Aliases for PROCR Gene
External Ids for PROCR Gene
Previous GeneCards Identifiers for PROCR Gene
The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013]
GeneCards Summary for PROCR Gene
PROCR (Protein C Receptor, Endothelial) is a Protein Coding gene. Diseases associated with PROCR include meningococcemia and thrombophilia. Among its related pathways are Hemostasis and Formation of Fibrin Clot (Clotting Cascade). GO annotations related to this gene include receptor activity.
UniProtKB/Swiss-Prot for PROCR Gene
Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation