma anticoagulant phenotypes, and risk of cardiovascular disease and mortality in older adults: the Cardiovascular Health Study. (PMID: 18680534) Reiner AP … Lange LA (Journal of thrombosis and haemostasis : JTH 2008) 3 22 45 60
  5. Endothelial protein C receptor polymorphisms and risk of myocardial infarction. (PMID: 18757851) Medina P … RECAVA Thrombosis Groups (Haematologica 2008) 3 22 45 60

Products for PROCR Gene

Sources for PROCR Gene

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