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Aliases for PROCR Gene

Aliases for PROCR Gene

  • Protein C Receptor, Endothelial 2 3
  • Activated Protein C Receptor 3 4
  • CD201 Antigen 3 4
  • APC Receptor 3 4
  • EPCR 3 4
  • Cell Cycle, Centrosome-Associated Protein 3
  • Endothelial Cell Protein C Receptor 4
  • Centrocyclin 3
  • CCD41 3
  • CCCA 3

External Ids for PROCR Gene

Previous GeneCards Identifiers for PROCR Gene

  • GC20P033518
  • GC20P034428
  • GC20P034476
  • GC20P034477
  • GC20P033223
  • GC20P033758
  • GC20P030537

Summaries for PROCR Gene

Entrez Gene Summary for PROCR Gene

  • The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013]

GeneCards Summary for PROCR Gene

PROCR (Protein C Receptor, Endothelial) is a Protein Coding gene. Diseases associated with PROCR include meningococcemia and thrombophilia. Among its related pathways are Hemostasis and Formation of Fibrin Clot (Clotting Cascade). GO annotations related to this gene include receptor activity.

UniProtKB/Swiss-Prot for PROCR Gene

  • Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation

Gene Wiki entry for PROCR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PROCR Gene

Genomics for PROCR Gene

Regulatory Elements for PROCR Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PROCR Gene

Chromosome:
20
Start:
35,171,937 bp from pter
End:
35,215,989 bp from pter
Size:
44,053 bases
Orientation:
Plus strand

Genomic View for PROCR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PROCR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PROCR Gene

Proteins for PROCR Gene

  • Protein details for PROCR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNN8-EPCR_HUMAN
    Recommended name:
    Endothelial protein C receptor
    Protein Accession:
    Q9UNN8
    Secondary Accessions:
    • B2RC04
    • Q14218
    • Q6IB56
    • Q96CB3
    • Q9ULX1

    Protein attributes for PROCR Gene

    Size:
    238 amino acids
    Molecular mass:
    26671 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PROCR Gene

neXtProt entry for PROCR Gene

Proteomics data for PROCR Gene at MOPED

Post-translational modifications for PROCR Gene

  • A soluble form exists; probably released by a metalloprotease. Seems to have the same activity as the membrane-bound form
  • N-glycosylated.
  • Glycosylation at Asn 47, Asn 64, Asn 136, and Asn 172
  • Modification sites at PhosphoSitePlus

Other Protein References for PROCR Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PROCR Gene

Domains & Families for PROCR Gene

Gene Families for PROCR Gene

Protein Domains for PROCR Gene

Suggested Antigen Peptide Sequences for PROCR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PROCR: view

No data available for UniProtKB/Swiss-Prot for PROCR Gene

Function for PROCR Gene

Molecular function for PROCR Gene

UniProtKB/Swiss-Prot Function:
Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation

Gene Ontology (GO) - Molecular Function for PROCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 7929370
GO:0005515 protein binding IPI 20826780
genes like me logo Genes that share ontologies with PROCR: view
genes like me logo Genes that share phenotypes with PROCR: view

Animal Models for PROCR Gene

MGI Knock Outs for PROCR:

Animal Model Products

CRISPR Products

miRNA for PROCR Gene

miRTarBase miRNAs that target PROCR

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PROCR Gene

Localization for PROCR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PROCR Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PROCR Gene COMPARTMENTS Subcellular localization image for PROCR gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytoskeleton 2
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for PROCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005813 centrosome IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7929370
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with PROCR: view

Pathways & Interactions for PROCR Gene

genes like me logo Genes that share pathways with PROCR: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PROCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IEA --
GO:0007596 blood coagulation TAS --
GO:0019882 antigen processing and presentation --
GO:0050819 negative regulation of coagulation IMP 19696402
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with PROCR: view

No data available for SIGNOR curated interactions for PROCR Gene

Drugs & Compounds for PROCR Gene

(8) Drugs for PROCR Gene - From: NovoSeek, DrugBank, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Drotrecogin alfa Approved, Investigational, Withdrawn Pharma Target 0
Nitric Oxide Approved Pharma 540
Phosphatidylethanolamine Experimental Pharma Target 0
1,10-phenanthroline Experimental Pharma 0
GED-APC Pharma 0

(8) Additional Compounds for PROCR Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cystathionine
Endotoxin
FIBRINOGEN
gamma-Carboxyglutamic acid
53445-96-8
HIRUDIN
genes like me logo Genes that share compounds with PROCR: view

Transcripts for PROCR Gene

mRNA/cDNA for PROCR Gene

Unigene Clusters for PROCR Gene

Protein C receptor, endothelial:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PROCR

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PROCR Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7
SP1: - - -
SP2: -
SP3: -
SP4:

Relevant External Links for PROCR Gene

GeneLoc Exon Structure for
PROCR
ECgene alternative splicing isoforms for
PROCR

Expression for PROCR Gene

mRNA expression in normal human tissues for PROCR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PROCR Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x5.3).

Protein differential expression in normal tissues from HIPED for PROCR Gene

This gene is overexpressed in Urine (25.1) and Serum (23.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PROCR Gene



SOURCE GeneReport for Unigene cluster for PROCR Gene Hs.647450

mRNA Expression by UniProt/SwissProt for PROCR Gene

Q9UNN8-EPCR_HUMAN
Tissue specificity: Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney
genes like me logo Genes that share expression patterns with PROCR: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for PROCR Gene

Orthologs for PROCR Gene

This gene was present in the common ancestor of chordates.

Orthologs for PROCR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PROCR 35
  • 79.85 (n)
  • 72 (a)
PROCR 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PROCR 35
  • 85.04 (n)
  • 77.78 (a)
PROCR 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Procr 35
  • 78.77 (n)
  • 68.61 (a)
Procr 16
Procr 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PROCR 35
  • 99.16 (n)
  • 98.74 (a)
PROCR 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Procr 35
  • 79.67 (n)
  • 69.51 (a)
oppossum
(Monodelphis domestica)
Mammalia PROCR 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PROCR 36
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves PROCR 35
  • 56.81 (n)
  • 42.47 (a)
PROCR 36
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PROCR 36
  • 34 (a)
OneToOne
Species with no ortholog for PROCR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PROCR Gene

ENSEMBL:
Gene Tree for PROCR (if available)
TreeFam:
Gene Tree for PROCR (if available)

Paralogs for PROCR Gene

No data available for Paralogs for PROCR Gene

Variants for PROCR Gene

Sequence variations from dbSNP and Humsavar for PROCR Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs140612906 -- 35,176,195(+) CCTGG(A/G)CTGTG missense, reference
rs140847619 -- 35,201,181(+) AAAAA(-/CCAC)AAAAG intron-variant
rs140609135 -- 35,205,089(+) CCAAC(A/G)TGGTG intron-variant
rs140466168 -- 35,209,871(+) ATAGC(C/G)TATGG intron-variant
rs140449000 -- 35,180,995(+) CCGAG(C/T)AGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PROCR Gene

Variant ID Type Subtype PubMed ID
nsv912861 CNV Gain 21882294
nsv912862 CNV Gain 21882294

Variation tolerance for PROCR Gene

Residual Variation Intolerance Score: 66.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.18; 69.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PROCR Gene

HapMap Linkage Disequilibrium report
PROCR
Human Gene Mutation Database (HGMD)
PROCR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PROCR Gene

Disorders for PROCR Gene

MalaCards: The human disease database

(6) MalaCards diseases for PROCR Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
meningococcemia
thrombophilia
  • hypercoagulability state
disseminated intravascular coagulation
  • dic
thrombophilia due to thrombin defect
  • thromboembolism
myocardial infarction
  • myocardial infarction, protection against
- elite association
Search PROCR in MalaCards View complete list of genes associated with diseases

Relevant External Links for PROCR

Genetic Association Database (GAD)
PROCR
Human Genome Epidemiology (HuGE) Navigator
PROCR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PROCR
genes like me logo Genes that share disorders with PROCR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PROCR Gene

Publications for PROCR Gene

  1. One single mRNA encodes the centrosomal protein CCD41 and the endothelial cell protein C receptor (EPCR). (PMID: 10518938) Rothbarth K. … Werner D. (FEBS Lett. 1999) 2 23 67
  2. Activation mechanism of anticoagulant protein C in large blood vessels involving the endothelial cell protein C receptor. (PMID: 9529319) Fukudome K. … Kimoto M. (J. Exp. Med. 1998) 23 25 67
  3. Factor VIIa interaction with endothelial cells and endothelial cell protein C receptor. (PMID: 20156643) Pendurthi U.R. … Rao L.V. (Thromb. Res. 2010) 23 67
  4. The endothelial cells downregulate the generation of factor VIIa through EPCR binding. (PMID: 20085578) Puy C. … Montes R. (Br. J. Haematol. 2010) 23 67
  5. Coagulation factor Xa cleaves protease-activated receptor-1 and mediates signaling dependent on binding to the endothelial protein C receptor. (PMID: 19895674) Schuepbach R.A. … Riewald M. (J. Thromb. Haemost. 2010) 23 67

Products for PROCR Gene

Sources for PROCR Gene

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