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Aliases for PROCR Gene

Aliases for PROCR Gene

  • Protein C Receptor 2 3 5
  • Protein C Receptor, Endothelial 2 3
  • Activated Protein C Receptor 3 4
  • CD201 Antigen 3 4
  • APC Receptor 3 4
  • EPCR 3 4
  • Cell Cycle, Centrosome-Associated Protein 3
  • Endothelial Cell Protein C Receptor 4
  • Endothelial Protein C Receptor 3
  • Centrocyclin 3
  • CCD41 3
  • CCCA 3

External Ids for PROCR Gene

Previous GeneCards Identifiers for PROCR Gene

  • GC20P033518
  • GC20P034428
  • GC20P034476
  • GC20P034477
  • GC20P033223
  • GC20P033758
  • GC20P030537

Summaries for PROCR Gene

Entrez Gene Summary for PROCR Gene

  • The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013]

GeneCards Summary for PROCR Gene

PROCR (Protein C Receptor) is a Protein Coding gene. Diseases associated with PROCR include Purpura Fulminans and Thrombophilia. Among its related pathways are Cell surface interactions at the vascular wall and Formation of Fibrin Clot (Clotting Cascade). GO annotations related to this gene include receptor activity.

UniProtKB/Swiss-Prot for PROCR Gene

  • Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.

Gene Wiki entry for PROCR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PROCR Gene

Genomics for PROCR Gene

Regulatory Elements for PROCR Gene

Enhancers for PROCR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F035410 1.1 ENCODE 23.6 +239.8 239848 2.1 HDGF PKNOX1 ARNT MLX WRNIP1 ZFP64 ARID4B SIN3A YBX1 DMAP1 RBM12 UQCC1 CPNE1 PROCR AAR2 TRPC4AP EIF6 RPL36P4 PIGU FAM83C
GH20F035091 0.6 ENCODE 21.9 -79.3 -79307 3.2 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 PROCR RBM12 NCOA6 CPNE1 RPL36P4 TRPC4AP ITCH ENSG00000272945 MMP24-AS1 PIR41538
GH20F036049 0.7 ENCODE 21.7 +879.2 879172 2.6 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 CPNE1 AAR2 RBM12 PROCR TGIF2 MYL9 RPL36P4 TRPC4AP CNBD2 DLGAP4-AS1
GH20F035765 1 FANTOM5 ENCODE 19.7 +597.6 597609 9.2 HDGF PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 CPNE1 RBM12 NCOA6 PHF20 AAR2 TRPC4AP PROCR RPF2P1 C20orf173 HMGB3P2
GH20F035170 0.8 ENCODE 19.5 +0.2 169 2.3 HDAC1 SREBF2 SIN3A YBX1 ZNF121 GLIS2 ZNF366 GATA2 SCRT2 RCOR1 PROCR RBM12 CPNE1 RPL36P4 TRPC4AP EDEM2 MMP24-AS1 ENSG00000278367
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PROCR on UCSC Golden Path with GeneCards custom track

Promoters for PROCR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001836964 463 1601 HDAC1 SIN3A YBX1 ZNF121 GLIS2 ZNF366 GATA2 SCRT2 RCOR1 ZNF263
ENSR00000400235 1563 201 ZNF362

Genomic Location for PROCR Gene

Chromosome:
20
Start:
35,171,937 bp from pter
End:
35,216,240 bp from pter
Size:
44,304 bases
Orientation:
Plus strand

Genomic View for PROCR Gene

Genes around PROCR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PROCR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PROCR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PROCR Gene

Proteins for PROCR Gene

  • Protein details for PROCR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNN8-EPCR_HUMAN
    Recommended name:
    Endothelial protein C receptor
    Protein Accession:
    Q9UNN8
    Secondary Accessions:
    • B2RC04
    • Q14218
    • Q6IB56
    • Q96CB3
    • Q9ULX1

    Protein attributes for PROCR Gene

    Size:
    238 amino acids
    Molecular mass:
    26671 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PROCR Gene

neXtProt entry for PROCR Gene

Post-translational modifications for PROCR Gene

  • A soluble form exists; probably released by a metalloprotease. Seems to have the same activity as the membrane-bound form.
  • N-glycosylated.
  • Glycosylation at Asn 47, Asn 64, Asn 136, and Asn 172
  • Modification sites at PhosphoSitePlus

Other Protein References for PROCR Gene

No data available for DME Specific Peptides for PROCR Gene

Domains & Families for PROCR Gene

Gene Families for PROCR Gene

Protein Domains for PROCR Gene

Suggested Antigen Peptide Sequences for PROCR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PROCR: view

No data available for UniProtKB/Swiss-Prot for PROCR Gene

Function for PROCR Gene

Molecular function for PROCR Gene

UniProtKB/Swiss-Prot Function:
Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.

Gene Ontology (GO) - Molecular Function for PROCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 7929370
GO:0005515 protein binding IPI 20826780
genes like me logo Genes that share ontologies with PROCR: view
genes like me logo Genes that share phenotypes with PROCR: view

Animal Models for PROCR Gene

MGI Knock Outs for PROCR:

Animal Model Products

  • Taconic Biosciences Mouse Models for PROCR

miRNA for PROCR Gene

miRTarBase miRNAs that target PROCR

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PROCR Gene

Localization for PROCR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PROCR Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PROCR Gene COMPARTMENTS Subcellular localization image for PROCR gene
Compartment Confidence
extracellular 5
plasma membrane 5
nucleus 3
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for PROCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005813 centrosome IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7929370
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with PROCR: view

Pathways & Interactions for PROCR Gene

genes like me logo Genes that share pathways with PROCR: view

Interacting Proteins for PROCR Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000216968%0d%0a9606.ENSP00000234071%0d%0a9606.ENSP00000321326%0d%0a9606.ENSP00000351717%0d%0a9606.ENSP00000264932%0d%0a9606.ENSP00000342070%0d%0a
Selected Interacting proteins: ENSP00000216968 Q9UNN8-EPCR_HUMAN for PROCR Gene via STRING UniProtKB IID

Symbol External ID(s) Details
HLA-B
HLA-A
HLA-C
HLA-DRB1
F2R

Gene Ontology (GO) - Biological Process for PROCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007596 blood coagulation TAS --
GO:0007599 hemostasis IEA --
GO:0050819 negative regulation of coagulation IMP 19696402
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with PROCR: view

No data available for SIGNOR curated interactions for PROCR Gene

Drugs & Compounds for PROCR Gene

(8) Drugs for PROCR Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Drotrecogin alfa Approved, Investigational, Withdrawn Pharma Target 0
Phosphatidylethanolamine Experimental Pharma Target 0
GED-APC Pharma 0

(8) Additional Compounds for PROCR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PROCR: view

Transcripts for PROCR Gene

mRNA/cDNA for PROCR Gene

Unigene Clusters for PROCR Gene

Protein C receptor, endothelial:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PROCR Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7
SP1: - - -
SP2: -
SP3: -
SP4:

Relevant External Links for PROCR Gene

GeneLoc Exon Structure for
PROCR
ECgene alternative splicing isoforms for
PROCR

Expression for PROCR Gene

mRNA expression in normal human tissues for PROCR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PROCR Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x5.3).

Protein differential expression in normal tissues from HIPED for PROCR Gene

This gene is overexpressed in Urine (25.1) and Serum (23.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PROCR Gene



NURSA nuclear receptor signaling pathways regulating expression of PROCR Gene:

PROCR

SOURCE GeneReport for Unigene cluster for PROCR Gene:

Hs.647450

mRNA Expression by UniProt/SwissProt for PROCR Gene:

Q9UNN8-EPCR_HUMAN
Tissue specificity: Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.
genes like me logo Genes that share expression patterns with PROCR: view

Primer Products

No data available for Protein tissue co-expression partners for PROCR Gene

Orthologs for PROCR Gene

This gene was present in the common ancestor of chordates.

Orthologs for PROCR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PROCR 34 35
  • 99.16 (n)
dog
(Canis familiaris)
Mammalia PROCR 34 35
  • 85.04 (n)
cow
(Bos Taurus)
Mammalia PROCR 34 35
  • 79.85 (n)
rat
(Rattus norvegicus)
Mammalia Procr 34
  • 79.67 (n)
mouse
(Mus musculus)
Mammalia Procr 34 16 35
  • 78.77 (n)
oppossum
(Monodelphis domestica)
Mammalia PROCR 35
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PROCR 35
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves PROCR 34 35
  • 56.81 (n)
lizard
(Anolis carolinensis)
Reptilia PROCR 35
  • 34 (a)
OneToOne
Species where no ortholog for PROCR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PROCR Gene

ENSEMBL:
Gene Tree for PROCR (if available)
TreeFam:
Gene Tree for PROCR (if available)

Paralogs for PROCR Gene

No data available for Paralogs for PROCR Gene

Variants for PROCR Gene

Sequence variations from dbSNP and Humsavar for PROCR Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1051056 -- 35,177,185(+) CATCC(A/C)CAATC intron-variant, utr-variant-3-prime
rs10564067 -- 35,180,848(+) TGTTG(-/TTTGTTT)TTTGT intron-variant
rs10747514 -- 35,187,566(+) TCTCT(A/G)AAAAT intron-variant
rs111285879 -- 35,193,989(+) CAGTG(A/G)GGTGT intron-variant
rs111308605 -- 35,179,102(+) GTTGC(A/G)GGCGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PROCR Gene

Variant ID Type Subtype PubMed ID
esv3645712 CNV gain 21293372

Variation tolerance for PROCR Gene

Residual Variation Intolerance Score: 66.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.18; 69.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PROCR Gene

Human Gene Mutation Database (HGMD)
PROCR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PROCR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PROCR Gene

Disorders for PROCR Gene

MalaCards: The human disease database

(7) MalaCards diseases for PROCR Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
purpura fulminans
  • purpura gangrenosa
thrombophilia
  • hypercoagulability state
thrombophilia due to thrombin defect
  • thromboembolism
purpura
  • purpuric disorder
meningococcemia
- elite association - COSMIC cancer census association via MalaCards
Search PROCR in MalaCards View complete list of genes associated with diseases

Relevant External Links for PROCR

Genetic Association Database (GAD)
PROCR
Human Genome Epidemiology (HuGE) Navigator
PROCR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PROCR
genes like me logo Genes that share disorders with PROCR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PROCR Gene

Publications for PROCR Gene

  1. The A6936G polymorphism of the endothelial protein C receptor gene is associated with the risk of unexplained foetal loss in Mediterranean European couples. (PMID: 19806250) Cochery-Nouvellon E. … Gris J.C. (Thromb. Haemost. 2009) 3 22 46 64
  2. Haplotypes of the EPCR gene, prothrombin levels, and the risk of venous thrombosis in carriers of the prothrombin G20210A mutation. (PMID: 18403391) Navarro S. … EspaA+a F. (Haematologica 2008) 3 22 46 64
  3. Association of endothelial protein C receptor haplotypes, factor V Leiden and recurrent first trimester pregnancy loss. (PMID: 18539144) Hopmeier P. … Dossenbach-Glaninger A. (Clin. Biochem. 2008) 3 22 46 64
  4. PROC, PROCR and PROS1 polymorphisms, plasma anticoagulant phenotypes, and risk of cardiovascular disease and mortality in older adults: the Cardiovascular Health Study. (PMID: 18680534) Reiner A.P. … Lange L.A. (J. Thromb. Haemost. 2008) 3 22 46 64
  5. Endothelial protein C receptor polymorphisms and risk of myocardial infarction. (PMID: 18757851) Medina P. … EspaA+a F. (Haematologica 2008) 3 22 46 64

Products for PROCR Gene

Sources for PROCR Gene

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